Biomarkers to Diagnose, Assess and Treat Chronic Spontaneous Urticaria: Not There Yet View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-12

AUTHORS

Corinne S. Happel, Sarbjit S. Saini

ABSTRACT

Purpose of Review Biomarkers to identify patients with chronic spontaneous urticaria (CSU), to grade clinical severity of CSU, and to guide therapy selection in patients with CSU have not yet been validated in any large CSU patient population. As such, there is insufficient evidence to recommend routine use of any particular biomarker. This review will summarize ongoing research in the field of biomarker development and how it could 1 day benefit diagnosis, severity grading, and treatment decisions in CSU. Recent Findings Second-generation antihistamines are the accepted first-line therapy in the treatment of CSU. The United States Food and Drug Administration (FDA) has approved omalizumab for use in CSU that is refractory to antihistamines. Multiple alternative pharmacologic therapies have been utilized with varying levels of success, although no others are FDA approved. Of the alternative therapies, cyclosporine is the best-studied. Hydroxychloroquine, sulfasalazine, dapsone, and colchicine are others that are frequently prescribed. While oral corticosteroids can provide symptomatic relief for most patients, using corticosteroids for more than a couple of weeks is not advised due to significant side effects. Regardless of which therapy is chosen, a significant fraction of patients do not respond. With the emerging market of biologic products targeting specific immunologic molecules, additional therapies for CSU are likely to become available in the next 10 years. Identifying biomarkers to assess disease response to therapy and to determine which patients are most likely to benefit from which therapy would greatly benefit the field. Summary The ideal tissue source for biomarker identification in CSU has not been determined. Basophil trafficking has been demonstrated to be abnormal in CSU and would benefit from further exploration. Autoreactive T cells have been recently identified in some CSU patients and combined with autologous serum skin test may be useful as a diagnostic tool. Finally, relative to the search for blood biomarkers, the skin has been a poorly charted territory as a possible source for biomarkers and would likely benefit from additional investigation. More... »

PAGES

438-449

References to SciGraph publications

  • 2016-06. Upregulated expression of substance P in basophils of the patients with chronic spontaneous urticaria: induction of histamine release and basophil accumulation by substance P in CELL BIOLOGY AND TOXICOLOGY
  • 2015-05. Suppression of Basophil FcɛRI Activation by Serum from Active Chronic Idiopathic/Spontaneous Urticaria (CIU/CSU) Subjects in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2015-01. Systemic inflammatory response and calcification markers in patients with long lasting moderate-severe chronic spontaneous urticaria in EUROPEAN JOURNAL OF DERMATOLOGY
  • 2015-12. Immunological events in chronic spontaneous urticaria in CLINICAL AND TRANSLATIONAL ALLERGY
  • 2015-12. Chronic urticaria merits serum vitamin D evaluation and supplementation; a randomized case control study in WORLD ALLERGY ORGANIZATION JOURNAL
  • 2015-03. Association of FCER1A genetic polymorphisms with risk for chronic spontaneous urticaria and efficacy of nonsedating H1-antihistamines in Chinese patients in ARCHIVES OF DERMATOLOGICAL RESEARCH
  • 2009-07. Basophil responsiveness in chronic urticaria in CURRENT ALLERGY AND ASTHMA REPORTS
  • 2014-11. Substance P Is Upregulated in the Serum of Patients with Chronic Spontaneous Urticaria in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2008-08. Basophil Phenotypes in Chronic Idiopathic Urticaria in Relation to Disease Activity and Autoantibodies in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2015-03. Efficacy and Safety of Omalizumab in Patients with Chronic Idiopathic/Spontaneous Urticaria who Remain Symptomatic on H1 Antihistamines: A Randomized, Placebo-Controlled Study in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40521-017-0147-z

    DOI

    http://dx.doi.org/10.1007/s40521-017-0147-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1092335925


