Defective JAK-STAT Pathway Signaling Contributes to Autoimmune Diseases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-10

AUTHORS

Charles J. Malemud

ABSTRACT

Here, we systematically review the published literature indicating that aberrant regulation of Janus kinase/signal transducers and activators of transcription (JAK-STAT) signaling was associated with the autoimmune disorders, rheumatoid arthritis, systemic lupus erythematosus, psoriasis/psoriatic arthritis, multiple sclerosis, inflammatory bowel diseases, and ankylosing spondylitis. The autoimmune disorders discussed in this review are characterized by several alterations resulting in abnormal JAK-STAT signaling. These abnormalities in JAK-STAT signaling include (1) constitutive activation of both the interleukin-6(IL-6)/interleukin-6 receptor (IL-6R) canonical and IL-6 trans-signaling pathway, the latter involving soluble IL-6R; (2) the hyperactivation of JAK/STAT signaling as a response to the significantly elevated levels of pro-inflammatory “immunocytokines”, exemplified by IL-6, IL-15, IL-17, IL-23, interferon-γ; and (3) the reduced activity of the negative regulators of JAK-STAT signaling, including suppressor of cytokine signaling and protein inhibitor of activated STATs as well as protein tyrosine phosphatases-1, -2, which was shown to inhibit STAT-signaling. The involvement of abnormal JAK-STAT signaling in autoimmune disorders has led to the development of JAK small molecule inhibitors (SMIs), such as tofacitinib, ruxolitinib, and baricitinib for the therapy of rheumatoid arthritis, psoriasis/psoriatic arthritis, and Crohn’s disease. However, the extent to which treatment of these diseases with JAK SMIs will result in blunting the “cross-talk” between the JAK-STAT signaling pathway and the other signaling pathways known to participate in autoimmune disorders remains to be determined, involving the mitogen-activated protein kinase pathway and the phosphatidylinositide/Akt/mechanistic target of rapamycin signaling pathway. More... »

PAGES

358-366

References to SciGraph publications

  • 2014-01. JAK/STAT/PKCδ molecular pathways in synovial fluid T lymphocytes reflect the in vivo T helper-17 expansion in psoriatic arthritis in IMMUNOLOGIC RESEARCH
  • 2017-05. Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease in NATURE MEDICINE
  • 2018-02. Tofacitinib: A New Oral Therapy for Psoriasis in CLINICAL DRUG INVESTIGATION
  • 2008-02. 'Tuning' of type I interferon–induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages in NATURE IMMUNOLOGY
  • 2017-04. The Role of STAT Signaling Pathways in the Pathogenesis of Systemic Lupus Erythematosus in CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
  • 2006-12. Bovine CD2-/NKp46+ cells are fully functional natural killer cells with a high activation status in BMC IMMUNOLOGY
  • 2017-04. JAK–STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects in DRUGS
  • 2016-06. Signal transducer and activator of transcription 5 is implicated in disease activity in adult and juvenile onset systemic lupus erythematosus in CLINICAL RHEUMATOLOGY
  • 2016-12. An integrative analysis of gene expression and molecular interaction data to identify dys-regulated sub-networks in inflammatory bowel disease in BMC BIOINFORMATICS
  • 2005-01. Activation Pattern of Signal Transducers and Activators of Transcription (STAT) Factors in Inflammatory Bowel Diseases in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2006-02. Regulation of cytokine signaling pathways by PIAS proteins in CELL RESEARCH
  • 2013. Regulation of Chondrocyte Matrix Metalloproteinase Gene Expression in PROTEASES IN HEALTH AND DISEASE
  • 2017-07. Advances in the Development of Janus Kinase Inhibitors in Inflammatory Bowel Disease: Future Prospects in DRUGS
  • 2004-08. Signaling by STATs in ARTHRITIS RESEARCH & THERAPY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40495-018-0151-4

    DOI

    http://dx.doi.org/10.1007/s40495-018-0151-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1106023855


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University Hospitals Case Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.443867.a", 
              "name": [
                "Department of Medicine, Division of Rheumatic Diseases, Case Western Reserve University School of Medicine, 44106, Cleveland, OH, USA", 
                "Department of Medicine, University Hospitals Cleveland Medical Center, Foley Medical Building, 2061 Cornell Road, Room 207, 44106-5076, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Malemud", 
            "givenName": "Charles J.", 
            "id": "sg:person.01167567230.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167567230.43"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1056/nejmoa1112072", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002267298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.178.5.2623", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002607144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2008.00625.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002699491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4103/0976-500x.155482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004102771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.2006.060822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004584186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mrfmmm.2010.01.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004651293"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.06.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005963020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2012.03.