Delineating a New Class of Membrane-Bound Guanylate Cyclases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-06

AUTHORS

Victor Muleya, Helen R. Irving

ABSTRACT

Membrane-bound guanylate cyclases (GCs) possessing intrinsic GC activity constitute a family of catalytically active membrane-associated proteins that play crucial roles in a myriad of signal transduction processes. Currently known membrane-bound GCs are catalytically monofunctional with a domain architecture that consists of an extracellular ligand-binding domain and an intracellular portion that is composed of an inactive kinase homology domain and a functional GC catalytic center. A novel class of GC-linked receptor kinases was unearthed using homology-guided bioinformatic data mining tools designed from annotated amino acid residues in the GC catalytic centers of lower eukaryotes. The GC catalytic center in this new class of membrane-bound GCs is encapsulated within an active kinase domain, thereby conferring a dual catalytic function to this class of proteins. This is contrary to currently known classical membrane-bound GCs, which are monofunctional. There are currently four members of this novel class of membrane-bound GCs which have been demonstrated to possess intrinsic GC and kinase activity. Although there is a paucity of information as to how the dual catalysis in bifunctional membrane-bound GCs is physiologically regulated, their mechanism of action may be markedly distinct from that of classical membrane-bound GCs. More... »

PAGES

1-13

References to SciGraph publications

  • 1998-03. Stomatal guard cell responses to kinetin and natriuretic peptides are cGMP-dependent in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2015-01. Structural basis for recognition of an endogenous peptide by the plant receptor kinase PEPR1 in CELL RESEARCH
  • 2001-03. BRI1 is a critical component of a plasma-membrane receptor for plant steroids in NATURE
  • 1989-03. A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor in NATURE
  • 2008-04. Is kinase activity essential for biological functions of BRI1? in CELL RESEARCH
  • 2005-09. Ca2+/calmodulin is critical for brassinosteroid biosynthesis and plant growth in NATURE
  • 2002-11. HAR1 mediates systemic regulation of symbiotic organ development in NATURE
  • 2001-09. WAKs: cell wall-associated kinases linking the cytoplasm to the extracellular matrix in PLANT MOLECULAR BIOLOGY
  • 2002-01. Photoreceptor specific guanylate cyclases in vertebrate phototransduction in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2009-01. Cyclic GMP acts as a common regulator for the transcriptional activation of the flavonoid biosynthetic pathway in soybean in PLANTA
  • 2008-12. The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase in BMC STRUCTURAL BIOLOGY
  • 2014-12. Calcium is the switch in the moonlighting dual function of the ligand-activated receptor kinase phytosulfokine receptor 1 in CELL COMMUNICATION AND SIGNALING
  • 2009-12. Molecular Cloning and Characterization of a Guanylyl Cyclase, PnGC-1, Involved in Light Signaling in Pharbitis nil in JOURNAL OF PLANT GROWTH REGULATION
  • 2010-01. The nuts and bolts of AGC protein kinases in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2002-01. Biochemistry and physiology of the natriuretic peptide receptor guanylyl cyclases in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2012-02. Brassinosteroid regulates stomatal development by GSK3-mediated inhibition of a MAPK pathway in NATURE
  • 1989-09. Differential activation by atrial and brain natriuretic peptides of two different receptor guanylate cyclases in NATURE
  • 2009-02. Analysis of phosphorylation of the BRI1/BAK1 complex in arabidopsis reveals amino acid residues critical for receptor formation and activation of BR signaling in MOLECULES AND CELLS
  • 2013-12. The Arabidopsis thaliana proteome harbors undiscovered multi-domain molecules with functional guanylyl cyclase catalytic centers in CELL COMMUNICATION AND SIGNALING
  • 2011-06. Structural insight into brassinosteroid perception by BRI1 in NATURE
  • 2012-08. Brassinosteroids, gibberellins and light-mediated signalling are the three-way controls of plant sprouting in NATURE CELL BIOLOGY
  • 2012-05. SPEECHLESS integrates brassinosteroid and stomata signalling pathways in NATURE CELL BIOLOGY
  • 2002-01. Natriuretic peptide receptor: Structure and signaling in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40362-015-0037-3

    DOI

    http://dx.doi.org/10.1007/s40362-015-0037-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038492869


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Monash University", 
              "id": "https://www.grid.ac/institutes/grid.1002.3", 
              "name": [
                "Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, 3052, Parkville, VIC, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Muleya", 
            "givenName": "Victor", 
            "id": "sg:person.0637123203.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637123203.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Monash University", 
              "id": "https://www.grid.ac/institutes/grid.1002.3", 
              "name": [
                "Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, 3052, Parkville, VIC, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Irving", 
            "givenName": "Helen R.", 
            "id": "sg:person.0605214247.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605214247.11"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.0607656103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000161002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20111871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000752169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20111871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000752169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.15.00306", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002217372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1014260204524", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002480995", 