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Johns Hopkins University", 
              "id": "https://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, 21224, Baltimore, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Happel", 
            "givenName": "Corinne S.", 
            "id": "sg:person.01014272144.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014272144.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Johns Hopkins University", 
              "id": "https://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, 21224, Baltimore, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saini", 
            "givenName": "Sarbjit S.", 
            "id": "sg:person.014203033437.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014203033437.53"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1111/cup.12471", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000771122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/all.12578", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000901062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2016.07.047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001463786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jid.2016.11.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002213908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jid.2016.11.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002213908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jid.2016.11.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002213908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2009.11.047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002401580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2014/974154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004279429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2014/650913", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004321076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2014.02.036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004481808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1067/mai.2002.123236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005533686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaip.2015.11.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005776251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000444085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006351799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2014.11.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007113196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.aller.2014.04.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007490059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jid.2015.13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007603512", 
              "https://doi.org/10.1038/jid.2015.13"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.3010302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007824443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/all.12056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008056205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0145751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010982490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jdermsci.2013.08.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011012959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0003319714552693", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011920786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0003319714552693", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011920786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1590/abd1806-4841.20165066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012579553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bjd.13621", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013817809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaad.2014.05.069", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014712373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jid.2014.226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015618496", 
              "https://doi.org/10.1038/jid.2014.226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/all.13083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015924470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2500/aap.2016.37.3971", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016235862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.anai.2014.02.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017776734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2016/3831071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017968542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.2.244.241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017993905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cea.12870", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019124566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cea.12348", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021697540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/md.0000000000003688", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022225275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/md.0000000000003688", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022225275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13601-015-0074-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022538254", 
              "https://doi.org/10.1186/s13601-015-0074-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1500611", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023420683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/all.12313", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023848574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3343/alm.2016.36.1.28", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024014296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1684/ejd.2014.2474", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024551621", 
              "https://doi.org/10.1684/ejd.2014.2474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10565-016-9330-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026347782", 
              "https://doi.org/10.1007/s10565-016-9330-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/jdv.13357", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026971805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3346/jkms.2014.29.1.43", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027183286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1398-9995.2010.02496.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028237917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40413-015-0066-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028698458", 
              "https://doi.org/10.1186/s40413-015-0066-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40413-015-0066-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028698458", 
