Health-Related Quality of Life in Chronic HCV-Infected Patients Switching to Pegylated-Interferon-Free Regimens (ANRS CO20 CUPIC Cohort Study and SIRIUS Trial) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-10

AUTHORS

Maria Patrizia Carrieri, Camelia Protopopescu, Zobair Younossi, Antoine Vilotitch, Hélène Fontaine, Ventzislava Petrov-Sanchez, Fabienne Marcellin, Fabrice Carrat, Christophe Hézode, Marc Bourlière, The CUPIC Study Group

ABSTRACT

OBJECTIVE: We aimed to compare health-related quality of life (HRQL) during and after hepatitis C virus (HCV) treatment in patients receiving pegylated-interferon (PEG-IFN)-containing therapy (including boceprevir or telaprevir-ANRS CO20 CUPIC cohort) who subsequently switched to PEG-IFN-free regimens (sofosbuvir + ledipasvir with or without ribavirin [RBV]-SIRIUS trial). METHODS: Two analyses were performed. The first compared physical (PCS) and mental (MCS) HRQL (MOS SF-12) scores during treatment between CUPIC and SIRIUS. The second compared PCS and MCS scores after treatment end between CUPIC and SIRIUS. The analyses used linear regression mixed models adjusted for pre-treatment HRQL scores, gender, and age at each visit. RESULTS: Among patients enrolled successively in both studies, 43 (corresponding to 212 HRQL assessments) and 43 (82 HRQL assessments) were eligible for the 'during' and 'post' treatment analyses, respectively. In the 'during-treatment' analysis, we found significantly higher PCS and MCS values during PEG-IFN-free treatment than for PEG-IFN-containing treatment. In the 'post-treatment' analysis, results showed significantly higher MCS values after PEG-IFN-free treatment than after PEG-IFN-containing treatment. No significant difference was found for PCS in the post-treatment analysis. CONCLUSIONS: These results highlight an improvement in both physical and mental HRQL during HCV treatment, but no major improvement in physical HRQL after treatment end, when comparing PEG-IFN-free regimens with PEG-IFN-containing regimens. This suggests that in the PEG-IFN-free regimens era, screening and comprehensive care of comorbidities and residual somatic symptoms during treatment, and especially after HCV clearance, are still needed to improve patient outcomes. More... »

PAGES

605-614

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40271-017-0232-1

DOI

http://dx.doi.org/10.1007/s40271-017-0232-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084038585

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28353221


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antiviral Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzimidazoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Comorbidity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Double-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Health Status", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis C, Chronic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mental Health", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligopeptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Patient Reported Outcome Measures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polyethylene Glycols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proline", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quality of Life", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sex Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sustained Virologic Response", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uridine Monophosphate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Facult\u00e9 de M\u00e9decine, Aix Marseille University, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Sant\u00e9 & Traitement de l\u2019Information M\u00e9dicale, 27 Bd. Jean Moulin, 13385, Marseille Cedex 5, France", 
            "ORS PACA (Observatoire R\u00e9gional de la Sant\u00e9 Provence-Alpes-C\u00f4te d\u2019Azur), Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carrieri", 
        "givenName": "Maria Patrizia", 
        "id": "sg:person.01324330327.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324330327.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Facult\u00e9 de M\u00e9decine, Aix Marseille University, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Sant\u00e9 & Traitement de l\u2019Information M\u00e9dicale, 27 Bd. Jean Moulin, 13385, Marseille Cedex 5, France", 
            "ORS PACA (Observatoire R\u00e9gional de la Sant\u00e9 Provence-Alpes-C\u00f4te d\u2019Azur), Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Protopopescu", 
        "givenName": "Camelia", 
        "id": "sg:person.01123072724.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123072724.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inova Fairfax Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417781.c", 
          "name": [
            "Department of Medicine, Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, 22039, Annandale, VA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Younossi", 
        "givenName": "Zobair", 
        "id": "sg:person.01245263262.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245263262.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Facult\u00e9 de M\u00e9decine, Aix Marseille University, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Sant\u00e9 & Traitement de l\u2019Information M\u00e9dicale, 27 Bd. Jean Moulin, 13385, Marseille Cedex 5, France", 
