Insulin resistance in obesity: an overview of fundamental alterations View Full Text


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Article Info

DATE

2018-02-03

AUTHORS

Rocco Barazzoni, Gianluca Gortan Cappellari, Maurizio Ragni, Enzo Nisoli

ABSTRACT

Obesity is a major health risk factor, and obesity-induced morbidity and complications account for huge costs for affected individuals, families, healthcare systems, and society at large. In particular, obesity is strongly associated with the development of insulin resistance, which in turn plays a key role in the pathogenesis of obesity-associated cardiometabolic complications, including metabolic syndrome components, type 2 diabetes, and cardiovascular diseases. Insulin sensitive tissues, including adipose tissue, skeletal muscle, and liver, are profoundly affected by obesity both at biomolecular and functional levels. Altered adipose organ function may play a fundamental pathogenetic role once fat accumulation has ensued. Modulation of insulin sensitivity appears to be, at least in part, related to changes in redox balance and oxidative stress as well as inflammation, with a relevant underlying role for mitochondrial dysfunction that may exacerbate these alterations. Nutrients and substrates as well as systems involved in host–nutrient interactions, including gut microbiota, have been also identified as modulators of metabolic pathways controlling insulin action. This review aims at providing an overview of these concepts and their potential inter-relationships in the development of insulin resistance, with particular regard to changes in adipose organ and skeletal muscle. More... »

PAGES

149-157

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40519-018-0481-6

    DOI

    http://dx.doi.org/10.1007/s40519-018-0481-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100806573

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29397563


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