Bioavailability and Pharmacokinetics of Dihydroartemisinin (DHA) and its Analogs—Mechanistic Studies on its ADME View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-02

AUTHORS

Uduma E. Osonwa, Ming Hu

ABSTRACT

Malaria is an infectious disease that continues to be linked with considerable morbidity and mortality, and significant social and economic impact in developing countries Malaria is transmitted from person to person by the bite of mosquitoes infected with the protozoan parasite Plasmodium spp. P. falciparum, P. vivax, P. malariae, and P. ovale. Of these, P. falciparum is responsible for over 90% of cases and almost all of the malaria deaths worldwide. This review discusses the epidemiology of malaria, its transmission and clinical manifestations, and the current malaria treatment regimens with emphasis on the artemisinins. Included are the efficacy of the artemisinins and their mechanism of action. Their low bioavailability was linked to extensive metabolism, as well as their chemical instability. Different factors that have permitted the emerging resistance to the artemisinins were showcased, probably as poor-dosing regimen and substandard products in developing countries. Also discussed were the plasmodial genes so far implicated in artemisinin resistance. Lastly, based on the available evidence with regard to bioavailability, metabolism, stability, drug transport, and pharmacokinetics, different approaches were proffered for formulations that will enhance therapeutics efficacy. More... »

PAGES

33-44

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40495-018-0120-y

DOI

http://dx.doi.org/10.1007/s40495-018-0120-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100832051


