High Frequency and Poor Prognosis of Late Childhood BCR-ABL-Positive and MLL-AF4-Positive ALL Define the Need for Advanced Molecular Diagnostics and ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-10

AUTHORS

Zafar Iqbal, Tanveer Akhtar, Tashfin Awan, Aamer Aleem, Noreen Sabir, Mahmood Rasool, Muhammad Absar, Afia M. Akram, Masood A. Shammas, Ijaz H. Shah, Muhammad Khalid, Abid S. Taj, Abid Jameel, Abdullah Alanazi, Ammara T. Gill, Jamil Amjad Hashmi, Akhtar Hussain, Muhammad Farooq Sabar, Ahmad M. Khalid, Mehmood Hussain Qazi, Sajjad Karim, Muhammad Hassan Siddiqi, Aamir Mahmood, Mudassar Iqbal, Anjum Saeed, Muhammad Imran Irfan

ABSTRACT

BACKGROUND: Fusion oncogenes (FOs) resulting from chromosomal abnormalities have an important role in leukemogenesis in pediatric B cell acute lymphoblastic leukemia (ALL). The most common FOs are BCR-ABL, MLL-AF4, ETV6-RUNX1, and TCF3-PBX1, all of which have important prognostic and drug selection implications. Moreover, frequencies of FOs have ethnic variations. We studied Pakistani frequencies of FOs, clinical pattern, and outcome in pediatric B-ALL. METHODS: FOs were studied in 188 patients at diagnosis using reverse transcriptase-polymerase chain reaction (RT-PCR) and interphase fluorescent in situ hybridization (FISH). Data were analyzed using SPSS version 17 (SPSS Inc., Chicago, IL, USA). RESULTS: FOs were detected in 87.2 % of patients. Mean overall survival was 70.9 weeks, 3-year survival was 31.9 %, and 3-year relapse-free survival was 18.1 %. Four patients died of drug toxicities. ETV6-RUNX1 (19.14 %) had better survival (110.9 weeks; p = 0.03); TCF3-PBX1 (2.1 %) was associated with inferior outcome and higher central nervous system (CNS) relapse risk; MLL-AF4 (18.1 %) was more common in the 8- to 15-year age group (24/34; p = 0.001) and was associated with organomegaly, low platelet count, and poor survival; and BCR-ABL (47.9 %) was associated with older age (7-15 years, 52/90), lower remission rates, shorter survival (43.73 ± 4.24 weeks) and higher white blood cell count. Overall, MLL-AF4 and BCR-ABL were detected in 66 % of B-ALL, presented in later childhood, and were associated with poor prognosis and inferior survival. CONCLUSIONS: This study reports the highest ethnic frequency of BCR-ABL FO in pediatric ALL, and is consistent with previous reports from our region. Poor prognosis BCR-ABL and MLL-AF4 was detected in two-thirds of pediatric B-ALL and is likely to be the reason for the already reported poor survival of childhood ALL in South-East Asia. Furthermore, MLL-AF4, usually most common in infants, presented in later childhood in most of the ALL patients, which was one of the unique findings in our study. The results presented here highlight the need for mandatory inclusion of molecular testing for pediatric ALL patients in clinical decision making, together with the incorporation of tyrosine kinase inhibitors, as well as hematopoietic stem cell transplantation facilities, to improve treatment outcome for patients in developing countries. More... »

PAGES

277-287

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40291-015-0149-0

DOI

http://dx.doi.org/10.1007/s40291-015-0149-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008213736

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26266519


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fusion Proteins, bcr-abl", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myeloid-Lymphoid Leukemia Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogene Proteins, Fusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pakistan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Precision Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Precursor B-Cell Lymphoblastic Leukemia-Lymphoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Lahore", 
          "id": "https://www.grid.ac/institutes/grid.440564.7", 
          "name": [
            "Medical Genetics/Hematology and Oncology, CLS, CAMS, King Saud Bin Abdulaziz University for Health Sciences/KAIMRC, King Abdulaziz Medical City, National Guard Health Affairs, 11426, Riyadh, Saudi Arabia", 
            "Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES) Group, Health Sciences/Parasitology Laboratories (HSL), Department of Zoology, University of the Punjab (ZPU), Lahore, Pakistan", 
            "Department of Biotechnology, University of Sargodha, Sargodha, Pakistan", 
            "Institute of Molecular Biology and Biotechnology (IMBB), Centre for Research in Molecular Medicine (CRiMM), The University of Lahore, Lahore, Pakistan", 
            "Pakistan Society for Molecular and Clinical Hematology (PSMH) & Hematology Oncology and Pharmacogenetic Engineering Sciences Group (HOPES), Lahore, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iqbal", 
        "givenName": "Zafar", 
        "id": "sg:person.015313253340.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015313253340.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of the Punjab", 
          "id": "https://www.grid.ac/institutes/grid.11173.35", 
          "name": [
            "Department of Zoology, Faculty of Biological Sciences, University of the Punjab, Lahore, Pakistan", 
            "Pakistan Society for Molecular and Clinical Hematology, Lahore, Pakistan", 
            "Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES) Group, Health Sciences/Parasitology Laboratories (HSL), Department of Zoology, University of the Punjab (ZPU), Lahore, Pakistan", 
            "Pakistan Society for Molecular and Clinical Hematology (PSMH) & Hematology Oncology and Pharmacogenetic Engineering Sciences Group (HOPES), Lahore, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akhtar", 
        "givenName": "Tanveer", 
        "id": "sg:person.01130207414.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130207414.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of the Punjab", 
          "id": "https://www.grid.ac/institutes/grid.11173.35", 
          "name": [
            "Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES) Group, Health Sciences/Parasitology Laboratories (HSL), Department of Zoology, University of the Punjab (ZPU), Lahore, Pakistan", 
            "Pakistan Society for Molecular and Clinical Hematology (PSMH) & Hematology Oncology and Pharmacogenetic Engineering Sciences Group (HOPES), Lahore, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Awan", 
        "givenName": "Tashfin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Hematology/Oncology, Department of Medicine, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aleem", 
        "givenName": "Aamer", 
        "id": "sg:person.01013552641.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013552641.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of the Punjab", 
          "id": "https://www.grid.ac/institutes/grid.11173.35", 
          "name": [
            "Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES) Group, Health Sciences/Parasitology Laboratories (HSL), Department of Zoology, University of the Punjab (ZPU), Lahore, Pakistan", 
            "Pakistan Society for Molecular and Clinical Hematology (PSMH) & Hematology Oncology and Pharmacogenetic Engineering Sciences Group (HOPES), Lahore, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sabir", 
        "givenName": "Noreen", 
        "id": "sg:person.01304345445.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304345445.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King Abdulaziz University", 
          "id": "https://www.grid.ac/institutes/grid.412125.1", 
          "name": [
            "Centre of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rasool", 
        "givenName": "Mahmood", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of the Punjab", 
          "id": "https://www.grid.ac/institutes/grid.11173.35", 
          "name": [
            "Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES) Group, Health Sciences/Parasitology Laboratories (HSL), Department of Zoology, University of the Punjab (ZPU), Lahore, Pakistan", 
            "Pakistan Society for Molecular and Clinical Hematology (PSMH) & Hematology Oncology and Pharmacogenetic Engineering Sciences Group (HOPES), Lahore, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Absar", 
        "givenName": "Muhammad", 
        "id": "sg:person.01125644745.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125644745.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of the Punjab", 
          "id": "https://www.grid.ac/institutes/grid.11173.35", 
          "name": [
            "Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES) Group, Health Sciences/Parasitology Laboratories (HSL), Department of Zoology, University of the Punjab (ZPU), Lahore, Pakistan", 
            "Pakistan Society for Molecular and Clinical Hematology (PSMH) & Hematology Oncology and Pharmacogenetic Engineering Sciences Group (HOPES), Lahore, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akram", 
        "givenName": "Afia M.", 
        "id": "sg:person.01177621245.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177621245.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Translational Genomic Instability Program, Harvard (Dana-Farber) Cancer Institute, Harvard Medical School, Harvard University, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shammas", 
        "givenName": "Masood A.", 
        "id": "sg:person.01222370436.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222370436.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Oncology, Allied Hospital, Punjab Medical College, Faisalabad, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shah", 
        "givenName": "Ijaz H.", 
        "id": "sg:person.01021034324.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021034324.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Oncology, Allied Hospital, Punjab Medical College, Faisalabad, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khalid", 
        "givenName": "Muhammad", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute of Radiotherapy and Nuclear Medicine, Peshawar, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taj", 
        "givenName": "Abid S.", 