              "https://doi.org/10.1023/a:1014260204524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10059-009-0023-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003243948", 
              "https://doi.org/10.1007/s10059-009-0023-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10059-009-0023-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003243948", 
              "https://doi.org/10.1007/s10059-009-0023-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10059-009-0023-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003243948", 
              "https://doi.org/10.1007/s10059-009-0023-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0808473105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003354464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2008.06.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003395409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1210799110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004019237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.10605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004184487"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12964-014-0060-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004755261", 
              "https://doi.org/10.1186/s12964-014-0060-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12964-014-0060-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004755261", 
              "https://doi.org/10.1186/s12964-014-0060-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m109.061713", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004954534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pmic.200701059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005378303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2471", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005557761", 
              "https://doi.org/10.1038/ncb2471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.273.2.1032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005799232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.168823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006079000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2551", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006642113", 
              "https://doi.org/10.1038/ncb2551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0008-6363(01)00543-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007060213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)00814-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008068888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1472-6807-8-42", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008179521", 
              "https://doi.org/10.1186/1472-6807-8-42"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1014209711793", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008477765", 
              "https://doi.org/10.1023/a:1014209711793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1399-3054.2010.01371.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008924213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1399-3054.2010.01371.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008924213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1104/pp.123.4.1247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009133443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.2001911", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010223237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0810249106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012005524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pbi.2007.08.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012138724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0074-7696(04)34001-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012368167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.060590", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012720306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.1997.7921", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013409656"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m109.097394", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013522037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.112.105049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015183157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s000180050149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015537944", 
              "https://doi.org/10.1007/s000180050149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tplants.2009.01.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016193561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)00812-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016606848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.010504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017050378"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.273.19.11695", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017205148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.12.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017405762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15252/embj.201489652", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017492063"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80357-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018522534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejcb.2009.11.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019566632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1104/pp.106.081109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020036374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0706403104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020080321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2005080818", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020229082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2005080818", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020229082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.111.084475", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020305305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000094745.28948.4d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020713847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000094745.28948.4d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020713847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000094745.28948.4d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020713847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.8.3571", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020860043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/338078a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021061605", 