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Nnamdi Azikiwe University", 
          "id": "https://www.grid.ac/institutes/grid.412207.2", 
          "name": [
            "Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, 1441 Moursund Street, 77030, Houston, TX, USA", 
            "Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Osonwa", 
        "givenName": "Uduma E.", 
        "id": "sg:person.012233405605.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012233405605.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Houston", 
          "id": "https://www.grid.ac/institutes/grid.266436.3", 
          "name": [
            "Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, 1441 Moursund Street, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hu", 
        "givenName": "Ming", 
        "id": "sg:person.01351361054.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351361054.30"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1128/aac.00635-13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001344170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-200039040-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001344850", 
          "https://doi.org/10.2165/00003088-200039040-00002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-200039040-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001344850", 
          "https://doi.org/10.2165/00003088-200039040-00002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1314981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001751558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.49.6.2180-2188.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002109862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.0030444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003303459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11095-015-1646-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003674534", 
          "https://doi.org/10.1007/s11095-015-1646-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0206-170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004056777", 
          "https://doi.org/10.1038/nm0206-170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0206-170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004056777", 
          "https://doi.org/10.1038/nm0206-170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1651-2227.2007.00452.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004303403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/pdr.0b013e3181eee738", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006090746", 
          "https://doi.org/10.1203/pdr.0b013e3181eee738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/pdr.0b013e3181eee738", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006090746", 
          "https://doi.org/10.1203/pdr.0b013e3181eee738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-11-s1-p99", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006317488", 
          "https://doi.org/10.1186/1475-2875-11-s1-p99"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2958.2003.03627.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007664723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.15-0665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007714005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.15-0665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007714005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.15-0665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007714005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-10-263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007868810", 
          "https://doi.org/10.1186/1475-2875-10-263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkn550", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008740150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010217292", 
          "https://doi.org/10.1038/nature12876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2014.07.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011341679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.2007.05753.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011420283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m806944200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011843912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-11-379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012071400", 
          "https://doi.org/10.1186/1475-2875-11-379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/js960001i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013667288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.00708-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014578994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-9-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015318796", 
          "https://doi.org/10.1186/1475-2875-9-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmc091737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015577541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.addr.2009.11.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016443547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4314/ijbcs.v7i1.31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016680396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4314/ijbcs.v7i1.31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016680396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2014.03.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017215830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0169-4758(99)01396-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017910581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/dmd.111.040006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019042822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003495-199652060-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020225837", 
          "https://doi.org/10.2165/00003495-199652060-00004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003495-199652060-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020225837", 
          "https://doi.org/10.2165/00003495-199652060-00004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmp1108322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020900302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pt.2007.11.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021318016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bdd.607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021832172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bcp.12809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021877215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1260403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022075703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1208/s12248-010-9209-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023187282", 
          "https://doi.org/10.1208/s12248-010-9209-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-8-112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024747758", 
          "https://doi.org/10.1186/1475-2875-8-112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep02513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027015989", 
          "https://doi.org/10.1038/srep02513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.26.16192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031568021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.2042-7158.1998.tb06173.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031647772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.2012.08180.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031921736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0269-283x.2004.00495.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032015110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2007.10.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032328309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/651562", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034542506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2210-1-12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036451926", 
          "https://doi.org/10.1186/1471-2210-1-12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.321.7254.154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036625200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2875-13-463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037452411", 
          "https://doi.org/10.1186/1475-2875-13-463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11095-015-1812-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037728537", 
          "https://doi.org/10.1007/s11095-015-1812-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.102.046409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038339204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/dmd.30.9.1005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038568645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0731-7085(97)00033-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038907526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clinthera.2011.04.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038957317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/fmb.10.136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039576689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmc0805011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041561416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci21682", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041881557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cmdc.200700064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041978995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.foodchem.2011.01.059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043968030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2011.12.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045754397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.2008.06413.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046059378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cmdc.201100184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047488270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1211205110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048905833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.0306-5251.2001.01519.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049145178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.0050128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050836782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.06232-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051860042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/pgmj.2004.028399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052024696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/pgmj.2004.028399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052024696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/dmd.30.4.370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052422708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)67787-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052975277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)60484-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053009002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.trstmh.2007.05.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054751487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jf202135j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055910044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jf202135j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055910044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm00011a011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055932488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/mp900013d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056214048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/mp900013d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056214048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10915810591007201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058377422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10915810591007201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058377422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10915810591007201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058377422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1155165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062457547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1215966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062465793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1215966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062465793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.328.5980.844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062603991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.c2637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062805757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.c2637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062805757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.139.1.5659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064281933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/eri.09.68", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068079996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/138955709787316074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069183000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/13895575113136660097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069183674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5251/abjna.2010.1.3.307.312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072730652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2000.62.210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074641030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2007.77.69", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077584372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/cbo9780511543470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1098726807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.19026/bjpt.6.5186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100851106"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-02", 
    "datePublishedReg": "2018-02-01", 
    "description": "Malaria is an infectious disease that continues to be linked with considerable morbidity and mortality, and significant social and economic impact in developing countries Malaria is transmitted from person to person by the bite of mosquitoes infected with the protozoan parasite Plasmodium spp. P. falciparum, P. vivax, P. malariae, and P. ovale. Of these, P. falciparum is responsible for over 90% of cases and almost all of the malaria deaths worldwide. This review discusses the epidemiology of malaria, its transmission and clinical manifestations, and the current malaria treatment regimens with emphasis on the artemisinins. Included are the efficacy of the artemisinins and their mechanism of action. Their low bioavailability was linked to extensive metabolism, as well as their chemical instability. Different factors that have permitted the emerging resistance to the artemisinins were showcased, probably as poor-dosing regimen and substandard products in developing countries. Also discussed were the plasmodial genes so far implicated in artemisinin resistance. Lastly, based on the available evidence with regard to bioavailability, metabolism, stability, drug transport, and pharmacokinetics, different approaches were proffered for formulations that will enhance therapeutics efficacy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s40495-018-0120-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2518329", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1051247", 
        "issn": [
          "2198-641X"
        ], 
        "name": "Current Pharmacology Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "Bioavailability and Pharmacokinetics of Dihydroartemisinin (DHA) and its Analogs\u2014Mechanistic Studies on its ADME", 
    "pagination": "33-44", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "85551f8bae9ab089e166194ff991a49a2b204e1bd074ddbf5be2b0b7682270c6"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s40495-018-0120-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100832051"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s40495-018-0120-y", 
      "https://app.dimensions.ai/details/publication/pub.1100832051"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000603.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s40495-018-0120-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40495-018-0120-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40495-018-0120-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40495-018-0120-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40495-018-0120-y'


 

This table displays all metadata directly associated to this object as RDF triples.