            "ORS PACA (Observatoire R\u00e9gional de la Sant\u00e9 Provence-Alpes-C\u00f4te d\u2019Azur), Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vilotitch", 
        "givenName": "Antoine", 
        "id": "sg:person.01263436002.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263436002.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Assistance Publique -Hopitaux De Paris", 
          "id": "https://www.grid.ac/institutes/grid.50550.35", 
          "name": [
            "INSERM, U1016, H\u00f4pital Cochin, 27 rue du Faubourg Saint Jacques, 75014, Paris, France", 
            "Hepatology Unit, Groupe hospitalier Cochin-H\u00f4tel Dieu, AP-HP, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fontaine", 
        "givenName": "H\u00e9l\u00e8ne", 
        "id": "sg:person.0673006267.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673006267.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales", 
          "id": "https://www.grid.ac/institutes/grid.453032.3", 
          "name": [
            "Unit for Basic and Clinical Research on Viral Hepatitis, ANRS (France Recherche Nord and Sud Sida-HIV H\u00e9patites FRENSH), Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Petrov-Sanchez", 
        "givenName": "Ventzislava", 
        "id": "sg:person.0733743621.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733743621.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Facult\u00e9 de M\u00e9decine, Aix Marseille University, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Sant\u00e9 & Traitement de l\u2019Information M\u00e9dicale, 27 Bd. Jean Moulin, 13385, Marseille Cedex 5, France", 
            "ORS PACA (Observatoire R\u00e9gional de la Sant\u00e9 Provence-Alpes-C\u00f4te d\u2019Azur), Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marcellin", 
        "givenName": "Fabienne", 
        "id": "sg:person.0671423404.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671423404.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Antoine", 
          "id": "https://www.grid.ac/institutes/grid.412370.3", 
          "name": [
            "Sorbonne Universities, UPMC University of Paris 06, INSERM, Pierre Louis Institute of Epidemiology and Public Health (IPLESP UMRS 1136), Paris, France", 
            "Public Health Unit, H\u00f4pital Saint-Antoine, AP-HP, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carrat", 
        "givenName": "Fabrice", 
        "id": "sg:person.0725234060.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725234060.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pitaux Universitaires Henri Mondor", 
          "id": "https://www.grid.ac/institutes/grid.412116.1", 
          "name": [
            "Department of Hepatology and Gastroenterology, H\u00f4pital Henri Mondor, AP-HP, University of Paris-Est, INSERM, U955, Cr\u00e9teil, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "H\u00e9zode", 
        "givenName": "Christophe", 
        "id": "sg:person.0645546730.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645546730.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint Joseph", 
          "id": "https://www.grid.ac/institutes/grid.414364.0", 
          "name": [
            "Department of Hepato-Gastroenterology, H\u00f4pital Saint Joseph, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bourli\u00e8re", 
        "givenName": "Marc", 
        "id": "sg:person.01355441765.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355441765.00"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "The CUPIC Study Group", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1365-2893.2010.01343.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017266632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2013.12.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019118337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.20659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019124306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2893.2012.01591.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022119227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpainsymman.2006.12.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024920079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/liv.12080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025939882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/meg.0b013e3283551dee", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027278017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/meg.0b013e3283551dee", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027278017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/liv.12886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028371919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2013.04.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030125063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(15)70050-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030974138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dld.2005.10.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033655641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mjt.0b013e3181960819", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034164014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mjt.0b013e3181960819", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034164014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mjt.0b013e3181960819", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034164014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cgh.2013.11.