Target specificity of the CRISPR-Cas9 system View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-06

AUTHORS

Xuebing Wu, Andrea J. Kriz, Phillip A. Sharp

ABSTRACT

The CRISPR-Cas9 system, naturally a defense mechanism in prokaryotes, has been repurposed as an RNA-guided DNA targeting platform. It has been widely used for genome editing and transcriptome modulation, and has shown great promise in correcting mutations in human genetic diseases. Off-target effects are a critical issue for all of these applications. Here we review the current status on the target specificity of the CRISPR-Cas9 system. More... »

PAGES

59-70

References to SciGraph publications

  • 2011-09. Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection in NATURE METHODS
  • 2013-09. Staying on target with CRISPR-Cas in NATURE BIOTECHNOLOGY
  • 2014-07. CRISPR transcriptional repression devices and layered circuits in mammalian cells in NATURE METHODS
  • 1995-02. Detection of mutations by cleavage of DNA heteroduplexes with bacteriophage resolvases in NATURE GENETICS
  • 2014-07. Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease in NATURE BIOTECHNOLOGY
  • 2013-10. Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system in CELL RESEARCH
  • 2010-03. CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea in NATURE REVIEWS GENETICS
  • 2009-10. ChIP–seq: advantages and challenges of a maturing technology in NATURE REVIEWS GENETICS
  • 2010-11. The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA in NATURE
  • 2013-09. CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering in NATURE BIOTECHNOLOGY
  • 2013-09. High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity in NATURE BIOTECHNOLOGY
  • 2011-06. Evolution and classification of the CRISPR–Cas systems in NATURE REVIEWS MICROBIOLOGY
  • 2011-09. An unbiased genome-wide analysis of zinc-finger nuclease specificity in NATURE BIOTECHNOLOGY
  • 2013-11. CRISPR interference (CRISPRi) for sequence-specific control of gene expression in NATURE PROTOCOLS
  • 2013-10. Cas9 as a versatile tool for engineering biology in NATURE METHODS
  • 2014-04. Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity in NATURE METHODS
  • 2014-06. Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype in NATURE BIOTECHNOLOGY
  • 2013-10. RNA-guided gene activation by CRISPR-Cas9–based transcription factors in NATURE METHODS
  • 2014-07. Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells in NATURE BIOTECHNOLOGY
  • 2014-03. Improving CRISPR-Cas nuclease specificity using truncated guide RNAs in NATURE BIOTECHNOLOGY
  • 2013-11. Orthogonal Cas9 proteins for RNA-guided gene regulation and editing in NATURE METHODS
  • 2013-04. Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing in NATURE METHODS
  • 2014-06. Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification in NATURE BIOTECHNOLOGY
  • 2014-06. Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing in NATURE BIOTECHNOLOGY
  • 2014-12. Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR–Cas9 system in NATURE COMMUNICATIONS
  • 2014-04. CRISPR-Cas systems for editing, regulating and targeting genomes in NATURE BIOTECHNOLOGY
  • 2014-02. E-CRISP: fast CRISPR target site identification in NATURE METHODS
  • 2014-03. Quantifying DNA double-strand breaks induced by site-specific endonucleases in living cells by ligation-mediated purification in NATURE PROTOCOLS
  • 2013-09. DNA targeting specificity of RNA-guided Cas9 nucleases in NATURE BIOTECHNOLOGY
  • 2013-09. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells in NATURE BIOTECHNOLOGY
  • 2014-03. DNA interrogation by the CRISPR RNA-guided endonuclease Cas9 in NATURE
  • 2013-03. RNA-guided editing of bacterial genomes using CRISPR-Cas systems in NATURE BIOTECHNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40484-014-0030-x

    DOI

    http://dx.doi.org/10.1007/s40484-014-0030-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1014529473