        "id": "sg:person.01233474472.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233474472.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Khyber Teaching Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415215.6", 
          "name": [
            "Hayatabad Medical Complex, Peshawar, Pakistan", 
            "Department of Oncology, Khyber Teaching Hospital, Peshawar, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jameel", 
        "givenName": "Abid", 
        "id": "sg:person.0746702427.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746702427.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King Abdulaziz Medical City", 
          "id": "https://www.grid.ac/institutes/grid.415254.3", 
          "name": [
            "Medical Genetics/Hematology and Oncology, CLS, CAMS, King Saud Bin Abdulaziz University for Health Sciences/KAIMRC, King Abdulaziz Medical City, National Guard Health Affairs, 11426, Riyadh, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alanazi", 
        "givenName": "Abdullah", 
        "id": "sg:person.01115725315.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115725315.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CoxHealth", 
          "id": "https://www.grid.ac/institutes/grid.431764.3", 
          "name": [
            "Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES) Group, Health Sciences/Parasitology Laboratories (HSL), Department of Zoology, University of the Punjab (ZPU), Lahore, Pakistan", 
            "Cox Health System, Springfield, MO, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gill", 
        "givenName": "Ammara T.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of the Punjab", 
          "id": "https://www.grid.ac/institutes/grid.11173.35", 
          "name": [
            "Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES) Group, Health Sciences/Parasitology Laboratories (HSL), Department of Zoology, University of the Punjab (ZPU), Lahore, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hashmi", 
        "givenName": "Jamil Amjad", 
        "id": "sg:person.01351007617.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351007617.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Peshawar", 
          "id": "https://www.grid.ac/institutes/grid.266976.a", 
          "name": [
            "Department of Biotechnology, University of Peshawar, Peshawar, Pakistan", 
            "Pakistan Society for Molecular and Clinical Hematology (PSMH) & Hematology Oncology and Pharmacogenetic Engineering Sciences Group (HOPES), Lahore, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hussain", 
        "givenName": "Akhtar", 
        "id": "sg:person.0706523151.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706523151.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of the Punjab", 
          "id": "https://www.grid.ac/institutes/grid.11173.35", 
          "name": [
            "Core DNA Facilities, Centre for Advanced Molecular Biology, University of the Punjab, Lahore, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sabar", 
        "givenName": "Muhammad Farooq", 
        "id": "sg:person.0701031045.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701031045.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sargodha", 
          "id": "https://www.grid.ac/institutes/grid.412782.a", 
          "name": [
            "Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES) Group, Health Sciences/Parasitology Laboratories (HSL), Department of Zoology, University of the Punjab (ZPU), Lahore, Pakistan", 
            "Department of Biotechnology, University of Sargodha, Sargodha, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khalid", 
        "givenName": "Ahmad M.", 
        "id": "sg:person.0711365573.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711365573.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Lahore", 
          "id": "https://www.grid.ac/institutes/grid.440564.7", 
          "name": [
            "Institute of Molecular Biology and Biotechnology (IMBB), Centre for Research in Molecular Medicine (CRiMM), The University of Lahore, Lahore, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qazi", 
        "givenName": "Mehmood Hussain", 
        "id": "sg:person.01056311706.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056311706.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King Abdulaziz University", 
          "id": "https://www.grid.ac/institutes/grid.412125.1", 
          "name": [
            "Centre of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karim", 
        "givenName": "Sajjad", 
        "id": "sg:person.0663400152.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663400152.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of the Punjab", 
          "id": "https://www.grid.ac/institutes/grid.11173.35", 
          "name": [
            "Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES) Group, Health Sciences/Parasitology Laboratories (HSL), Department of Zoology, University of the Punjab (ZPU), Lahore, Pakistan", 
            "Pakistan Society for Molecular and Clinical Hematology (PSMH) & Hematology Oncology and Pharmacogenetic Engineering Sciences Group (HOPES), Lahore, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Siddiqi", 
        "givenName": "Muhammad Hassan", 
        "id": "sg:person.01203546322.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203546322.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Stem Cell Research Group, Department of Anatomy, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mahmood", 
        "givenName": "Aamir", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of the Punjab", 
          "id": "https://www.grid.ac/institutes/grid.11173.35", 
          "name": [
            "Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES) Group, Health Sciences/Parasitology Laboratories (HSL), Department of Zoology, University of the Punjab (ZPU), Lahore, Pakistan", 
            "Asian Medical Institute and National Surgical Centre, Kant, Kyrgyzstan", 
            "Pakistan Society for Molecular and Clinical Hematology (PSMH) & Hematology Oncology and Pharmacogenetic Engineering Sciences Group (HOPES), Lahore, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iqbal", 
        "givenName": "Mudassar", 
        "id": "sg:person.01251511324.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251511324.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King Saud University", 
          "id": "https://www.grid.ac/institutes/grid.56302.32", 
          "name": [
            "Prince Abdullah Bin Khalid Celiac Disease Research Chair, King Saud University, Riyadh, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saeed", 
        "givenName": "Anjum", 
        "id": "sg:person.01203174244.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203174244.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sargodha", 
          "id": "https://www.grid.ac/institutes/grid.412782.a", 
          "name": [
            "Department of Chemistry, University of Sargodha, Sargodha, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Irfan", 
        "givenName": "Muhammad Imran", 
        "id": "sg:person.010505271200.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010505271200.36"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/mph.0b013e3182422ca0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002231027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0b013e3182422ca0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002231027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(12)70377-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002311788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2404577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002878947", 
          "https://doi.org/10.1038/sj.leu.2404577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0b013e318286d241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004021651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0b013e318286d241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004021651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0b013e318286d241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004021651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0b013e318030ac4c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004381878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0b013e318030ac4c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004381878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10428194.2014.910662", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004905540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7314/apjcp.2012.13.11.5469", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007280520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2013.48.6522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007967482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2014.30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008558028", 
          "https://doi.org/10.1038/leu.2014.30"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2014.30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008558028", 
          "https://doi.org/10.1038/leu.2014.30"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.28531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009247380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)62187-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011676133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403540", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012422677", 
          "https://doi.org/10.1038/sj.leu.2403540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403540", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012422677", 