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035995692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcg.0000000000000055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038715997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcg.0000000000000055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038715997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2004.11.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043343433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.21565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043772122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/apt.13090", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048435037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/apt.12354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048582741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-230x-13-16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048602699", 
          "https://doi.org/10.1186/1471-230x-13-16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/meg.0000000000000612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048775483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/meg.0000000000000612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048775483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/17474124.2014.888949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050895486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/07853890109002089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051133156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1012588218728", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051815426", 
          "https://doi.org/10.1023/a:1012588218728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cgh.2015.07.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052268245"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-10", 
    "datePublishedReg": "2017-10-01", 
    "description": "OBJECTIVE: We aimed to compare health-related quality of life (HRQL) during and after hepatitis C virus (HCV) treatment in patients receiving pegylated-interferon (PEG-IFN)-containing therapy (including boceprevir or telaprevir-ANRS CO20 CUPIC cohort) who subsequently switched to PEG-IFN-free regimens (sofosbuvir\u00a0+\u00a0ledipasvir with or without ribavirin [RBV]-SIRIUS trial).\nMETHODS: Two analyses were performed. The first compared physical (PCS) and mental (MCS) HRQL (MOS SF-12) scores during treatment between CUPIC and SIRIUS. The second compared PCS and MCS scores after treatment end between CUPIC and SIRIUS. The analyses used linear regression mixed models adjusted for pre-treatment HRQL scores, gender, and age at each visit.\nRESULTS: Among patients enrolled successively in both studies, 43 (corresponding to 212 HRQL assessments) and 43 (82 HRQL assessments) were eligible for the 'during' and 'post' treatment analyses, respectively. In the 'during-treatment' analysis, we found significantly higher PCS and MCS values during PEG-IFN-free treatment than for PEG-IFN-containing treatment. In the 'post-treatment' analysis, results showed significantly higher MCS values after PEG-IFN-free treatment than after PEG-IFN-containing treatment. No significant difference was found for PCS in the post-treatment analysis.\nCONCLUSIONS: These results highlight an improvement in both physical and mental HRQL during HCV treatment, but no major improvement in physical HRQL after treatment end, when comparing PEG-IFN-free regimens with PEG-IFN-containing regimens. This suggests that in the PEG-IFN-free regimens era, screening and comprehensive care of comorbidities and residual somatic symptoms during treatment, and especially after HCV clearance, are still needed to improve patient outcomes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s40271-017-0232-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1038760", 
        "issn": [
          "1178-1653", 
          "1178-1661"
        ], 
        "name": "The Patient - Patient-Centered Outcomes Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Health-Related Quality of Life in Chronic HCV-Infected Patients Switching to Pegylated-Interferon-Free Regimens (ANRS CO20 CUPIC Cohort Study and SIRIUS Trial)", 
    "pagination": "605-614", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "cd08a71ed83de7b91bdd56efcb45f99dfa0385865266627504606f777706d128"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28353221"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101309314"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s40271-017-0232-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084038585"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s40271-017-0232-1", 
      "https://app.dimensions.ai/details/publication/pub.1084038585"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113641_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs40271-017-0232-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40271-017-0232-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40271-017-0232-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40271-017-0232-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40271-017-0232-1'


 

This table displays all metadata directly associated to this object as RDF triples.

