Non-persistence with antiplatelet therapy in elderly patients after a transient ischemic attack View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-12

AUTHORS

Martin Wawruch, Dusan Zatko, Gejza Wimmer, Jan Luha, Sona Wimmerova, Peter Kukumberg, Jan Murin, Adam Hloska, Tomas Tesar, Rashmi Shah

ABSTRACT

BACKGROUND: Antiplatelet therapy following a transient ischemic attack (TIA) constitutes an important secondary prevention measure. AIMS: The study was aimed at evaluating the development of non-persistence with antiplatelet therapy in elderly patients after a TIA and identifying patient-related characteristics associated with the probability of non-persistence during the follow-up period. METHODS: The study cohort (n = 854) was selected from the database of the largest health insurance provider of the Slovak Republic. It included patients aged ≥65 years, in whom antiplatelet medication was initiated following a TIA diagnosis during the period between 1 January 2010 and 31 December 2010. Each patient was followed for a period of 3 years from the date of the first antiplatelet medication prescription associated with TIA diagnosis. Patients in whom there was a treatment gap of at least 6 months without antiplatelet medication prescription were defined as "non-persistent". The factors predicting non-persistence were identified in the Cox proportional hazards model. RESULTS: At the end of the follow-up period, 345 (40.4%) patients were non-persistent with antiplatelet medication. Protective factors decreasing a patient´s likelihood of becoming non-persistent were age ≥75 years [hazard ratio (HR) = 0.75], polypharmacy (concurrent use of ≥6 drugs) (HR = 0.79), arterial hypertension (HR = 0.68), diabetes mellitus (HR = 0.74), hypercholesterolemia (HR = 0.75), and antiplatelet medication switching during the follow-up period (HR = 0.73). CONCLUSIONS: It is concluded that following a TIA, elderly patients aged <75 years or those with normal serum cholesterol levels, without certain comorbid conditions and polypharmacy may benefit from special counselling to encourage persistence with secondary preventive medication. More... »

PAGES

1121-1127

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40520-017-0745-4

DOI

http://dx.doi.org/10.1007/s40520-017-0745-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084040423

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28284002


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curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40520-017-0745-4'

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curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40520-017-0745-4'


 

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