344 TRIPLES      21 PREDICATES      112 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s40495-018-0120-y schema:about anzsrc-for:11
2 anzsrc-for:1108
3 schema:author N98a466e15b3e43a5912c60cd9ce9d6e4
4 schema:citation sg:pub.10.1007/s11095-015-1646-x
5 sg:pub.10.1007/s11095-015-1812-1
6 sg:pub.10.1038/nature12876
7 sg:pub.10.1038/nm0206-170
8 sg:pub.10.1038/srep02513
9 sg:pub.10.1186/1471-2210-1-12
10 sg:pub.10.1186/1475-2875-10-263
11 sg:pub.10.1186/1475-2875-11-379
12 sg:pub.10.1186/1475-2875-11-s1-p99
13 sg:pub.10.1186/1475-2875-13-463
14 sg:pub.10.1186/1475-2875-8-112
15 sg:pub.10.1186/1475-2875-9-1
16 sg:pub.10.1203/pdr.0b013e3181eee738
17 sg:pub.10.1208/s12248-010-9209-x
18 sg:pub.10.2165/00003088-200039040-00002
19 sg:pub.10.2165/00003495-199652060-00004
20 https://doi.org/10.1002/bdd.607
21 https://doi.org/10.1002/cmdc.200700064
22 https://doi.org/10.1002/cmdc.201100184
23 https://doi.org/10.1016/j.addr.2009.11.024
24 https://doi.org/10.1016/j.bmcl.2011.12.011
25 https://doi.org/10.1016/j.cell.2014.07.011
26 https://doi.org/10.1016/j.clinthera.2011.04.017
27 https://doi.org/10.1016/j.foodchem.2011.01.059
28 https://doi.org/10.1016/j.ijpharm.2007.10.008
29 https://doi.org/10.1016/j.ijpharm.2014.03.036
30 https://doi.org/10.1016/j.pt.2007.11.008
31 https://doi.org/10.1016/j.trstmh.2007.05.010
32 https://doi.org/10.1016/s0140-6736(05)67787-2
33 https://doi.org/10.1016/s0140-6736(12)60484-x
34 https://doi.org/10.1016/s0169-4758(99)01396-4
35 https://doi.org/10.1016/s0731-7085(97)00033-2
36 https://doi.org/10.1017/cbo9780511543470
37 https://doi.org/10.1021/jf202135j
38 https://doi.org/10.1021/jm00011a011
39 https://doi.org/10.1021/js960001i
40 https://doi.org/10.1021/mp900013d
41 https://doi.org/10.1046/j.0306-5251.2001.01519.x
42 https://doi.org/10.1046/j.1365-2958.2003.03627.x
43 https://doi.org/10.1056/nejmc0805011
44 https://doi.org/10.1056/nejmc091737
45 https://doi.org/10.1056/nejmoa1314981
46 https://doi.org/10.1056/nejmp1108322
47 https://doi.org/10.1073/pnas.1211205110
48 https://doi.org/10.1074/jbc.273.26.16192
49 https://doi.org/10.1074/jbc.m806944200
50 https://doi.org/10.1080/10915810591007201
51 https://doi.org/10.1086/651562
52 https://doi.org/10.1093/jac/dkn550
53 https://doi.org/10.1111/bcp.12809
54 https://doi.org/10.1111/j.0269-283x.2004.00495.x
55 https://doi.org/10.1111/j.1365-2958.2007.05753.x
56 https://doi.org/10.1111/j.1365-2958.2008.06413.x
57 https://doi.org/10.1111/j.1365-2958.2012.08180.x
58 https://doi.org/10.1111/j.1651-2227.2007.00452.x
59 https://doi.org/10.1111/j.2042-7158.1998.tb06173.x
60 https://doi.org/10.1124/dmd.111.040006
61 https://doi.org/10.1124/dmd.30.4.370
62 https://doi.org/10.1124/dmd.30.9.1005
63 https://doi.org/10.1124/jpet.102.046409
64 https://doi.org/10.1126/science.1155165
65 https://doi.org/10.1126/science.1215966
66 https://doi.org/10.1126/science.1260403
67 https://doi.org/10.1126/science.328.5980.844
68 https://doi.org/10.1128/aac.00635-13
69 https://doi.org/10.1128/aac.00708-06
70 https://doi.org/10.1128/aac.06232-11
71 https://doi.org/10.1128/aac.49.6.2180-2188.2005
72 https://doi.org/10.1136/bmj.321.7254.154
73 https://doi.org/10.1136/bmj.c2637
74 https://doi.org/10.1136/pgmj.2004.028399
75 https://doi.org/10.1172/jci21682
76 https://doi.org/10.1210/endo.139.1.5659
77 https://doi.org/10.1371/journal.pmed.0030444
78 https://doi.org/10.1371/journal.pmed.0050128
79 https://doi.org/10.1586/eri.09.68
80 https://doi.org/10.19026/bjpt.6.5186
81 https://doi.org/10.2174/138955709787316074
82 https://doi.org/10.2174/13895575113136660097
83 https://doi.org/10.2217/fmb.10.136
84 https://doi.org/10.4269/ajtmh.15-0665
85 https://doi.org/10.4269/ajtmh.2000.62.210
86 https://doi.org/10.4269/ajtmh.2007.77.69
87 https://doi.org/10.4314/ijbcs.v7i1.31
88 https://doi.org/10.5251/abjna.2010.1.3.307.312
89 schema:datePublished 2018-02
90 schema:datePublishedReg 2018-02-01
91 schema:description Malaria is an infectious disease that continues to be linked with considerable morbidity and mortality, and significant social and economic impact in developing countries Malaria is transmitted from person to person by the bite of mosquitoes infected with the protozoan parasite Plasmodium spp. P. falciparum, P. vivax, P. malariae, and P. ovale. Of these, P. falciparum is responsible for over 90% of cases and almost all of the malaria deaths worldwide. This review discusses the epidemiology of malaria, its transmission and clinical manifestations, and the current malaria treatment regimens with emphasis on the artemisinins. Included are the efficacy of the artemisinins and their mechanism of action. Their low bioavailability was linked to extensive metabolism, as well as their chemical instability. Different factors that have permitted the emerging resistance to the artemisinins were showcased, probably as poor-dosing regimen and substandard products in developing countries. Also discussed were the plasmodial genes so far implicated in artemisinin resistance. Lastly, based on the available evidence with regard to bioavailability, metabolism, stability, drug transport, and pharmacokinetics, different approaches were proffered for formulations that will enhance therapeutics efficacy.