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25722925


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Massachusetts Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA", 
                "Computational and Systems Biology Graduate Program, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wu", 
            "givenName": "Xuebing", 
            "id": "sg:person.0757512235.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757512235.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Massachusetts Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Department of Biology, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kriz", 
            "givenName": "Andrea J.", 
            "id": "sg:person.01256206610.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256206610.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Massachusetts Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA", 
                "Department of Biology, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sharp", 
            "givenName": "Phillip A.", 
            "id": "sg:person.01147001662.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147001662.05"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.mib.2011.03.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001559405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2845", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002278800", 
              "https://doi.org/10.1038/nmeth.2845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.08.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002481722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2684", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003437173", 
              "https://doi.org/10.1038/nbt.2684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004290844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.micro.112408.134123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005066090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005460200", 
              "https://doi.org/10.1038/nrg2749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005460200", 
              "https://doi.org/10.1038/nrg2749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2641", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006115199", 
              "https://doi.org/10.1038/nrg2641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2641", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006115199", 
              "https://doi.org/10.1038/nrg2641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2673", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007302590", 
              "https://doi.org/10.1038/nbt.2673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.02.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008291683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2013.10.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008524552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2649", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008703730", 
              "https://doi.org/10.1038/nmeth.2649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2013.132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009361018", 
              "https://doi.org/10.1038/nprot.2013.132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2623", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009511624", 
              "https://doi.org/10.1038/nbt.2623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009515358", 
              "https://doi.org/10.1038/nature09523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009515358", 
              "https://doi.org/10.1038/nature09523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.162339.113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010306401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2014.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010396170", 
              "https://doi.org/10.1038/nprot.2014.031"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkt716", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011013289"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011531387", 
              "https://doi.org/10.1038/nbt.2884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2408", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011565053", 
              "https://doi.org/10.1038/nmeth.2408"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2647", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012543463", 
              "https://doi.org/10.1038/nbt.2647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2908", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012868720", 
              "https://doi.org/10.1038/nbt.2908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2014.04.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012990723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014213089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gku402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015304040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0295-177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015620800", 
              "https://doi.org/10.1038/ng0295-177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.06.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018287305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.113.160713", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019065457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.113.160713", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019065457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1231143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019873131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2508", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019888616", 
              "https://doi.org/10.1038/nbt.2508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.171264.113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019923892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkv137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020062000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gku410", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020146143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro2577", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020345829", 
              "https://doi.org/10.1038/nrmicro2577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.161638.113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021526947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1179555", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022007081"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1179555", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022007081"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1232033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022072971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/sb400081r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022403918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.18.10570", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022863238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2812", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023043883", 
              "https://doi.org/10.1038/nmeth.2812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2600", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024354143", 