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006017596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bjd.12049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006314201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m207999200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006558628"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.2005.037929", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007206227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0889-857x(05)70136-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008756315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0130078", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009225841"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1112168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009290091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pharep.2016.04.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009335347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.21942", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009501599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1109071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010422264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12016-016-8550-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016203724", 
              "https://doi.org/10.1007/s12016-016-8550-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/dddt.s82599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016253082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0301-472x(00)00652-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017508957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0016-5085(94)90614-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018221919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cr.7310027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018273845", 
              "https://doi.org/10.1038/sj.cr.7310027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cr.7310027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018273845", 
              "https://doi.org/10.1038/sj.cr.7310027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0070738", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018471825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0038338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019494331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fphar.2016.00455", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019996657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4172/2155-9899.1000422", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020443287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0961203311409963", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021685569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0961203311409963", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021685569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0961203311409963", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021685569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.rhu.0000166673.34461.33", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023636044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.rhu.0000166673.34461.33", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023636044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.rhu.0000166673.34461.33", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023636044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.rhu.0000166673.34461.33", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023636044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humimm.2015.09.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023906190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.30613", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027393396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.36.1.45", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027545926"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10067-016-3250-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028077083", 
              "https://doi.org/10.1007/s10067-016-3250-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(10)61354-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028914094"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/17512433.2016.1154785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029619501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/17512433.2016.1154785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029619501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/17512433.2016.1154785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029619501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/13543784.2016.1189900", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030282023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/rheumatology/kem198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030490892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.biochem.73.011303.074118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031244606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.10764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031290817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2172-7-10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032351125", 
              "https://doi.org/10.1186/1471-2172-7-10"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/imt.12.20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032479730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clim.2016.09.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032569327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12859-016-0886-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033225730", 
              "https://doi.org/10.1186/s12859-016-0886-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0961203310367660", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033375867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0961203310367660", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033375867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0961203310367660", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033375867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.16.1.293", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033509267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12026-013-8481-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033527738", 
