Economic Evaluations of Gastroesophageal Reflux Disease Medical Management View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-08

AUTHORS

Andrew J. Gawron, Dustin D. French, John E. Pandolfino, Colin W. Howden

ABSTRACT

BACKGROUND: Gastroesophageal reflux disease (GERD) contributes to substantial medication use and costs worldwide. Economic evaluations provide insight into the value of healthcare, taking into account cost, quality, and benefits of particular treatments. OBJECTIVES: Our objectives were to systematically review the existing literature to identify economic evaluations of GERD management strategies, to assess the scientific quality of these reports, and to summarize the economic outcomes of these evaluations. METHODS: We identified economic evaluations and cost studies of GERD management strategies by searching PubMed and the UK NHS Economic Evaluation Database via the Cochrane Library. Searching was restricted to articles in English-language journals from July 2003 to July 2013. Cost-identification articles were excluded from the final analysis. RESULTS: Eighteen articles were included in the final analysis; 61 % of these met all criteria for quality reporting. Overall, proton pump inhibitor (PPI) therapy was preferred (most effective and least costly) as empiric therapy for patients with reflux symptoms, except in patient populations with high Helicobacter pylori prevalence (>40 %). Initial empiric PPI therapy (vs. initial endoscopy stratification or H. pylori testing) is likely the most cost-effective initial strategy for patients with typical GERD symptoms. Surgery may be cost effective in patients with chronic GERD symptoms at time horizons of 3-10 years. Endoscopic anti-reflux procedures were not cost effective based on available data. CONCLUSIONS: Further economic evaluations should adhere to standard reporting measures of cost estimates and outcomes, and should attempt to account for and compare the large heterogeneity of patient phenotypes and treatment effects seen with anti-reflux therapies. More... »

PAGES

745-758

References to SciGraph publications

  • 2008-02. Management Strategy for Patients With Gastroesophageal Reflux Disease: A Comparison Between Empirical Treatment With Esomeprazole and Endoscopy-Oriented Treatment in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2006-03. Chronic Laryngitis Associated with Gastroesophageal Reflux: Prospective Assessment of Differences in Practice Patterns Between Gastroenterologists and ENT Physicians in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2010-11. The Gain in Quality-Adjusted Life Months by Switching to Esomeprazole in Those With Continued Reflux Symptoms in Primary Care: EncomPASS—A Cluster-Randomized Trial in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2006-09. The Burden of Gastrointestinal and Liver Diseases, 2006 in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2013-07. Proton Pump Inhibitor Prescriptions and Subsequent Use in US Veterans Diagnosed with Gastroesophageal Reflux Disease in JOURNAL OF GENERAL INTERNAL MEDICINE
  • 2007-10. A Comparison of the Cost Effectiveness of Pharmacotherapy or Surgery (Laparoscopic Fundoplication) in the Treatment of GORD in PHARMACOECONOMICS
  • 2005-06. Primary-Care Physicians' Perceptions and Practices on the Management of GERD: Results of a National Survey in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2004-06. Re-examination of the Cost-Effectiveness of Surgical Versus Medical Therapy in Patients With Gastroesophageal Reflux Disease: The Value of Long-Term Data Collection in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2005-11. “Proton-pump inhibitor-first” strategy versus “step-up” strategy for the acute treatment of reflux esophagitis: a cost-effectiveness analysis in Japan in JOURNAL OF GASTROENTEROLOGY
  • 2012-12. Unsedated peroral wireless pH capsule placement vs. standard pH testing: A randomized study and cost analysis in BMC GASTROENTEROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40273-014-0164-8

    DOI

    http://dx.doi.org/10.1007/s40273-014-0164-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1017375039