              "https://doi.org/10.1038/nmeth.2600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.171322.113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024649491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkq319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024844693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkq319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024844693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2013.11.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027005875"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2681", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028304735", 
              "https://doi.org/10.1038/nmeth.2681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibs.2009.05.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032505928"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.099085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032936413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2014.04.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033259425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1948", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033698278", 
              "https://doi.org/10.1038/nbt.1948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.08.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034724285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1316064110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034946777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m114.564625", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035370902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1400822111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035810401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037342101", 
              "https://doi.org/10.1038/nature13011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkm349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037729138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddu125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037875677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2842", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038520013", 
              "https://doi.org/10.1038/nbt.2842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btu048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038756964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.05.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039182708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btt764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041543272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2675", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041659759", 
              "https://doi.org/10.1038/nbt.2675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1225829", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041850060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/pbi.12200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042007688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.103341", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042199515"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0100448", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042244721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1308335110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043136564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkt464", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043253969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043348902", 
              "https://doi.org/10.1038/nbt.2916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043519930", 
              "https://doi.org/10.1038/nbt.2889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1246981", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043810806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1246981", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043810806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1670", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043918422", 
              "https://doi.org/10.1038/nmeth.1670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2014.03.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044439504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms4964", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045605027", 
              "https://doi.org/10.1038/ncomms4964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2013/270805", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045793628"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.113.155879", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047932291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.113.155879", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047932291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2013.05.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048229289"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2013.122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048353952", 
              "https://doi.org/10.1038/cr.2013.122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2014.06.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048567409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2808", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048637524", 
              "https://doi.org/10.1038/nbt.2808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048836104", 
              "https://doi.org/10.1038/nmeth.2969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053226125", 
              "https://doi.org/10.1038/nbt.2909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2144/04364pf01", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076825945"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/005074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085109322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/005074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085109322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/005074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085109322"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-06", 
        "datePublishedReg": "2014-06-01", 
        "description": "The CRISPR-Cas9 system, naturally a defense mechanism in prokaryotes, has been repurposed as an RNA-guided DNA targeting platform. It has been widely used for genome editing and transcriptome modulation, and has shown great promise in correcting mutations in human genetic diseases. Off-target effects are a critical issue for all of these applications. Here we review the current status on the target specificity of the CRISPR-Cas9 system.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s40484-014-0030-x", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2635203", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438804", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2510997", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2435520", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2479866", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1050640", 
            "issn": [
              "2095-4689", 
              "2095-4697"
            ], 
            "name": "Quantitative Biology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "2"