              "https://doi.org/10.1186/s40413-015-0066-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.anai.2015.12.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029699841"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.anai.2014.06.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029766377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000451084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029921843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaip.2014.06.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029979525"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2015.06.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030681176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2014.04.036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032204140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2016.04.036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033526808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00403-014-1525-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035511535", 
              "https://doi.org/10.1007/s00403-014-1525-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jid.2008.55", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037167275", 
              "https://doi.org/10.1038/jid.2008.55"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jid.2014.512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038212463", 
              "https://doi.org/10.1038/jid.2014.512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cyto.2015.04.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038416090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2016.06.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039991432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2016/5032051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040152407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.iac.2013.09.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040837361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5021/ad.2015.27.4.423", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041037168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1398-9995.2011.02704.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041616846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2015/926167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041846388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/ced.12413", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042196907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bjd.12991", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042456914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2015.12.1342", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042822129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2016.06.049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043850384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000346896", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044214007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2016.10.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044485563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4103/0019-5154.143607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049831901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jdermsci.2014.09.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049998865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11882-009-0040-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051470358", 
              "https://doi.org/10.1007/s11882-009-0040-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11882-009-0040-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051470358", 
              "https://doi.org/10.1007/s11882-009-0040-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cup.12673", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052321485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1117/1.jbo.19.1.010901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052398395"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/gtmb.2014.0193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059268267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2340/00015555-1486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070751589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7754/clin.lab.2015.150226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074028233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000455099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083851025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000453453", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083851027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2016.12.965", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084083772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2016.12.965", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084083772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaip.2016.11.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084084235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaip.2016.11.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084084235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mop.0000000000000489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084195660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mop.0000000000000489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084195660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/jdv.14221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084214506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2017.03.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085118437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2500/ar.2017.8.0199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085875984"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-12", 
        "datePublishedReg": "2017-12-01", 
        "description": "Purpose of Review Biomarkers to identify patients with chronic spontaneous urticaria (CSU), to grade clinical severity of CSU, and to guide therapy selection in patients with CSU have not yet been validated in any large CSU patient population. As such, there is insufficient evidence to recommend routine use of any particular biomarker. This review will summarize ongoing research in the field of biomarker development and how it could 1 day benefit diagnosis, severity grading, and treatment decisions in CSU. Recent Findings Second-generation antihistamines are the accepted first-line therapy in the treatment of CSU. The United States Food and Drug Administration (FDA) has approved omalizumab for use in CSU that is refractory to antihistamines. Multiple alternative pharmacologic therapies have been utilized with varying levels of success, although no others are FDA approved. Of the alternative therapies, cyclosporine is the best-studied. Hydroxychloroquine, sulfasalazine, dapsone, and colchicine are others that are frequently prescribed. While oral corticosteroids can provide symptomatic relief for most patients, using corticosteroids for more than a couple of weeks is not advised due to significant side effects. Regardless of which therapy is chosen, a significant fraction of patients do not respond. With the emerging market of biologic products targeting specific immunologic molecules, additional therapies for CSU are likely to become available in the next 10 years. Identifying biomarkers to assess disease response to therapy and to determine which patients are most likely to benefit from which therapy would greatly benefit the field. Summary The ideal tissue source for biomarker identification in CSU has not been determined. Basophil trafficking has been demonstrated to be abnormal in CSU and would benefit from further exploration. Autoreactive T cells have been recently identified in some CSU patients and combined with autologous serum skin test may be useful as a diagnostic tool. Finally, relative to the search for blood biomarkers, the skin has been a poorly charted territory as a possible source for biomarkers and would likely benefit from additional investigation.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s40521-017-0147-z", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1049722", 