          "https://doi.org/10.1038/sj.leu.2403540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.2003.04558.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016157687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2011.08824.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019131257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.12.3927", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020978466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(02)08782-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022153891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/88.1.24", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022194970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajh.23307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023898349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0b013e3180f61bcf", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024293564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0b013e3180f61bcf", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024293564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-05-0833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024882379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.1999.01747.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025370525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2012.080432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025797374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/08880018.2014.935837", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026338287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2014.58.9747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027828443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2015.108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029299263", 
          "https://doi.org/10.1038/bjc.2015.108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4137/cin.s11831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031177461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.38.0345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031859738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mpo.1220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032702399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3346/jkms.2005.20.1.36", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033486457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3346/jkms.2005.20.1.36", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033486457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2401592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034947020", 
          "https://doi.org/10.1038/sj.leu.2401592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2401592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034947020", 
          "https://doi.org/10.1038/sj.leu.2401592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/2040620714565963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035706387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/2040620714565963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035706387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2013.08.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036197787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.24584", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037166285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.seminhematol.2013.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037886897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cancergencyto.2010.04.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039033946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cancergen.2013.05.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039463920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2006-01-024729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041143310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0b013e31820e7361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042193129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0b013e31820e7361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042193129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mpo.1225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042455090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-02-070342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043143043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12032-009-9232-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047532757", 
          "https://doi.org/10.1007/s12032-009-9232-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12032-009-9232-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047532757", 
          "https://doi.org/10.1007/s12032-009-9232-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1743-7563.2010.01370.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050983121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11899-012-0122-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051125417", 
          "https://doi.org/10.1007/s11899-012-0122-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2004-04-1616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052019538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.28854", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053050285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2401257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053509094", 
          "https://doi.org/10.1038/sj.leu.2401257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2401257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053509094", 
          "https://doi.org/10.1038/sj.leu.2401257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0087602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053665744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074687794", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075301044", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077254461", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078419120", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078436416", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078495350", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1990.8.8.1380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078749555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078836443", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082384450", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082878892", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082900521", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-10", 
    "datePublishedReg": "2015-10-01", 
    "description": "BACKGROUND: Fusion oncogenes (FOs) resulting from chromosomal abnormalities have an important role in leukemogenesis in pediatric B cell acute lymphoblastic leukemia (ALL). The most common FOs are BCR-ABL, MLL-AF4, ETV6-RUNX1, and TCF3-PBX1, all of which have important prognostic and drug selection implications. Moreover, frequencies of FOs have ethnic variations. We studied Pakistani frequencies of FOs, clinical pattern, and outcome in pediatric B-ALL.\nMETHODS: FOs were studied in 188 patients at diagnosis using reverse transcriptase-polymerase chain reaction (RT-PCR) and interphase fluorescent in situ hybridization (FISH). Data were analyzed using SPSS version 17 (SPSS Inc., Chicago, IL, USA).\nRESULTS: FOs were detected in 87.2\u00a0% of patients. Mean overall survival was 70.9\u00a0weeks, 3-year survival was 31.9\u00a0%, and 3-year relapse-free survival was 18.1\u00a0%. Four patients died of drug toxicities. ETV6-RUNX1 (19.14\u00a0%) had better survival (110.9\u00a0weeks; p\u00a0=\u00a00.03); TCF3-PBX1 (2.1\u00a0%) was associated with inferior outcome and higher central nervous system (CNS) relapse risk; MLL-AF4 (18.1\u00a0%) was more common in the 8- to 15-year age group (24/34; p\u00a0=\u00a00.001) and was associated with organomegaly, low platelet count, and poor survival; and BCR-ABL (47.9\u00a0%) was associated with older age (7-15\u00a0years, 52/90), lower remission rates, shorter survival (43.73\u00a0\u00b1\u00a04.24\u00a0weeks) and higher white blood cell count. Overall, MLL-AF4 and BCR-ABL were detected in 66\u00a0% of B-ALL, presented in later childhood, and were associated with poor prognosis and inferior survival.\nCONCLUSIONS: This study reports the highest ethnic frequency of BCR-ABL FO in pediatric ALL, and is consistent with previous reports from our region. Poor prognosis BCR-ABL and MLL-AF4 was detected in two-thirds of pediatric B-ALL and is likely to be the reason for the already reported poor survival of childhood ALL in South-East Asia. Furthermore, MLL-AF4, usually most common in infants, presented in later childhood in most of the ALL patients, which was one of the unique findings in our study. The results presented here highlight the need for mandatory inclusion of molecular testing for pediatric ALL patients in clinical decision making, together with the incorporation of tyrosine kinase inhibitors, as well as hematopoietic stem cell transplantation facilities, to improve treatment outcome for patients in developing countries.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s40291-015-0149-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1036392", 
        "issn": [
          "1177-1062", 
          "1179-2000"
        ], 
        "name": "Molecular Diagnosis & Therapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "High Frequency and Poor Prognosis of Late Childhood BCR-ABL-Positive and MLL-AF4-Positive ALL Define the Need for Advanced Molecular Diagnostics and Improved Therapeutic Strategies in Pediatric B-ALL in Pakistan", 
    "pagination": "277-287", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "272186c0eab1b509095cfd60ccf4b0b99f48306bf2da0dc5c5522fe6ef403545"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26266519"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101264260"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s40291-015-0149-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1008213736"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s40291-015-0149-0", 
      "https://app.dimensions.ai/details/publication/pub.1008213736"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000520.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs40291-015-0149-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40291-015-0149-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40291-015-0149-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40291-015-0149-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40291-015-0149-0'


 

This table displays all metadata directly associated to this object as RDF triples.