          }
        ], 
        "name": "Target specificity of the CRISPR-Cas9 system", 
        "pagination": "59-70", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "4537b090b6bc5d953a9723d3e2b0d5456c94492cec9db181ea0432cc07f54941"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25722925"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101639642"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s40484-014-0030-x"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1014529473"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s40484-014-0030-x", 
          "https://app.dimensions.ai/details/publication/pub.1014529473"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T00:18", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000521.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs40484-014-0030-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40484-014-0030-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40484-014-0030-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40484-014-0030-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40484-014-0030-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    376 TRIPLES      21 PREDICATES      112 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s40484-014-0030-x schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author Nf8fc60506b274593a31eabce6246da5f
    4 schema:citation sg:pub.10.1038/cr.2013.122
    5 sg:pub.10.1038/nature09523
    6 sg:pub.10.1038/nature13011
    7 sg:pub.10.1038/nbt.1948
    8 sg:pub.10.1038/nbt.2508
    9 sg:pub.10.1038/nbt.2623
    10 sg:pub.10.1038/nbt.2647
    11 sg:pub.10.1038/nbt.2673
    12 sg:pub.10.1038/nbt.2675
    13 sg:pub.10.1038/nbt.2684
    14 sg:pub.10.1038/nbt.2808
    15 sg:pub.10.1038/nbt.2842
    16 sg:pub.10.1038/nbt.2884
    17 sg:pub.10.1038/nbt.2889
    18 sg:pub.10.1038/nbt.2908
    19 sg:pub.10.1038/nbt.2909
    20 sg:pub.10.1038/nbt.2916
    21 sg:pub.10.1038/ncomms4964
    22 sg:pub.10.1038/ng0295-177
    23 sg:pub.10.1038/nmeth.1670
    24 sg:pub.10.1038/nmeth.2408
    25 sg:pub.10.1038/nmeth.2600
    26 sg:pub.10.1038/nmeth.2649
    27 sg:pub.10.1038/nmeth.2681
    28 sg:pub.10.1038/nmeth.2812
    29 sg:pub.10.1038/nmeth.2845
    30 sg:pub.10.1038/nmeth.2969
    31 sg:pub.10.1038/nprot.2013.132
    32 sg:pub.10.1038/nprot.2014.031
    33 sg:pub.10.1038/nrg2641
    34 sg:pub.10.1038/nrg2749
    35 sg:pub.10.1038/nrmicro2577
    36 https://doi.org/10.1016/j.cell.2013.02.022
    37 https://doi.org/10.1016/j.cell.2013.06.044
    38 https://doi.org/10.1016/j.cell.2013.08.021
    39 https://doi.org/10.1016/j.cell.2013.08.022
    40 https://doi.org/10.1016/j.cell.2013.12.001
    41 https://doi.org/10.1016/j.cell.2014.02.001
    42 https://doi.org/10.1016/j.cell.2014.05.010
    43 https://doi.org/10.1016/j.mib.2011.03.005
    44 https://doi.org/10.1016/j.molcel.2013.05.001
    45 https://doi.org/10.1016/j.molcel.2014.03.011
    46 https://doi.org/10.1016/j.molcel.2014.04.022
    47 https://doi.org/10.1016/j.stem.2013.10.016
    48 https://doi.org/10.1016/j.stem.2013.11.002
    49 https://doi.org/10.1016/j.stem.2014.04.020
    50 https://doi.org/10.1016/j.stem.2014.06.011
    51 https://doi.org/10.1016/j.tibs.2009.05.002
    52 https://doi.org/10.1021/sb400081r
    53 https://doi.org/10.1073/pnas.1308335110
    54 https://doi.org/10.1073/pnas.1316064110
    55 https://doi.org/10.1073/pnas.1400822111
    56 https://doi.org/10.1073/pnas.95.18.10570
    57 https://doi.org/10.1074/jbc.m114.564625
    58 https://doi.org/10.1093/bioinformatics/btt764
    59 https://doi.org/10.1093/bioinformatics/btu048
    60 https://doi.org/10.1093/hmg/ddu125
    61 https://doi.org/10.1093/nar/gkm349
    62 https://doi.org/10.1093/nar/gkq319
    63 https://doi.org/10.1093/nar/gkt464
    64 https://doi.org/10.1093/nar/gkt716
    65 https://doi.org/10.1093/nar/gku402
    66 https://doi.org/10.1093/nar/gku410
    67 https://doi.org/10.1093/nar/gkv137
    68 https://doi.org/10.1101/005074
    69 https://doi.org/10.1101/gr.161638.113
    70 https://doi.org/10.1101/gr.162339.113
    71 https://doi.org/10.1101/gr.171264.113
    72 https://doi.org/10.1101/gr.171322.113
    73 https://doi.org/10.1111/pbi.12200
    74 https://doi.org/10.1126/science.1179555
    75 https://doi.org/10.1126/science.1225829
    76 https://doi.org/10.1126/science.1231143
    77 https://doi.org/10.1126/science.1232033
    78 https://doi.org/10.1126/science.1246981
    79 https://doi.org/10.1146/annurev.micro.112408.134123
    80 https://doi.org/10.1155/2013/270805
    81 https://doi.org/10.1242/dev.099085
    82 https://doi.org/10.1242/dev.103341
    83 https://doi.org/10.1371/journal.pone.0100448
    84 https://doi.org/10.1534/genetics.113.155879
    85 https://doi.org/10.1534/genetics.113.160713
    86 https://doi.org/10.2144/04364pf01
    87 schema:datePublished 2014-06
    88 schema:datePublishedReg 2014-06-01
    89 schema:description The CRISPR-Cas9 system, naturally a defense mechanism in prokaryotes, has been repurposed as an RNA-guided DNA targeting platform. It has been widely used for genome editing and transcriptome modulation, and has shown great promise in correcting mutations in human genetic diseases. Off-target effects are a critical issue for all of these applications. Here we review the current status on the target specificity of the CRISPR-Cas9 system.
    90 schema:genre research_article
    91 schema:inLanguage en
    92 schema:isAccessibleForFree true
    93 schema:isPartOf N0bf1576e263541b4bb517b2ba8d9ffb3
    94 Nc35d229a09924e6880a642eb800fb98a
    95 sg:journal.1050640
    96 schema:name Target specificity of the CRISPR-Cas9 system
    97 schema:pagination 59-70
    98 schema:productId N45432ec79cce4568babe10892cd30115
    99 N97f77797698a4b08b9fd501a91f06834
    100 N9e3a5b01aba142068dd688c83f4331d7
    101 Nb85c168334df4808abfd391ef9d3ebd5
    102 Nd73d865bbf1a4257b8e236badb76de11
    103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014529473
    104 https://doi.org/10.1007/s40484-014-0030-x
    105 schema:sdDatePublished 2019-04-11T00:18
    106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    107 schema:sdPublisher Nd7d58a3e4a8b4915ab43d1a95ad13bdb
    108 schema:url http://link.springer.com/10.1007%2Fs40484-014-0030-x
    109 sgo:license sg:explorer/license/
    110 sgo:sdDataset articles
    111 rdf:type schema:ScholarlyArticle
    112 N0bf1576e263541b4bb517b2ba8d9ffb3 schema:issueNumber 2
    113 rdf:type schema:PublicationIssue
    114 N0d41b914bd5a428fb000cc58fae2e293 rdf:first sg:person.01256206610.22
    115 rdf:rest Ne72babe8dddc4c8fb00fe6fb115176ea
    116 N45432ec79cce4568babe10892cd30115 schema:name doi
    117 schema:value 10.1007/s40484-014-0030-x
    118 rdf:type schema:PropertyValue
    119 N97f77797698a4b08b9fd501a91f06834 schema:name dimensions_id
    120 schema:value pub.1014529473
    121 rdf:type schema:PropertyValue
    122 N9e3a5b01aba142068dd688c83f4331d7 schema:name readcube_id
    123 schema:value 4537b090b6bc5d953a9723d3e2b0d5456c94492cec9db181ea0432cc07f54941
    124 rdf:type schema:PropertyValue
    125 Nb85c168334df4808abfd391ef9d3ebd5 schema:name pubmed_id
    126 schema:value 25722925
    127 rdf:type schema:PropertyValue
    128 Nc35d229a09924e6880a642eb800fb98a schema:volumeNumber 2
    129 rdf:type schema:PublicationVolume
    130 Nd73d865bbf1a4257b8e236badb76de11 schema:name nlm_unique_id
    131 schema:value 101639642