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24807469


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cost-Benefit Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Data Interpretation, Statistical", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Endoscopy, Gastrointestinal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gastroesophageal Reflux", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Health Care Costs", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Helicobacter Infections", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Helicobacter pylori", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proton Pump Inhibitors", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Northwestern University", 
              "id": "https://www.grid.ac/institutes/grid.16753.36", 
              "name": [
                "Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, 750 N. Lake Shore Drive, 10th Floor, 60611, Chicago, IL, USA", 
                "Center for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gawron", 
            "givenName": "Andrew J.", 
            "id": "sg:person.0672063755.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672063755.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Northwestern University", 
              "id": "https://www.grid.ac/institutes/grid.16753.36", 
              "name": [
                "Center for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA", 
                "Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "French", 
            "givenName": "Dustin D.", 
            "id": "sg:person.0622216651.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622216651.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Northwestern University", 
              "id": "https://www.grid.ac/institutes/grid.16753.36", 
              "name": [
                "Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, 750 N. Lake Shore Drive, 10th Floor, 60611, Chicago, IL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pandolfino", 
            "givenName": "John E.", 
            "id": "sg:person.01224616510.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224616510.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Northwestern University", 
              "id": "https://www.grid.ac/institutes/grid.16753.36", 
              "name": [
                "Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, 750 N. Lake Shore Drive, 10th Floor, 60611, Chicago, IL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Howden", 
            "givenName": "Colin W.", 
            "id": "sg:person.0773557610.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773557610.14"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1111/j.1365-2036.2007.03265.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001638948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.b2576", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004696668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/00365520510023873", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005213220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bpg.2010.09.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005986268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cgh.2006.09.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007396583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9343(97)00308-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008304569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.dld.2006.02.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009886352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2005.41364.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013646082", 
              "https://doi.org/10.1111/j.1572-0241.2005.41364.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2005.41364.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013646082", 
              "https://doi.org/10.1111/j.1572-0241.2005.41364.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2007.01659.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014853802", 
              "https://doi.org/10.1111/j.1572-0241.2007.01659.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0056060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017247100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2012.08.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017400322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jval.2010.09.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017481130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11606-013-2345-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020975007", 
              "https://doi.org/10.1007/s11606-013-2345-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00019053-200725100-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021954889", 
              "https://doi.org/10.2165/00019053-200725100-00003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2008/765458", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022384265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1185/03007990903035745", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022951422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2010.368", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025981962", 
              "https://doi.org/10.1038/ajg.2010.368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2010.368", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025981962", 
