Role of lung ultrasound for the etiological diagnosis of acute lower respiratory tract infection (ALRTI) in children: a prospective study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-06-19

AUTHORS

Danilo Buonsenso, Annamaria Musolino, Valentina Ferro, Cristina De Rose, Rosa Morello, Chiara Ventola, Flora Marzia Liotti, Rita De Sanctis, Antonio Chiaretti, Daniele Guerino Biasucci, Teresa Spanu, Maurizio Sanguinetti, Piero Valentini

ABSTRACT

OBJECTIVE AND DESIGN: Our prospective study assesses the role of detailed lung ultrasound (LUS) features to discriminate the etiological diagnosis of acute lower respiratory tract infection (ALRTI) in children. METHODOLOGY: We analyzed patients aged from 1 month to 17 years admitted between March 2018 and April 2020 who were hospitalized for ALRTI. For all patients, history, clinical parameters, microbiological data, and lung ultrasound data were collected. Patients were stratified into three main groups ("bacterial", "viral", "atypical") according to the presumed microbial etiology and LUS findings evaluated according to the etiological group. Nasopharyngeal swabs were obtained from all patients. A qualitative diagnostic test developed by Nurex S.r.l. was used for identification of bacterial and fungal DNA in respiratory samples. The Seegene Allplex™ Respiratory assays were used for the molecular diagnosis of viral respiratory pathogens. In addition, bacterial culture of blood and respiratory samples were performed, when indicated. RESULTS: A total of 186 children with suspected ALRTI (44% female) with an average age of 6 were enrolled in the study. We found that some ultrasound findings as size, number and distribution of consolidations, the position and motion of air bronchograms, pleural effusions and distribution of vertical artifacts significantly differ (p < 0.05) in children with bacterial, viral and atypical ALRTI. CONCLUSION: Our study provides a detailed analysis of LUS features able to predict the ALRTI ethology in children. These findings may help the physicians to better manage a child with ALRTI and to offer personalized approach, from diagnosis to treatment and follow-up. More... »

PAGES

1-13

References to SciGraph publications

  • 2020-05-02. Gastroesophageal and gastric ultrasound in children: the state of the art in JOURNAL OF ULTRASOUND
  • 2020-04-21. Sonographic signs and patterns of COVID-19 pneumonia in THE ULTRASOUND JOURNAL
  • 2008-03. Ultrasound diagnosis of pneumonia in children in LA RADIOLOGIA MEDICA
  • 2020-05-04. What’s new in lung ultrasound during the COVID-19 pandemic in INTENSIVE CARE MEDICINE
  • 2017-03-09. Clinical features and inflammatory markers in pediatric pneumonia: a prospective study in EUROPEAN JOURNAL OF PEDIATRICS
  • 2020-03-11. Inferior epigastric artery pseudoaneurysm secondary to port placement during a robot-assisted laparoscopic radical cystectomy in JOURNAL OF ULTRASOUND
  • 2018-12-07. Lung ultrasound for the diagnosis of pneumonia in children with acute bronchiolitis in BMC PULMONARY MEDICINE
  • 2020-08-05. Aspiration pneumonia in children with neurological disorders: a new indication for lung ultrasound? A case series in JOURNAL OF ULTRASOUND
  • 2014-10-14. The radiological diagnosis of pneumonia in children in PNEUMONIA
  • 2019-11-29. The Usefulness of Lung Ultrasound for the Aetiological Diagnosis of Community-Acquired Pneumonia in Children in SCIENTIFIC REPORTS
  • 2017-09-21. Lung ultrasound for the diagnosis of community-acquired pneumonia in children in PEDIATRIC RADIOLOGY
  • 2018-12-14. Pediatric encephalic ultrasonography: the essentials in JOURNAL OF ULTRASOUND
  • 2020-04-23. An unusual onset of pediatric acute lymphoblastic leukemia in JOURNAL OF ULTRASOUND
  • 2020-11-28. Duodenal hematoma in pediatric age: a rare case report in JOURNAL OF ULTRASOUND
  • 2019-08-24. Lung ultrasound in infants with bronchiolitis in BMC PULMONARY MEDICINE
  • 2012-07-10. Prospective application of clinician-performed lung ultrasonography during the 2009 H1N1 influenza A pandemic: distinguishing viral from bacterial pneumonia in THE ULTRASOUND JOURNAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40477-021-00600-z

    DOI

    http://dx.doi.org/10.1007/s40477-021-00600-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1139010653

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34146336


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Microbiology", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Global Health Research Institute, Istituto di Igiene, Universit\u00e0 Cattolica del Sacro Cuore, Roma, Italia", 
              "id": "http://www.grid.ac/institutes/grid.8142.f", 
              "name": [
                "Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy", 
                "Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy", 
                "Global Health Research Institute, Istituto di Igiene, Universit\u00e0 Cattolica del Sacro Cuore, Roma, Italia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Buonsenso", 
            "givenName": "Danilo", 
            "id": "sg:person.0710454713.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710454713.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatric Emergency Medicine, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.414125.7", 
