Treatment Preferences in Germany Differ Among Apheresis Patients with Severe Hypercholesterolemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-04

AUTHORS

Axel C. Mühlbacher, Andrew Sadler, Franz-Werner Dippel, Christin Juhnke

ABSTRACT

BACKGROUND: Severe hypercholesterolemia is a major risk factor of death in patients with coronary heart disease. New adjunctive drug therapies (proprotein convertase subtilisin/kexin type 9 [PCSK9] inhibitors) have gained approval in Europe and the USA. OBJECTIVE: In this empirical study, we documented preferences regarding adjuvant drug therapy in apheresis-treated patients with severe familial hypercholesterolemia. METHODS: We conducted a systematic literature search to identify patient-relevant outcomes in patients with severe hypercholesterolemia currently undergoing apheresis. Data were used to generate a semi-structured qualitative interview that enabled seven patient-relevant characteristics with three levels each to be identified. For the discrete choice experiment, an experimental design (7 × 3) was generated using NGene Software that consisted of 96 choices divided into eight blocks. The survey was conducted between November 2015 and April 2016 using computer-assisted personal interviews. RESULTS: The survey was completed by 348 patients (64.9% male). The random parameter logit estimation showed predominance for the attribute 'reduction of LDL-C (low-density lipoprotein cholesterol) level'. 'Risk of myopathy' and 'frequency of apheresis' dominated next. Within the random parameter logit estimation, all coefficients were significant (P ≤ 0.01). The latent class analysis identified three patient groups. The first group (126 patients) found 'reduction of LDL-C level in blood' to be most important. This group focused solely on this treatment outcome independently of apheresis frequency or additional injections. The second group (106 patients) focused on three attributes: 'frequency of apheresis', 'risk of myopathy', and 'reduction of LDL-C level in blood'. Respondents clearly considered a high frequency of apheresis to have a negative impact. The third group (116 patients) demonstrated the highest preference for apheresis. These patients have adjusted to apheresis for > 10 years. CONCLUSION: Regarding patient preference, clinical efficacy seems to dominate. Hence, 'reduction of LDC-C in blood' was ranked highest above patient-relevant modes of administration and adverse effects. In the patient groups identified, reduction of apheresis was important for only a subsegment (30%) of patients. Another 30% wanted effective LDL-C reduction by whatever means necessary. Most strikingly, another 30% preferred higher frequencies of apheresis. More... »

PAGES

477-493

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40273-018-0614-9

DOI

http://dx.doi.org/10.1007/s40273-018-0614-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100740071