335 TRIPLES      21 PREDICATES      77 URIs      45 LITERALS      33 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s40271-017-0232-1 schema:about N14e2b64ea9d44cc8a3ba9ea1fdbab1a0
2 N15275d97cabf457ca2542f43016ac639
3 N2414db2afbc84713874fea99583911a1
4 N2ed1c5efa18c4cd68a246c72c614846e
5 N39a620bd4b6a407e9014076a0965199a
6 N41c57e0b2c244435b333b5b93e220850
7 N5a3e64ea275849beb6599fd8ff1e97b3
8 N5fd1caaa8bb245869311dd14122c8192
9 N6dfbf6e2342941d88b75715ae07f22a5
10 N6f8bd372b72e4d3591a3f7695de0b99e
11 N7a7608a2b4494ef49a7b6432c0ae6082
12 N7e767008fbd84ef39e4ad025348cd107
13 N82de6d56e76f448e922fac3fc575a525
14 N8376a471b00e46deb20bbef2619e5793
15 N8c475b70105f418bafe0b6a3e2ec830a
16 N8dbe1012f4de460ba04a1c2c8fab900d
17 N9a38cda9cc384ea2948f4fe1f28fa93c
18 Na437cec92f77441cb46f04cdbcd388aa
19 Nabab2fac2ab74f89a3f1f56e0b782988
20 Nb014bdef5fb349198c1fa57babc9027a
21 Nc1bed89774ac4e91a631960f47c1ec04
22 Nc40bc8ac0d8747569d0bf2ec5e48f8f2
23 Ncf943e7f44144bbdb9d16094256fb9b9
24 Nf10fa48ab11d41a1ae4811837d380ffe
25 anzsrc-for:11
26 anzsrc-for:1117
27 schema:author N23b2000c506045109b5b19e134bfc3e4
28 schema:citation sg:pub.10.1023/a:1012588218728
29 sg:pub.10.1186/1471-230x-13-16
30 https://doi.org/10.1002/hep.20659
31 https://doi.org/10.1002/hep.21565
32 https://doi.org/10.1016/j.cgh.2013.11.032
33 https://doi.org/10.1016/j.cgh.2015.07.035
34 https://doi.org/10.1016/j.dld.2005.10.008
35 https://doi.org/10.1016/j.jhep.2004.11.018
36 https://doi.org/10.1016/j.jhep.2013.04.035
37 https://doi.org/10.1016/j.jhep.2013.12.006
38 https://doi.org/10.1016/j.jpainsymman.2006.12.014
39 https://doi.org/10.1016/s1473-3099(15)70050-2
40 https://doi.org/10.1097/mcg.0000000000000055
41 https://doi.org/10.1097/meg.0000000000000612
42 https://doi.org/10.1097/meg.0b013e3283551dee
43 https://doi.org/10.1097/mjt.0b013e3181960819
44 https://doi.org/10.1111/apt.12354
45 https://doi.org/10.1111/apt.13090
46 https://doi.org/10.1111/j.1365-2893.2010.01343.x
47 https://doi.org/10.1111/j.1365-2893.2012.01591.x
48 https://doi.org/10.1111/liv.12080
49 https://doi.org/10.1111/liv.12886
50 https://doi.org/10.1586/17474124.2014.888949
51 https://doi.org/10.3109/07853890109002089
52 schema:datePublished 2017-10
53 schema:datePublishedReg 2017-10-01
54 schema:description OBJECTIVE: We aimed to compare health-related quality of life (HRQL) during and after hepatitis C virus (HCV) treatment in patients receiving pegylated-interferon (PEG-IFN)-containing therapy (including boceprevir or telaprevir-ANRS CO20 CUPIC cohort) who subsequently switched to PEG-IFN-free regimens (sofosbuvir + ledipasvir with or without ribavirin [RBV]-SIRIUS trial). METHODS: Two analyses were performed. The first compared physical (PCS) and mental (MCS) HRQL (MOS SF-12) scores during treatment between CUPIC and SIRIUS. The second compared PCS and MCS scores after treatment end between CUPIC and SIRIUS. The analyses used linear regression mixed models adjusted for pre-treatment HRQL scores, gender, and age at each visit. RESULTS: Among patients enrolled successively in both studies, 43 (corresponding to 212 HRQL assessments) and 43 (82 HRQL assessments) were eligible for the 'during' and 'post' treatment analyses, respectively. In the 'during-treatment' analysis, we found significantly higher PCS and MCS values during PEG-IFN-free treatment than for PEG-IFN-containing treatment. In the 'post-treatment' analysis, results showed significantly higher MCS values after PEG-IFN-free treatment than after PEG-IFN-containing treatment. No significant difference was found for PCS in the post-treatment analysis. CONCLUSIONS: These results highlight an improvement in both physical and mental HRQL during HCV treatment, but no major improvement in physical HRQL after treatment end, when comparing PEG-IFN-free regimens with PEG-IFN-containing regimens. This suggests that in the PEG-IFN-free regimens era, screening and comprehensive care of comorbidities and residual somatic symptoms during treatment, and especially after HCV clearance, are still needed to improve patient outcomes.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree false