              "name": [
                "Department of Pediatric Emergency Medicine, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Musolino", 
            "givenName": "Annamaria", 
            "id": "sg:person.015766400224.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015766400224.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatric Emergency Medicine, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.414125.7", 
              "name": [
                "Department of Pediatric Emergency Medicine, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferro", 
            "givenName": "Valentina", 
            "id": "sg:person.01041261321.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041261321.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.411075.6", 
              "name": [
                "Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "De Rose", 
            "givenName": "Cristina", 
            "id": "sg:person.011267606237.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011267606237.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.411075.6", 
              "name": [
                "Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Morello", 
            "givenName": "Rosa", 
            "id": "sg:person.013430314571.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013430314571.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.411075.6", 
              "name": [
                "Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ventola", 
            "givenName": "Chiara", 
            "id": "sg:person.010371777241.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010371777241.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.8142.f", 
              "name": [
                "Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liotti", 
            "givenName": "Flora Marzia", 
            "id": "sg:person.01337377117.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337377117.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.411075.6", 
              "name": [
                "Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "De Sanctis", 
            "givenName": "Rita", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.411075.6", 
              "name": [
                "Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chiaretti", 
            "givenName": "Antonio", 
            "id": "sg:person.0634272231.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634272231.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Anesthesia and Intensive Care, Fondazione Policlinico Universitario \u201cA.Gemelli\u201d, Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.411075.6", 
              "name": [
                "Department of Anesthesia and Intensive Care, Fondazione Policlinico Universitario \u201cA.Gemelli\u201d, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Biasucci", 
            "givenName": "Daniele Guerino", 
            "id": "sg:person.01256104166.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256104166.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.414603.4", 
              "name": [
                "Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy", 
                "Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Spanu", 
            "givenName": "Teresa", 
            "id": "sg:person.01046410371.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046410371.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.414603.4", 
              "name": [
                "Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy", 
                "Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sanguinetti", 
            "givenName": "Maurizio", 
            "id": "sg:person.0775516471.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775516471.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.411075.6", 
              "name": [
                "Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Valentini", 
            "givenName": "Piero", 
            "id": "sg:person.01005531475.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005531475.10"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1186/s13089-020-00171-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1126868783", 
              "https://doi.org/10.1186/s13089-020-00171-w"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40477-020-00545-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1132974410", 
              "https://doi.org/10.1007/s40477-020-00545-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40477-020-00461-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1126921656", 
              "https://doi.org/10.1007/s40477-020-00461-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-020-06048-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1127350888", 
              "https://doi.org/10.1007/s00134-020-06048-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12890-019-0925-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1120523989", 