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29388056


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Neubrandenburg University of Applied Sciences", 
          "id": "https://www.grid.ac/institutes/grid.461681.c", 
          "name": [
            "Professur Gesundheits\u00f6konomie und Medizinmanagement, Hochschule Neubrandenburg, Brodaer Stra\u00dfe 2, 17033, Neubrandenburg, Germany", 
            "Gesellschaft f\u00fcr empirische Beratung GmbH (GEB), Denzlingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00fchlbacher", 
        "givenName": "Axel C.", 
        "id": "sg:person.01306077736.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306077736.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Neubrandenburg University of Applied Sciences", 
          "id": "https://www.grid.ac/institutes/grid.461681.c", 
          "name": [
            "Professur Gesundheits\u00f6konomie und Medizinmanagement, Hochschule Neubrandenburg, Brodaer Stra\u00dfe 2, 17033, Neubrandenburg, Germany", 
            "Gesellschaft f\u00fcr empirische Beratung GmbH (GEB), Denzlingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sadler", 
        "givenName": "Andrew", 
        "id": "sg:person.0657330160.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657330160.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Sanofi Deutschland GmbH, Evidenzbasierte Medizin/HEOR, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dippel", 
        "givenName": "Franz-Werner", 
        "id": "sg:person.01325342277.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325342277.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Neubrandenburg University of Applied Sciences", 
          "id": "https://www.grid.ac/institutes/grid.461681.c", 
          "name": [
            "Professur Gesundheits\u00f6konomie und Medizinmanagement, Hochschule Neubrandenburg, Brodaer Stra\u00dfe 2, 17033, Neubrandenburg, Germany", 
            "Gesellschaft f\u00fcr empirische Beratung GmbH (GEB), Denzlingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Juhnke", 
        "givenName": "Christin", 
        "id": "sg:person.01354641253.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354641253.87"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.atherosclerosissup.2012.10.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000023699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.csda.2004.11.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001022923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4337/9781781003152.00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002009428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/tacg.s44315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002524991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10705510701575396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004013106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosissup.2014.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004458267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3727/108354210x12724863327605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004904433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00019053-200826080-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008806799", 
          "https://doi.org/10.2165/00019053-200826080-00004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40258-016-0232-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008935933", 
          "https://doi.org/10.1007/s40258-016-0232-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jocm.2015.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010622849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacl.2011.03.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010638078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/clc.4960220106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011624418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosissup.2014.07.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015828547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/ceor.s43087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017820578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1369-6513.2000.00093.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018946418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosissup.2014.07.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021491942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/a0018963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021557563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4020-5753-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022634734", 
          "https://doi.org/10.1007/978-1-4020-5753-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4020-5753-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022634734", 
          "https://doi.org/10.1007/978-1-4020-5753-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lungcan.2010.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024987177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2012.02.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025530888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/hex.12201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027459351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00036840801964633", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028283934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1996.03530260066035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029253460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jval.2010.11.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030781921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jval.2015.09.2937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031334096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/1312067-200801040-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031743483", 
          "https://doi.org/10.2165/1312067-200801040-00003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/1312067-200801040-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031743483", 
          "https://doi.org/10.2165/1312067-200801040-00003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jval.2014.08.1898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034106064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1501031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035722374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0277-9536(85)90079-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038523649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1369-7625.2006.00401.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041459706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clinthera.2015.07.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041862146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0277-9536(02)00056-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042922187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40258-013-0023-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044899013", 
          "https://doi.org/10.1007/s40258-013-0023-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/1312067-200801040-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046787896", 
          "https://doi.org/10.2165/1312067-200801040-00009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/1312067-200801040-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046787896", 