              "https://doi.org/10.1007/s12026-013-8481-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2005.40615.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033961311", 
              "https://doi.org/10.1111/j.1572-0241.2005.40615.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.semcdb.2008.07.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034150200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4155/fmc.15.55", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035362741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.51.3.379", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036397691"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0705268104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036413299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejcb.2011.07.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037271337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5772/52506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037594713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.193.4.471", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038982061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.34400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039491619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/ar1197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040997508", 
              "https://doi.org/10.1186/ar1197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/annrheumdis-2014-207201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041335411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cytogfr.2008.08.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041400583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041677961", 
              "https://doi.org/10.1038/ni1548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3899/jrheum.130683", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043063467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4172/2161-1149.1000147", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043219198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cytogfr.2015.07.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045078698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.200322875", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045240064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.phrs.2013.06.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046390814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4614-9233-7_5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047469362", 
              "https://doi.org/10.1007/978-1-4614-9233-7_5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/intimm/dxm045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047973936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/exd.12128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051953193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001574-199907000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060137658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001574-199907000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060137658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001574-199907000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060137658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.277.5332.1630", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062557957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15761/imm.1000158", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068046959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1615/critrevimmunol.2016015517", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068131572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1573397054023146", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069204907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1573397111309010010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069205206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/157436209789057467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069213794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2741/4054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070916215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.14.4280", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071360631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/jkst.24134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072305385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4172/2161-1149.1000113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072334768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.164.7.3894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074607408"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074879558", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.168.3.1113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074984117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.169.10.6020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075187689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.173.10.6241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076962441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077439931", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077509141", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1101228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078442900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1403254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079194342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/1744666x.2017.1291342", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083552901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gutjnl-2016-312735", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083845095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gutjnl-2016-312735", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083845095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/ijms18030484", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083892178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40265-017-0701-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084038530", 