              "https://doi.org/10.1038/338078a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(90)90497-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023424213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35066597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023629382", 
              "https://doi.org/10.1038/35066597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35066597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023629382", 
              "https://doi.org/10.1038/35066597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0896-6273(92)90035-c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023773984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.peptides.2004.08.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023932603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1010691701578", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024080544", 
              "https://doi.org/10.1023/a:1010691701578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00344-009-9105-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024165705", 
              "https://doi.org/10.1007/s00344-009-9105-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00344-009-9105-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024165705", 
              "https://doi.org/10.1007/s00344-009-9105-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00344-009-9105-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024165705", 
              "https://doi.org/10.1007/s00344-009-9105-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1478-811x-11-48", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024461316", 
              "https://doi.org/10.1186/1478-811x-11-48"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1071/fp09242", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025439224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-313x.2005.02616.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025443784"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-313x.2005.02616.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025443784"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0021054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027386919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027524436", 
              "https://doi.org/10.1038/nature10178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1104/pp.124.2.751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027953305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pharmthera.2004.08.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028183279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m210983200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028850253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0008904", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029427304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.104.025387", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029482946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2005.06.057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029920190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2005.06.057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029920190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030815156", 
              "https://doi.org/10.1038/nrm2822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030815156", 
              "https://doi.org/10.1038/nrm2822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1000191107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030848887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.105.031393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031703449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cellsig.2011.09.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031804503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0603729103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032007984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1108321109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032122033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0812220106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032149697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01231", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032555823", 
              "https://doi.org/10.1038/nature01231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pharmthera.2010.12.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033512472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.94.25.13414", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033895462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.106.047795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034094756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1002452", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034553199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.11.3.393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034790407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/protein/13.1.59", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035388373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2007050550", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036386164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2007050550", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036386164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.13.2.303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037621568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0704965104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037702845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00425-008-0839-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038899773", 