530 TRIPLES      21 PREDICATES      104 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s40291-015-0149-0 schema:about N0779c583d3974f32bdd0038e2949092c
2 N1a9177c0223f405db3c317fc0b94529e
3 N2f42cec2d5e84dfcb8b03e5b32b82153
4 N398dcafd3c344108a6b72534a952cccf
5 N4e6afb5478d24dfa876146a3e230464a
6 N507676bd2486426db3284872556fa4fb
7 N5a2df85ef24949cb9c6663bc23aa7310
8 N84bd304bb107444a95f173ac10937158
9 N8b861eabc45c4002bb4751c3b7e68f4c
10 N8edcaba1d501471abebd5cfc10188d73
11 Nc29a9536e2d34545a8b55052f1eb17b3
12 Nc2af8e2f09fe43c0823dec8fff074f9e
13 Nc3d4c1574950431eb5283731f578523d
14 Ne8304cb1d59f43f9997d2c9bb05f4ab8
15 Nf0730f292b3d469b9d00ab832d5a9542
16 Nfa3db0e464cd4e428a82138dd3e42680
17 Nfc1c2522ab65455d82b2af5e02532bb2
18 anzsrc-for:11
19 anzsrc-for:1102
20 schema:author Naf115860dd6c4b7894519211f8cfeebc
21 schema:citation sg:pub.10.1007/s11899-012-0122-5
22 sg:pub.10.1007/s12032-009-9232-x
23 sg:pub.10.1038/bjc.2015.108
24 sg:pub.10.1038/leu.2014.30
25 sg:pub.10.1038/sj.leu.2401257
26 sg:pub.10.1038/sj.leu.2401592
27 sg:pub.10.1038/sj.leu.2403540
28 sg:pub.10.1038/sj.leu.2404577
29 https://app.dimensions.ai/details/publication/pub.1074687794
30 https://app.dimensions.ai/details/publication/pub.1075301044
31 https://app.dimensions.ai/details/publication/pub.1077254461
32 https://app.dimensions.ai/details/publication/pub.1078419120
33 https://app.dimensions.ai/details/publication/pub.1078436416
34 https://app.dimensions.ai/details/publication/pub.1078495350
35 https://app.dimensions.ai/details/publication/pub.1078836443
36 https://app.dimensions.ai/details/publication/pub.1082384450
37 https://app.dimensions.ai/details/publication/pub.1082878892
38 https://app.dimensions.ai/details/publication/pub.1082900521
39 https://doi.org/10.1002/ajh.23307
40 https://doi.org/10.1002/cncr.28531
41 https://doi.org/10.1002/ijc.28854
42 https://doi.org/10.1002/mpo.1220
43 https://doi.org/10.1002/mpo.1225
44 https://doi.org/10.1002/pbc.24584
45 https://doi.org/10.1016/j.cancergen.2013.05.017
46 https://doi.org/10.1016/j.cancergencyto.2010.04.010
47 https://doi.org/10.1016/j.ejca.2013.08.027
48 https://doi.org/10.1016/s0140-6736(02)08782-2
49 https://doi.org/10.1016/s0140-6736(12)62187-4
50 https://doi.org/10.1016/s1470-2045(12)70377-7
51 https://doi.org/10.1046/j.1365-2141.1999.01747.x
52 https://doi.org/10.1046/j.1365-2141.2003.04558.x
53 https://doi.org/10.1053/j.seminhematol.2013.10.001
54 https://doi.org/10.1093/jnci/88.1.24
55 https://doi.org/10.1097/mph.0b013e318030ac4c
56 https://doi.org/10.1097/mph.0b013e3180f61bcf
57 https://doi.org/10.1097/mph.0b013e31820e7361
58 https://doi.org/10.1097/mph.0b013e3182422ca0
59 https://doi.org/10.1097/mph.0b013e318286d241
60 https://doi.org/10.1111/j.1365-2141.2011.08824.x
61 https://doi.org/10.1111/j.1743-7563.2010.01370.x
62 https://doi.org/10.1158/1055-9965.epi-05-0833
63 https://doi.org/10.1177/2040620714565963
64 https://doi.org/10.1182/blood-2004-04-1616
65 https://doi.org/10.1182/blood-2006-01-024729
66 https://doi.org/10.1182/blood-2007-02-070342
67 https://doi.org/10.1200/jco.1990.8.8.1380
68 https://doi.org/10.1200/jco.2007.12.3927
69 https://doi.org/10.1200/jco.2011.38.0345
70 https://doi.org/10.1200/jco.2013.48.6522
71 https://doi.org/10.1200/jco.2014.58.9747
72 https://doi.org/10.1371/journal.pone.0087602
73 https://doi.org/10.3109/08880018.2014.935837
74 https://doi.org/10.3109/10428194.2014.910662
75 https://doi.org/10.3324/haematol.2012.080432
76 https://doi.org/10.3346/jkms.2005.20.1.36
77 https://doi.org/10.4137/cin.s11831
78 https://doi.org/10.7314/apjcp.2012.13.11.5469
79 schema:datePublished 2015-10
80 schema:datePublishedReg 2015-10-01
81 schema:description BACKGROUND: Fusion oncogenes (FOs) resulting from chromosomal abnormalities have an important role in leukemogenesis in pediatric B cell acute lymphoblastic leukemia (ALL). The most common FOs are BCR-ABL, MLL-AF4, ETV6-RUNX1, and TCF3-PBX1, all of which have important prognostic and drug selection implications. Moreover, frequencies of FOs have ethnic variations. We studied Pakistani frequencies of FOs, clinical pattern, and outcome in pediatric B-ALL. METHODS: FOs were studied in 188 patients at diagnosis using reverse transcriptase-polymerase chain reaction (RT-PCR) and interphase fluorescent in situ hybridization (FISH). Data were analyzed using SPSS version 17 (SPSS Inc., Chicago, IL, USA). RESULTS: FOs were detected in 87.2 % of patients. Mean overall survival was 70.9 weeks, 3-year survival was 31.9 %, and 3-year relapse-free survival was 18.1 %. Four patients died of drug toxicities. ETV6-RUNX1 (19.14 %) had better survival (110.9 weeks; p = 0.03); TCF3-PBX1 (2.1 %) was associated with inferior outcome and higher central nervous system (CNS) relapse risk; MLL-AF4 (18.1 %) was more common in the 8- to 15-year age group (24/34; p = 0.001) and was associated with organomegaly, low platelet count, and poor survival; and BCR-ABL (47.9 %) was associated with older age (7-15 years, 52/90), lower remission rates, shorter survival (43.73 ± 4.24 weeks) and higher white blood cell count. Overall, MLL-AF4 and BCR-ABL were detected in 66 % of B-ALL, presented in later childhood, and were associated with poor prognosis and inferior survival. CONCLUSIONS: This study reports the highest ethnic frequency of BCR-ABL FO in pediatric ALL, and is consistent with previous reports from our region. Poor prognosis BCR-ABL and MLL-AF4 was detected in two-thirds of pediatric B-ALL and is likely to be the reason for the already reported poor survival of childhood ALL in South-East Asia. Furthermore, MLL-AF4, usually most common in infants, presented in later childhood in most of the ALL patients, which was one of the unique findings in our study. The results presented here highlight the need for mandatory inclusion of molecular testing for pediatric ALL patients in clinical decision making, together with the incorporation of tyrosine kinase inhibitors, as well as hematopoietic stem cell transplantation facilities, to improve treatment outcome for patients in developing countries.