              "https://doi.org/10.1007/s40265-017-0701-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40265-017-0701-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084038530", 
              "https://doi.org/10.1007/s40265-017-0701-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.16081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084373198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.4307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084508963", 
              "https://doi.org/10.1038/nm.4307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.4307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084508963", 
              "https://doi.org/10.1038/nm.4307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/bor.0000000000000399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084603187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/bor.0000000000000399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084603187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1189/jlb.3mr0117-033r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084826426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4172/2476-1966.1000112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084839212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.201646872", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085123594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1606910", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085131615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0176994", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085152056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40265-017-0755-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085444493", 
              "https://doi.org/10.1007/s40265-017-0755-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40265-017-0755-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085444493", 
              "https://doi.org/10.1007/s40265-017-0755-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.201646680", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085707952"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(17)31618-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086040585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/14656566.2017.1378343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091617326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/jir.s93797", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091986208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/dth.12555", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092133397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1615977", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092274246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1615975", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092274251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40261-017-0596-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092478687", 
              "https://doi.org/10.1007/s40261-017-0596-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cyto.2017.10.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092597463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.jmedchem.7b01598", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100158276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.jmedchem.7b01598", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100158276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/ijms19010171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100265449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/rmdopen-2017-000581", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100395700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/rmdopen-2017-000581", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100395700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/17512433.2018.1445967", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101221702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/14712598.2018.1445223", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101226834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bcp.13612", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103425330"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-10", 
        "datePublishedReg": "2018-10-01", 
        "description": "Here, we systematically review the published literature indicating that aberrant regulation of Janus kinase/signal transducers and activators of transcription (JAK-STAT) signaling was associated with the autoimmune disorders, rheumatoid arthritis, systemic lupus erythematosus, psoriasis/psoriatic arthritis, multiple sclerosis, inflammatory bowel diseases, and ankylosing spondylitis. The autoimmune disorders discussed in this review are characterized by several alterations resulting in abnormal JAK-STAT signaling. These abnormalities in JAK-STAT signaling include (1) constitutive activation of both the interleukin-6(IL-6)/interleukin-6 receptor (IL-6R) canonical and IL-6 trans-signaling pathway, the latter involving soluble IL-6R; (2) the hyperactivation of JAK/STAT signaling as a response to the significantly elevated levels of pro-inflammatory \u201cimmunocytokines\u201d, exemplified by IL-6, IL-15, IL-17, IL-23, interferon-\u03b3; and (3) the reduced activity of the negative regulators of JAK-STAT signaling, including suppressor of cytokine signaling and protein inhibitor of activated STATs as well as protein tyrosine phosphatases-1, -2, which was shown to inhibit STAT-signaling. The involvement of abnormal JAK-STAT signaling in autoimmune disorders has led to the development of JAK small molecule inhibitors (SMIs), such as tofacitinib, ruxolitinib, and baricitinib for the therapy of rheumatoid arthritis, psoriasis/psoriatic arthritis, and Crohn\u2019s disease. However, the extent to which treatment of these diseases with JAK SMIs will result in blunting the \u201ccross-talk\u201d between the JAK-STAT signaling pathway and the other signaling pathways known to participate in autoimmune disorders remains to be determined, involving the mitogen-activated protein kinase pathway and the phosphatidylinositide/Akt/mechanistic target of rapamycin signaling pathway.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s40495-018-0151-4", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2439151", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1051247", 