            "issn": [
              "2196-3053"
            ], 
            "name": "Current Treatment Options in Allergy", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "4"
          }
        ], 
        "name": "Biomarkers to Diagnose, Assess and Treat Chronic Spontaneous Urticaria: Not There Yet", 
        "pagination": "438-449", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "c8df6a856b82b7ef85b057ab19c538a96d06865eb0e10ee818cf499589d47e83"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s40521-017-0147-z"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1092335925"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s40521-017-0147-z", 
          "https://app.dimensions.ai/details/publication/pub.1092335925"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T14:19", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000568.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs40521-017-0147-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40521-017-0147-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40521-017-0147-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40521-017-0147-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40521-017-0147-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    317 TRIPLES      21 PREDICATES      107 URIs      19 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s40521-017-0147-z schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author N75e980cd65a64c129ceb9a8f563a118f
    4 schema:citation sg:pub.10.1007/s00403-014-1525-z
    5 sg:pub.10.1007/s10565-016-9330-4
    6 sg:pub.10.1007/s11882-009-0040-3
    7 sg:pub.10.1038/jid.2008.55
    8 sg:pub.10.1038/jid.2014.226
    9 sg:pub.10.1038/jid.2014.512
    10 sg:pub.10.1038/jid.2015.13
    11 sg:pub.10.1186/s13601-015-0074-7
    12 sg:pub.10.1186/s40413-015-0066-z
    13 sg:pub.10.1684/ejd.2014.2474
    14 https://doi.org/10.1016/j.aller.2014.04.002
    15 https://doi.org/10.1016/j.anai.2014.02.014
    16 https://doi.org/10.1016/j.anai.2014.06.011
    17 https://doi.org/10.1016/j.anai.2015.12.007
    18 https://doi.org/10.1016/j.cyto.2015.04.016
    19 https://doi.org/10.1016/j.iac.2013.09.012
    20 https://doi.org/10.1016/j.jaad.2014.05.069
    21 https://doi.org/10.1016/j.jaci.2009.11.047
    22 https://doi.org/10.1016/j.jaci.2014.02.036
    23 https://doi.org/10.1016/j.jaci.2014.04.036
    24 https://doi.org/10.1016/j.jaci.2014.11.016
    25 https://doi.org/10.1016/j.jaci.2015.06.004
    26 https://doi.org/10.1016/j.jaci.2015.12.1342
    27 https://doi.org/10.1016/j.jaci.2016.04.036
    28 https://doi.org/10.1016/j.jaci.2016.06.023
    29 https://doi.org/10.1016/j.jaci.2016.06.049
    30 https://doi.org/10.1016/j.jaci.2016.07.047
    31 https://doi.org/10.1016/j.jaci.2016.10.017
    32 https://doi.org/10.1016/j.jaci.2016.12.965
    33 https://doi.org/10.1016/j.jaci.2017.03.006
    34 https://doi.org/10.1016/j.jaip.2014.06.004
    35 https://doi.org/10.1016/j.jaip.2015.11.025
    36 https://doi.org/10.1016/j.jaip.2016.11.037
    37 https://doi.org/10.1016/j.jdermsci.2013.08.011
    38 https://doi.org/10.1016/j.jdermsci.2014.09.012
    39 https://doi.org/10.1016/j.jid.2016.11.025
    40 https://doi.org/10.1056/nejmoa1500611
    41 https://doi.org/10.1067/mai.2002.123236
    42 https://doi.org/10.1089/gtmb.2014.0193
    43 https://doi.org/10.1097/md.0000000000003688
    44 https://doi.org/10.1097/mop.0000000000000489
    45 https://doi.org/10.1111/all.12056
    46 https://doi.org/10.1111/all.12313
    47 https://doi.org/10.1111/all.12578
    48 https://doi.org/10.1111/all.13083
    49 https://doi.org/10.1111/bjd.12991
    50 https://doi.org/10.1111/bjd.13621
    51 https://doi.org/10.1111/cea.12348
    52 https://doi.org/10.1111/cea.12870
    53 https://doi.org/10.1111/ced.12413
    54 https://doi.org/10.1111/cup.12471
    55 https://doi.org/10.1111/cup.12673
    56 https://doi.org/10.1111/j.1398-9995.2010.02496.x
    57 https://doi.org/10.1111/j.1398-9995.2011.02704.x
    58 https://doi.org/10.1111/jdv.13357
    59 https://doi.org/10.1111/jdv.14221
    60 https://doi.org/10.1117/1.jbo.19.1.010901
    61 https://doi.org/10.1126/scitranslmed.3010302
    62 https://doi.org/10.1136/bmj.2.244.241
    63 https://doi.org/10.1155/2014/650913
    64 https://doi.org/10.1155/2014/974154
    65 https://doi.org/10.1155/2015/926167
    66 https://doi.org/10.1155/2016/3831071
    67 https://doi.org/10.1155/2016/5032051
    68 https://doi.org/10.1159/000346896
    69 https://doi.org/10.1159/000444085
    70 https://doi.org/10.1159/000451084
    71 https://doi.org/10.1159/000453453
    72 https://doi.org/10.1159/000455099
    73 https://doi.org/10.1177/0003319714552693
    74 https://doi.org/10.1371/journal.pone.0145751
    75 https://doi.org/10.1590/abd1806-4841.20165066
    76 https://doi.org/10.2340/00015555-1486
    77 https://doi.org/10.2500/aap.2016.37.3971
    78 https://doi.org/10.2500/ar.2017.8.0199
    79 https://doi.org/10.3343/alm.2016.36.1.28
    80 https://doi.org/10.3346/jkms.2014.29.1.43
    81 https://doi.org/10.4103/0019-5154.143607
    82 https://doi.org/10.5021/ad.2015.27.4.423
    83 https://doi.org/10.7754/clin.lab.2015.150226
    84 schema:datePublished 2017-12
    85 schema:datePublishedReg 2017-12-01
    86 schema:description Purpose of Review Biomarkers to identify patients with chronic spontaneous urticaria (CSU), to grade clinical severity of CSU, and to guide therapy selection in patients with CSU have not yet been validated in any large CSU patient population. As such, there is insufficient evidence to recommend routine use of any particular biomarker. This review will summarize ongoing research in the field of biomarker development and how it could 1 day benefit diagnosis, severity grading, and treatment decisions in CSU. Recent Findings Second-generation antihistamines are the accepted first-line therapy in the treatment of CSU. The United States Food and Drug Administration (FDA) has approved omalizumab for use in CSU that is refractory to antihistamines. Multiple alternative pharmacologic therapies have been utilized with varying levels of success, although no others are FDA approved. Of the alternative therapies, cyclosporine is the best-studied. Hydroxychloroquine, sulfasalazine, dapsone, and colchicine are others that are frequently prescribed. While oral corticosteroids can provide symptomatic relief for most patients, using corticosteroids for more than a couple of weeks is not advised due to significant side effects. Regardless of which therapy is chosen, a significant fraction of patients do not respond. With the emerging market of biologic products targeting specific immunologic molecules, additional therapies for CSU are likely to become available in the next 10 years. Identifying biomarkers to assess disease response to therapy and to determine which patients are most likely to benefit from which therapy would greatly benefit the field. Summary The ideal tissue source for biomarker identification in CSU has not been determined. Basophil trafficking has been demonstrated to be abnormal in CSU and would benefit from further exploration. Autoreactive T cells have been recently identified in some CSU patients and combined with autologous serum skin test may be useful as a diagnostic tool. Finally, relative to the search for blood biomarkers, the skin has been a poorly charted territory as a possible source for biomarkers and would likely benefit from additional investigation.