82 schema:genre research_article
83 schema:inLanguage en
84 schema:isAccessibleForFree false
85 schema:isPartOf Na314e78fbcfc41a6947000d4981b57cc
86 Nd1fa33a7e22e48d7b4eda5733e7db98f
87 sg:journal.1036392
88 schema:name High Frequency and Poor Prognosis of Late Childhood BCR-ABL-Positive and MLL-AF4-Positive ALL Define the Need for Advanced Molecular Diagnostics and Improved Therapeutic Strategies in Pediatric B-ALL in Pakistan
89 schema:pagination 277-287
90 schema:productId N2495ff8cb31d4c5aa510fd4fccfa925a
91 N3b602d71666e4816b6b886328df4d6de
92 N47fa387e26bb4ef8adc0871d1d250b20
93 N9cddf04998654868aac05ca1ae4590f7
94 Ncbd83ac654b047e1991ade59c4abb7c0
95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008213736
96 https://doi.org/10.1007/s40291-015-0149-0
97 schema:sdDatePublished 2019-04-10T15:53
98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
99 schema:sdPublisher N8a465fce132a4a0f9aa31b0bb20d71bd
100 schema:url http://link.springer.com/10.1007%2Fs40291-015-0149-0
101 sgo:license sg:explorer/license/
102 sgo:sdDataset articles
103 rdf:type schema:ScholarlyArticle
104 N0779c583d3974f32bdd0038e2949092c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Infant
106 rdf:type schema:DefinedTerm
107 N1a6e0a64959e47b9b2f3f9d4b4706d80 rdf:first sg:person.0663400152.49
108 rdf:rest Nd89fd0929d4e468dbf17206d270c5803
109 N1a8bb193e64d4154bf33ef9bb10a17b0 rdf:first sg:person.01130207414.13
110 rdf:rest Nb39f5e9b57eb4123b2ab768d05ba05f0
111 N1a9177c0223f405db3c317fc0b94529e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Humans
113 rdf:type schema:DefinedTerm
114 N2495ff8cb31d4c5aa510fd4fccfa925a schema:name dimensions_id
115 schema:value pub.1008213736
116 rdf:type schema:PropertyValue
117 N2f42cec2d5e84dfcb8b03e5b32b82153 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Child, Preschool
119 rdf:type schema:DefinedTerm
120 N302372fec7744e32bb739c384ee28af2 rdf:first sg:person.01115725315.06
121 rdf:rest Ne530ceb6bfe84cd98f252b20a250a19b
122 N398dcafd3c344108a6b72534a952cccf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name In Situ Hybridization, Fluorescence
124 rdf:type schema:DefinedTerm
125 N3b602d71666e4816b6b886328df4d6de schema:name readcube_id
126 schema:value 272186c0eab1b509095cfd60ccf4b0b99f48306bf2da0dc5c5522fe6ef403545
127 rdf:type schema:PropertyValue
128 N3c45e6ad59e943baabacd3a71ff28cdc rdf:first N3d1d76901eed415cab7f30eb60dfdafd
129 rdf:rest Nc5510dbddbe048e78a5dc562888ef2db
130 N3d1d76901eed415cab7f30eb60dfdafd schema:affiliation Nfbc261c38f584e5e84f540eb0d7006aa
131 schema:familyName Mahmood
132 schema:givenName Aamir
133 rdf:type schema:Person
134 N47fa387e26bb4ef8adc0871d1d250b20 schema:name nlm_unique_id
135 schema:value 101264260
136 rdf:type schema:PropertyValue
137 N4e6afb5478d24dfa876146a3e230464a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Pakistan
139 rdf:type schema:DefinedTerm
140 N5054b267510743728f99f033bc8fd4ed schema:affiliation Nb81c0d0074d141e3a1ff64732bdabc96
141 schema:familyName Khalid
142 schema:givenName Muhammad
143 rdf:type schema:Person
144 N507676bd2486426db3284872556fa4fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Child
146 rdf:type schema:DefinedTerm
147 N5a2df85ef24949cb9c6663bc23aa7310 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Female
149 rdf:type schema:DefinedTerm
150 N63c04f35df974f6b8ff59d06a4122629 rdf:first sg:person.0701031045.34
151 rdf:rest Ne63d0b4fcafc4ab29cb15d21cf5d7b5d
152 N6f94e619761b41ca9f4ca3c9016df958 schema:affiliation https://www.grid.ac/institutes/grid.11173.35
153 schema:familyName Awan
154 schema:givenName Tashfin
155 rdf:type schema:Person
156 N84bd304bb107444a95f173ac10937158 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Precision Medicine
158 rdf:type schema:DefinedTerm
159 N8637a1ad0dfc421298edbb9cad3cee5f rdf:first sg:person.01177621245.30
160 rdf:rest Nd16b54e3e97d490f884f55bb4a7f7dbb
161 N8a465fce132a4a0f9aa31b0bb20d71bd schema:name Springer Nature - SN SciGraph project
162 rdf:type schema:Organization
163 N8b861eabc45c4002bb4751c3b7e68f4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Myeloid-Lymphoid Leukemia Protein
165 rdf:type schema:DefinedTerm
166 N8e63976810e14a958a1dd41de71f3ec3 rdf:first Nb73301166d744f609dbd502b13bd0757
167 rdf:rest Na8face9d626f4dee92580fa5a59e0922
168 N8edcaba1d501471abebd5cfc10188d73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Survival Analysis
170 rdf:type schema:DefinedTerm
171 N90ce47fb1aeb478c8c7aa088ced5cd11 rdf:first sg:person.01056311706.44
172 rdf:rest N1a6e0a64959e47b9b2f3f9d4b4706d80
173 N9cddf04998654868aac05ca1ae4590f7 schema:name doi
174 schema:value 10.1007/s40291-015-0149-0
175 rdf:type schema:PropertyValue
176 Na1bcd43482ac456ea108025199495002 schema:name Department of Oncology, Allied Hospital, Punjab Medical College, Faisalabad, Pakistan
177 rdf:type schema:Organization
178 Na314e78fbcfc41a6947000d4981b57cc schema:volumeNumber 19
179 rdf:type schema:PublicationVolume
180 Na5752ac9b3804de18181370c4083e237 rdf:first N5054b267510743728f99f033bc8fd4ed
181 rdf:rest Na87f1b5bc1d649e8b5c7bb4b60253d05
182 Na631254ef7014dee968e134aeaccff6a schema:name Division of Hematology/Oncology, Department of Medicine, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
183 rdf:type schema:Organization
184 Na7291bebbf66494f9df17702f21bcd72 rdf:first sg:person.01203174244.01
185 rdf:rest Nd4d0faa2eecf434482d25c85595c7f98
186 Na87f1b5bc1d649e8b5c7bb4b60253d05 rdf:first sg:person.01233474472.57
187 rdf:rest Nec06cb75c3c3417084bfa189c822f2f4
188 Na8face9d626f4dee92580fa5a59e0922 rdf:first sg:person.01125644745.27
189 rdf:rest N8637a1ad0dfc421298edbb9cad3cee5f
190 Naf115860dd6c4b7894519211f8cfeebc rdf:first sg:person.015313253340.69
191 rdf:rest N1a8bb193e64d4154bf33ef9bb10a17b0
192 Nb39f5e9b57eb4123b2ab768d05ba05f0 rdf:first N6f94e619761b41ca9f4ca3c9016df958
