Repurposing Anti-inflammatory Agents for Mood Disorders: an Updated Review of Current Evidence View Full Text


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Article Info

DATE

2022-07-08

AUTHORS

Mary E. Kittur, Brett D. M. Jones, Nasia Dai, Mariam Mahboob, Muhammad I. Husain

ABSTRACT

Purpose of ReviewTo provide an updated summary on the field of immunopsychiatry as it pertains to clinical and therapeutic translation in mood disorders (major depressive disorder [MDD] and bipolar disorder [BD]).Recent FindingsAn updated scoping review of a previous publication by Jones et al. identified five recently published RCTs that continue to explore the anti-depressive efficacy of established immunomodulating agents (minocycline, celecoxib, and aspirin). Consistent with our earlier scoping review, study results remain conflicting, and there is still insufficient support for the clinical utility of any anti-inflammatory agent for the treatment of mood disorders.SummaryDespite extensive evidence supporting a pathophysiological association between inflammatory activation and depressive symptoms, the repurposing of anti-inflammatory agents as novel antidepressant treatments is still an unrealized goal. As highlighted across scoping reviews, published clinical trials remain insensitive to the inherent heterogeneity of patients with mood disorders. We suggest that more nuanced methodological approaches, such as stratification of participants by inflammatory tone or clinical presentation, are required before real translational advances can be made. More... »

PAGES

346-362

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