92 schema:genre research_article
93 schema:inLanguage en
94 schema:isAccessibleForFree false
95 schema:isPartOf Nb9660c98b4db4747baae852e1e661d1e
96 Nfdb56aafcac84402a8eb808330ca7c77
97 sg:journal.1051247
98 schema:name Bioavailability and Pharmacokinetics of Dihydroartemisinin (DHA) and its Analogs—Mechanistic Studies on its ADME
99 schema:pagination 33-44
100 schema:productId N072151c581b14e03890ce69f821404e9
101 N8f2f43eda3a548418a6caa068332e98a
102 Naca8fbaeb69d4b08a4d64ecac37a0fff
103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100832051
104 https://doi.org/10.1007/s40495-018-0120-y
105 schema:sdDatePublished 2019-04-10T21:54
106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
107 schema:sdPublisher N2f86abcc888c4347a697233070355e9e
108 schema:url http://link.springer.com/10.1007/s40495-018-0120-y
109 sgo:license sg:explorer/license/
110 sgo:sdDataset articles
111 rdf:type schema:ScholarlyArticle
112 N072151c581b14e03890ce69f821404e9 schema:name dimensions_id
113 schema:value pub.1100832051
114 rdf:type schema:PropertyValue
115 N2f86abcc888c4347a697233070355e9e schema:name Springer Nature - SN SciGraph project
116 rdf:type schema:Organization
117 N8f2f43eda3a548418a6caa068332e98a schema:name readcube_id
118 schema:value 85551f8bae9ab089e166194ff991a49a2b204e1bd074ddbf5be2b0b7682270c6
119 rdf:type schema:PropertyValue
120 N98a466e15b3e43a5912c60cd9ce9d6e4 rdf:first sg:person.012233405605.46
121 rdf:rest Nca9657fac0ee48049252eccbaa259aa8
122 Naca8fbaeb69d4b08a4d64ecac37a0fff schema:name doi
123 schema:value 10.1007/s40495-018-0120-y
124 rdf:type schema:PropertyValue
125 Nb9660c98b4db4747baae852e1e661d1e schema:volumeNumber 4
126 rdf:type schema:PublicationVolume
127 Nca9657fac0ee48049252eccbaa259aa8 rdf:first sg:person.01351361054.30
128 rdf:rest rdf:nil
129 Nfdb56aafcac84402a8eb808330ca7c77 schema:issueNumber 1
130 rdf:type schema:PublicationIssue
131 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
132 schema:name Medical and Health Sciences
133 rdf:type schema:DefinedTerm
134 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
135 schema:name Medical Microbiology
136 rdf:type schema:DefinedTerm
137 sg:grant.2518329 http://pending.schema.org/fundedItem sg:pub.10.1007/s40495-018-0120-y
138 rdf:type schema:MonetaryGrant
139 sg:journal.1051247 schema:issn 2198-641X
140 schema:name Current Pharmacology Reports
141 rdf:type schema:Periodical
142 sg:person.012233405605.46 schema:affiliation https://www.grid.ac/institutes/grid.412207.2
143 schema:familyName Osonwa
144 schema:givenName Uduma E.
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012233405605.46
146 rdf:type schema:Person
147 sg:person.01351361054.30 schema:affiliation https://www.grid.ac/institutes/grid.266436.3
148 schema:familyName Hu
149 schema:givenName Ming
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351361054.30
151 rdf:type schema:Person
152 sg:pub.10.1007/s11095-015-1646-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003674534
153 https://doi.org/10.1007/s11095-015-1646-x
154 rdf:type schema:CreativeWork
155 sg:pub.10.1007/s11095-015-1812-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037728537
156 https://doi.org/10.1007/s11095-015-1812-1
157 rdf:type schema:CreativeWork
158 sg:pub.10.1038/nature12876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010217292
159 https://doi.org/10.1038/nature12876
160 rdf:type schema:CreativeWork
161 sg:pub.10.1038/nm0206-170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004056777
162 https://doi.org/10.1038/nm0206-170
163 rdf:type schema:CreativeWork
164 sg:pub.10.1038/srep02513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027015989
165 https://doi.org/10.1038/srep02513
166 rdf:type schema:CreativeWork
167 sg:pub.10.1186/1471-2210-1-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036451926
168 https://doi.org/10.1186/1471-2210-1-12
169 rdf:type schema:CreativeWork
170 sg:pub.10.1186/1475-2875-10-263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007868810
171 https://doi.org/10.1186/1475-2875-10-263
172 rdf:type schema:CreativeWork
173 sg:pub.10.1186/1475-2875-11-379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012071400
174 https://doi.org/10.1186/1475-2875-11-379
175 rdf:type schema:CreativeWork
176 sg:pub.10.1186/1475-2875-11-s1-p99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006317488
177 https://doi.org/10.1186/1475-2875-11-s1-p99
178 rdf:type schema:CreativeWork
179 sg:pub.10.1186/1475-2875-13-463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037452411
180 https://doi.org/10.1186/1475-2875-13-463
181 rdf:type schema:CreativeWork
182 sg:pub.10.1186/1475-2875-8-112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024747758
183 https://doi.org/10.1186/1475-2875-8-112
184 rdf:type schema:CreativeWork
185 sg:pub.10.1186/1475-2875-9-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015318796
186 https://doi.org/10.1186/1475-2875-9-1
187 rdf:type schema:CreativeWork
188 sg:pub.10.1203/pdr.0b013e3181eee738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006090746
189 https://doi.org/10.1203/pdr.0b013e3181eee738
190 rdf:type schema:CreativeWork
191 sg:pub.10.1208/s12248-010-9209-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023187282