            "issn": [
              "2198-641X"
            ], 
            "name": "Current Pharmacology Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "4"
          }
        ], 
        "name": "Defective JAK-STAT Pathway Signaling Contributes to Autoimmune Diseases", 
        "pagination": "358-366", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "eb648a52bc1118339a1a32d97d9c65287c0f791983bff574cd1e3ec04fcae176"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s40495-018-0151-4"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1106023855"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s40495-018-0151-4", 
          "https://app.dimensions.ai/details/publication/pub.1106023855"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:00", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000568.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs40495-018-0151-4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40495-018-0151-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40495-018-0151-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40495-018-0151-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40495-018-0151-4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    416 TRIPLES      21 PREDICATES      141 URIs      19 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s40495-018-0151-4 schema:about anzsrc-for:11
    2 anzsrc-for:1107
    3 schema:author N8f30a745cacd4981aabbf393ced38523
    4 schema:citation sg:pub.10.1007/978-1-4614-9233-7_5
    5 sg:pub.10.1007/s10067-016-3250-9
    6 sg:pub.10.1007/s12016-016-8550-y
    7 sg:pub.10.1007/s12026-013-8481-0
    8 sg:pub.10.1007/s40261-017-0596-y
    9 sg:pub.10.1007/s40265-017-0701-9
    10 sg:pub.10.1007/s40265-017-0755-8
    11 sg:pub.10.1038/ni1548
    12 sg:pub.10.1038/nm.4307
    13 sg:pub.10.1038/sj.cr.7310027
    14 sg:pub.10.1111/j.1572-0241.2005.40615.x
    15 sg:pub.10.1186/1471-2172-7-10
    16 sg:pub.10.1186/ar1197
    17 sg:pub.10.1186/s12859-016-0886-z
    18 https://app.dimensions.ai/details/publication/pub.1074879558
    19 https://app.dimensions.ai/details/publication/pub.1077439931
    20 https://app.dimensions.ai/details/publication/pub.1077509141
    21 https://doi.org/10.1002/ana.10764
    22 https://doi.org/10.1002/art.21942
    23 https://doi.org/10.1002/art.30613
    24 https://doi.org/10.1002/art.34400
    25 https://doi.org/10.1002/eji.200322875
    26 https://doi.org/10.1002/eji.201646680
    27 https://doi.org/10.1002/eji.201646872
    28 https://doi.org/10.1016/0016-5085(94)90614-9
    29 https://doi.org/10.1016/j.cell.2007.06.033
    30 https://doi.org/10.1016/j.clim.2016.09.014
    31 https://doi.org/10.1016/j.cyto.2017.10.022
    32 https://doi.org/10.1016/j.cytogfr.2008.08.003
    33 https://doi.org/10.1016/j.cytogfr.2015.07.006
    34 https://doi.org/10.1016/j.ejcb.2011.07.006
    35 https://doi.org/10.1016/j.humimm.2015.09.037
    36 https://doi.org/10.1016/j.immuni.2012.03.013
    37 https://doi.org/10.1016/j.mrfmmm.2010.01.017
    38 https://doi.org/10.1016/j.pharep.2016.04.001
    39 https://doi.org/10.1016/j.phrs.2013.06.007
    40 https://doi.org/10.1016/j.semcdb.2008.07.010
    41 https://doi.org/10.1016/s0140-6736(10)61354-2
    42 https://doi.org/10.1016/s0140-6736(17)31618-5
    43 https://doi.org/10.1016/s0301-472x(00)00652-4
    44 https://doi.org/10.1016/s0889-857x(05)70136-8
    45 https://doi.org/10.1021/acs.jmedchem.7b01598
    46 https://doi.org/10.1056/nejmoa1109071
    47 https://doi.org/10.1056/nejmoa1112072
    48 https://doi.org/10.1056/nejmoa1112168
    49 https://doi.org/10.1056/nejmoa1606910
    50 https://doi.org/10.1056/nejmoa1615975
    51 https://doi.org/10.1056/nejmoa1615977
    52 https://doi.org/10.1073/pnas.0705268104
    53 https://doi.org/10.1074/jbc.m207999200
    54 https://doi.org/10.1080/13543784.2016.1189900
    55 https://doi.org/10.1080/14656566.2017.1378343
    56 https://doi.org/10.1080/14712598.2018.1445223
    57 https://doi.org/10.1080/1744666x.2017.1291342
    58 https://doi.org/10.1080/17512433.2018.1445967
    59 https://doi.org/10.1084/jem.193.4.471
    60 https://doi.org/10.1093/intimm/dxm045
    61 https://doi.org/10.1093/rheumatology/kem198
    62 https://doi.org/10.1097/00001574-199907000-00003
    63 https://doi.org/10.1097/01.rhu.0000166673.34461.33
    64 https://doi.org/10.1097/bor.0000000000000399
    65 https://doi.org/10.1111/bcp.13612
    66 https://doi.org/10.1111/bjd.12049
    67 https://doi.org/10.1111/dth.12555
    68 https://doi.org/10.1111/exd.12128
    69 https://doi.org/10.1111/j.1600-065x.2008.00625.x
    70 https://doi.org/10.1126/science.277.5332.1630
    71 https://doi.org/10.1136/annrheumdis-2014-207201
    72 https://doi.org/10.1136/ard.2005.037929
    73 https://doi.org/10.1136/ard.2006.060822
    74 https://doi.org/10.1136/gut.36.1.45
    75 https://doi.org/10.1136/gut.51.3.379
    76 https://doi.org/10.1136/gutjnl-2016-312735
    77 https://doi.org/10.1136/rmdopen-2017-000581
    78 https://doi.org/10.1146/annurev.biochem.73.011303.074118
    79 https://doi.org/10.1146/annurev.immunol.16.1.293
    80 https://doi.org/10.1177/0961203310367660
    81 https://doi.org/10.1177/0961203311409963
    82 https://doi.org/10.1189/jlb.3mr0117-033r
    83 https://doi.org/10.1371/journal.pone.0038338
    84 https://doi.org/10.1371/journal.pone.0070738
    85 https://doi.org/10.1371/journal.pone.0130078