              "https://doi.org/10.1007/s00425-008-0839-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00425-008-0839-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038899773", 
              "https://doi.org/10.1007/s00425-008-0839-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10794", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039056119", 
              "https://doi.org/10.1038/nature10794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2008.36", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040147763", 
              "https://doi.org/10.1038/cr.2008.36"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0000449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041466147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.12.5535", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042393543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/pcp/pcd009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042726177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/tpj.12050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042939595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/tpj.12445", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043528415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gki566", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043828333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1104/pp.121.3.743", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045030714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/341068a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045147650", 
              "https://doi.org/10.1038/341068a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3732/ajb.1200264", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045638208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1014257621362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046999077", 
              "https://doi.org/10.1023/a:1014257621362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(89)90513-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047297562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2005.05.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047521028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03973", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047682355", 
              "https://doi.org/10.1038/nature03973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03973", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047682355", 
              "https://doi.org/10.1038/nature03973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03973", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047682355", 
              "https://doi.org/10.1038/nature03973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1469-8137.2008.02710.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047961506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2014.161", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048206247", 
              "https://doi.org/10.1038/cr.2014.161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/tpj.12460", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048671797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80700-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049355759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci115862", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050622107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2007.04923.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053053863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ar020128g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055149652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ar020128g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055149652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi00014a025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055157217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi900441v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055209706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi900441v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055209706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi962008k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055212720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi962008k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055212720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi992800w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055219015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi992800w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055219015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bst20140223", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056717774"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bst20140223", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056717774"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1069607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062445932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3291115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062604905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.2003253", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062682702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2741/1613", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070913899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/psb.18891", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072307440"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075071607", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079010284", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1989.tb03518.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079046846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079418096", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fasebj.9.8.7768349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082499300"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-06", 
        "datePublishedReg": "2016-06-01", 
