Imaging of molecular target modulation in oncology: challenges of early clinical trials View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-02

AUTHORS

Carleen Cullinane, Benjamin Solomon, Rodney J. Hicks

ABSTRACT

The development of molecularly targeted anticancer therapies has resulted in a paradigm shift in the clinical drug development process. Phase 1 studies now routinely incorporate pharmacodynamic biomarker endpoints, specifically to evaluate whether a targeted therapy has the desired impact on its target and whether this leads to clinical benefit. Non-invasive molecular imaging using positron emission tomography (PET) has shown promise in this setting, in particular where target modulation directly impacts on glucose metabolism or cell proliferation. In this review, we discuss the challenges in identifying PET biomarkers of target modulation by a novel targeted therapy in the preclinical setting and in their translation into the clinical setting. More... »

PAGES

5-12

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40336-013-0047-6

DOI

http://dx.doi.org/10.1007/s40336-013-0047-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033446187


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Division of Cancer Research, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, VIC, Australia", 
            "Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cullinane", 
        "givenName": "Carleen", 
        "id": "sg:person.01103043021.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103043021.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Division of Cancer Medicine, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, VIC, Australia", 
            "Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Solomon", 
        "givenName": "Benjamin", 
        "id": "sg:person.0637735526.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637735526.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Division of Cancer Research, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, VIC, Australia", 
            "Centre for Cancer Imaging, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, VIC, Australia", 
            "Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hicks", 
        "givenName": "Rodney J.", 
        "id": "sg:person.01121233254.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121233254.97"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.cell.2009.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000064051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12149-013-0694-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000535738", 
          "https://doi.org/10.1007/s12149-013-0694-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-3198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000577060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-0312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000677605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejrad.2009.03.051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001087050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0004(00)89005-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001616450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2008.12.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002022371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-1433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002070983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/3337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004161257", 
          "https://doi.org/10.1038/3337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/3337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004161257", 
          "https://doi.org/10.1038/3337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-09-1181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005827941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.109.071217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005967644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.111.099200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006670004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2012.188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007357547", 
          "https://doi.org/10.1038/nrclinonc.2012.188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2011-10-388298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008456233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.112.112201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012067028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.38.9346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016970422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.18.2.753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017397772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2012.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018554931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-1213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018817251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c000023200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020147426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.07.3049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020547992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-11-0240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021359255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-0783", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022163401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.02.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023540354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-1302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024663946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.109.070425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026051689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81519-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027843076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-12-0372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028196580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35106065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029289076", 
          "https://doi.org/10.1038/35106065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35106065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029289076", 
          "https://doi.org/10.1038/35106065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.24.2.514-526.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030930242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1085/jgp.8.6.519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031385086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-2285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032586664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032620847", 
          "https://doi.org/10.1038/nature09454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032620847", 
          "https://doi.org/10.1038/nature09454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2011.01.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035459376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.112.108456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035880669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.39.1938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037167342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2011.11.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037424371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-12-1819", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038209014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/bmm.09.61", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039562895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mds478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040076521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2191-219x-2-22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040377561", 
          "https://doi.org/10.1186/2191-219x-2-22"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2003.11.147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041531440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.110.086967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042382513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-0898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044111952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045800863", 
          "https://doi.org/10.1038/nature07567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.26630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046602717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-012-2177-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049736827", 
          "https://doi.org/10.1007/s00259-012-2177-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-8-39", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050587923", 
          "https://doi.org/10.1186/1479-5876-8-39"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.seminoncol.2010.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052708757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2006.01.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053067745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.123.3191.309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062467291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.05.140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064204176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075070880", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075189846", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-02", 
    "datePublishedReg": "2014-02-01", 
    "description": "The development of molecularly targeted anticancer therapies has resulted in a paradigm shift in the clinical drug development process. Phase 1 studies now routinely incorporate pharmacodynamic biomarker endpoints, specifically to evaluate whether a targeted therapy has the desired impact on its target and whether this leads to clinical benefit. Non-invasive molecular imaging using positron emission tomography (PET) has shown promise in this setting, in particular where target modulation directly impacts on glucose metabolism or cell proliferation. In this review, we discuss the challenges in identifying PET biomarkers of target modulation by a novel targeted therapy in the preclinical setting and in their translation into the clinical setting.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s40336-013-0047-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1048970", 
        "issn": [
          "2281-5872", 
          "2281-7565"
        ], 
        "name": "Clinical and Translational Imaging", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "name": "Imaging of molecular target modulation in oncology: challenges of early clinical trials", 
    "pagination": "5-12", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9f54869a34f73a77c5d0dc0b559a89e1ae7aa7dace978d1782178efe719024fd"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s40336-013-0047-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033446187"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s40336-013-0047-6", 
      "https://app.dimensions.ai/details/publication/pub.1033446187"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000522.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs40336-013-0047-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40336-013-0047-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40336-013-0047-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40336-013-0047-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40336-013-0047-6'


