The Role of the Calcitonin Peptide Family in Prostate Cancer and Bone Metastasis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-09

AUTHORS

Jessica Isabel Warrington, Gareth Owain Richards, Ning Wang

ABSTRACT

PURPOSE OF REVIEW: This study is to highlight recent discoveries associated with the role of calcitonin peptide family and their receptors in prostate cancer progression and bone metastasis. RECENT FINDINGS: Studies have linked adrenomedullin (AM), calcitonin (CT) and calcitonin gene-related peptide (CGRP) to the spread of prostate tumours to the bone. AM can induce a metastatic phenotype in prostate cancer cells through its action on TRPV2 calcium channels and is also capable of influencing localised levels of RANKL in the bone to favour tumourigenesis. CT utilises A-kinase anchoring proteins to indirectly act on PKA and promote metastasis in prostate cancer. The receptor for CT contains a PDZ-binding domain, the deletion of which stops metastasis to the bone in orthotopic prostate models. SUMMARY: Recent findings show strong evidence for the role of calcitonin peptides and receptors in prostate cancer and bone metastasis. Further research could provide potential prognostic markers and therapeutic targets for prostate cancer patients. More... »

PAGES

197-203

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40610-017-0071-9

DOI

http://dx.doi.org/10.1007/s40610-017-0071-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090946178

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28845385


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