          "https://doi.org/10.2165/1312067-200801040-00009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40271-015-0118-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049295779", 
          "https://doi.org/10.1007/s40271-015-0118-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40271-015-0118-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049295779", 
          "https://doi.org/10.1007/s40271-015-0118-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10198-014-0622-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050041525", 
          "https://doi.org/10.1007/s10198-014-0622-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10198-014-0622-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050041525", 
          "https://doi.org/10.1007/s10198-014-0622-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/mder.s98889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053727008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0032-1330500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057277399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/208753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058528340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/259131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058572612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehw388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059577126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehw388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059577126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076997830", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3238/arztebl.2014.0523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078959575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40271-017-0249-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085931920", 
          "https://doi.org/10.1007/s40271-017-0249-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40271-017-0249-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085931920", 
          "https://doi.org/10.1007/s40271-017-0249-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40271-017-0249-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085931920", 
          "https://doi.org/10.1007/s40271-017-0249-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40271-017-0249-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085931920", 
          "https://doi.org/10.1007/s40271-017-0249-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40271-017-0250-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085934943", 
          "https://doi.org/10.1007/s40271-017-0250-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40271-017-0250-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085934943", 
          "https://doi.org/10.1007/s40271-017-0250-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40271-017-0250-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085934943", 
          "https://doi.org/10.1007/s40271-017-0250-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/cbo9780511753831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1098665042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/cbo9780511610356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1098712532"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-04", 
    "datePublishedReg": "2018-04-01", 
    "description": "BACKGROUND: Severe hypercholesterolemia is a major risk factor of death in patients with coronary heart disease. New adjunctive drug therapies (proprotein convertase subtilisin/kexin type 9 [PCSK9] inhibitors) have gained approval in Europe and the USA.\nOBJECTIVE: In this empirical study, we documented preferences regarding adjuvant drug therapy in apheresis-treated patients with severe familial hypercholesterolemia.\nMETHODS: We conducted a systematic literature search to identify patient-relevant outcomes in patients with severe hypercholesterolemia currently undergoing apheresis. Data were used to generate a semi-structured qualitative interview that enabled seven patient-relevant characteristics with three levels each to be identified. For the discrete choice experiment, an experimental design (7\u00a0\u00d7\u00a03) was generated using NGene Software that consisted of 96 choices divided into eight blocks. The survey was conducted between November 2015 and April 2016 using computer-assisted personal interviews.\nRESULTS: The survey was completed by 348 patients (64.9% male). The random parameter logit estimation showed predominance for the attribute 'reduction of LDL-C (low-density lipoprotein cholesterol) level'. 'Risk of myopathy' and 'frequency of apheresis' dominated next. Within the random parameter logit estimation, all coefficients were significant (P\u00a0\u2264\u00a00.01). The latent class analysis identified three patient groups. The first group (126 patients) found 'reduction of LDL-C level\u00a0in blood' to be most important. This group focused solely on this treatment outcome independently of apheresis frequency or additional injections. The second group (106 patients) focused on three attributes: 'frequency of apheresis', 'risk of myopathy', and 'reduction of LDL-C level\u00a0in blood'. Respondents clearly considered a high frequency of apheresis to have a negative impact. The third group (116 patients) demonstrated the highest preference for apheresis. These patients have adjusted to apheresis for\u00a0>\u00a010\u00a0years.\nCONCLUSION: Regarding patient preference, clinical efficacy seems to dominate. Hence, 'reduction of LDC-C in blood' was ranked highest above patient-relevant modes of administration and adverse effects. In the patient groups identified, reduction of apheresis was important for only a subsegment (30%) of patients. Another 30% wanted effective LDL-C reduction by whatever means necessary. Most strikingly, another 30% preferred higher frequencies of apheresis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s40273-018-0614-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1102812", 
        "issn": [
          "1170-7690", 
          "1179-2027"
        ], 
        "name": "PharmacoEconomics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "36"
      }
    ], 
    "name": "Treatment Preferences in Germany Differ Among Apheresis Patients with Severe Hypercholesterolemia", 
    "pagination": "477-493", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3f54dfbb85daf8dda57aeb9e264a5e50326a73516ad67543a7e87282f1abc645"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29388056"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9212404"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s40273-018-0614-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100740071"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s40273-018-0614-9", 
      "https://app.dimensions.ai/details/publication/pub.1100740071"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000354_0000000354/records_11704_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs40273-018-0614-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40273-018-0614-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40273-018-0614-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40273-018-0614-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40273-018-0614-9'