192 https://doi.org/10.1208/s12248-010-9209-x
193 rdf:type schema:CreativeWork
194 sg:pub.10.2165/00003088-200039040-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001344850
195 https://doi.org/10.2165/00003088-200039040-00002
196 rdf:type schema:CreativeWork
197 sg:pub.10.2165/00003495-199652060-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020225837
198 https://doi.org/10.2165/00003495-199652060-00004
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1002/bdd.607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021832172
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1002/cmdc.200700064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041978995
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1002/cmdc.201100184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047488270
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.addr.2009.11.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016443547
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.bmcl.2011.12.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045754397
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.cell.2014.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011341679
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.clinthera.2011.04.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038957317
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.foodchem.2011.01.059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043968030
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.ijpharm.2007.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032328309
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/j.ijpharm.2014.03.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017215830
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/j.pt.2007.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021318016
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.trstmh.2007.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054751487
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/s0140-6736(05)67787-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052975277
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/s0140-6736(12)60484-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053009002
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/s0169-4758(99)01396-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017910581
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/s0731-7085(97)00033-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038907526
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1017/cbo9780511543470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1098726807
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1021/jf202135j schema:sameAs https://app.dimensions.ai/details/publication/pub.1055910044
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1021/jm00011a011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055932488
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1021/js960001i schema:sameAs https://app.dimensions.ai/details/publication/pub.1013667288
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1021/mp900013d schema:sameAs https://app.dimensions.ai/details/publication/pub.1056214048
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1046/j.0306-5251.2001.01519.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049145178
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1046/j.1365-2958.2003.03627.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007664723
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1056/nejmc0805011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041561416
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1056/nejmc091737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015577541
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1056/nejmoa1314981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001751558
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1056/nejmp1108322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020900302
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1073/pnas.1211205110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048905833
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1074/jbc.273.26.16192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031568021
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1074/jbc.m806944200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011843912
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1080/10915810591007201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058377422
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1086/651562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034542506
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1093/jac/dkn550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008740150
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1111/bcp.12809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021877215
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1111/j.0269-283x.2004.00495.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032015110