              "https://doi.org/10.1186/s12890-019-0925-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40477-018-0349-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110639174", 
              "https://doi.org/10.1007/s40477-018-0349-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.15172/pneu.2014.5/482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067592931", 
              "https://doi.org/10.15172/pneu.2014.5/482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11547-008-0247-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022912721", 
              "https://doi.org/10.1007/s11547-008-0247-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40477-020-00520-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1129908716", 
              "https://doi.org/10.1007/s40477-020-00520-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-019-54499-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1123014281", 
              "https://doi.org/10.1038/s41598-019-54499-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40477-020-00442-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1125562065", 
              "https://doi.org/10.1007/s40477-020-00442-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00431-017-2887-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084021960", 
              "https://doi.org/10.1007/s00431-017-2887-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40477-020-00471-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1127332650", 
              "https://doi.org/10.1007/s40477-020-00471-w"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00247-017-3910-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091886787", 
              "https://doi.org/10.1007/s00247-017-3910-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2036-7902-4-16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049548986", 
              "https://doi.org/10.1186/2036-7902-4-16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12890-018-0750-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110465161", 
              "https://doi.org/10.1186/s12890-018-0750-1"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2021-06-19", 
        "datePublishedReg": "2021-06-19", 
        "description": "OBJECTIVE AND DESIGN: Our prospective study assesses the role of detailed lung ultrasound (LUS) features to discriminate the etiological diagnosis of acute lower respiratory tract infection (ALRTI) in children.\nMETHODOLOGY: We analyzed patients aged from 1\u00a0month to 17\u00a0years admitted between March 2018 and April 2020 who were hospitalized for ALRTI. For all patients, history, clinical parameters, microbiological data, and lung ultrasound data were collected. Patients were stratified into three main groups (\"bacterial\", \"viral\", \"atypical\") according to the presumed microbial etiology and LUS findings evaluated according to the etiological group. Nasopharyngeal swabs were obtained from all patients. A qualitative diagnostic test developed by Nurex S.r.l. was used for identification of bacterial and fungal DNA in respiratory samples. The Seegene Allplex\u2122 Respiratory assays were used for the molecular diagnosis of viral respiratory pathogens. In addition, bacterial culture of blood and respiratory samples were performed, when indicated.\nRESULTS: A total of 186 children with suspected ALRTI (44% female) with an average age of 6 were enrolled in the study. We found that some ultrasound findings as size, number and distribution of consolidations, the position and motion of air bronchograms, pleural effusions and distribution of vertical artifacts significantly differ (p\u2009<\u20090.05) in children with bacterial, viral and atypical ALRTI.\nCONCLUSION: Our study provides a detailed analysis of LUS features able to predict the ALRTI ethology in children. These findings may help the physicians to better manage a child with ALRTI and to offer personalized approach, from diagnosis to treatment and follow-up.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s40477-021-00600-z", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1035539", 
            "issn": [
              "1971-3495", 
              "1876-7931"
            ], 
            "name": "Journal of Ultrasound", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }
        ], 
        "keywords": [
          "acute lower respiratory tract infection", 
          "lower respiratory tract infections", 
          "respiratory tract infections", 
          "lung ultrasound", 
          "tract infections", 
          "prospective study", 
          "etiological diagnosis", 
          "respiratory samples", 
          "viral respiratory pathogens", 
          "LUS findings", 
          "distribution of consolidation", 
          "air bronchogram", 
          "pleural effusion", 
          "nasopharyngeal swabs", 
          "clinical parameters", 
          "microbial etiology", 
          "ultrasound findings", 
          "etiological groups", 
          "respiratory pathogens", 
          "average age", 
          "Seegene Allplex", 
          "patients", 
          "personalized approach", 
          "diagnostic tests", 
          "diagnosis", 