 

This table displays all metadata directly associated to this object as RDF triples.

247 TRIPLES      21 PREDICATES      81 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s40336-013-0047-6 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N4d28a2794e0d43bc9107b29d6551d3fd
4 schema:citation sg:pub.10.1007/s00259-012-2177-x
5 sg:pub.10.1007/s12149-013-0694-8
6 sg:pub.10.1038/3337
7 sg:pub.10.1038/35106065
8 sg:pub.10.1038/nature07567
9 sg:pub.10.1038/nature09454
10 sg:pub.10.1038/nrclinonc.2012.188
11 sg:pub.10.1186/1479-5876-8-39
12 sg:pub.10.1186/2191-219x-2-22
13 https://app.dimensions.ai/details/publication/pub.1075070880
14 https://app.dimensions.ai/details/publication/pub.1075189846
15 https://doi.org/10.1002/cncr.26630
16 https://doi.org/10.1016/j.bbrc.2003.11.147
17 https://doi.org/10.1016/j.cell.2009.09.002
18 https://doi.org/10.1016/j.cell.2011.02.013
19 https://doi.org/10.1016/j.cellsig.2011.01.016
20 https://doi.org/10.1016/j.ejca.2006.01.026
21 https://doi.org/10.1016/j.ejca.2011.11.035
22 https://doi.org/10.1016/j.ejca.2012.05.001
23 https://doi.org/10.1016/j.ejrad.2009.03.051
24 https://doi.org/10.1016/j.molcel.2008.12.026
25 https://doi.org/10.1016/s0092-8674(00)81519-6
26 https://doi.org/10.1016/s0968-0004(00)89005-2
27 https://doi.org/10.1053/j.seminoncol.2010.11.005
28 https://doi.org/10.1074/jbc.c000023200
29 https://doi.org/10.1085/jgp.8.6.519
30 https://doi.org/10.1093/annonc/mds478
31 https://doi.org/10.1126/science.123.3191.309
32 https://doi.org/10.1128/mcb.18.2.753
33 https://doi.org/10.1128/mcb.24.2.514-526.2004
34 https://doi.org/10.1158/0008-5472.can-05-2285
35 https://doi.org/10.1158/0008-5472.can-06-0898
36 https://doi.org/10.1158/1078-0432.ccr-05-1302
37 https://doi.org/10.1158/1078-0432.ccr-08-0312
38 https://doi.org/10.1158/1078-0432.ccr-09-1213
39 https://doi.org/10.1158/1078-0432.ccr-11-0783
40 https://doi.org/10.1158/1078-0432.ccr-11-1433
41 https://doi.org/10.1158/1078-0432.ccr-11-3198
42 https://doi.org/10.1158/1078-0432.ccr-12-0372
43 https://doi.org/10.1158/1078-0432.ccr-12-1819
44 https://doi.org/10.1158/1535-7163.mct-09-1181
45 https://doi.org/10.1158/1535-7163.mct-11-0240
46 https://doi.org/10.1182/blood-2011-10-388298
47 https://doi.org/10.1200/jco.2004.05.140
48 https://doi.org/10.1200/jco.2006.07.3049
49 https://doi.org/10.1200/jco.2011.38.9346
50 https://doi.org/10.1200/jco.2011.39.1938
51 https://doi.org/10.2217/bmm.09.61
52 https://doi.org/10.2967/jnumed.109.070425
53 https://doi.org/10.2967/jnumed.109.071217
54 https://doi.org/10.2967/jnumed.110.086967
55 https://doi.org/10.2967/jnumed.111.099200
56 https://doi.org/10.2967/jnumed.112.108456
57 https://doi.org/10.2967/jnumed.112.112201
58 schema:datePublished 2014-02
59 schema:datePublishedReg 2014-02-01
60 schema:description The development of molecularly targeted anticancer therapies has resulted in a paradigm shift in the clinical drug development process. Phase 1 studies now routinely incorporate pharmacodynamic biomarker endpoints, specifically to evaluate whether a targeted therapy has the desired impact on its target and whether this leads to clinical benefit. Non-invasive molecular imaging using positron emission tomography (PET) has shown promise in this setting, in particular where target modulation directly impacts on glucose metabolism or cell proliferation. In this review, we discuss the challenges in identifying PET biomarkers of target modulation by a novel targeted therapy in the preclinical setting and in their translation into the clinical setting.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf N283755b2759047e9ad931cf5b5cee6a9
65 N36798cdbd27f46fdaaa299d997c19dd6
66 sg:journal.1048970
67 schema:name Imaging of molecular target modulation in oncology: challenges of early clinical trials
68 schema:pagination 5-12
69 schema:productId N28e95f4ec9524666870bd2c74ba43ba9
70 N29de3d4411954a39bbd071b25a54383f
71 Nce092a8fd5fd440cb46c9f52b3bf20a6
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033446187
73 https://doi.org/10.1007/s40336-013-0047-6
74 schema:sdDatePublished 2019-04-10T22:34
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher Na6da20259ca2485ca98a6930cd61a05b
77 schema:url http://link.springer.com/10.1007%2Fs40336-013-0047-6
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N0e4d4f6f95224ac09e88d42fc7131d6e rdf:first sg:person.0637735526.53
82 rdf:rest N423922fdca764afea7d3c56f736b4bb2
83 N283755b2759047e9ad931cf5b5cee6a9 schema:volumeNumber 2
84 rdf:type schema:PublicationVolume
85 N28e95f4ec9524666870bd2c74ba43ba9 schema:name dimensions_id
86 schema:value pub.1033446187
87 rdf:type schema:PropertyValue
88 N29de3d4411954a39bbd071b25a54383f schema:name doi
89 schema:value 10.1007/s40336-013-0047-6
90 rdf:type schema:PropertyValue
91 N36798cdbd27f46fdaaa299d997c19dd6 schema:issueNumber 1
92 rdf:type schema:PublicationIssue