58 schema:isPartOf N382213c14f1243bd9a3825446b91a06f
59 Nbc5bf24cde13479597a0db169c5ea401
60 sg:journal.1038760
61 schema:name Health-Related Quality of Life in Chronic HCV-Infected Patients Switching to Pegylated-Interferon-Free Regimens (ANRS CO20 CUPIC Cohort Study and SIRIUS Trial)
62 schema:pagination 605-614
63 schema:productId N0ad3719692d0448f9377c92cf63a4c98
64 N8300709240374ac7a71fdf331584d1da
65 Nb5239d48749542168e5a58b18d9dbe50
66 Nbf521e63c98348d2a97079f4e6ee8edf
67 Nc8bc8545be674a2eac63a6caa983f2b0
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084038585
69 https://doi.org/10.1007/s40271-017-0232-1
70 schema:sdDatePublished 2019-04-11T10:29
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher Nd793cd5745d146208d1afc08f2c4c60b
73 schema:url https://link.springer.com/10.1007%2Fs40271-017-0232-1
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N0ad3719692d0448f9377c92cf63a4c98 schema:name dimensions_id
78 schema:value pub.1084038585
79 rdf:type schema:PropertyValue
80 N1476ce03bdbb4bbda4fd9e14e6e277a0 rdf:first sg:person.0725234060.17
81 rdf:rest N3b2e4714e5124900a9d2d7c8993e21c2
82 N14e2b64ea9d44cc8a3ba9ea1fdbab1a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Age Factors
84 rdf:type schema:DefinedTerm
85 N15275d97cabf457ca2542f43016ac639 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Oligopeptides
87 rdf:type schema:DefinedTerm
88 N23b2000c506045109b5b19e134bfc3e4 rdf:first sg:person.01324330327.99
89 rdf:rest Ne58886428a5545cfadd6eac6ed64d464
90 N2414db2afbc84713874fea99583911a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Uridine Monophosphate
92 rdf:type schema:DefinedTerm
93 N2bec5eb5df144b26ba34c0f94f8d7fc5 rdf:first sg:person.01245263262.85
94 rdf:rest N39a63619b08b40babd3ec13ac2c282aa
95 N2ed1c5efa18c4cd68a246c72c614846e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Health Status
97 rdf:type schema:DefinedTerm
98 N382213c14f1243bd9a3825446b91a06f schema:volumeNumber 10
99 rdf:type schema:PublicationVolume
100 N39a620bd4b6a407e9014076a0965199a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Comorbidity
102 rdf:type schema:DefinedTerm
103 N39a63619b08b40babd3ec13ac2c282aa rdf:first sg:person.01263436002.67
104 rdf:rest N7c0e478f884b4af0b8bca6e2eca6fb93
105 N3a69be528fe444c58aa93891278c8dce schema:name Faculté de Médecine, Aix Marseille University, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale, 27 Bd. Jean Moulin, 13385, Marseille Cedex 5, France
106 ORS PACA (Observatoire Régional de la Santé Provence-Alpes-Côte d’Azur), Marseille, France
107 rdf:type schema:Organization
108 N3b2e4714e5124900a9d2d7c8993e21c2 rdf:first sg:person.0645546730.39
109 rdf:rest N57432be97d4c456092ad6a6f1d18e799
110 N41c57e0b2c244435b333b5b93e220850 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Female
112 rdf:type schema:DefinedTerm
113 N57432be97d4c456092ad6a6f1d18e799 rdf:first sg:person.01355441765.00
114 rdf:rest Nce60b430bb834b2381f3733eaeaeac54
115 N5a3e64ea275849beb6599fd8ff1e97b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Middle Aged
117 rdf:type schema:DefinedTerm
118 N5fd1caaa8bb245869311dd14122c8192 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Sex Factors
120 rdf:type schema:DefinedTerm
121 N6dfbf6e2342941d88b75715ae07f22a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Double-Blind Method
123 rdf:type schema:DefinedTerm
124 N6f8bd372b72e4d3591a3f7695de0b99e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Severity of Illness Index
126 rdf:type schema:DefinedTerm
127 N7a7608a2b4494ef49a7b6432c0ae6082 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Benzimidazoles
129 rdf:type schema:DefinedTerm
130 N7b6a2fcbaa9344c1856735c6d2aa4ce4 rdf:first sg:person.0733743621.15
131 rdf:rest Nef7331367b8b4d88a856b617799ca300
132 N7c0e478f884b4af0b8bca6e2eca6fb93 rdf:first sg:person.0673006267.89