 

This table displays all metadata directly associated to this object as RDF triples.

243 TRIPLES      21 PREDICATES      76 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s40273-018-0614-9 schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author Ne6030a61ef724010af12571b0db6a16c
4 schema:citation sg:pub.10.1007/978-1-4020-5753-3
5 sg:pub.10.1007/s10198-014-0622-4
6 sg:pub.10.1007/s40258-013-0023-3
7 sg:pub.10.1007/s40258-016-0232-7
8 sg:pub.10.1007/s40271-015-0118-z
9 sg:pub.10.1007/s40271-017-0249-5
10 sg:pub.10.1007/s40271-017-0250-z
11 sg:pub.10.2165/00019053-200826080-00004
12 sg:pub.10.2165/1312067-200801040-00003
13 sg:pub.10.2165/1312067-200801040-00009
14 https://app.dimensions.ai/details/publication/pub.1076997830
15 https://doi.org/10.1001/jama.1996.03530260066035
16 https://doi.org/10.1002/clc.4960220106
17 https://doi.org/10.1016/0277-9536(85)90079-6
18 https://doi.org/10.1016/j.atherosclerosis.2012.02.019
19 https://doi.org/10.1016/j.atherosclerosissup.2012.10.021
20 https://doi.org/10.1016/j.atherosclerosissup.2014.07.003
21 https://doi.org/10.1016/j.atherosclerosissup.2014.07.004
22 https://doi.org/10.1016/j.atherosclerosissup.2014.07.006
23 https://doi.org/10.1016/j.clinthera.2015.07.008
24 https://doi.org/10.1016/j.csda.2004.11.004
25 https://doi.org/10.1016/j.jacl.2011.03.001
26 https://doi.org/10.1016/j.jocm.2015.09.001
27 https://doi.org/10.1016/j.jval.2010.11.013
28 https://doi.org/10.1016/j.jval.2014.08.1898
29 https://doi.org/10.1016/j.jval.2015.09.2937
30 https://doi.org/10.1016/j.lungcan.2010.05.001
31 https://doi.org/10.1016/s0277-9536(02)00056-4
32 https://doi.org/10.1017/cbo9780511610356
33 https://doi.org/10.1017/cbo9780511753831
34 https://doi.org/10.1037/a0018963
35 https://doi.org/10.1046/j.1369-6513.2000.00093.x
36 https://doi.org/10.1055/s-0032-1330500
37 https://doi.org/10.1056/nejmoa1501031
38 https://doi.org/10.1080/00036840801964633
39 https://doi.org/10.1080/10705510701575396
40 https://doi.org/10.1086/208753
41 https://doi.org/10.1086/259131
42 https://doi.org/10.1093/eurheartj/ehw388
43 https://doi.org/10.1111/hex.12201
44 https://doi.org/10.1111/j.1369-7625.2006.00401.x
45 https://doi.org/10.2147/ceor.s43087
46 https://doi.org/10.2147/mder.s98889
47 https://doi.org/10.2147/tacg.s44315
48 https://doi.org/10.3238/arztebl.2014.0523
49 https://doi.org/10.3727/108354210x12724863327605
50 https://doi.org/10.4337/9781781003152.00021
51 schema:datePublished 2018-04
52 schema:datePublishedReg 2018-04-01
53 schema:description BACKGROUND: Severe hypercholesterolemia is a major risk factor of death in patients with coronary heart disease. New adjunctive drug therapies (proprotein convertase subtilisin/kexin type 9 [PCSK9] inhibitors) have gained approval in Europe and the USA. OBJECTIVE: In this empirical study, we documented preferences regarding adjuvant drug therapy in apheresis-treated patients with severe familial hypercholesterolemia. METHODS: We conducted a systematic literature search to identify patient-relevant outcomes in patients with severe hypercholesterolemia currently undergoing apheresis. Data were used to generate a semi-structured qualitative interview that enabled seven patient-relevant characteristics with three levels each to be identified. For the discrete choice experiment, an experimental design (7 × 3) was generated using NGene Software that consisted of 96 choices divided into eight blocks. The survey was conducted between November 2015 and April 2016 using computer-assisted personal interviews. RESULTS: The survey was completed by 348 patients (64.9% male). The random parameter logit estimation showed predominance for the attribute 'reduction of LDL-C (low-density lipoprotein cholesterol) level'. 'Risk of myopathy' and 'frequency of apheresis' dominated next. Within the random parameter logit estimation, all coefficients were significant (P ≤ 0.01). The latent class analysis identified three patient groups. The first group (126 patients) found 'reduction of LDL-C level in blood' to be most important. This group focused solely on this treatment outcome independently of apheresis frequency or additional injections. The second group (106 patients) focused on three attributes: 'frequency of apheresis', 'risk of myopathy', and 'reduction of LDL-C level in blood'. Respondents clearly considered a high frequency of apheresis to have a negative impact. The third group (116 patients) demonstrated the highest preference for apheresis. These patients have adjusted to apheresis for > 10 years. CONCLUSION: Regarding patient preference, clinical efficacy seems to dominate. Hence, 'reduction of LDC-C in blood' was ranked highest above patient-relevant modes of administration and adverse effects. In the patient groups identified, reduction of apheresis was important for only a subsegment (30%) of patients. Another 30% wanted effective LDL-C reduction by whatever means necessary. Most strikingly, another 30% preferred higher frequencies of apheresis.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree false
57 schema:isPartOf N675a83ecdcb147dea6e7d81329387dc2
58 Nc3026e21d03e4845aab088eae830cd23
59 sg:journal.1102812
60 schema:name Treatment Preferences in Germany Differ Among Apheresis Patients with Severe Hypercholesterolemia
61 schema:pagination 477-493