          "microbiological data", 
          "qualitative diagnostic test", 
          "vertical artifacts", 
          "molecular diagnosis", 
          "children", 
          "respiratory assay", 
          "infection", 
          "ultrasound", 
          "bacterial culture", 
          "findings", 
          "bronchogram", 
          "ultrasound data", 
          "group", 
          "effusion", 
          "etiology", 
          "Allplex", 
          "study", 
          "physicians", 
          "swabs", 
          "blood", 
          "main groups", 
          "months", 
          "age", 
          "treatment", 
          "total", 
          "role", 
          "assays", 
          "pathogens", 
          "years", 
          "fungal DNA", 
          "samples", 
          "data", 
          "history", 
          "test", 
          "objective", 
          "culture", 
          "DNA", 
          "identification", 
          "addition", 
          "number", 
          "consolidation", 
          "analysis", 
          "distribution", 
          "S.r", 
          "size", 
          "approach", 
          "detailed analysis", 
          "parameters", 
          "position", 
          "design", 
          "artifacts", 
          "motion", 
          "ethology", 
          "detailed lung ultrasound", 
          "lung ultrasound data", 
          "Nurex S.r", 
          "atypical ALRTI", 
          "ALRTI ethology"
        ], 
        "name": "Role of lung ultrasound for the etiological diagnosis of acute lower respiratory tract infection (ALRTI) in children: a prospective study", 
        "pagination": "1-13", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1139010653"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s40477-021-00600-z"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "34146336"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s40477-021-00600-z", 
          "https://app.dimensions.ai/details/publication/pub.1139010653"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T19:01", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_919.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s40477-021-00600-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40477-021-00600-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40477-021-00600-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40477-021-00600-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40477-021-00600-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    301 TRIPLES      22 PREDICATES      123 URIs      99 LITERALS      5 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s40477-021-00600-z schema:about anzsrc-for:11
    2 anzsrc-for:1108
    3 schema:author N05662bb672734969b234b19f44690cb7
    4 schema:citation sg:pub.10.1007/s00134-020-06048-9
    5 sg:pub.10.1007/s00247-017-3910-1
    6 sg:pub.10.1007/s00431-017-2887-y
    7 sg:pub.10.1007/s11547-008-0247-8
    8 sg:pub.10.1007/s40477-018-0349-7
    9 sg:pub.10.1007/s40477-020-00442-1
    10 sg:pub.10.1007/s40477-020-00461-y
    11 sg:pub.10.1007/s40477-020-00471-w
    12 sg:pub.10.1007/s40477-020-00520-4
    13 sg:pub.10.1007/s40477-020-00545-9
    14 sg:pub.10.1038/s41598-019-54499-y
    15 sg:pub.10.1186/2036-7902-4-16
    16 sg:pub.10.1186/s12890-018-0750-1
    17 sg:pub.10.1186/s12890-019-0925-4
    18 sg:pub.10.1186/s13089-020-00171-w
    19 sg:pub.10.15172/pneu.2014.5/482
    20 schema:datePublished 2021-06-19
    21 schema:datePublishedReg 2021-06-19
    22 schema:description OBJECTIVE AND DESIGN: Our prospective study assesses the role of detailed lung ultrasound (LUS) features to discriminate the etiological diagnosis of acute lower respiratory tract infection (ALRTI) in children. METHODOLOGY: We analyzed patients aged from 1 month to 17 years admitted between March 2018 and April 2020 who were hospitalized for ALRTI. For all patients, history, clinical parameters, microbiological data, and lung ultrasound data were collected. Patients were stratified into three main groups ("bacterial", "viral", "atypical") according to the presumed microbial etiology and LUS findings evaluated according to the etiological group. Nasopharyngeal swabs were obtained from all patients. A qualitative diagnostic test developed by Nurex S.r.l. was used for identification of bacterial and fungal DNA in respiratory samples. The Seegene Allplex™ Respiratory assays were used for the molecular diagnosis of viral respiratory pathogens. In addition, bacterial culture of blood and respiratory samples were performed, when indicated. RESULTS: A total of 186 children with suspected ALRTI (44% female) with an average age of 6 were enrolled in the study. We found that some ultrasound findings as size, number and distribution of consolidations, the position and motion of air bronchograms, pleural effusions and distribution of vertical artifacts significantly differ (p < 0.05) in children with bacterial, viral and atypical ALRTI. CONCLUSION: Our study provides a detailed analysis of LUS features able to predict the ALRTI ethology in children. These findings may help the physicians to better manage a child with ALRTI and to offer personalized approach, from diagnosis to treatment and follow-up.