    86 https://doi.org/10.1371/journal.pone.0176994
    87 https://doi.org/10.15761/imm.1000158
    88 https://doi.org/10.1586/17512433.2016.1154785
    89 https://doi.org/10.1615/critrevimmunol.2016015517
    90 https://doi.org/10.18632/oncotarget.16081
    91 https://doi.org/10.2147/dddt.s82599
    92 https://doi.org/10.2147/jir.s93797
    93 https://doi.org/10.2174/1573397054023146
    94 https://doi.org/10.2174/1573397111309010010
    95 https://doi.org/10.2174/157436209789057467
    96 https://doi.org/10.2217/imt.12.20
    97 https://doi.org/10.2741/4054
    98 https://doi.org/10.3389/fphar.2016.00455
    99 https://doi.org/10.3390/ijms18030484
    100 https://doi.org/10.3390/ijms19010171
    101 https://doi.org/10.3748/wjg.14.4280
    102 https://doi.org/10.3899/jrheum.130683
    103 https://doi.org/10.4049/jimmunol.1101228
    104 https://doi.org/10.4049/jimmunol.1403254
    105 https://doi.org/10.4049/jimmunol.164.7.3894
    106 https://doi.org/10.4049/jimmunol.168.3.1113
    107 https://doi.org/10.4049/jimmunol.169.10.6020
    108 https://doi.org/10.4049/jimmunol.173.10.6241
    109 https://doi.org/10.4049/jimmunol.178.5.2623
    110 https://doi.org/10.4103/0976-500x.155482
    111 https://doi.org/10.4155/fmc.15.55
    112 https://doi.org/10.4161/jkst.24134
    113 https://doi.org/10.4172/2155-9899.1000422
    114 https://doi.org/10.4172/2161-1149.1000113
    115 https://doi.org/10.4172/2161-1149.1000147
    116 https://doi.org/10.4172/2476-1966.1000112
    117 https://doi.org/10.5772/52506
    118 schema:datePublished 2018-10
    119 schema:datePublishedReg 2018-10-01
    120 schema:description Here, we systematically review the published literature indicating that aberrant regulation of Janus kinase/signal transducers and activators of transcription (JAK-STAT) signaling was associated with the autoimmune disorders, rheumatoid arthritis, systemic lupus erythematosus, psoriasis/psoriatic arthritis, multiple sclerosis, inflammatory bowel diseases, and ankylosing spondylitis. The autoimmune disorders discussed in this review are characterized by several alterations resulting in abnormal JAK-STAT signaling. These abnormalities in JAK-STAT signaling include (1) constitutive activation of both the interleukin-6(IL-6)/interleukin-6 receptor (IL-6R) canonical and IL-6 trans-signaling pathway, the latter involving soluble IL-6R; (2) the hyperactivation of JAK/STAT signaling as a response to the significantly elevated levels of pro-inflammatory “immunocytokines”, exemplified by IL-6, IL-15, IL-17, IL-23, interferon-γ; and (3) the reduced activity of the negative regulators of JAK-STAT signaling, including suppressor of cytokine signaling and protein inhibitor of activated STATs as well as protein tyrosine phosphatases-1, -2, which was shown to inhibit STAT-signaling. The involvement of abnormal JAK-STAT signaling in autoimmune disorders has led to the development of JAK small molecule inhibitors (SMIs), such as tofacitinib, ruxolitinib, and baricitinib for the therapy of rheumatoid arthritis, psoriasis/psoriatic arthritis, and Crohn’s disease. However, the extent to which treatment of these diseases with JAK SMIs will result in blunting the “cross-talk” between the JAK-STAT signaling pathway and the other signaling pathways known to participate in autoimmune disorders remains to be determined, involving the mitogen-activated protein kinase pathway and the phosphatidylinositide/Akt/mechanistic target of rapamycin signaling pathway.
    121 schema:genre research_article
    122 schema:inLanguage en
    123 schema:isAccessibleForFree false
    124 schema:isPartOf N42554f9d82b441d3b81a5107a9cb879e
    125 N6c88cfb24f1c45e884b129bb2b2e075f
    126 sg:journal.1051247
    127 schema:name Defective JAK-STAT Pathway Signaling Contributes to Autoimmune Diseases
    128 schema:pagination 358-366
    129 schema:productId N2ff8a5ac4f8d48b293ec0f0e9440b28a
    130 N326694d4138c48e3808ea426e73914f8
    131 Nd38cf0d32d904c1da3a7c70cc6736ebc
    132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106023855
    133 https://doi.org/10.1007/s40495-018-0151-4
    134 schema:sdDatePublished 2019-04-10T16:00
    135 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    136 schema:sdPublisher N9b08378f3199470488d425a31db14104
    137 schema:url https://link.springer.com/10.1007%2Fs40495-018-0151-4
    138 sgo:license sg:explorer/license/
    139 sgo:sdDataset articles
    140 rdf:type schema:ScholarlyArticle
    141 N2ff8a5ac4f8d48b293ec0f0e9440b28a schema:name readcube_id
    142 schema:value eb648a52bc1118339a1a32d97d9c65287c0f791983bff574cd1e3ec04fcae176
    143 rdf:type schema:PropertyValue
    144 N326694d4138c48e3808ea426e73914f8 schema:name doi
    145 schema:value 10.1007/s40495-018-0151-4
    146 rdf:type schema:PropertyValue
    147 N42554f9d82b441d3b81a5107a9cb879e schema:issueNumber 5
    148 rdf:type schema:PublicationIssue
    149 N6c88cfb24f1c45e884b129bb2b2e075f schema:volumeNumber 4
    150 rdf:type schema:PublicationVolume
    151 N8f30a745cacd4981aabbf393ced38523 rdf:first sg:person.01167567230.43
    152 rdf:rest rdf:nil
    153 N9b08378f3199470488d425a31db14104 schema:name Springer Nature - SN SciGraph project
    154 rdf:type schema:Organization
    155 Nd38cf0d32d904c1da3a7c70cc6736ebc schema:name dimensions_id
    156 schema:value pub.1106023855
    157 rdf:type schema:PropertyValue
    158 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    159 schema:name Medical and Health Sciences
    160 rdf:type schema:DefinedTerm
    161 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    162 schema:name Immunology
    163 rdf:type schema:DefinedTerm
    164 sg:grant.2439151 http://pending.schema.org/fundedItem sg:pub.10.1007/s40495-018-0151-4
    165 rdf:type schema:MonetaryGrant
    166 sg:journal.1051247 schema:issn 2198-641X
    167 schema:name Current Pharmacology Reports
    168 rdf:type schema:Periodical
    169 sg:person.01167567230.43 schema:affiliation https://www.grid.ac/institutes/grid.443867.a
    170 schema:familyName Malemud
    171 schema:givenName Charles J.