62 schema:productId N1f59cb65c249485a852de6c955ef2550
63 N4ec72fc712ee4b43b1b8c0c216ea8731
64 N5de31dc965d44ed3b820c04680cc8aad
65 N9d020ba3c7694712a9d3f4fcce5de26e
66 Nb0864e87194345dfabf0a0f15e77f9c5
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100740071
68 https://doi.org/10.1007/s40273-018-0614-9
69 schema:sdDatePublished 2019-04-11T11:18
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher Nbc30273a2d544c1789bcb7a33785179c
72 schema:url https://link.springer.com/10.1007%2Fs40273-018-0614-9
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N09926ff59bfd4ce08c6d25feef79c599 rdf:first sg:person.0657330160.56
77 rdf:rest N69218efa3ea74106bf45a64cef2c6848
78 N1f59cb65c249485a852de6c955ef2550 schema:name nlm_unique_id
79 schema:value 9212404
80 rdf:type schema:PropertyValue
81 N4ec72fc712ee4b43b1b8c0c216ea8731 schema:name doi
82 schema:value 10.1007/s40273-018-0614-9
83 rdf:type schema:PropertyValue
84 N5de31dc965d44ed3b820c04680cc8aad schema:name readcube_id
85 schema:value 3f54dfbb85daf8dda57aeb9e264a5e50326a73516ad67543a7e87282f1abc645
86 rdf:type schema:PropertyValue
87 N675a83ecdcb147dea6e7d81329387dc2 schema:issueNumber 4
88 rdf:type schema:PublicationIssue
89 N69218efa3ea74106bf45a64cef2c6848 rdf:first sg:person.01325342277.13
90 rdf:rest Ne9a580c4d23249a2b4ea8affe481db0a
91 N9d020ba3c7694712a9d3f4fcce5de26e schema:name dimensions_id
92 schema:value pub.1100740071
93 rdf:type schema:PropertyValue
94 Nb0864e87194345dfabf0a0f15e77f9c5 schema:name pubmed_id
95 schema:value 29388056
96 rdf:type schema:PropertyValue
97 Nb2ad558cd00e415984276f691765343f schema:name Sanofi Deutschland GmbH, Evidenzbasierte Medizin/HEOR, Berlin, Germany
98 rdf:type schema:Organization
99 Nbc30273a2d544c1789bcb7a33785179c schema:name Springer Nature - SN SciGraph project
100 rdf:type schema:Organization
101 Nc3026e21d03e4845aab088eae830cd23 schema:volumeNumber 36
102 rdf:type schema:PublicationVolume
103 Ne6030a61ef724010af12571b0db6a16c rdf:first sg:person.01306077736.30
104 rdf:rest N09926ff59bfd4ce08c6d25feef79c599
105 Ne9a580c4d23249a2b4ea8affe481db0a rdf:first sg:person.01354641253.87
106 rdf:rest rdf:nil
107 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
108 schema:name Medical and Health Sciences
109 rdf:type schema:DefinedTerm
110 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
111 schema:name Cardiorespiratory Medicine and Haematology
112 rdf:type schema:DefinedTerm
113 sg:journal.1102812 schema:issn 1170-7690
114 1179-2027
115 schema:name PharmacoEconomics
116 rdf:type schema:Periodical
117 sg:person.01306077736.30 schema:affiliation https://www.grid.ac/institutes/grid.461681.c
118 schema:familyName Mühlbacher
119 schema:givenName Axel C.
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306077736.30
121 rdf:type schema:Person
122 sg:person.01325342277.13 schema:affiliation Nb2ad558cd00e415984276f691765343f
123 schema:familyName Dippel
124 schema:givenName Franz-Werner
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325342277.13
126 rdf:type schema:Person
127 sg:person.01354641253.87 schema:affiliation https://www.grid.ac/institutes/grid.461681.c
128 schema:familyName Juhnke
129 schema:givenName Christin
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354641253.87
131 rdf:type schema:Person
132 sg:person.0657330160.56 schema:affiliation https://www.grid.ac/institutes/grid.461681.c
133 schema:familyName Sadler
134 schema:givenName Andrew
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657330160.56
136 rdf:type schema:Person
137 sg:pub.10.1007/978-1-4020-5753-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022634734
138 https://doi.org/10.1007/978-1-4020-5753-3
139 rdf:type schema:CreativeWork
140 sg:pub.10.1007/s10198-014-0622-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050041525
141 https://doi.org/10.1007/s10198-014-0622-4
142 rdf:type schema:CreativeWork
143 sg:pub.10.1007/s40258-013-0023-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044899013
144 https://doi.org/10.1007/s40258-013-0023-3
145 rdf:type schema:CreativeWork
146 sg:pub.10.1007/s40258-016-0232-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008935933
147 https://doi.org/10.1007/s40258-016-0232-7
148 rdf:type schema:CreativeWork
149 sg:pub.10.1007/s40271-015-0118-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1049295779
150 https://doi.org/10.1007/s40271-015-0118-z
151 rdf:type schema:CreativeWork
152 sg:pub.10.1007/s40271-017-0249-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085931920
153 https://doi.org/10.1007/s40271-017-0249-5
154 rdf:type schema:CreativeWork
155 sg:pub.10.1007/s40271-017-0250-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1085934943
156 https://doi.org/10.1007/s40271-017-0250-z
157 rdf:type schema:CreativeWork
158 sg:pub.10.2165/00019053-200826080-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008806799
159 https://doi.org/10.2165/00019053-200826080-00004
160 rdf:type schema:CreativeWork
161 sg:pub.10.2165/1312067-200801040-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031743483
162 https://doi.org/10.2165/1312067-200801040-00003
163 rdf:type schema:CreativeWork
164 sg:pub.10.2165/1312067-200801040-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046787896
165 https://doi.org/10.2165/1312067-200801040-00009
166 rdf:type schema:CreativeWork
167 https://app.dimensions.ai/details/publication/pub.1076997830 schema:CreativeWork