    23 schema:genre article
    24 schema:inLanguage en
    25 schema:isAccessibleForFree true
    26 schema:isPartOf sg:journal.1035539
    27 schema:keywords ALRTI ethology
    28 Allplex
    29 DNA
    30 LUS findings
    31 Nurex S.r
    32 S.r
    33 Seegene Allplex
    34 acute lower respiratory tract infection
    35 addition
    36 age
    37 air bronchogram
    38 analysis
    39 approach
    40 artifacts
    41 assays
    42 atypical ALRTI
    43 average age
    44 bacterial culture
    45 blood
    46 bronchogram
    47 children
    48 clinical parameters
    49 consolidation
    50 culture
    51 data
    52 design
    53 detailed analysis
    54 detailed lung ultrasound
    55 diagnosis
    56 diagnostic tests
    57 distribution
    58 distribution of consolidation
    59 effusion
    60 ethology
    61 etiological diagnosis
    62 etiological groups
    63 etiology
    64 findings
    65 fungal DNA
    66 group
    67 history
    68 identification
    69 infection
    70 lower respiratory tract infections
    71 lung ultrasound
    72 lung ultrasound data
    73 main groups
    74 microbial etiology
    75 microbiological data
    76 molecular diagnosis
    77 months
    78 motion
    79 nasopharyngeal swabs
    80 number
    81 objective
    82 parameters
    83 pathogens
    84 patients
    85 personalized approach
    86 physicians
    87 pleural effusion
    88 position
    89 prospective study
    90 qualitative diagnostic test
    91 respiratory assay
    92 respiratory pathogens
    93 respiratory samples
    94 respiratory tract infections
    95 role
    96 samples
    97 size
    98 study
    99 swabs
    100 test
    101 total
    102 tract infections
    103 treatment
    104 ultrasound
    105 ultrasound data
    106 ultrasound findings
    107 vertical artifacts
    108 viral respiratory pathogens
    109 years
    110 schema:name Role of lung ultrasound for the etiological diagnosis of acute lower respiratory tract infection (ALRTI) in children: a prospective study
    111 schema:pagination 1-13
    112 schema:productId N7f8cae76f68844d086262363d99a33f5
    113 Na0fd8f3f852845868e701157b3b81dbc
    114 Ne4602df6b86c411689544f44b6607577
    115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1139010653
    116 https://doi.org/10.1007/s40477-021-00600-z
    117 schema:sdDatePublished 2022-01-01T19:01
    118 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    119 schema:sdPublisher Nd84a8e25d98a4a928fb267cac129ef6e
    120 schema:url https://doi.org/10.1007/s40477-021-00600-z
    121 sgo:license sg:explorer/license/
    122 sgo:sdDataset articles
    123 rdf:type schema:ScholarlyArticle
    124 N05662bb672734969b234b19f44690cb7 rdf:first sg:person.0710454713.30
    125 rdf:rest Nf037e307e5a340cf8b57586a926dc421
    126 N32ea7178b3764a6bb733579fd1884935 rdf:first sg:person.0634272231.70
    127 rdf:rest Nbcef4f1c88344f1e98f222ba2c0d5a2c
    128 N48d622f418944a039b160f97c2463bc0 rdf:first sg:person.0775516471.70
    129 rdf:rest Nce9bafd848094200983b14b5642b6830
    130 N4c46b4be606a413c9671144368b4d06f rdf:first sg:person.01041261321.13
    131 rdf:rest Nc598b179b2f5403bb56d06698bd6e3b6
    132 N581ff750c4c14e25bb67339d753792c3 rdf:first sg:person.01337377117.77
    133 rdf:rest Nbbdaa45024904e1e8d9b9ebc328d7e91
    134 N7d43eed73a0b4595b5c26a207fbb23db rdf:first sg:person.01046410371.03
    135 rdf:rest N48d622f418944a039b160f97c2463bc0
    136 N7f8cae76f68844d086262363d99a33f5 schema:name pubmed_id
    137 schema:value 34146336
    138 rdf:type schema:PropertyValue
    139 N88bf02aa18b740c7a6691ccacb718784 schema:affiliation grid-institutes:grid.411075.6
    140 schema:familyName De Sanctis
    141 schema:givenName Rita
    142 rdf:type schema:Person
    143 Na0fd8f3f852845868e701157b3b81dbc schema:name dimensions_id
    144 schema:value pub.1139010653
    145 rdf:type schema:PropertyValue
    146 Nb182c8d695c044238ff921b5885e49bd rdf:first sg:person.013430314571.34
    147 rdf:rest Nbadb8ba76be346ef8a913f3a0146d3e7
    148 Nbadb8ba76be346ef8a913f3a0146d3e7 rdf:first sg:person.010371777241.00
    149 rdf:rest N581ff750c4c14e25bb67339d753792c3
    150 Nbbdaa45024904e1e8d9b9ebc328d7e91 rdf:first N88bf02aa18b740c7a6691ccacb718784
    151 rdf:rest N32ea7178b3764a6bb733579fd1884935
    152 Nbcef4f1c88344f1e98f222ba2c0d5a2c rdf:first sg:person.01256104166.48