193 rdf:rest Ndb3169955fb84aaf9b733d5b45fd4982
194 Nb73301166d744f609dbd502b13bd0757 schema:affiliation https://www.grid.ac/institutes/grid.412125.1
195 schema:familyName Rasool
196 schema:givenName Mahmood
197 rdf:type schema:Person
198 Nb81c0d0074d141e3a1ff64732bdabc96 schema:name Department of Oncology, Allied Hospital, Punjab Medical College, Faisalabad, Pakistan
199 rdf:type schema:Organization
200 Nbcf2e0c2aef94ffeb64bd0596cbe17f9 schema:name Institute of Radiotherapy and Nuclear Medicine, Peshawar, Pakistan
201 rdf:type schema:Organization
202 Nc29a9536e2d34545a8b55052f1eb17b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Fusion Proteins, bcr-abl
204 rdf:type schema:DefinedTerm
205 Nc2af8e2f09fe43c0823dec8fff074f9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Treatment Outcome
207 rdf:type schema:DefinedTerm
208 Nc3d4c1574950431eb5283731f578523d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
210 rdf:type schema:DefinedTerm
211 Nc5510dbddbe048e78a5dc562888ef2db rdf:first sg:person.01251511324.91
212 rdf:rest Na7291bebbf66494f9df17702f21bcd72
213 Ncbd83ac654b047e1991ade59c4abb7c0 schema:name pubmed_id
214 schema:value 26266519
215 rdf:type schema:PropertyValue
216 Nd16b54e3e97d490f884f55bb4a7f7dbb rdf:first sg:person.01222370436.31
217 rdf:rest Nec21d51c1c7e44a19de4958e2684eca6
218 Nd1fa33a7e22e48d7b4eda5733e7db98f schema:issueNumber 5
219 rdf:type schema:PublicationIssue
220 Nd4d0faa2eecf434482d25c85595c7f98 rdf:first sg:person.010505271200.36
221 rdf:rest rdf:nil
222 Nd89fd0929d4e468dbf17206d270c5803 rdf:first sg:person.01203546322.94
223 rdf:rest N3c45e6ad59e943baabacd3a71ff28cdc
224 Ndb3169955fb84aaf9b733d5b45fd4982 rdf:first sg:person.01013552641.38
225 rdf:rest Nf6e25843d446485ca7bba2bb7dbb3606
226 Ne5182749c8da4fbfbff5d2425e8101e4 rdf:first sg:person.0706523151.96
227 rdf:rest N63c04f35df974f6b8ff59d06a4122629
228 Ne530ceb6bfe84cd98f252b20a250a19b rdf:first Nebe925cb4dd64f8d86bd4e9c36e90511
229 rdf:rest Nee95dfb7f56b4c2f86b293dd4027be1e
230 Ne63d0b4fcafc4ab29cb15d21cf5d7b5d rdf:first sg:person.0711365573.64
231 rdf:rest N90ce47fb1aeb478c8c7aa088ced5cd11
232 Ne8304cb1d59f43f9997d2c9bb05f4ab8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
233 schema:name Prognosis
234 rdf:type schema:DefinedTerm
235 Nebe925cb4dd64f8d86bd4e9c36e90511 schema:affiliation https://www.grid.ac/institutes/grid.431764.3
236 schema:familyName Gill
237 schema:givenName Ammara T.
238 rdf:type schema:Person
239 Nec06cb75c3c3417084bfa189c822f2f4 rdf:first sg:person.0746702427.97
240 rdf:rest N302372fec7744e32bb739c384ee28af2
241 Nec21d51c1c7e44a19de4958e2684eca6 rdf:first sg:person.01021034324.03
242 rdf:rest Na5752ac9b3804de18181370c4083e237
243 Nee95dfb7f56b4c2f86b293dd4027be1e rdf:first sg:person.01351007617.31
244 rdf:rest Ne5182749c8da4fbfbff5d2425e8101e4
245 Nf0730f292b3d469b9d00ab832d5a9542 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
246 schema:name Oncogene Proteins, Fusion
247 rdf:type schema:DefinedTerm
248 Nf6e25843d446485ca7bba2bb7dbb3606 rdf:first sg:person.01304345445.45
249 rdf:rest N8e63976810e14a958a1dd41de71f3ec3
250 Nfa3db0e464cd4e428a82138dd3e42680 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
251 schema:name Male
252 rdf:type schema:DefinedTerm
253 Nfbc261c38f584e5e84f540eb0d7006aa schema:name Stem Cell Research Group, Department of Anatomy, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
254 rdf:type schema:Organization
255 Nfc1c2522ab65455d82b2af5e02532bb2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
256 schema:name Adolescent
257 rdf:type schema:DefinedTerm
258 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
259 schema:name Medical and Health Sciences
260 rdf:type schema:DefinedTerm
261 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
262 schema:name Cardiorespiratory Medicine and Haematology
263 rdf:type schema:DefinedTerm
264 sg:journal.1036392 schema:issn 1177-1062
265 1179-2000
266 schema:name Molecular Diagnosis & Therapy
267 rdf:type schema:Periodical
268 sg:person.01013552641.38 schema:affiliation Na631254ef7014dee968e134aeaccff6a
269 schema:familyName Aleem
270 schema:givenName Aamer
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013552641.38
272 rdf:type schema:Person
273 sg:person.01021034324.03 schema:affiliation Na1bcd43482ac456ea108025199495002
274 schema:familyName Shah
275 schema:givenName Ijaz H.
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021034324.03
277 rdf:type schema:Person
278 sg:person.010505271200.36 schema:affiliation https://www.grid.ac/institutes/grid.412782.a
279 schema:familyName Irfan
280 schema:givenName Muhammad Imran
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010505271200.36
282 rdf:type schema:Person
283 sg:person.01056311706.44 schema:affiliation https://www.grid.ac/institutes/grid.440564.7
284 schema:familyName Qazi
285 schema:givenName Mehmood Hussain
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056311706.44
287 rdf:type schema:Person
288 sg:person.01115725315.06 schema:affiliation https://www.grid.ac/institutes/grid.415254.3
289 schema:familyName Alanazi
290 schema:givenName Abdullah
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115725315.06
292 rdf:type schema:Person
293 sg:person.01125644745.27 schema:affiliation https://www.grid.ac/institutes/grid.11173.35
294 schema:familyName Absar
295 schema:givenName Muhammad
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125644745.27
297 rdf:type schema:Person
298 sg:person.01130207414.13 schema:affiliation https://www.grid.ac/institutes/grid.11173.35
299 schema:familyName Akhtar
300 schema:givenName Tanveer
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130207414.13
302 rdf:type schema:Person
303 sg:person.01177621245.30 schema:affiliation https://www.grid.ac/institutes/grid.11173.35
304 schema:familyName Akram
305 schema:givenName Afia M.