        "description": "Membrane-bound guanylate cyclases (GCs) possessing intrinsic GC activity constitute a family of catalytically active membrane-associated proteins that play crucial roles in a myriad of signal transduction processes. Currently known membrane-bound GCs are catalytically monofunctional with a domain architecture that consists of an extracellular ligand-binding domain and an intracellular portion that is composed of an inactive kinase homology domain and a functional GC catalytic center. A novel class of GC-linked receptor kinases was unearthed using homology-guided bioinformatic data mining tools designed from annotated amino acid residues in the GC catalytic centers of lower eukaryotes. The GC catalytic center in this new class of membrane-bound GCs is encapsulated within an active kinase domain, thereby conferring a dual catalytic function to this class of proteins. This is contrary to currently known classical membrane-bound GCs, which are monofunctional. There are currently four members of this novel class of membrane-bound GCs which have been demonstrated to possess intrinsic GC and kinase activity. Although there is a paucity of information as to how the dual catalysis in bifunctional membrane-bound GCs is physiologically regulated, their mechanism of action may be markedly distinct from that of classical membrane-bound GCs.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s40362-015-0037-3", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3569769", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1136608", 
            "issn": [
              "2213-7793"
            ], 
            "name": "Springer Science Reviews", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "4"
          }
        ], 
        "name": "Delineating a New Class of Membrane-Bound Guanylate Cyclases", 
        "pagination": "1-13", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "b75d04778e98e4808d9af9b3f2daef73642082c6964b32c7da70a698af5c3a8f"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s40362-015-0037-3"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1038492869"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s40362-015-0037-3", 
          "https://app.dimensions.ai/details/publication/pub.1038492869"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T19:59", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000523.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs40362-015-0037-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40362-015-0037-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40362-015-0037-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40362-015-0037-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40362-015-0037-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    443 TRIPLES      21 PREDICATES      145 URIs      19 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s40362-015-0037-3 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author Naae1f812811342a6ab0648c80a27acb5
    4 schema:citation sg:pub.10.1007/s000180050149
    5 sg:pub.10.1007/s00344-009-9105-8
    6 sg:pub.10.1007/s00425-008-0839-5
    7 sg:pub.10.1007/s10059-009-0023-1
    8 sg:pub.10.1023/a:1010691701578
    9 sg:pub.10.1023/a:1014209711793
    10 sg:pub.10.1023/a:1014257621362
    11 sg:pub.10.1023/a:1014260204524
    12 sg:pub.10.1038/338078a0
    13 sg:pub.10.1038/341068a0
    14 sg:pub.10.1038/35066597
    15 sg:pub.10.1038/cr.2008.36
    16 sg:pub.10.1038/cr.2014.161
    17 sg:pub.10.1038/nature01231
    18 sg:pub.10.1038/nature03973
    19 sg:pub.10.1038/nature10178
    20 sg:pub.10.1038/nature10794
    21 sg:pub.10.1038/ncb2471
    22 sg:pub.10.1038/ncb2551
    23 sg:pub.10.1038/nrm2822
    24 sg:pub.10.1186/1472-6807-8-42
    25 sg:pub.10.1186/1478-811x-11-48
    26 sg:pub.10.1186/s12964-014-0060-z
    27 https://app.dimensions.ai/details/publication/pub.1075071607
    28 https://app.dimensions.ai/details/publication/pub.1079010284
    29 https://app.dimensions.ai/details/publication/pub.1079418096
    30 https://doi.org/10.1002/j.1460-2075.1989.tb03518.x
    31 https://doi.org/10.1002/pmic.200701059
    32 https://doi.org/10.1002/prot.10605
    33 https://doi.org/10.1006/bbrc.1997.7921
    34 https://doi.org/10.1016/0092-8674(89)90513-8
    35 https://doi.org/10.1016/0092-8674(90)90497-3
    36 https://doi.org/10.1016/0896-6273(92)90035-c
    37 https://doi.org/10.1016/j.cellsig.2011.09.001
    38 https://doi.org/10.1016/j.devcel.2005.05.001
    39 https://doi.org/10.1016/j.devcel.2008.06.011
    40 https://doi.org/10.1016/j.ejcb.2009.11.001
    41 https://doi.org/10.1016/j.jmb.2005.06.057
    42 https://doi.org/10.1016/j.molcel.2008.12.024
    43 https://doi.org/10.1016/j.pbi.2007.08.015
    44 https://doi.org/10.1016/j.peptides.2004.08.027
    45 https://doi.org/10.1016/j.pharmthera.2004.08.003
    46 https://doi.org/10.1016/j.pharmthera.2010.12.005
    47 https://doi.org/10.1016/j.tplants.2009.01.010
    48 https://doi.org/10.1016/s0008-6363(01)00543-0
    49 https://doi.org/10.1016/s0074-7696(04)34001-5
    50 https://doi.org/10.1016/s0092-8674(00)80357-8
    51 https://doi.org/10.1016/s0092-8674(00)80700-x
    52 https://doi.org/10.1016/s0092-8674(02)00812-7
    53 https://doi.org/10.1016/s0092-8674(02)00814-0
    54 https://doi.org/10.1021/ar020128g
    55 https://doi.org/10.1021/bi00014a025
    56 https://doi.org/10.1021/bi900441v
    57 https://doi.org/10.1021/bi962008k
    58 https://doi.org/10.1021/bi992800w
    59 https://doi.org/10.1042/bj20111871
    60 https://doi.org/10.1042/bst20140223
    61 https://doi.org/10.1071/fp09242
    62 https://doi.org/10.1073/pnas.0603729103
    63 https://doi.org/10.1073/pnas.0607656103
    64 https://doi.org/10.1073/pnas.0704965104
    65 https://doi.org/10.1073/pnas.0706403104
    66 https://doi.org/10.1073/pnas.0808473105
    67 https://doi.org/10.1073/pnas.0810249106
    68 https://doi.org/10.1073/pnas.0812220106
    69 https://doi.org/10.1073/pnas.1000191107
    70 https://doi.org/10.1073/pnas.1108321109
    71 https://doi.org/10.1073/pnas.1210799110
    72 https://doi.org/10.1073/pnas.92.12.5535
    73 https://doi.org/10.1073/pnas.92.8.3571
    74 https://doi.org/10.1073/pnas.94.25.13414
    75 https://doi.org/10.1074/jbc.273.19.11695
    76 https://doi.org/10.1074/jbc.273.2.1032