    132 rdf:type schema:PropertyValue
    133 Nd7d58a3e4a8b4915ab43d1a95ad13bdb schema:name Springer Nature - SN SciGraph project
    134 rdf:type schema:Organization
    135 Ne72babe8dddc4c8fb00fe6fb115176ea rdf:first sg:person.01147001662.05
    136 rdf:rest rdf:nil
    137 Nf8fc60506b274593a31eabce6246da5f rdf:first sg:person.0757512235.54
    138 rdf:rest N0d41b914bd5a428fb000cc58fae2e293
    139 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    140 schema:name Biological Sciences
    141 rdf:type schema:DefinedTerm
    142 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    143 schema:name Genetics
    144 rdf:type schema:DefinedTerm
    145 sg:grant.2435520 http://pending.schema.org/fundedItem sg:pub.10.1007/s40484-014-0030-x
    146 rdf:type schema:MonetaryGrant
    147 sg:grant.2438804 http://pending.schema.org/fundedItem sg:pub.10.1007/s40484-014-0030-x
    148 rdf:type schema:MonetaryGrant
    149 sg:grant.2479866 http://pending.schema.org/fundedItem sg:pub.10.1007/s40484-014-0030-x
    150 rdf:type schema:MonetaryGrant
    151 sg:grant.2510997 http://pending.schema.org/fundedItem sg:pub.10.1007/s40484-014-0030-x
    152 rdf:type schema:MonetaryGrant
    153 sg:grant.2635203 http://pending.schema.org/fundedItem sg:pub.10.1007/s40484-014-0030-x
    154 rdf:type schema:MonetaryGrant
    155 sg:journal.1050640 schema:issn 2095-4689
    156 2095-4697
    157 schema:name Quantitative Biology
    158 rdf:type schema:Periodical
    159 sg:person.01147001662.05 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
    160 schema:familyName Sharp
    161 schema:givenName Phillip A.
    162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147001662.05
    163 rdf:type schema:Person
    164 sg:person.01256206610.22 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
    165 schema:familyName Kriz
    166 schema:givenName Andrea J.
    167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256206610.22
    168 rdf:type schema:Person
    169 sg:person.0757512235.54 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
    170 schema:familyName Wu
    171 schema:givenName Xuebing
    172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757512235.54
    173 rdf:type schema:Person
    174 sg:pub.10.1038/cr.2013.122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048353952
    175 https://doi.org/10.1038/cr.2013.122
    176 rdf:type schema:CreativeWork
    177 sg:pub.10.1038/nature09523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009515358
    178 https://doi.org/10.1038/nature09523
    179 rdf:type schema:CreativeWork
    180 sg:pub.10.1038/nature13011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037342101
    181 https://doi.org/10.1038/nature13011
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1038/nbt.1948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033698278
    184 https://doi.org/10.1038/nbt.1948
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1038/nbt.2508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019888616
    187 https://doi.org/10.1038/nbt.2508
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1038/nbt.2623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009511624
    190 https://doi.org/10.1038/nbt.2623
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1038/nbt.2647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012543463
    193 https://doi.org/10.1038/nbt.2647
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1038/nbt.2673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007302590
    196 https://doi.org/10.1038/nbt.2673
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1038/nbt.2675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041659759
    199 https://doi.org/10.1038/nbt.2675
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1038/nbt.2684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003437173
    202 https://doi.org/10.1038/nbt.2684
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/nbt.2808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048637524
    205 https://doi.org/10.1038/nbt.2808
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/nbt.2842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038520013
    208 https://doi.org/10.1038/nbt.2842
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/nbt.2884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011531387
    211 https://doi.org/10.1038/nbt.2884
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/nbt.2889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043519930
    214 https://doi.org/10.1038/nbt.2889
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/nbt.2908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012868720
    217 https://doi.org/10.1038/nbt.2908
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/nbt.2909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053226125
    220 https://doi.org/10.1038/nbt.2909
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/nbt.2916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043348902
    223 https://doi.org/10.1038/nbt.2916
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/ncomms4964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045605027
    226 https://doi.org/10.1038/ncomms4964
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/ng0295-177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015620800
    229 https://doi.org/10.1038/ng0295-177
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/nmeth.1670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043918422
    232 https://doi.org/10.1038/nmeth.1670
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/nmeth.2408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011565053
    235 https://doi.org/10.1038/nmeth.2408
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/nmeth.2600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024354143
    238 https://doi.org/10.1038/nmeth.2600
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/nmeth.2649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008703730
    241 https://doi.org/10.1038/nmeth.2649
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/nmeth.2681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028304735
    244 https://doi.org/10.1038/nmeth.2681
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/nmeth.2812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023043883
    247 https://doi.org/10.1038/nmeth.2812
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/nmeth.2845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002278800
    250 https://doi.org/10.1038/nmeth.2845
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/nmeth.2969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048836104
    253 https://doi.org/10.1038/nmeth.2969
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/nprot.2013.132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009361018
    256 https://doi.org/10.1038/nprot.2013.132
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/nprot.2014.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010396170
    259 https://doi.org/10.1038/nprot.2014.031
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/nrg2641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006115199
    262 https://doi.org/10.1038/nrg2641
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/nrg2749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005460200
    265 https://doi.org/10.1038/nrg2749
