Análisis de coste-utilidad de indacaterol frente a tiotropio en el tratamiento de la EPOC en España View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-09

AUTHORS

Max Brosa-Riestra, Ferran Pérez-Alcántara, Luis Borderías-Clau, Juan Bautista Galdiz-Iturri, Maribel Riera-Febrer, Montse Figueras-Sabaté

ABSTRACT

La enfermedad pulmonar obstructiva crónica (EPOC) es una patología asociada a una alta morbilidad y caracterizada por una progresiva limitación del flujo pulmonar. Indacaterol es un nuevo agonista adrenérgico beta-2 de larga duración que combina rapidez de acción y broncodilatación sostenida durante 24 horas. El objetivo de este estudio fue evaluar la eficiencia de indacaterol frente a tiotropio en el manejo de la EPOC en España. Se realizó un análisis de coste-utilidad mediante un modelo de Markov con ciclos de 12 semanas, representado por los estados de gravedad de la EPOC leve, moderada, grave y muy grave. Las probabilidades de transición entre estados a corto plazo se basaron en los valores de FEV1 en pre-broncodilatación de un ensayo clínico controlado que comparaba indacaterol y tiotropio, mientras que para el largo plazo se tomaron datos de la literatura. Con un horizonte temporal de 5 años, se estimaron tanto los años de vida ajustados por calidad (AVAC) como los costes médicos directos de cada alternativa. La perspectiva del análisis fue la del Sistema Nacional de Salud, aplicando una tasa de descuento del 3 %. Los resultados mostraron que indacaterol era una alternativa dominante frente a tiotropio. Se estimó un ahorro por paciente de 134 € y 147 € (para indacaterol 150 mcg y 300 mcg, respectivamente) y un mayor número de AVAC ganados (0,02 y 0,03, respectivamente). El análisis de sensibilidad probabilístico realizado confirmó la consistencia de los resultados obtenidos. Indacaterol podría considerarse una alternativa eficiente en comparación con tiotropio en el tratamiento de la EPOC. More... »

PAGES

89-97

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40277-013-0011-x

DOI

http://dx.doi.org/10.1007/s40277-013-0011-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036029570


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40 schema:description La enfermedad pulmonar obstructiva crónica (EPOC) es una patología asociada a una alta morbilidad y caracterizada por una progresiva limitación del flujo pulmonar. Indacaterol es un nuevo agonista adrenérgico beta-2 de larga duración que combina rapidez de acción y broncodilatación sostenida durante 24 horas. El objetivo de este estudio fue evaluar la eficiencia de indacaterol frente a tiotropio en el manejo de la EPOC en España. Se realizó un análisis de coste-utilidad mediante un modelo de Markov con ciclos de 12 semanas, representado por los estados de gravedad de la EPOC leve, moderada, grave y muy grave. Las probabilidades de transición entre estados a corto plazo se basaron en los valores de FEV1 en pre-broncodilatación de un ensayo clínico controlado que comparaba indacaterol y tiotropio, mientras que para el largo plazo se tomaron datos de la literatura. Con un horizonte temporal de 5 años, se estimaron tanto los años de vida ajustados por calidad (AVAC) como los costes médicos directos de cada alternativa. La perspectiva del análisis fue la del Sistema Nacional de Salud, aplicando una tasa de descuento del 3 %. Los resultados mostraron que indacaterol era una alternativa dominante frente a tiotropio. Se estimó un ahorro por paciente de 134 € y 147 € (para indacaterol 150 mcg y 300 mcg, respectivamente) y un mayor número de AVAC ganados (0,02 y 0,03, respectivamente). El análisis de sensibilidad probabilístico realizado confirmó la consistencia de los resultados obtenidos. Indacaterol podría considerarse una alternativa eficiente en comparación con tiotropio en el tratamiento de la EPOC.
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