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1111/j.1365-2958.2007.05753.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011420283
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1111/j.1365-2958.2008.06413.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046059378
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1111/j.1365-2958.2012.08180.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031921736
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1111/j.1651-2227.2007.00452.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004303403
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1111/j.2042-7158.1998.tb06173.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031647772
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1124/dmd.111.040006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019042822
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1124/dmd.30.4.370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052422708
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1124/dmd.30.9.1005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038568645
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1124/jpet.102.046409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038339204
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1126/science.1155165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062457547
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1126/science.1215966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062465793
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1126/science.1260403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022075703
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1126/science.328.5980.844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062603991
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1128/aac.00635-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001344170
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1128/aac.00708-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014578994
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1128/aac.06232-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051860042
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1128/aac.49.6.2180-2188.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002109862
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1136/bmj.321.7254.154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036625200
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1136/bmj.c2637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062805757
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1136/pgmj.2004.028399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052024696
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1172/jci21682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041881557
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1210/endo.139.1.5659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064281933
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1371/journal.pmed.0030444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003303459
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1371/journal.pmed.0050128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050836782
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1586/eri.09.68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068079996
319 rdf:type schema:CreativeWork
320 https://doi.org/10.19026/bjpt.6.5186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100851106
321 rdf:type schema:CreativeWork
322 https://doi.org/10.2174/138955709787316074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069183000
323 rdf:type schema:CreativeWork
324 https://doi.org/10.2174/13895575113136660097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069183674
325 rdf:type schema:CreativeWork
326 https://doi.org/10.2217/fmb.10.136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039576689
327 rdf:type schema:CreativeWork
328 https://doi.org/10.4269/ajtmh.15-0665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007714005
329 rdf:type schema:CreativeWork
330 https://doi.org/10.4269/ajtmh.2000.62.210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074641030
331 rdf:type schema:CreativeWork
332 https://doi.org/10.4269/ajtmh.2007.77.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077584372
333 rdf:type schema:CreativeWork
334 https://doi.org/10.4314/ijbcs.v7i1.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016680396
335 rdf:type schema:CreativeWork
336 https://doi.org/10.5251/abjna.2010.1.3.307.312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072730652
337 rdf:type schema:CreativeWork
338 https://www.grid.ac/institutes/grid.266436.3 schema:alternateName University of Houston
339 schema:name Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, 1441 Moursund Street, 77030, Houston, TX, USA
340 rdf:type schema:Organization
341 https://www.grid.ac/institutes/grid.412207.2 schema:alternateName Nnamdi Azikiwe University
342 schema:name Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria
343 Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, 1441 Moursund Street, 77030, Houston, TX, USA
344 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...