    153 rdf:rest N7d43eed73a0b4595b5c26a207fbb23db
    154 Nc598b179b2f5403bb56d06698bd6e3b6 rdf:first sg:person.011267606237.69
    155 rdf:rest Nb182c8d695c044238ff921b5885e49bd
    156 Nce9bafd848094200983b14b5642b6830 rdf:first sg:person.01005531475.10
    157 rdf:rest rdf:nil
    158 Nd84a8e25d98a4a928fb267cac129ef6e schema:name Springer Nature - SN SciGraph project
    159 rdf:type schema:Organization
    160 Ne4602df6b86c411689544f44b6607577 schema:name doi
    161 schema:value 10.1007/s40477-021-00600-z
    162 rdf:type schema:PropertyValue
    163 Nf037e307e5a340cf8b57586a926dc421 rdf:first sg:person.015766400224.27
    164 rdf:rest N4c46b4be606a413c9671144368b4d06f
    165 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    166 schema:name Medical and Health Sciences
    167 rdf:type schema:DefinedTerm
    168 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
    169 schema:name Medical Microbiology
    170 rdf:type schema:DefinedTerm
    171 sg:journal.1035539 schema:issn 1876-7931
    172 1971-3495
    173 schema:name Journal of Ultrasound
    174 schema:publisher Springer Nature
    175 rdf:type schema:Periodical
    176 sg:person.01005531475.10 schema:affiliation grid-institutes:grid.411075.6
    177 schema:familyName Valentini
    178 schema:givenName Piero
    179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005531475.10
    180 rdf:type schema:Person
    181 sg:person.010371777241.00 schema:affiliation grid-institutes:grid.411075.6
    182 schema:familyName Ventola
    183 schema:givenName Chiara
    184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010371777241.00
    185 rdf:type schema:Person
    186 sg:person.01041261321.13 schema:affiliation grid-institutes:grid.414125.7
    187 schema:familyName Ferro
    188 schema:givenName Valentina
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041261321.13
    190 rdf:type schema:Person
    191 sg:person.01046410371.03 schema:affiliation grid-institutes:grid.414603.4
    192 schema:familyName Spanu
    193 schema:givenName Teresa
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046410371.03
    195 rdf:type schema:Person
    196 sg:person.011267606237.69 schema:affiliation grid-institutes:grid.411075.6
    197 schema:familyName De Rose
    198 schema:givenName Cristina
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011267606237.69
    200 rdf:type schema:Person
    201 sg:person.01256104166.48 schema:affiliation grid-institutes:grid.411075.6
    202 schema:familyName Biasucci
    203 schema:givenName Daniele Guerino
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256104166.48
    205 rdf:type schema:Person
    206 sg:person.01337377117.77 schema:affiliation grid-institutes:grid.8142.f
    207 schema:familyName Liotti
    208 schema:givenName Flora Marzia
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337377117.77
    210 rdf:type schema:Person
    211 sg:person.013430314571.34 schema:affiliation grid-institutes:grid.411075.6
    212 schema:familyName Morello
    213 schema:givenName Rosa
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013430314571.34
    215 rdf:type schema:Person
    216 sg:person.015766400224.27 schema:affiliation grid-institutes:grid.414125.7
    217 schema:familyName Musolino
    218 schema:givenName Annamaria
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015766400224.27
    220 rdf:type schema:Person
    221 sg:person.0634272231.70 schema:affiliation grid-institutes:grid.411075.6
    222 schema:familyName Chiaretti
    223 schema:givenName Antonio
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634272231.70
    225 rdf:type schema:Person
    226 sg:person.0710454713.30 schema:affiliation grid-institutes:grid.8142.f
    227 schema:familyName Buonsenso
    228 schema:givenName Danilo
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710454713.30
    230 rdf:type schema:Person
    231 sg:person.0775516471.70 schema:affiliation grid-institutes:grid.414603.4
    232 schema:familyName Sanguinetti
    233 schema:givenName Maurizio
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775516471.70
    235 rdf:type schema:Person
    236 sg:pub.10.1007/s00134-020-06048-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1127350888
    237 https://doi.org/10.1007/s00134-020-06048-9