              "https://doi.org/10.1038/ajg.2010.368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1067/s0016-5107(03)01889-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027411961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2036.2003.01526.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027914353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1205544", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031973015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jval.2013.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034227837"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3111/13696990701815545", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036922451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2008.08.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037620962"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-005-1704-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039812515", 
              "https://doi.org/10.1007/s00535-005-1704-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-005-1704-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039812515", 
              "https://doi.org/10.1007/s00535-005-1704-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2006.00723.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039844311", 
              "https://doi.org/10.1111/j.1572-0241.2006.00723.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2008.12.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039881262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2008.08.045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041570942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-230x-12-58", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042984466", 
              "https://doi.org/10.1186/1471-230x-12-58"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2004.30891.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044020468", 
              "https://doi.org/10.1111/j.1572-0241.2004.30891.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.4933", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046383104"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2006.00502.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049986390", 
              "https://doi.org/10.1111/j.1572-0241.2006.00502.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2006.00502.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049986390", 
              "https://doi.org/10.1111/j.1572-0241.2006.00502.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1524-4733.2008.00399.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051614277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.285.18.2331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052782849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1185/030079905x65330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053059106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1185/030079905x65330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053059106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004836-200205000-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053376267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004836-200205000-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053376267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0016-5107(03)01889-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054587174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3310/hta12310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071139035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3310/hta17220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071139340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077885479", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-08", 
        "datePublishedReg": "2014-08-01", 
        "description": "BACKGROUND: Gastroesophageal reflux disease (GERD) contributes to substantial medication use and costs worldwide. Economic evaluations provide insight into the value of healthcare, taking into account cost, quality, and benefits of particular treatments.\nOBJECTIVES: Our objectives were to systematically review the existing literature to identify economic evaluations of GERD management strategies, to assess the scientific quality of these reports, and to summarize the economic outcomes of these evaluations.\nMETHODS: We identified economic evaluations and cost studies of GERD management strategies by searching PubMed and the UK NHS Economic Evaluation Database via the Cochrane Library. Searching was restricted to articles in English-language journals from July 2003 to July 2013. Cost-identification articles were excluded from the final analysis.\nRESULTS: Eighteen articles were included in the final analysis; 61 % of these met all criteria for quality reporting. Overall, proton pump inhibitor (PPI) therapy was preferred (most effective and least costly) as empiric therapy for patients with reflux symptoms, except in patient populations with high Helicobacter pylori prevalence (>40 %). Initial empiric PPI therapy (vs. initial endoscopy stratification or H. pylori testing) is likely the most cost-effective initial strategy for patients with typical GERD symptoms. Surgery may be cost effective in patients with chronic GERD symptoms at time horizons of 3-10 years. Endoscopic anti-reflux procedures were not cost effective based on available data.\nCONCLUSIONS: Further economic evaluations should adhere to standard reporting measures of cost estimates and outcomes, and should attempt to account for and compare the large heterogeneity of patient phenotypes and treatment effects seen with anti-reflux therapies.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s40273-014-0164-8", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2499431", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2685053", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2500428", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1102812", 
            "issn": [
              "1170-7690", 
              "1179-2027"
            ], 
            "name": "PharmacoEconomics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "8", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "32"
          }
        ], 