    172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167567230.43
    173 rdf:type schema:Person
    174 sg:pub.10.1007/978-1-4614-9233-7_5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047469362
    175 https://doi.org/10.1007/978-1-4614-9233-7_5
    176 rdf:type schema:CreativeWork
    177 sg:pub.10.1007/s10067-016-3250-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028077083
    178 https://doi.org/10.1007/s10067-016-3250-9
    179 rdf:type schema:CreativeWork
    180 sg:pub.10.1007/s12016-016-8550-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1016203724
    181 https://doi.org/10.1007/s12016-016-8550-y
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1007/s12026-013-8481-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033527738
    184 https://doi.org/10.1007/s12026-013-8481-0
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1007/s40261-017-0596-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1092478687
    187 https://doi.org/10.1007/s40261-017-0596-y
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1007/s40265-017-0701-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084038530
    190 https://doi.org/10.1007/s40265-017-0701-9
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1007/s40265-017-0755-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085444493
    193 https://doi.org/10.1007/s40265-017-0755-8
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1038/ni1548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041677961
    196 https://doi.org/10.1038/ni1548
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1038/nm.4307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084508963
    199 https://doi.org/10.1038/nm.4307
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1038/sj.cr.7310027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018273845
    202 https://doi.org/10.1038/sj.cr.7310027
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1111/j.1572-0241.2005.40615.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033961311
    205 https://doi.org/10.1111/j.1572-0241.2005.40615.x
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1186/1471-2172-7-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032351125
    208 https://doi.org/10.1186/1471-2172-7-10
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1186/ar1197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040997508
    211 https://doi.org/10.1186/ar1197
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1186/s12859-016-0886-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1033225730
    214 https://doi.org/10.1186/s12859-016-0886-z
    215 rdf:type schema:CreativeWork
    216 https://app.dimensions.ai/details/publication/pub.1074879558 schema:CreativeWork
    217 https://app.dimensions.ai/details/publication/pub.1077439931 schema:CreativeWork
    218 https://app.dimensions.ai/details/publication/pub.1077509141 schema:CreativeWork
    219 https://doi.org/10.1002/ana.10764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031290817
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1002/art.21942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009501599
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1002/art.30613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027393396
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1002/art.34400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039491619
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1002/eji.200322875 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045240064
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1002/eji.201646680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085707952
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1002/eji.201646872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085123594
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1016/0016-5085(94)90614-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018221919
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1016/j.cell.2007.06.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005963020
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1016/j.clim.2016.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032569327
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1016/j.cyto.2017.10.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092597463
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1016/j.cytogfr.2008.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041400583
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1016/j.cytogfr.2015.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045078698
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1016/j.ejcb.2011.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037271337
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/j.humimm.2015.09.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023906190
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/j.immuni.2012.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006017596
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/j.mrfmmm.2010.01.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004651293
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/j.pharep.2016.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009335347
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/j.phrs.2013.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046390814
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1016/j.semcdb.2008.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034150200
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/s0140-6736(10)61354-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028914094
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/s0140-6736(17)31618-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086040585
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/s0301-472x(00)00652-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017508957
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/s0889-857x(05)70136-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008756315
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1021/acs.jmedchem.7b01598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100158276
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1056/nejmoa1109071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010422264
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1056/nejmoa1112072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002267298
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1056/nejmoa1112168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009290091
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1056/nejmoa1606910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085131615
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1056/nejmoa1615975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092274251
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1056/nejmoa1615977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092274246
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1073/pnas.0705268104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036413299
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1074/jbc.m207999200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006558628
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1080/13543784.2016.1189900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030282023
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1080/14656566.2017.1378343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091617326
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1080/14712598.2018.1445223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101226834
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1080/1744666x.2017.1291342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083552901
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1080/17512433.2018.1445967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101221702
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1084/jem.193.4.471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038982061
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1093/intimm/dxm045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047973936