    77 https://doi.org/10.1074/jbc.m109.061713
    78 https://doi.org/10.1074/jbc.m109.097394
    79 https://doi.org/10.1074/jbc.m110.168823
    80 https://doi.org/10.1074/jbc.m210983200
    81 https://doi.org/10.1093/nar/gki566
    82 https://doi.org/10.1093/pcp/pcd009
    83 https://doi.org/10.1093/protein/13.1.59
    84 https://doi.org/10.1096/fasebj.9.8.7768349
    85 https://doi.org/10.1101/gad.2001911
    86 https://doi.org/10.1104/pp.106.081109
    87 https://doi.org/10.1104/pp.121.3.743
    88 https://doi.org/10.1104/pp.123.4.1247
    89 https://doi.org/10.1104/pp.124.2.751
    90 https://doi.org/10.1105/tpc.010504
    91 https://doi.org/10.1105/tpc.104.025387
    92 https://doi.org/10.1105/tpc.105.031393
    93 https://doi.org/10.1105/tpc.106.047795
    94 https://doi.org/10.1105/tpc.11.3.393
    95 https://doi.org/10.1105/tpc.111.084475
    96 https://doi.org/10.1105/tpc.112.105049
    97 https://doi.org/10.1105/tpc.13.2.303
    98 https://doi.org/10.1105/tpc.15.00306
    99 https://doi.org/10.1111/j.1365-313x.2005.02616.x
    100 https://doi.org/10.1111/j.1399-3054.2010.01371.x
    101 https://doi.org/10.1111/j.1469-8137.2008.02710.x
    102 https://doi.org/10.1111/j.1471-4159.2007.04923.x
    103 https://doi.org/10.1111/tpj.12050
    104 https://doi.org/10.1111/tpj.12445
    105 https://doi.org/10.1111/tpj.12460
    106 https://doi.org/10.1126/science.1069607
    107 https://doi.org/10.1126/science.3291115
    108 https://doi.org/10.1126/scisignal.2003253
    109 https://doi.org/10.1161/01.res.0000094745.28948.4d
    110 https://doi.org/10.1172/jci115862
    111 https://doi.org/10.1242/dev.060590
    112 https://doi.org/10.1371/journal.pgen.1002452
    113 https://doi.org/10.1371/journal.pone.0000449
    114 https://doi.org/10.1371/journal.pone.0008904
    115 https://doi.org/10.1371/journal.pone.0021054
    116 https://doi.org/10.15252/embj.201489652
    117 https://doi.org/10.1681/asn.2005080818
    118 https://doi.org/10.1681/asn.2007050550
    119 https://doi.org/10.2741/1613
    120 https://doi.org/10.3732/ajb.1200264
    121 https://doi.org/10.4161/psb.18891
    122 schema:datePublished 2016-06
    123 schema:datePublishedReg 2016-06-01
    124 schema:description Membrane-bound guanylate cyclases (GCs) possessing intrinsic GC activity constitute a family of catalytically active membrane-associated proteins that play crucial roles in a myriad of signal transduction processes. Currently known membrane-bound GCs are catalytically monofunctional with a domain architecture that consists of an extracellular ligand-binding domain and an intracellular portion that is composed of an inactive kinase homology domain and a functional GC catalytic center. A novel class of GC-linked receptor kinases was unearthed using homology-guided bioinformatic data mining tools designed from annotated amino acid residues in the GC catalytic centers of lower eukaryotes. The GC catalytic center in this new class of membrane-bound GCs is encapsulated within an active kinase domain, thereby conferring a dual catalytic function to this class of proteins. This is contrary to currently known classical membrane-bound GCs, which are monofunctional. There are currently four members of this novel class of membrane-bound GCs which have been demonstrated to possess intrinsic GC and kinase activity. Although there is a paucity of information as to how the dual catalysis in bifunctional membrane-bound GCs is physiologically regulated, their mechanism of action may be markedly distinct from that of classical membrane-bound GCs.
    125 schema:genre research_article
    126 schema:inLanguage en
    127 schema:isAccessibleForFree false
    128 schema:isPartOf N1ae31d0f9d6949b092683e2aee53e019
    129 Nf7da9c65cc0742518c785cd42bb5d23c
    130 sg:journal.1136608
    131 schema:name Delineating a New Class of Membrane-Bound Guanylate Cyclases
    132 schema:pagination 1-13
    133 schema:productId N272abfa6b5c544dcaac92cff8c060ad4
    134 N4eba4ee93a3749b48a0f8299393d86ff
    135 N5034c797d83341e4af9efaa57d40eb83
    136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038492869
    137 https://doi.org/10.1007/s40362-015-0037-3
    138 schema:sdDatePublished 2019-04-10T19:59
    139 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    140 schema:sdPublisher Na83faca1a867408ebba7a4e893209661
    141 schema:url http://link.springer.com/10.1007%2Fs40362-015-0037-3
    142 sgo:license sg:explorer/license/
    143 sgo:sdDataset articles
    144 rdf:type schema:ScholarlyArticle
    145 N1ae31d0f9d6949b092683e2aee53e019 schema:issueNumber 1
    146 rdf:type schema:PublicationIssue
    147 N272abfa6b5c544dcaac92cff8c060ad4 schema:name readcube_id
    148 schema:value b75d04778e98e4808d9af9b3f2daef73642082c6964b32c7da70a698af5c3a8f
    149 rdf:type schema:PropertyValue
    150 N4eba4ee93a3749b48a0f8299393d86ff schema:name dimensions_id
    151 schema:value pub.1038492869
    152 rdf:type schema:PropertyValue
    153 N5034c797d83341e4af9efaa57d40eb83 schema:name doi
    154 schema:value 10.1007/s40362-015-0037-3
    155 rdf:type schema:PropertyValue
    156 Na83faca1a867408ebba7a4e893209661 schema:name Springer Nature - SN SciGraph project
    157 rdf:type schema:Organization
    158 Naae1f812811342a6ab0648c80a27acb5 rdf:first sg:person.0637123203.55
    159 rdf:rest Nbe9c86ed47394e2e893e0c5e5a38065c
    160 Nbe9c86ed47394e2e893e0c5e5a38065c rdf:first sg:person.0605214247.11
    161 rdf:rest rdf:nil
    162 Nf7da9c65cc0742518c785cd42bb5d23c schema:volumeNumber 4
    163 rdf:type schema:PublicationVolume
    164 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    165 schema:name Biological Sciences
    166 rdf:type schema:DefinedTerm
    167 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    168 schema:name Biochemistry and Cell Biology
    169 rdf:type schema:DefinedTerm
    170 sg:grant.3569769 http://pending.schema.org/fundedItem sg:pub.10.1007/s40362-015-0037-3
    171 rdf:type schema:MonetaryGrant
    172 sg:journal.1136608 schema:issn 2213-7793
    173 schema:name Springer Science Reviews
    174 rdf:type schema:Periodical
    175 sg:person.0605214247.11 schema:affiliation https://www.grid.ac/institutes/grid.1002.3
    176 schema:familyName Irving
    177 schema:givenName Helen R.