168 https://doi.org/10.1001/jama.1996.03530260066035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029253460
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1002/clc.4960220106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011624418
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/0277-9536(85)90079-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038523649
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/j.atherosclerosis.2012.02.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025530888
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/j.atherosclerosissup.2012.10.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000023699
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.atherosclerosissup.2014.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004458267
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.atherosclerosissup.2014.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015828547
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.atherosclerosissup.2014.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021491942
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.clinthera.2015.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041862146
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.csda.2004.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001022923
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.jacl.2011.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010638078
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.jocm.2015.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010622849
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/j.jval.2010.11.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030781921
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/j.jval.2014.08.1898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034106064
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/j.jval.2015.09.2937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031334096
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.lungcan.2010.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024987177
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/s0277-9536(02)00056-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042922187
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1017/cbo9780511610356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1098712532
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1017/cbo9780511753831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1098665042
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1037/a0018963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021557563
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1046/j.1369-6513.2000.00093.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018946418
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1055/s-0032-1330500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057277399
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1056/nejmoa1501031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035722374
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1080/00036840801964633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028283934
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1080/10705510701575396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004013106
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1086/208753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058528340
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1086/259131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058572612
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1093/eurheartj/ehw388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059577126
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1111/hex.12201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027459351
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1111/j.1369-7625.2006.00401.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041459706
227 rdf:type schema:CreativeWork
228 https://doi.org/10.2147/ceor.s43087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017820578
229 rdf:type schema:CreativeWork
230 https://doi.org/10.2147/mder.s98889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053727008
231 rdf:type schema:CreativeWork
232 https://doi.org/10.2147/tacg.s44315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002524991
233 rdf:type schema:CreativeWork
234 https://doi.org/10.3238/arztebl.2014.0523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078959575
235 rdf:type schema:CreativeWork
236 https://doi.org/10.3727/108354210x12724863327605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004904433
237 rdf:type schema:CreativeWork
238 https://doi.org/10.4337/9781781003152.00021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002009428
239 rdf:type schema:CreativeWork
240 https://www.grid.ac/institutes/grid.461681.c schema:alternateName Neubrandenburg University of Applied Sciences
241 schema:name Gesellschaft für empirische Beratung GmbH (GEB), Denzlingen, Germany
242 Professur Gesundheitsökonomie und Medizinmanagement, Hochschule Neubrandenburg, Brodaer Straße 2, 17033, Neubrandenburg, Germany
243 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...