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1007/s00247-017-3910-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091886787
    240 https://doi.org/10.1007/s00247-017-3910-1
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1007/s00431-017-2887-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1084021960
    243 https://doi.org/10.1007/s00431-017-2887-y
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1007/s11547-008-0247-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022912721
    246 https://doi.org/10.1007/s11547-008-0247-8
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1007/s40477-018-0349-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110639174
    249 https://doi.org/10.1007/s40477-018-0349-7
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1007/s40477-020-00442-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1125562065
    252 https://doi.org/10.1007/s40477-020-00442-1
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1007/s40477-020-00461-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1126921656
    255 https://doi.org/10.1007/s40477-020-00461-y
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1007/s40477-020-00471-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1127332650
    258 https://doi.org/10.1007/s40477-020-00471-w
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1007/s40477-020-00520-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1129908716
    261 https://doi.org/10.1007/s40477-020-00520-4
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1007/s40477-020-00545-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132974410
    264 https://doi.org/10.1007/s40477-020-00545-9
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/s41598-019-54499-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1123014281
    267 https://doi.org/10.1038/s41598-019-54499-y
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1186/2036-7902-4-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049548986
    270 https://doi.org/10.1186/2036-7902-4-16
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1186/s12890-018-0750-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110465161
    273 https://doi.org/10.1186/s12890-018-0750-1
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1186/s12890-019-0925-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1120523989
    276 https://doi.org/10.1186/s12890-019-0925-4
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1186/s13089-020-00171-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1126868783
    279 https://doi.org/10.1186/s13089-020-00171-w
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.15172/pneu.2014.5/482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067592931
    282 https://doi.org/10.15172/pneu.2014.5/482
    283 rdf:type schema:CreativeWork
    284 grid-institutes:grid.411075.6 schema:alternateName Department of Anesthesia and Intensive Care, Fondazione Policlinico Universitario “A.Gemelli”, Rome, Italy
    285 Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy
    286 schema:name Department of Anesthesia and Intensive Care, Fondazione Policlinico Universitario “A.Gemelli”, Rome, Italy
    287 Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy
    288 rdf:type schema:Organization
    289 grid-institutes:grid.414125.7 schema:alternateName Department of Pediatric Emergency Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
    290 schema:name Department of Pediatric Emergency Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
    291 rdf:type schema:Organization
    292 grid-institutes:grid.414603.4 schema:alternateName Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
    293 schema:name Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy
    294 Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
    295 rdf:type schema:Organization
    296 grid-institutes:grid.8142.f schema:alternateName Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy
    297 Global Health Research Institute, Istituto di Igiene, Università Cattolica del Sacro Cuore, Roma, Italia
    298 schema:name Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy
    299 Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy
    300 Global Health Research Institute, Istituto di Igiene, Università Cattolica del Sacro Cuore, Roma, Italia
    301 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...