93 N423922fdca764afea7d3c56f736b4bb2 rdf:first sg:person.01121233254.97
94 rdf:rest rdf:nil
95 N4d28a2794e0d43bc9107b29d6551d3fd rdf:first sg:person.01103043021.13
96 rdf:rest N0e4d4f6f95224ac09e88d42fc7131d6e
97 Na6da20259ca2485ca98a6930cd61a05b schema:name Springer Nature - SN SciGraph project
98 rdf:type schema:Organization
99 Nce092a8fd5fd440cb46c9f52b3bf20a6 schema:name readcube_id
100 schema:value 9f54869a34f73a77c5d0dc0b559a89e1ae7aa7dace978d1782178efe719024fd
101 rdf:type schema:PropertyValue
102 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
103 schema:name Medical and Health Sciences
104 rdf:type schema:DefinedTerm
105 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
106 schema:name Clinical Sciences
107 rdf:type schema:DefinedTerm
108 sg:journal.1048970 schema:issn 2281-5872
109 2281-7565
110 schema:name Clinical and Translational Imaging
111 rdf:type schema:Periodical
112 sg:person.01103043021.13 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
113 schema:familyName Cullinane
114 schema:givenName Carleen
115 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103043021.13
116 rdf:type schema:Person
117 sg:person.01121233254.97 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
118 schema:familyName Hicks
119 schema:givenName Rodney J.
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121233254.97
121 rdf:type schema:Person
122 sg:person.0637735526.53 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
123 schema:familyName Solomon
124 schema:givenName Benjamin
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637735526.53
126 rdf:type schema:Person
127 sg:pub.10.1007/s00259-012-2177-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049736827
128 https://doi.org/10.1007/s00259-012-2177-x
129 rdf:type schema:CreativeWork
130 sg:pub.10.1007/s12149-013-0694-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000535738
131 https://doi.org/10.1007/s12149-013-0694-8
132 rdf:type schema:CreativeWork
133 sg:pub.10.1038/3337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004161257
134 https://doi.org/10.1038/3337
135 rdf:type schema:CreativeWork
136 sg:pub.10.1038/35106065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029289076
137 https://doi.org/10.1038/35106065
138 rdf:type schema:CreativeWork
139 sg:pub.10.1038/nature07567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045800863
140 https://doi.org/10.1038/nature07567
141 rdf:type schema:CreativeWork
142 sg:pub.10.1038/nature09454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032620847
143 https://doi.org/10.1038/nature09454
144 rdf:type schema:CreativeWork
145 sg:pub.10.1038/nrclinonc.2012.188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007357547
146 https://doi.org/10.1038/nrclinonc.2012.188
147 rdf:type schema:CreativeWork
148 sg:pub.10.1186/1479-5876-8-39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050587923
149 https://doi.org/10.1186/1479-5876-8-39
150 rdf:type schema:CreativeWork
151 sg:pub.10.1186/2191-219x-2-22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040377561
152 https://doi.org/10.1186/2191-219x-2-22
153 rdf:type schema:CreativeWork
154 https://app.dimensions.ai/details/publication/pub.1075070880 schema:CreativeWork
155 https://app.dimensions.ai/details/publication/pub.1075189846 schema:CreativeWork
156 https://doi.org/10.1002/cncr.26630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046602717
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1016/j.bbrc.2003.11.147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041531440
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/j.cell.2009.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000064051
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/j.cell.2011.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023540354
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/j.cellsig.2011.01.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035459376
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/j.ejca.2006.01.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053067745
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/j.ejca.2011.11.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037424371
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/j.ejca.2012.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018554931
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/j.ejrad.2009.03.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001087050
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/j.molcel.2008.12.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002022371
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/s0092-8674(00)81519-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027843076
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/s0968-0004(00)89005-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001616450