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/nrmicro2577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020345829
    268 https://doi.org/10.1038/nrmicro2577
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/j.cell.2013.02.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008291683
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/j.cell.2013.06.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018287305
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/j.cell.2013.08.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002481722
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/j.cell.2013.08.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034724285
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.cell.2013.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014213089
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.cell.2014.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004290844
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.cell.2014.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039182708
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/j.mib.2011.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001559405
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/j.molcel.2013.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048229289
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/j.molcel.2014.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044439504
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.molcel.2014.04.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012990723
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/j.stem.2013.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008524552
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/j.stem.2013.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027005875
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/j.stem.2014.04.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033259425
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/j.stem.2014.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048567409
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/j.tibs.2009.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032505928
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1021/sb400081r schema:sameAs https://app.dimensions.ai/details/publication/pub.1022403918
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1073/pnas.1308335110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043136564
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1073/pnas.1316064110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034946777
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1073/pnas.1400822111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035810401
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1073/pnas.95.18.10570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022863238
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1074/jbc.m114.564625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035370902
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1093/bioinformatics/btt764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041543272
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1093/bioinformatics/btu048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038756964
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1093/hmg/ddu125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037875677
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1093/nar/gkm349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037729138
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1093/nar/gkq319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024844693
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1093/nar/gkt464 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043253969
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1093/nar/gkt716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011013289
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1093/nar/gku402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015304040
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1093/nar/gku410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020146143
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1093/nar/gkv137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020062000
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1101/005074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085109322
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1101/gr.161638.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021526947
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1101/gr.162339.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010306401
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1101/gr.171264.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019923892
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1101/gr.171322.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024649491
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1111/pbi.12200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042007688
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1126/science.1179555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022007081
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1126/science.1225829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041850060
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1126/science.1231143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019873131
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1126/science.1232033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022072971
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1126/science.1246981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043810806
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1146/annurev.micro.112408.134123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005066090
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1155/2013/270805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045793628
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1242/dev.099085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032936413
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1242/dev.103341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042199515
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1371/journal.pone.0100448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042244721
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1534/genetics.113.155879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047932291
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1534/genetics.113.160713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019065457
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.2144/04364pf01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076825945
    371 rdf:type schema:CreativeWork
    372 https://www.grid.ac/institutes/grid.116068.8 schema:alternateName Massachusetts Institute of Technology
    373 schema:name Computational and Systems Biology Graduate Program, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA
    374 David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA
    375 Department of Biology, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA
    376 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...