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177621245.30
307 rdf:type schema:Person
308 sg:person.01203174244.01 schema:affiliation https://www.grid.ac/institutes/grid.56302.32
309 schema:familyName Saeed
310 schema:givenName Anjum
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203174244.01
312 rdf:type schema:Person
313 sg:person.01203546322.94 schema:affiliation https://www.grid.ac/institutes/grid.11173.35
314 schema:familyName Siddiqi
315 schema:givenName Muhammad Hassan
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203546322.94
317 rdf:type schema:Person
318 sg:person.01222370436.31 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
319 schema:familyName Shammas
320 schema:givenName Masood A.
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222370436.31
322 rdf:type schema:Person
323 sg:person.01233474472.57 schema:affiliation Nbcf2e0c2aef94ffeb64bd0596cbe17f9
324 schema:familyName Taj
325 schema:givenName Abid S.
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233474472.57
327 rdf:type schema:Person
328 sg:person.01251511324.91 schema:affiliation https://www.grid.ac/institutes/grid.11173.35
329 schema:familyName Iqbal
330 schema:givenName Mudassar
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251511324.91
332 rdf:type schema:Person
333 sg:person.01304345445.45 schema:affiliation https://www.grid.ac/institutes/grid.11173.35
334 schema:familyName Sabir
335 schema:givenName Noreen
336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304345445.45
337 rdf:type schema:Person
338 sg:person.01351007617.31 schema:affiliation https://www.grid.ac/institutes/grid.11173.35
339 schema:familyName Hashmi
340 schema:givenName Jamil Amjad
341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351007617.31
342 rdf:type schema:Person
343 sg:person.015313253340.69 schema:affiliation https://www.grid.ac/institutes/grid.440564.7
344 schema:familyName Iqbal
345 schema:givenName Zafar
346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015313253340.69
347 rdf:type schema:Person
348 sg:person.0663400152.49 schema:affiliation https://www.grid.ac/institutes/grid.412125.1
349 schema:familyName Karim
350 schema:givenName Sajjad
351 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663400152.49
352 rdf:type schema:Person
353 sg:person.0701031045.34 schema:affiliation https://www.grid.ac/institutes/grid.11173.35
354 schema:familyName Sabar
355 schema:givenName Muhammad Farooq
356 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701031045.34
357 rdf:type schema:Person
358 sg:person.0706523151.96 schema:affiliation https://www.grid.ac/institutes/grid.266976.a
359 schema:familyName Hussain
360 schema:givenName Akhtar
361 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706523151.96
362 rdf:type schema:Person
363 sg:person.0711365573.64 schema:affiliation https://www.grid.ac/institutes/grid.412782.a
364 schema:familyName Khalid
365 schema:givenName Ahmad M.
366 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711365573.64
367 rdf:type schema:Person
368 sg:person.0746702427.97 schema:affiliation https://www.grid.ac/institutes/grid.415215.6
369 schema:familyName Jameel
370 schema:givenName Abid
371 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746702427.97
372 rdf:type schema:Person
373 sg:pub.10.1007/s11899-012-0122-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051125417
374 https://doi.org/10.1007/s11899-012-0122-5
375 rdf:type schema:CreativeWork
376 sg:pub.10.1007/s12032-009-9232-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047532757
377 https://doi.org/10.1007/s12032-009-9232-x
378 rdf:type schema:CreativeWork
379 sg:pub.10.1038/bjc.2015.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029299263
380 https://doi.org/10.1038/bjc.2015.108
381 rdf:type schema:CreativeWork
382 sg:pub.10.1038/leu.2014.30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008558028
383 https://doi.org/10.1038/leu.2014.30
384 rdf:type schema:CreativeWork
385 sg:pub.10.1038/sj.leu.2401257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053509094
386 https://doi.org/10.1038/sj.leu.2401257
387 rdf:type schema:CreativeWork
388 sg:pub.10.1038/sj.leu.2401592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034947020
389 https://doi.org/10.1038/sj.leu.2401592
390 rdf:type schema:CreativeWork
391 sg:pub.10.1038/sj.leu.2403540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012422677
392 https://doi.org/10.1038/sj.leu.2403540
393 rdf:type schema:CreativeWork
394 sg:pub.10.1038/sj.leu.2404577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002878947
395 https://doi.org/10.1038/sj.leu.2404577
396 rdf:type schema:CreativeWork
397 https://app.dimensions.ai/details/publication/pub.1074687794 schema:CreativeWork
398 https://app.dimensions.ai/details/publication/pub.1075301044 schema:CreativeWork
399 https://app.dimensions.ai/details/publication/pub.1077254461 schema:CreativeWork
400 https://app.dimensions.ai/details/publication/pub.1078419120 schema:CreativeWork
401 https://app.dimensions.ai/details/publication/pub.1078436416 schema:CreativeWork
402 https://app.dimensions.ai/details/publication/pub.1078495350 schema:CreativeWork
403 https://app.dimensions.ai/details/publication/pub.1078836443 schema:CreativeWork
404 https://app.dimensions.ai/details/publication/pub.1082384450 schema:CreativeWork
405 https://app.dimensions.ai/details/publication/pub.1082878892 schema:CreativeWork
406 https://app.dimensions.ai/details/publication/pub.1082900521 schema:CreativeWork
407 https://doi.org/10.1002/ajh.23307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023898349
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1002/cncr.28531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009247380
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1002/ijc.28854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053050285
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1002/mpo.1220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032702399
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1002/mpo.1225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042455090
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1002/pbc.24584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037166285
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1016/j.cancergen.2013.05.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039463920
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1016/j.cancergencyto.2010.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039033946
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1016/j.ejca.2013.08.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036197787
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1016/s0140-6736(02)08782-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022153891
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1016/s0140-6736(12)62187-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011676133
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1016/s1470-2045(12)70377-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002311788
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1046/j.1365-2141.1999.01747.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025370525
432 rdf:type schema:CreativeWork
433 https://doi.org/10.1046/j.1365-2141.2003.04558.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016157687
434 rdf:type schema:CreativeWork
435 https://doi.org/10.1053/j.seminhematol.2013.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037886897
436 rdf:type schema:CreativeWork
437 https://doi.org/10.1093/jnci/88.1.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022194970
438 rdf:type schema:CreativeWork