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605214247.11
    179 rdf:type schema:Person
    180 sg:person.0637123203.55 schema:affiliation https://www.grid.ac/institutes/grid.1002.3
    181 schema:familyName Muleya
    182 schema:givenName Victor
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637123203.55
    184 rdf:type schema:Person
    185 sg:pub.10.1007/s000180050149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015537944
    186 https://doi.org/10.1007/s000180050149
    187 rdf:type schema:CreativeWork
    188 sg:pub.10.1007/s00344-009-9105-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024165705
    189 https://doi.org/10.1007/s00344-009-9105-8
    190 rdf:type schema:CreativeWork
    191 sg:pub.10.1007/s00425-008-0839-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038899773
    192 https://doi.org/10.1007/s00425-008-0839-5
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1007/s10059-009-0023-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003243948
    195 https://doi.org/10.1007/s10059-009-0023-1
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1023/a:1010691701578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024080544
    198 https://doi.org/10.1023/a:1010691701578
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1023/a:1014209711793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008477765
    201 https://doi.org/10.1023/a:1014209711793
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1023/a:1014257621362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046999077
    204 https://doi.org/10.1023/a:1014257621362
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1023/a:1014260204524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002480995
    207 https://doi.org/10.1023/a:1014260204524
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/338078a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021061605
    210 https://doi.org/10.1038/338078a0
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/341068a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045147650
    213 https://doi.org/10.1038/341068a0
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/35066597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023629382
    216 https://doi.org/10.1038/35066597
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/cr.2008.36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040147763
    219 https://doi.org/10.1038/cr.2008.36
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/cr.2014.161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048206247
    222 https://doi.org/10.1038/cr.2014.161
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/nature01231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032555823
    225 https://doi.org/10.1038/nature01231
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/nature03973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047682355
    228 https://doi.org/10.1038/nature03973
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/nature10178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027524436
    231 https://doi.org/10.1038/nature10178
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/nature10794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039056119
    234 https://doi.org/10.1038/nature10794
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/ncb2471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005557761
    237 https://doi.org/10.1038/ncb2471
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/ncb2551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006642113
    240 https://doi.org/10.1038/ncb2551
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nrm2822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030815156
    243 https://doi.org/10.1038/nrm2822
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1186/1472-6807-8-42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008179521
    246 https://doi.org/10.1186/1472-6807-8-42
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1186/1478-811x-11-48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024461316
    249 https://doi.org/10.1186/1478-811x-11-48
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1186/s12964-014-0060-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1004755261
    252 https://doi.org/10.1186/s12964-014-0060-z
    253 rdf:type schema:CreativeWork
    254 https://app.dimensions.ai/details/publication/pub.1075071607 schema:CreativeWork
    255 https://app.dimensions.ai/details/publication/pub.1079010284 schema:CreativeWork
    256 https://app.dimensions.ai/details/publication/pub.1079418096 schema:CreativeWork
    257 https://doi.org/10.1002/j.1460-2075.1989.tb03518.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079046846
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1002/pmic.200701059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005378303
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1002/prot.10605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004184487
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1006/bbrc.1997.7921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013409656
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/0092-8674(89)90513-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047297562
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/0092-8674(90)90497-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023424213
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/0896-6273(92)90035-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1023773984
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/j.cellsig.2011.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031804503
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/j.devcel.2005.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047521028
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/j.devcel.2008.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003395409
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/j.ejcb.2009.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019566632
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/j.jmb.2005.06.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029920190
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/j.molcel.2008.12.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017405762
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.pbi.2007.08.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012138724
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.peptides.2004.08.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023932603
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.pharmthera.2004.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028183279
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/j.pharmthera.2010.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033512472
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/j.tplants.2009.01.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016193561
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/s0008-6363(01)00543-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007060213
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/s0074-7696(04)34001-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012368167
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/s0092-8674(00)80357-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018522534
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/s0092-8674(00)80700-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049355759
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/s0092-8674(02)00812-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016606848
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/s0092-8674(02)00814-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008068888
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1021/ar020128g schema:sameAs https://app.dimensions.ai/details/publication/pub.1055149652
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1021/bi00014a025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055157217
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1021/bi900441v schema:sameAs https://app.dimensions.ai/details/publication/pub.1055209706
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1021/bi962008k schema:sameAs https://app.dimensions.ai/details/publication/pub.1055212720
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1021/bi992800w schema:sameAs https://app.dimensions.ai/details/publication/pub.1055219015
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1042/bj20111871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000752169