        "name": "Economic Evaluations of Gastroesophageal Reflux Disease Medical Management", 
        "pagination": "745-758", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "52c7ef7a257cb15d6b5e46172e29211d15621258a670a5b970be72ff3381e2f4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24807469"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9212404"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s40273-014-0164-8"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1017375039"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s40273-014-0164-8", 
          "https://app.dimensions.ai/details/publication/pub.1017375039"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T13:19", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000521.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs40273-014-0164-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40273-014-0164-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40273-014-0164-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40273-014-0164-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40273-014-0164-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    260 TRIPLES      21 PREDICATES      77 URIs      30 LITERALS      18 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s40273-014-0164-8 schema:about N0ec8a06b627a4cb0b5f7ca6a24a99682
    2 N3a94fc9eeaec4ea58230a17e1b14e8a7
    3 N64a6b06889514135bc98e070f8fe4705
    4 N7f3af39761614f7d8ad604a4bbc6e891
    5 Na26b473a22fa45ce9280e52a13ce92e1
    6 Nac217f7b71774587962981e631b8dd6d
    7 Nbd40b31bc3924c00aa214e10ed6b3ca8
    8 Nc35fb2e4b66d40a18b6a5911b969faa6
    9 Nd95ad77b96d54573a74be4946f68b274
    10 anzsrc-for:11
    11 anzsrc-for:1103
    12 schema:author N66ae51d3827a456981ae7d6239d35874
    13 schema:citation sg:pub.10.1007/s00535-005-1704-y
    14 sg:pub.10.1007/s11606-013-2345-0
    15 sg:pub.10.1038/ajg.2010.368
    16 sg:pub.10.1111/j.1572-0241.2004.30891.x
    17 sg:pub.10.1111/j.1572-0241.2005.41364.x
    18 sg:pub.10.1111/j.1572-0241.2006.00502.x
    19 sg:pub.10.1111/j.1572-0241.2006.00723.x
    20 sg:pub.10.1111/j.1572-0241.2007.01659.x
    21 sg:pub.10.1186/1471-230x-12-58
    22 sg:pub.10.2165/00019053-200725100-00003
    23 https://app.dimensions.ai/details/publication/pub.1077885479
    24 https://doi.org/10.1001/jama.285.18.2331
    25 https://doi.org/10.1002/bjs.4933
    26 https://doi.org/10.1016/j.bpg.2010.09.006
    27 https://doi.org/10.1016/j.cgh.2006.09.016
    28 https://doi.org/10.1016/j.dld.2006.02.015
    29 https://doi.org/10.1016/j.jval.2010.09.004
    30 https://doi.org/10.1016/j.jval.2013.02.002
    31 https://doi.org/10.1016/s0002-9343(97)00308-2
    32 https://doi.org/10.1016/s0016-5107(03)01889-3
    33 https://doi.org/10.1046/j.1365-2036.2003.01526.x
    34 https://doi.org/10.1053/j.gastro.2008.08.044
    35 https://doi.org/10.1053/j.gastro.2008.08.045
    36 https://doi.org/10.1053/j.gastro.2008.12.015
    37 https://doi.org/10.1053/j.gastro.2012.08.002
    38 https://doi.org/10.1056/nejmoa1205544
    39 https://doi.org/10.1067/s0016-5107(03)01889-3
    40 https://doi.org/10.1080/00365520510023873
    41 https://doi.org/10.1097/00004836-200205000-00006
    42 https://doi.org/10.1111/j.1365-2036.2007.03265.x
    43 https://doi.org/10.1111/j.1524-4733.2008.00399.x
    44 https://doi.org/10.1136/bmj.b2576
    45 https://doi.org/10.1155/2008/765458
    46 https://doi.org/10.1185/030079905x65330
    47 https://doi.org/10.1185/03007990903035745
    48 https://doi.org/10.1371/journal.pone.0056060
    49 https://doi.org/10.3111/13696990701815545
    50 https://doi.org/10.3310/hta12310
    51 https://doi.org/10.3310/hta17220
    52 schema:datePublished 2014-08
    53 schema:datePublishedReg 2014-08-01
    54 schema:description BACKGROUND: Gastroesophageal reflux disease (GERD) contributes to substantial medication use and costs worldwide. Economic evaluations provide insight into the value of healthcare, taking into account cost, quality, and benefits of particular treatments. OBJECTIVES: Our objectives were to systematically review the existing literature to identify economic evaluations of GERD management strategies, to assess the scientific quality of these reports, and to summarize the economic outcomes of these evaluations. METHODS: We identified economic evaluations and cost studies of GERD management strategies by searching PubMed and the UK NHS Economic Evaluation Database via the Cochrane Library. Searching was restricted to articles in English-language journals from July 2003 to July 2013. Cost-identification articles were excluded from the final analysis. RESULTS: Eighteen articles were included in the final analysis; 61 % of these met all criteria for quality reporting. Overall, proton pump inhibitor (PPI) therapy was preferred (most effective and least costly) as empiric therapy for patients with reflux symptoms, except in patient populations with high Helicobacter pylori prevalence (>40 %). Initial empiric PPI therapy (vs. initial endoscopy stratification or H. pylori testing) is likely the most cost-effective initial strategy for patients with typical GERD symptoms. Surgery may be cost effective in patients with chronic GERD symptoms at time horizons of 3-10 years. Endoscopic anti-reflux procedures were not cost effective based on available data. CONCLUSIONS: Further economic evaluations should adhere to standard reporting measures of cost estimates and outcomes, and should attempt to account for and compare the large heterogeneity of patient phenotypes and treatment effects seen with anti-reflux therapies.
    55 schema:genre research_article
    56 schema:inLanguage en
    57 schema:isAccessibleForFree true
    58 schema:isPartOf N509709c9d59a433e80fd404744581561
    59 Nce08e1c0eef44762842d2652a9c01367
    60 sg:journal.1102812
    61 schema:name Economic Evaluations of Gastroesophageal Reflux Disease Medical Management