133 rdf:rest N7b6a2fcbaa9344c1856735c6d2aa4ce4
134 N7e767008fbd84ef39e4ad025348cd107 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Sustained Virologic Response
136 rdf:type schema:DefinedTerm
137 N82de6d56e76f448e922fac3fc575a525 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Male
139 rdf:type schema:DefinedTerm
140 N8300709240374ac7a71fdf331584d1da schema:name doi
141 schema:value 10.1007/s40271-017-0232-1
142 rdf:type schema:PropertyValue
143 N8376a471b00e46deb20bbef2619e5793 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Proline
145 rdf:type schema:DefinedTerm
146 N8c475b70105f418bafe0b6a3e2ec830a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Humans
148 rdf:type schema:DefinedTerm
149 N8dbe1012f4de460ba04a1c2c8fab900d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Hepatitis C, Chronic
151 rdf:type schema:DefinedTerm
152 N983cb7ec02bf4a1785b0f347100580cc schema:name Faculté de Médecine, Aix Marseille University, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale, 27 Bd. Jean Moulin, 13385, Marseille Cedex 5, France
153 ORS PACA (Observatoire Régional de la Santé Provence-Alpes-Côte d’Azur), Marseille, France
154 rdf:type schema:Organization
155 N9a38cda9cc384ea2948f4fe1f28fa93c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Mental Health
157 rdf:type schema:DefinedTerm
158 Na437cec92f77441cb46f04cdbcd388aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Antiviral Agents
160 rdf:type schema:DefinedTerm
161 Nabab2fac2ab74f89a3f1f56e0b782988 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Fluorenes
163 rdf:type schema:DefinedTerm
164 Nb014bdef5fb349198c1fa57babc9027a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Quality of Life
166 rdf:type schema:DefinedTerm
167 Nb4660a1a49d744349eea58a4df3fcc12 schema:name Faculté de Médecine, Aix Marseille University, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale, 27 Bd. Jean Moulin, 13385, Marseille Cedex 5, France
168 ORS PACA (Observatoire Régional de la Santé Provence-Alpes-Côte d’Azur), Marseille, France
169 rdf:type schema:Organization
170 Nb5239d48749542168e5a58b18d9dbe50 schema:name nlm_unique_id
171 schema:value 101309314
172 rdf:type schema:PropertyValue
173 Nbc5bf24cde13479597a0db169c5ea401 schema:issueNumber 5
174 rdf:type schema:PublicationIssue
175 Nbf521e63c98348d2a97079f4e6ee8edf schema:name pubmed_id
176 schema:value 28353221
177 rdf:type schema:PropertyValue
178 Nc1bed89774ac4e91a631960f47c1ec04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Patient Reported Outcome Measures
180 rdf:type schema:DefinedTerm
181 Nc40bc8ac0d8747569d0bf2ec5e48f8f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Cohort Studies
183 rdf:type schema:DefinedTerm
184 Nc8bc8545be674a2eac63a6caa983f2b0 schema:name readcube_id
185 schema:value cd08a71ed83de7b91bdd56efcb45f99dfa0385865266627504606f777706d128
186 rdf:type schema:PropertyValue
187 Nce60b430bb834b2381f3733eaeaeac54 rdf:first Nd6dc6b8f4be548fca1ec4e33a6e34f82
188 rdf:rest rdf:nil
189 Ncf943e7f44144bbdb9d16094256fb9b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Polyethylene Glycols
191 rdf:type schema:DefinedTerm
192 Nd6dc6b8f4be548fca1ec4e33a6e34f82 schema:familyName The CUPIC Study Group
193 rdf:type schema:Person
194 Nd793cd5745d146208d1afc08f2c4c60b schema:name Springer Nature - SN SciGraph project
195 rdf:type schema:Organization
196 Ne58886428a5545cfadd6eac6ed64d464 rdf:first sg:person.01123072724.28
197 rdf:rest N2bec5eb5df144b26ba34c0f94f8d7fc5
198 Ne836af2a0c6d41ed8e46ba9e77a7a035 schema:name Faculté de Médecine, Aix Marseille University, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale, 27 Bd. Jean Moulin, 13385, Marseille Cedex 5, France
199 ORS PACA (Observatoire Régional de la Santé Provence-Alpes-Côte d’Azur), Marseille, France
200 rdf:type schema:Organization
201 Nef7331367b8b4d88a856b617799ca300 rdf:first sg:person.0671423404.46
202 rdf:rest N1476ce03bdbb4bbda4fd9e14e6e277a0
203 Nf10fa48ab11d41a1ae4811837d380ffe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Aged
