Procalcitonin as a Diagnostic, Therapeutic, and Prognostic Tool: a Critical Review View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Fabrício Torres de Carvalho, Roberto Rabello Filho, Lucas Bulgarelli, Ary Serpa Neto, Rodrigo Octavio Deliberato

ABSTRACT

The target of this review is to highlight the current evidence about the utility of procalcitonin (PCT) in different clinical conditions, such as sepsis, respiratory tract infections, urinary tract infections, and bacteremias. The authors aim to discuss the potential benefits and limitations of this biomarker and propose how to safely individualize antibiotic treatment in clinical practice. Many studies have demonstrated that PCT measurements increase within 6–12 h after bacterial invasion and correlate with disease severity and outcomes of patients with infection. Consequently, they can detect the presence and monitor the status of the bacterial infection, as an objectively and quickly available marker. PCT-guided algorithms have positive effects in reducing antimicrobial use and mortality, especially in sepsis and respiratory tract infections. However, the adherence to PCT-guided strategies is variable and more studies are needed to validate its regular clinical use on other frequent sites of infections (e.g., skin/soft tissues, bone, CNS) and on specific populations such as immunocompromised patients, since it can be truly recognized as a tool able to reduce antibiotic exposure and costs, improving quality of medical assistance safely. More... »

PAGES

1-11

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40506-019-0178-z

DOI

http://dx.doi.org/10.1007/s40506-019-0178-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112262307


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