    62 schema:pagination 745-758
    63 schema:productId N1a19410d8412447481c0d7e6aca31d99
    64 N778ccf265bbe4264a864710806304067
    65 Nef07fc0f56d44db395757021fc6c08a7
    66 Nf700f3cc913b47e6b07dff8ac23b156b
    67 Nfaf43c17e0484c3696bf308637829022
    68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017375039
    69 https://doi.org/10.1007/s40273-014-0164-8
    70 schema:sdDatePublished 2019-04-10T13:19
    71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    72 schema:sdPublisher Nb96d9df9811e4c4989e03f206e528705
    73 schema:url http://link.springer.com/10.1007%2Fs40273-014-0164-8
    74 sgo:license sg:explorer/license/
    75 sgo:sdDataset articles
    76 rdf:type schema:ScholarlyArticle
    77 N0ec8a06b627a4cb0b5f7ca6a24a99682 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    78 schema:name Gastroesophageal Reflux
    79 rdf:type schema:DefinedTerm
    80 N1a19410d8412447481c0d7e6aca31d99 schema:name doi
    81 schema:value 10.1007/s40273-014-0164-8
    82 rdf:type schema:PropertyValue
    83 N274c686a886e42a58857cbe587b20ce6 rdf:first sg:person.0622216651.70
    84 rdf:rest Nece0a6b21eff4ee2b8e446b99cc5ad35
    85 N3a94fc9eeaec4ea58230a17e1b14e8a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    86 schema:name Cost-Benefit Analysis
    87 rdf:type schema:DefinedTerm
    88 N509709c9d59a433e80fd404744581561 schema:volumeNumber 32
    89 rdf:type schema:PublicationVolume
    90 N64a6b06889514135bc98e070f8fe4705 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    91 schema:name Data Interpretation, Statistical
    92 rdf:type schema:DefinedTerm
    93 N66ae51d3827a456981ae7d6239d35874 rdf:first sg:person.0672063755.44
    94 rdf:rest N274c686a886e42a58857cbe587b20ce6
    95 N778ccf265bbe4264a864710806304067 schema:name readcube_id
    96 schema:value 52c7ef7a257cb15d6b5e46172e29211d15621258a670a5b970be72ff3381e2f4
    97 rdf:type schema:PropertyValue
    98 N7f3af39761614f7d8ad604a4bbc6e891 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Endoscopy, Gastrointestinal
    100 rdf:type schema:DefinedTerm
    101 N8d46fd269b124d7698c8264a4944ded0 rdf:first sg:person.0773557610.14
    102 rdf:rest rdf:nil
    103 Na26b473a22fa45ce9280e52a13ce92e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Helicobacter pylori
    105 rdf:type schema:DefinedTerm
    106 Nac217f7b71774587962981e631b8dd6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Health Care Costs
    108 rdf:type schema:DefinedTerm
    109 Nb96d9df9811e4c4989e03f206e528705 schema:name Springer Nature - SN SciGraph project
    110 rdf:type schema:Organization
    111 Nbd40b31bc3924c00aa214e10ed6b3ca8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Proton Pump Inhibitors
    113 rdf:type schema:DefinedTerm
    114 Nc35fb2e4b66d40a18b6a5911b969faa6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Humans
    116 rdf:type schema:DefinedTerm
    117 Nce08e1c0eef44762842d2652a9c01367 schema:issueNumber 8
    118 rdf:type schema:PublicationIssue
    119 Nd95ad77b96d54573a74be4946f68b274 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Helicobacter Infections
    121 rdf:type schema:DefinedTerm
    122 Nece0a6b21eff4ee2b8e446b99cc5ad35 rdf:first sg:person.01224616510.22
    123 rdf:rest N8d46fd269b124d7698c8264a4944ded0
    124 Nef07fc0f56d44db395757021fc6c08a7 schema:name pubmed_id
    125 schema:value 24807469
    126 rdf:type schema:PropertyValue
    127 Nf700f3cc913b47e6b07dff8ac23b156b schema:name dimensions_id
    128 schema:value pub.1017375039
    129 rdf:type schema:PropertyValue
    130 Nfaf43c17e0484c3696bf308637829022 schema:name nlm_unique_id
    131 schema:value 9212404
    132 rdf:type schema:PropertyValue
    133 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    134 schema:name Medical and Health Sciences
    135 rdf:type schema:DefinedTerm
    136 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    137 schema:name Clinical Sciences
    138 rdf:type schema:DefinedTerm
    139 sg:grant.2499431 http://pending.schema.org/fundedItem sg:pub.10.1007/s40273-014-0164-8
    140 rdf:type schema:MonetaryGrant
    141 sg:grant.2500428 http://pending.schema.org/fundedItem sg:pub.10.1007/s40273-014-0164-8
    142 rdf:type schema:MonetaryGrant
    143 sg:grant.2685053 http://pending.schema.org/fundedItem sg:pub.10.1007/s40273-014-0164-8
    144 rdf:type schema:MonetaryGrant
    145 sg:journal.1102812 schema:issn 1170-7690
    146 1179-2027
    147 schema:name PharmacoEconomics
    148 rdf:type schema:Periodical
    149 sg:person.01224616510.22 schema:affiliation https://www.grid.ac/institutes/grid.16753.36
    150 schema:familyName Pandolfino
    151 schema:givenName John E.
    152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224616510.22
    153 rdf:type schema:Person
    154 sg:person.0622216651.70 schema:affiliation https://www.grid.ac/institutes/grid.16753.36
    155 schema:familyName French
    156 schema:givenName Dustin D.
    157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622216651.70
    158 rdf:type schema:Person
    159 sg:person.0672063755.44 schema:affiliation https://www.grid.ac/institutes/grid.16753.36
    160 schema:familyName Gawron
    161 schema:givenName Andrew J.
    162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672063755.44
    163 rdf:type schema:Person
    164 sg:person.0773557610.14 schema:affiliation https://www.grid.ac/institutes/grid.16753.36
    165 schema:familyName Howden
    166 schema:givenName Colin W.
    167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773557610.14
    168 rdf:type schema:Person
    169 sg:pub.10.1007/s00535-005-1704-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1039812515
    170 https://doi.org/10.1007/s00535-005-1704-y
    171 rdf:type schema:CreativeWork
    172 sg:pub.10.1007/s11606-013-2345-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020975007
    173 https://doi.org/10.1007/s11606-013-2345-0
