Economic Evaluations of Gastroesophageal Reflux Disease Medical Management View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-08

AUTHORS

Andrew J. Gawron, Dustin D. French, John E. Pandolfino, Colin W. Howden

ABSTRACT

BACKGROUND: Gastroesophageal reflux disease (GERD) contributes to substantial medication use and costs worldwide. Economic evaluations provide insight into the value of healthcare, taking into account cost, quality, and benefits of particular treatments. OBJECTIVES: Our objectives were to systematically review the existing literature to identify economic evaluations of GERD management strategies, to assess the scientific quality of these reports, and to summarize the economic outcomes of these evaluations. METHODS: We identified economic evaluations and cost studies of GERD management strategies by searching PubMed and the UK NHS Economic Evaluation Database via the Cochrane Library. Searching was restricted to articles in English-language journals from July 2003 to July 2013. Cost-identification articles were excluded from the final analysis. RESULTS: Eighteen articles were included in the final analysis; 61 % of these met all criteria for quality reporting. Overall, proton pump inhibitor (PPI) therapy was preferred (most effective and least costly) as empiric therapy for patients with reflux symptoms, except in patient populations with high Helicobacter pylori prevalence (>40 %). Initial empiric PPI therapy (vs. initial endoscopy stratification or H. pylori testing) is likely the most cost-effective initial strategy for patients with typical GERD symptoms. Surgery may be cost effective in patients with chronic GERD symptoms at time horizons of 3-10 years. Endoscopic anti-reflux procedures were not cost effective based on available data. CONCLUSIONS: Further economic evaluations should adhere to standard reporting measures of cost estimates and outcomes, and should attempt to account for and compare the large heterogeneity of patient phenotypes and treatment effects seen with anti-reflux therapies. More... »

PAGES

745-758

References to SciGraph publications

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  • 2010-11. The Gain in Quality-Adjusted Life Months by Switching to Esomeprazole in Those With Continued Reflux Symptoms in Primary Care: EncomPASS—A Cluster-Randomized Trial in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2006-09. The Burden of Gastrointestinal and Liver Diseases, 2006 in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
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  • 2007-10. A Comparison of the Cost Effectiveness of Pharmacotherapy or Surgery (Laparoscopic Fundoplication) in the Treatment of GORD in PHARMACOECONOMICS
  • 2005-06. Primary-Care Physicians' Perceptions and Practices on the Management of GERD: Results of a National Survey in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2004-06. Re-examination of the Cost-Effectiveness of Surgical Versus Medical Therapy in Patients With Gastroesophageal Reflux Disease: The Value of Long-Term Data Collection in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2005-11. “Proton-pump inhibitor-first” strategy versus “step-up” strategy for the acute treatment of reflux esophagitis: a cost-effectiveness analysis in Japan in JOURNAL OF GASTROENTEROLOGY
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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40273-014-0164-8

    DOI

    http://dx.doi.org/10.1007/s40273-014-0164-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1017375039

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24807469


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

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    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40273-014-0164-8'

    N-Triples is a line-based linked data format ideal for batch operations.

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    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40273-014-0164-8'


     

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