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1093/rheumatology/kem198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030490892
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1097/00001574-199907000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060137658
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1097/01.rhu.0000166673.34461.33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023636044
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1097/bor.0000000000000399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084603187
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1111/bcp.13612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103425330
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1111/bjd.12049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006314201
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1111/dth.12555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092133397
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1111/exd.12128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051953193
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1111/j.1600-065x.2008.00625.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002699491
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1126/science.277.5332.1630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062557957
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1136/annrheumdis-2014-207201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041335411
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1136/ard.2005.037929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007206227
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1136/ard.2006.060822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004584186
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1136/gut.36.1.45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027545926
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1136/gut.51.3.379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036397691
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1136/gutjnl-2016-312735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083845095
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1136/rmdopen-2017-000581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100395700
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1146/annurev.biochem.73.011303.074118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031244606
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1146/annurev.immunol.16.1.293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033509267
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1177/0961203310367660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033375867
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1177/0961203311409963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021685569
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1189/jlb.3mr0117-033r schema:sameAs https://app.dimensions.ai/details/publication/pub.1084826426
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1371/journal.pone.0038338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019494331
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1371/journal.pone.0070738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018471825
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1371/journal.pone.0130078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009225841
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1371/journal.pone.0176994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085152056
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.15761/imm.1000158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068046959
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1586/17512433.2016.1154785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029619501
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1615/critrevimmunol.2016015517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068131572
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.18632/oncotarget.16081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084373198
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.2147/dddt.s82599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016253082
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.2147/jir.s93797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091986208
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.2174/1573397054023146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069204907
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.2174/1573397111309010010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069205206
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.2174/157436209789057467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069213794
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.2217/imt.12.20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032479730
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.2741/4054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070916215
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.3389/fphar.2016.00455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019996657
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.3390/ijms18030484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083892178
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.3390/ijms19010171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100265449
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.3748/wjg.14.4280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071360631
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.3899/jrheum.130683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043063467
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.4049/jimmunol.1101228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078442900
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.4049/jimmunol.1403254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079194342
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.4049/jimmunol.164.7.3894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074607408
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.4049/jimmunol.168.3.1113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074984117
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.4049/jimmunol.169.10.6020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075187689
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.4049/jimmunol.173.10.6241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076962441
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.4049/jimmunol.178.5.2623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002607144
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.4103/0976-500x.155482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004102771
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.4155/fmc.15.55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035362741
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.4161/jkst.24134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072305385
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.4172/2155-9899.1000422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020443287
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.4172/2161-1149.1000113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072334768
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.4172/2161-1149.1000147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043219198
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.4172/2476-1966.1000112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084839212
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.5772/52506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037594713
    412 rdf:type schema:CreativeWork
    413 https://www.grid.ac/institutes/grid.443867.a schema:alternateName University Hospitals Case Medical Center
    414 schema:name Department of Medicine, Division of Rheumatic Diseases, Case Western Reserve University School of Medicine, 44106, Cleveland, OH, USA
    415 Department of Medicine, University Hospitals Cleveland Medical Center, Foley Medical Building, 2061 Cornell Road, Room 207, 44106-5076, Cleveland, OH, USA
    416 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...