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1042/bst20140223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056717774
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1071/fp09242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025439224
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1073/pnas.0603729103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032007984
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1073/pnas.0607656103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000161002
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1073/pnas.0704965104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037702845
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1073/pnas.0706403104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020080321
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1073/pnas.0808473105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003354464
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1073/pnas.0810249106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012005524
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1073/pnas.0812220106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032149697
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1073/pnas.1000191107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030848887
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1073/pnas.1108321109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032122033
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1073/pnas.1210799110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004019237
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1073/pnas.92.12.5535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042393543
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1073/pnas.92.8.3571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020860043
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1073/pnas.94.25.13414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033895462
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1074/jbc.273.19.11695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017205148
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1074/jbc.273.2.1032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005799232
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1074/jbc.m109.061713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004954534
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1074/jbc.m109.097394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013522037
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1074/jbc.m110.168823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006079000
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1074/jbc.m210983200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028850253
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1093/nar/gki566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043828333
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1093/pcp/pcd009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042726177
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1093/protein/13.1.59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035388373
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1096/fasebj.9.8.7768349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082499300
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1101/gad.2001911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010223237
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1104/pp.106.081109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020036374
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1104/pp.121.3.743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045030714
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1104/pp.123.4.1247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009133443
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1104/pp.124.2.751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027953305
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1105/tpc.010504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017050378
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1105/tpc.104.025387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029482946
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1105/tpc.105.031393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031703449
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1105/tpc.106.047795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034094756
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1105/tpc.11.3.393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034790407
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1105/tpc.111.084475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020305305
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1105/tpc.112.105049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015183157
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1105/tpc.13.2.303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037621568
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1105/tpc.15.00306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002217372
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1111/j.1365-313x.2005.02616.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025443784
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1111/j.1399-3054.2010.01371.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008924213
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1111/j.1469-8137.2008.02710.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047961506
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1111/j.1471-4159.2007.04923.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053053863
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1111/tpj.12050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042939595
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1111/tpj.12445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043528415
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1111/tpj.12460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048671797
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1126/science.1069607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445932
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1126/science.3291115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062604905
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1126/scisignal.2003253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062682702
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1161/01.res.0000094745.28948.4d schema:sameAs https://app.dimensions.ai/details/publication/pub.1020713847
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1172/jci115862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050622107
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1242/dev.060590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012720306
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1371/journal.pgen.1002452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034553199
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1371/journal.pone.0000449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041466147
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1371/journal.pone.0008904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029427304
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1371/journal.pone.0021054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027386919
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.15252/embj.201489652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017492063
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1681/asn.2005080818 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020229082
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1681/asn.2007050550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036386164
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.2741/1613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070913899
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.3732/ajb.1200264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045638208
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.4161/psb.18891 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072307440
    440 rdf:type schema:CreativeWork
    441 https://www.grid.ac/institutes/grid.1002.3 schema:alternateName Monash University
    442 schema:name Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, 3052, Parkville, VIC, Australia
    443 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...