Molecular Control of Growth-Related Sodium-Phosphate Co-transporter (SLC34A3) View Full Text


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Article Info

DATE

2019-03

AUTHORS

Hiroko Segawa, Ichiro Kaneko, Yuji Shiozaki, Mikiko Ito, Sawako Tatsumi, Ken-Ichi Miyamoto

ABSTRACT

The type IIa sodium-dependent inorganic phosphate transporter (NaPi-IIa) has a central regulatory role in inorganic phosphate (Pi) homeostasis. Many studies have reported on the functions and regulatory mechanisms of NaPi-IIa. NaPi-IIc, however, was initially identified as a NaPi transporter required for growth in rodents. The gene encoding NaPi-IIc is causative for hereditary hypophosphatemic rickets with hypercalciuria and considered to be a critical NaPi transporter in the human kidney. However, the physiological roles and regulatory mechanisms of NaPi-IIc are not sufficiently elucidated. Recent studies show that NaPi-IIc is tightly regulated by a variety of agonists and physiological conditions via partially defined molecular mechanisms, including transcriptional and posttranscriptional regulation, protein phosphorylation, trafficking (endocytosis, exocytosis, and recycling), and the association of NaPi-IIc with interacting protein complexes. These data provide further information about understanding of human renal Pi handling. Here, we review recent findings regarding the molecular control of NaPi-IIc transporters. More... »

PAGES

1-8

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40610-019-0112-7

    DOI

    http://dx.doi.org/10.1007/s40610-019-0112-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111627913


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