Chikungunya and Its Interaction With the Host Cell View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-01-21

AUTHORS

Licia Bordi, Claudia Caglioti, Eleonora Lalle, Concetta Castilletti, Maria Rosaria Capobianchi

ABSTRACT

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus belonging to the Togaviridae family. It is a virus with a single-stranded, positive sense RNA genome, maintained in a sylvatic and urban cycle, involving humans and mosquitoes from Aedes species, mainly Aedes aegypti and Aedes albopictus. In less than 10 years, CHIKV has spread from the coast of Kenya throughout the Indian Ocean, Pacific Ocean, and Caribbean regions, causing millions of infections in over 50 countries. In other words, CHIKV has emerged as a true global pathogen. The clinical signs include non-specific flu-like symptoms and a characteristic rash accompanied by joint pain that may last long time after the resolution of the infection. The molecular mechanism underlying the chronic polyarthralgia in patients is not well understood. In this review, we summarize the CHIKV genome organization, replication, epidemiology, clinical manifestations, and immunopathogenesis with particular emphasis on host-pathogen interactions. More... »

PAGES

22-29

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40475-015-0038-y

DOI

http://dx.doi.org/10.1007/s40475-015-0038-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002569398


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