    87 schema:genre research_article
    88 schema:inLanguage en
    89 schema:isAccessibleForFree false
    90 schema:isPartOf N035ff513b33e467b86da839cf0e986c6
    91 N1ed73f242e43409ba9bdd07ca1eec00c
    92 sg:journal.1049722
    93 schema:name Biomarkers to Diagnose, Assess and Treat Chronic Spontaneous Urticaria: Not There Yet
    94 schema:pagination 438-449
    95 schema:productId N43bd25b76f7b42eb92e027525f057de9
    96 N86a66672dce7494cb1c92dc884f40094
    97 Neb183b08a3174575a8c15b5083af67e2
    98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092335925
    99 https://doi.org/10.1007/s40521-017-0147-z
    100 schema:sdDatePublished 2019-04-10T14:19
    101 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    102 schema:sdPublisher N5bbe05d4d3554003bee1c2d1738e18ab
    103 schema:url https://link.springer.com/10.1007%2Fs40521-017-0147-z
    104 sgo:license sg:explorer/license/
    105 sgo:sdDataset articles
    106 rdf:type schema:ScholarlyArticle
    107 N035ff513b33e467b86da839cf0e986c6 schema:issueNumber 4
    108 rdf:type schema:PublicationIssue
    109 N1ed73f242e43409ba9bdd07ca1eec00c schema:volumeNumber 4
    110 rdf:type schema:PublicationVolume
    111 N43bd25b76f7b42eb92e027525f057de9 schema:name dimensions_id
    112 schema:value pub.1092335925
    113 rdf:type schema:PropertyValue
    114 N5bbe05d4d3554003bee1c2d1738e18ab schema:name Springer Nature - SN SciGraph project
    115 rdf:type schema:Organization
    116 N75e980cd65a64c129ceb9a8f563a118f rdf:first sg:person.01014272144.55
    117 rdf:rest N9f735fac75a54389a90235c2b8d4eb4c
    118 N86a66672dce7494cb1c92dc884f40094 schema:name doi
    119 schema:value 10.1007/s40521-017-0147-z
    120 rdf:type schema:PropertyValue
    121 N9f735fac75a54389a90235c2b8d4eb4c rdf:first sg:person.014203033437.53
    122 rdf:rest rdf:nil
    123 Neb183b08a3174575a8c15b5083af67e2 schema:name readcube_id
    124 schema:value c8df6a856b82b7ef85b057ab19c538a96d06865eb0e10ee818cf499589d47e83
    125 rdf:type schema:PropertyValue
    126 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    127 schema:name Medical and Health Sciences
    128 rdf:type schema:DefinedTerm
    129 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    130 schema:name Oncology and Carcinogenesis
    131 rdf:type schema:DefinedTerm
    132 sg:journal.1049722 schema:issn 2196-3053
    133 schema:name Current Treatment Options in Allergy
    134 rdf:type schema:Periodical
    135 sg:person.01014272144.55 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
    136 schema:familyName Happel
    137 schema:givenName Corinne S.
    138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014272144.55
    139 rdf:type schema:Person
    140 sg:person.014203033437.53 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
    141 schema:familyName Saini
    142 schema:givenName Sarbjit S.
    143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014203033437.53
    144 rdf:type schema:Person
    145 sg:pub.10.1007/s00403-014-1525-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1035511535
    146 https://doi.org/10.1007/s00403-014-1525-z
    147 rdf:type schema:CreativeWork
    148 sg:pub.10.1007/s10565-016-9330-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026347782
    149 https://doi.org/10.1007/s10565-016-9330-4
    150 rdf:type schema:CreativeWork
    151 sg:pub.10.1007/s11882-009-0040-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051470358
    152 https://doi.org/10.1007/s11882-009-0040-3
    153 rdf:type schema:CreativeWork
    154 sg:pub.10.1038/jid.2008.55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037167275
    155 https://doi.org/10.1038/jid.2008.55
    156 rdf:type schema:CreativeWork
    157 sg:pub.10.1038/jid.2014.226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015618496
    158 https://doi.org/10.1038/jid.2014.226
    159 rdf:type schema:CreativeWork
    160 sg:pub.10.1038/jid.2014.512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038212463
    161 https://doi.org/10.1038/jid.2014.512
    162 rdf:type schema:CreativeWork
    163 sg:pub.10.1038/jid.2015.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007603512
    164 https://doi.org/10.1038/jid.2015.13
    165 rdf:type schema:CreativeWork
    166 sg:pub.10.1186/s13601-015-0074-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022538254
    167 https://doi.org/10.1186/s13601-015-0074-7
    168 rdf:type schema:CreativeWork
    169 sg:pub.10.1186/s40413-015-0066-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1028698458
    170 https://doi.org/10.1186/s40413-015-0066-z
    171 rdf:type schema:CreativeWork
    172 sg:pub.10.1684/ejd.2014.2474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024551621
    173 https://doi.org/10.1684/ejd.2014.2474
    174 rdf:type schema:CreativeWork
    175 https://doi.org/10.1016/j.aller.2014.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007490059
    176 rdf:type schema:CreativeWork
    177 https://doi.org/10.1016/j.anai.2014.02.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017776734
    178 rdf:type schema:CreativeWork
    179 https://doi.org/10.1016/j.anai.2014.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029766377
    180 rdf:type schema:CreativeWork
    181 https://doi.org/10.1016/j.anai.2015.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029699841
    182 rdf:type schema:CreativeWork
    183 https://doi.org/10.1016/j.cyto.2015.04.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038416090
    184 rdf:type schema:CreativeWork
    185 https://doi.org/10.1016/j.iac.2013.09.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040837361
    186 rdf:type schema:CreativeWork
    187 https://doi.org/10.1016/j.jaad.2014.05.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014712373
    188 rdf:type schema:CreativeWork
    189 https://doi.org/10.1016/j.jaci.2009.11.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002401580
    190 rdf:type schema:CreativeWork
    191 https://doi.org/10.1016/j.jaci.2014.02.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004481808
    192 rdf:type schema:CreativeWork
    193 https://doi.org/10.1016/j.jaci.2014.04.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032204140
    194 rdf:type schema:CreativeWork
    195 https://doi.org/10.1016/j.jaci.2014.11.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007113196
    196 rdf:type schema:CreativeWork
    197 https://doi.org/10.1016/j.jaci.2015.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030681176
    198 rdf:type schema:CreativeWork
    199 https://doi.org/10.1016/j.jaci.2015.12.1342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042822129
    200 rdf:type schema:CreativeWork
    201 https://doi.org/10.1016/j.jaci.2016.04.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033526808
    202 rdf:type schema:CreativeWork
    203 https://doi.org/10.1016/j.jaci.2016.06.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039991432
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1016/j.jaci.2016.06.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043850384