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1053/j.seminoncol.2010.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052708757
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1074/jbc.c000023200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020147426
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1085/jgp.8.6.519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031385086
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1093/annonc/mds478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040076521
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1126/science.123.3191.309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062467291
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1128/mcb.18.2.753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017397772
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1128/mcb.24.2.514-526.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030930242
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1158/0008-5472.can-05-2285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032586664
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1158/0008-5472.can-06-0898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044111952
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1158/1078-0432.ccr-05-1302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024663946
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1158/1078-0432.ccr-08-0312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000677605
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1158/1078-0432.ccr-09-1213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018817251
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1158/1078-0432.ccr-11-0783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022163401
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1158/1078-0432.ccr-11-1433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002070983
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1158/1078-0432.ccr-11-3198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000577060
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1158/1078-0432.ccr-12-0372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028196580
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1158/1078-0432.ccr-12-1819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038209014
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1158/1535-7163.mct-09-1181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005827941
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1158/1535-7163.mct-11-0240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021359255
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1182/blood-2011-10-388298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008456233
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1200/jco.2004.05.140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204176
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1200/jco.2006.07.3049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020547992
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1200/jco.2011.38.9346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016970422
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1200/jco.2011.39.1938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037167342
227 rdf:type schema:CreativeWork
228 https://doi.org/10.2217/bmm.09.61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039562895
229 rdf:type schema:CreativeWork
230 https://doi.org/10.2967/jnumed.109.070425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026051689
231 rdf:type schema:CreativeWork
232 https://doi.org/10.2967/jnumed.109.071217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005967644
233 rdf:type schema:CreativeWork
234 https://doi.org/10.2967/jnumed.110.086967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042382513
235 rdf:type schema:CreativeWork
236 https://doi.org/10.2967/jnumed.111.099200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006670004
237 rdf:type schema:CreativeWork
238 https://doi.org/10.2967/jnumed.112.108456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035880669
239 rdf:type schema:CreativeWork
240 https://doi.org/10.2967/jnumed.112.112201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012067028
241 rdf:type schema:CreativeWork
242 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
243 schema:name Centre for Cancer Imaging, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, VIC, Australia
244 Division of Cancer Medicine, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, VIC, Australia
245 Division of Cancer Research, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, VIC, Australia
246 Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia
247 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...