439 https://doi.org/10.1097/mph.0b013e318030ac4c schema:sameAs https://app.dimensions.ai/details/publication/pub.1004381878
440 rdf:type schema:CreativeWork
441 https://doi.org/10.1097/mph.0b013e3180f61bcf schema:sameAs https://app.dimensions.ai/details/publication/pub.1024293564
442 rdf:type schema:CreativeWork
443 https://doi.org/10.1097/mph.0b013e31820e7361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042193129
444 rdf:type schema:CreativeWork
445 https://doi.org/10.1097/mph.0b013e3182422ca0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002231027
446 rdf:type schema:CreativeWork
447 https://doi.org/10.1097/mph.0b013e318286d241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004021651
448 rdf:type schema:CreativeWork
449 https://doi.org/10.1111/j.1365-2141.2011.08824.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019131257
450 rdf:type schema:CreativeWork
451 https://doi.org/10.1111/j.1743-7563.2010.01370.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050983121
452 rdf:type schema:CreativeWork
453 https://doi.org/10.1158/1055-9965.epi-05-0833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024882379
454 rdf:type schema:CreativeWork
455 https://doi.org/10.1177/2040620714565963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035706387
456 rdf:type schema:CreativeWork
457 https://doi.org/10.1182/blood-2004-04-1616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052019538
458 rdf:type schema:CreativeWork
459 https://doi.org/10.1182/blood-2006-01-024729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041143310
460 rdf:type schema:CreativeWork
461 https://doi.org/10.1182/blood-2007-02-070342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043143043
462 rdf:type schema:CreativeWork
463 https://doi.org/10.1200/jco.1990.8.8.1380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078749555
464 rdf:type schema:CreativeWork
465 https://doi.org/10.1200/jco.2007.12.3927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020978466
466 rdf:type schema:CreativeWork
467 https://doi.org/10.1200/jco.2011.38.0345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031859738
468 rdf:type schema:CreativeWork
469 https://doi.org/10.1200/jco.2013.48.6522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007967482
470 rdf:type schema:CreativeWork
471 https://doi.org/10.1200/jco.2014.58.9747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027828443
472 rdf:type schema:CreativeWork
473 https://doi.org/10.1371/journal.pone.0087602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053665744
474 rdf:type schema:CreativeWork
475 https://doi.org/10.3109/08880018.2014.935837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026338287
476 rdf:type schema:CreativeWork
477 https://doi.org/10.3109/10428194.2014.910662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004905540
478 rdf:type schema:CreativeWork
479 https://doi.org/10.3324/haematol.2012.080432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025797374
480 rdf:type schema:CreativeWork
481 https://doi.org/10.3346/jkms.2005.20.1.36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033486457
482 rdf:type schema:CreativeWork
483 https://doi.org/10.4137/cin.s11831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031177461
484 rdf:type schema:CreativeWork
485 https://doi.org/10.7314/apjcp.2012.13.11.5469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007280520
486 rdf:type schema:CreativeWork
487 https://www.grid.ac/institutes/grid.11173.35 schema:alternateName University of the Punjab
488 schema:name Asian Medical Institute and National Surgical Centre, Kant, Kyrgyzstan
489 Core DNA Facilities, Centre for Advanced Molecular Biology, University of the Punjab, Lahore, Pakistan
490 Department of Zoology, Faculty of Biological Sciences, University of the Punjab, Lahore, Pakistan
491 Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES) Group, Health Sciences/Parasitology Laboratories (HSL), Department of Zoology, University of the Punjab (ZPU), Lahore, Pakistan
492 Pakistan Society for Molecular and Clinical Hematology (PSMH) & Hematology Oncology and Pharmacogenetic Engineering Sciences Group (HOPES), Lahore, Pakistan
493 Pakistan Society for Molecular and Clinical Hematology, Lahore, Pakistan
494 rdf:type schema:Organization
495 https://www.grid.ac/institutes/grid.266976.a schema:alternateName University of Peshawar
496 schema:name Department of Biotechnology, University of Peshawar, Peshawar, Pakistan
497 Pakistan Society for Molecular and Clinical Hematology (PSMH) & Hematology Oncology and Pharmacogenetic Engineering Sciences Group (HOPES), Lahore, Pakistan
498 rdf:type schema:Organization
499 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
500 schema:name Translational Genomic Instability Program, Harvard (Dana-Farber) Cancer Institute, Harvard Medical School, Harvard University, Boston, MA, USA
501 rdf:type schema:Organization
502 https://www.grid.ac/institutes/grid.412125.1 schema:alternateName King Abdulaziz University
503 schema:name Centre of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia
504 rdf:type schema:Organization
505 https://www.grid.ac/institutes/grid.412782.a schema:alternateName University of Sargodha
506 schema:name Department of Biotechnology, University of Sargodha, Sargodha, Pakistan
507 Department of Chemistry, University of Sargodha, Sargodha, Pakistan
508 Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES) Group, Health Sciences/Parasitology Laboratories (HSL), Department of Zoology, University of the Punjab (ZPU), Lahore, Pakistan
509 rdf:type schema:Organization
510 https://www.grid.ac/institutes/grid.415215.6 schema:alternateName Khyber Teaching Hospital
511 schema:name Department of Oncology, Khyber Teaching Hospital, Peshawar, Pakistan
512 Hayatabad Medical Complex, Peshawar, Pakistan
513 rdf:type schema:Organization
514 https://www.grid.ac/institutes/grid.415254.3 schema:alternateName King Abdulaziz Medical City
515 schema:name Medical Genetics/Hematology and Oncology, CLS, CAMS, King Saud Bin Abdulaziz University for Health Sciences/KAIMRC, King Abdulaziz Medical City, National Guard Health Affairs, 11426, Riyadh, Saudi Arabia
516 rdf:type schema:Organization
517 https://www.grid.ac/institutes/grid.431764.3 schema:alternateName CoxHealth
518 schema:name Cox Health System, Springfield, MO, USA
519 Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES) Group, Health Sciences/Parasitology Laboratories (HSL), Department of Zoology, University of the Punjab (ZPU), Lahore, Pakistan
520 rdf:type schema:Organization
521 https://www.grid.ac/institutes/grid.440564.7 schema:alternateName University of Lahore
522 schema:name Department of Biotechnology, University of Sargodha, Sargodha, Pakistan
523 Hematology Oncology and Pharmacogenetic Engineering Sciences (HOPES) Group, Health Sciences/Parasitology Laboratories (HSL), Department of Zoology, University of the Punjab (ZPU), Lahore, Pakistan
524 Institute of Molecular Biology and Biotechnology (IMBB), Centre for Research in Molecular Medicine (CRiMM), The University of Lahore, Lahore, Pakistan
525 Medical Genetics/Hematology and Oncology, CLS, CAMS, King Saud Bin Abdulaziz University for Health Sciences/KAIMRC, King Abdulaziz Medical City, National Guard Health Affairs, 11426, Riyadh, Saudi Arabia
526 Pakistan Society for Molecular and Clinical Hematology (PSMH) & Hematology Oncology and Pharmacogenetic Engineering Sciences Group (HOPES), Lahore, Pakistan
527 rdf:type schema:Organization
528 https://www.grid.ac/institutes/grid.56302.32 schema:alternateName King Saud University
529 schema:name Prince Abdullah Bin Khalid Celiac Disease Research Chair, King Saud University, Riyadh, Saudi Arabia
530 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...