Perioperative Management of Patients with Hepatopulmonary Syndrome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09-17

AUTHORS

Andrew I. Gagnon, Andre De Wolf, Jana Hudcova, David A. Axelrod

ABSTRACT

Purpose of ReviewHepatopulmonary syndrome (HPS) is a syndrome of hypoxemia in patients with advanced liver disease, which results in significant mortality in the absence of liver transplantation. Management of HPS is complex both prior to and following liver transplantation as illustrated by a case presentation. This review considers the pathophysiology, diagnosis, assessment of severity, and treatment of HPS with a particular emphasis on perioperative management.Recent FindingsScreening for HPS should be performed in all liver transplant candidates with room air saturation less than 97%. Diagnosis of HPS has been standardized with the use of agitated saline-enhanced echocardiography. Treatment modalities for profound hypoxemia include patient positioning, transtracheal oxygenation, nitric oxide therapy, intravenous methylene blue, and extracorporeal membrane oxygenation. Fortunately, patients with HPS who undergo successful liver transplantation will often have complete resolution of the symptoms related to HPS, although this may require weeks to months.SummaryDespite technical challenges, liver transplantation for HPS can be safely performed provided patients are identified and appropriately managed. Physicians caring for these patients should be prepared to use all available interventions including extracorporeal oxygenation to allow time for the HPS to resolve and oxygenation to improve. Further investigation is needed to identify effective medical treatments to mitigate HPS-related hypoxemia. More... »

PAGES

282-288

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40472-018-0208-7

DOI

http://dx.doi.org/10.1007/s40472-018-0208-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107040404


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