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1038/ajg.2010.368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025981962
    176 https://doi.org/10.1038/ajg.2010.368
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1111/j.1572-0241.2004.30891.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044020468
    179 https://doi.org/10.1111/j.1572-0241.2004.30891.x
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1111/j.1572-0241.2005.41364.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013646082
    182 https://doi.org/10.1111/j.1572-0241.2005.41364.x
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1111/j.1572-0241.2006.00502.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049986390
    185 https://doi.org/10.1111/j.1572-0241.2006.00502.x
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1111/j.1572-0241.2006.00723.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039844311
    188 https://doi.org/10.1111/j.1572-0241.2006.00723.x
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1111/j.1572-0241.2007.01659.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014853802
    191 https://doi.org/10.1111/j.1572-0241.2007.01659.x
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1186/1471-230x-12-58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042984466
    194 https://doi.org/10.1186/1471-230x-12-58
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.2165/00019053-200725100-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021954889
    197 https://doi.org/10.2165/00019053-200725100-00003
    198 rdf:type schema:CreativeWork
    199 https://app.dimensions.ai/details/publication/pub.1077885479 schema:CreativeWork
    200 https://doi.org/10.1001/jama.285.18.2331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052782849
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1002/bjs.4933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046383104
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1016/j.bpg.2010.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005986268
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1016/j.cgh.2006.09.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007396583
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1016/j.dld.2006.02.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009886352
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1016/j.jval.2010.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017481130
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1016/j.jval.2013.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034227837
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1016/s0002-9343(97)00308-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008304569
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1016/s0016-5107(03)01889-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054587174
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1046/j.1365-2036.2003.01526.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027914353
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1053/j.gastro.2008.08.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037620962
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1053/j.gastro.2008.08.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041570942
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1053/j.gastro.2008.12.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039881262
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1053/j.gastro.2012.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017400322
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1056/nejmoa1205544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031973015
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1067/s0016-5107(03)01889-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027411961
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1080/00365520510023873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005213220
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1097/00004836-200205000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053376267
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1111/j.1365-2036.2007.03265.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001638948
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1111/j.1524-4733.2008.00399.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051614277
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1136/bmj.b2576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004696668
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1155/2008/765458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022384265
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1185/030079905x65330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053059106
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1185/03007990903035745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022951422
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1371/journal.pone.0056060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017247100
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.3111/13696990701815545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036922451
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.3310/hta12310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071139035
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.3310/hta17220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071139340
    255 rdf:type schema:CreativeWork
    256 https://www.grid.ac/institutes/grid.16753.36 schema:alternateName Northwestern University
    257 schema:name Center for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    258 Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    259 Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, 750 N. Lake Shore Drive, 10th Floor, 60611, Chicago, IL, USA
    260 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...