205 rdf:type schema:DefinedTerm
206 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
207 schema:name Medical and Health Sciences
208 rdf:type schema:DefinedTerm
209 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
210 schema:name Public Health and Health Services
211 rdf:type schema:DefinedTerm
212 sg:journal.1038760 schema:issn 1178-1653
213 1178-1661
214 schema:name The Patient - Patient-Centered Outcomes Research
215 rdf:type schema:Periodical
216 sg:person.01123072724.28 schema:affiliation Nb4660a1a49d744349eea58a4df3fcc12
217 schema:familyName Protopopescu
218 schema:givenName Camelia
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123072724.28
220 rdf:type schema:Person
221 sg:person.01245263262.85 schema:affiliation https://www.grid.ac/institutes/grid.417781.c
222 schema:familyName Younossi
223 schema:givenName Zobair
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245263262.85
225 rdf:type schema:Person
226 sg:person.01263436002.67 schema:affiliation N983cb7ec02bf4a1785b0f347100580cc
227 schema:familyName Vilotitch
228 schema:givenName Antoine
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263436002.67
230 rdf:type schema:Person
231 sg:person.01324330327.99 schema:affiliation N3a69be528fe444c58aa93891278c8dce
232 schema:familyName Carrieri
233 schema:givenName Maria Patrizia
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324330327.99
235 rdf:type schema:Person
236 sg:person.01355441765.00 schema:affiliation https://www.grid.ac/institutes/grid.414364.0
237 schema:familyName Bourlière
238 schema:givenName Marc
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355441765.00
240 rdf:type schema:Person
241 sg:person.0645546730.39 schema:affiliation https://www.grid.ac/institutes/grid.412116.1
242 schema:familyName Hézode
243 schema:givenName Christophe
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645546730.39
245 rdf:type schema:Person
246 sg:person.0671423404.46 schema:affiliation Ne836af2a0c6d41ed8e46ba9e77a7a035
247 schema:familyName Marcellin
248 schema:givenName Fabienne
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671423404.46
250 rdf:type schema:Person
251 sg:person.0673006267.89 schema:affiliation https://www.grid.ac/institutes/grid.50550.35
252 schema:familyName Fontaine
253 schema:givenName Hélène
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673006267.89
255 rdf:type schema:Person
256 sg:person.0725234060.17 schema:affiliation https://www.grid.ac/institutes/grid.412370.3
257 schema:familyName Carrat
258 schema:givenName Fabrice
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725234060.17
260 rdf:type schema:Person
261 sg:person.0733743621.15 schema:affiliation https://www.grid.ac/institutes/grid.453032.3
262 schema:familyName Petrov-Sanchez
263 schema:givenName Ventzislava
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733743621.15
265 rdf:type schema:Person
266 sg:pub.10.1023/a:1012588218728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051815426
267 https://doi.org/10.1023/a:1012588218728
268 rdf:type schema:CreativeWork
269 sg:pub.10.1186/1471-230x-13-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048602699
270 https://doi.org/10.1186/1471-230x-13-16
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1002/hep.20659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019124306
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1002/hep.21565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043772122
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.cgh.2013.11.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035995692
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/j.cgh.2015.07.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052268245
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.dld.2005.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033655641
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.jhep.2004.11.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043343433
