Neuroinflammation and Neuroimmunomodulation in Alzheimer’s Disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-10

AUTHORS

Yin Hong, Jun Xu, Yue Hu, Lin Li, Zhen Dong, Ting-ke Zhu, Yan-qiu Wei

ABSTRACT

This review provides an updated summary of our current understanding of the role of neuroinflammation in Alzheimer’s disease (AD). We introduce the main cellular and molecular players in AD-related neuroinflammation, highlight the latest discovery on how inflammasome participates in the development of AD, and discuss potential neuroimmunomodulation approaches for AD prevention and therapy. AD is characterized by the abnormal accumulation or aggregation of proteins such as amyloid β (Aβ) and tau, which could act as danger-associated molecular patterns that engage pattern-recognition receptors to activate inflammatory signaling pathways and promote the production and release of a variety of inflammatory mediators. While the role of neuroinflammatory response in AD is complex and poorly understood, it is generally considered that consistent neuroinflammation has detrimental effects and facilitate the progression of AD. In particular, recent evidence suggests that targeting Nod-like receptor protein 3 (NLRP3) inflammasome could slow the deposition of Aβ plaques in the brain and improve neurological outcome in AD patients. Neuroinflammation plays an important role in AD. Further elucidation of molecular mechanisms underlying AD-related neuroinflammatory response would help develop novel strategies for the prevention and treatment of AD. More... »

PAGES

408-413

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40495-018-0148-z

DOI

http://dx.doi.org/10.1007/s40495-018-0148-z

DIMENSIONS

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