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1016/j.jaci.2016.07.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001463786
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1016/j.jaci.2016.10.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044485563
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1016/j.jaci.2016.12.965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084083772
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1016/j.jaci.2017.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085118437
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1016/j.jaip.2014.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029979525
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1016/j.jaip.2015.11.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005776251
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1016/j.jaip.2016.11.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084084235
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1016/j.jdermsci.2013.08.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011012959
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1016/j.jdermsci.2014.09.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049998865
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1016/j.jid.2016.11.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002213908
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1056/nejmoa1500611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023420683
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1067/mai.2002.123236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005533686
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1089/gtmb.2014.0193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059268267
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1097/md.0000000000003688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022225275
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1097/mop.0000000000000489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084195660
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1111/all.12056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008056205
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1111/all.12313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023848574
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1111/all.12578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000901062
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1111/all.13083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015924470
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1111/bjd.12991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042456914
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1111/bjd.13621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013817809
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1111/cea.12348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021697540
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1111/cea.12870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019124566
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1111/ced.12413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042196907
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1111/cup.12471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000771122
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1111/cup.12673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052321485
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1111/j.1398-9995.2010.02496.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028237917
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1111/j.1398-9995.2011.02704.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041616846
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1111/jdv.13357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026971805
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1111/jdv.14221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084214506
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1117/1.jbo.19.1.010901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052398395
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1126/scitranslmed.3010302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007824443
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1136/bmj.2.244.241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017993905
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1155/2014/650913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004321076
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1155/2014/974154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004279429
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1155/2015/926167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041846388
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1155/2016/3831071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017968542
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1155/2016/5032051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040152407
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1159/000346896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044214007
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1159/000444085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006351799
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1159/000451084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029921843
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1159/000453453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083851027
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1159/000455099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083851025
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1177/0003319714552693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011920786
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1371/journal.pone.0145751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010982490
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1590/abd1806-4841.20165066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012579553
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.2340/00015555-1486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070751589
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.2500/aap.2016.37.3971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016235862
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.2500/ar.2017.8.0199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085875984
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.3343/alm.2016.36.1.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024014296
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.3346/jkms.2014.29.1.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027183286
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.4103/0019-5154.143607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049831901
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.5021/ad.2015.27.4.423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041037168
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.7754/clin.lab.2015.150226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074028233
    314 rdf:type schema:CreativeWork
    315 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
    316 schema:name Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, 21224, Baltimore, MD, USA
    317 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...