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/j.jhep.2013.04.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030125063
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.jhep.2013.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019118337
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.jpainsymman.2006.12.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024920079
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/s1473-3099(15)70050-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030974138
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1097/mcg.0000000000000055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038715997
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1097/meg.0000000000000612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048775483
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1097/meg.0b013e3283551dee schema:sameAs https://app.dimensions.ai/details/publication/pub.1027278017
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1097/mjt.0b013e3181960819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034164014
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1111/apt.12354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048582741
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1111/apt.13090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048435037
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1111/j.1365-2893.2010.01343.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017266632
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1111/j.1365-2893.2012.01591.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022119227
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1111/liv.12080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025939882
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1111/liv.12886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028371919
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1586/17474124.2014.888949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050895486
313 rdf:type schema:CreativeWork
314 https://doi.org/10.3109/07853890109002089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051133156
315 rdf:type schema:CreativeWork
316 https://www.grid.ac/institutes/grid.412116.1 schema:alternateName Hôpitaux Universitaires Henri Mondor
317 schema:name Department of Hepatology and Gastroenterology, Hôpital Henri Mondor, AP-HP, University of Paris-Est, INSERM, U955, Créteil, France
318 rdf:type schema:Organization
319 https://www.grid.ac/institutes/grid.412370.3 schema:alternateName Hôpital Saint-Antoine
320 schema:name Public Health Unit, Hôpital Saint-Antoine, AP-HP, Paris, France
321 Sorbonne Universities, UPMC University of Paris 06, INSERM, Pierre Louis Institute of Epidemiology and Public Health (IPLESP UMRS 1136), Paris, France
322 rdf:type schema:Organization
323 https://www.grid.ac/institutes/grid.414364.0 schema:alternateName Hôpital Saint Joseph
324 schema:name Department of Hepato-Gastroenterology, Hôpital Saint Joseph, Marseille, France
325 rdf:type schema:Organization
326 https://www.grid.ac/institutes/grid.417781.c schema:alternateName Inova Fairfax Hospital
327 schema:name Department of Medicine, Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, 22039, Annandale, VA, USA
328 rdf:type schema:Organization
329 https://www.grid.ac/institutes/grid.453032.3 schema:alternateName Agence Nationale de Recherches sur le Sida et les Hépatites Virales
330 schema:name Unit for Basic and Clinical Research on Viral Hepatitis, ANRS (France Recherche Nord and Sud Sida-HIV Hépatites FRENSH), Paris, France
331 rdf:type schema:Organization
332 https://www.grid.ac/institutes/grid.50550.35 schema:alternateName Assistance Publique -Hopitaux De Paris
333 schema:name Hepatology Unit, Groupe hospitalier Cochin-Hôtel Dieu, AP-HP, Paris, France
334 INSERM, U1016, Hôpital Cochin, 27 rue du Faubourg Saint Jacques, 75014, Paris, France
335 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...