Ulcerative Colitis: Shifting Sands View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-03-02

AUTHORS

Geert R. A. M. D’Haens, James O. Lindsay, Remo Panaccione, Stefan Schreiber

ABSTRACT

Ulcerative colitis (UC) is a chronic inflammatory bowel disease associated with considerable disease burden. We review some current misconceptions about UC in adults with the aim of optimizing care for patients. Although UC and Crohn’s disease (CD) are considered discrete diseases, distinctions between them are not always clear-cut and phenotypes may change over time. Patient management should take into account disease manifestations, disease severity and extent, and response to prior treatments. Although disease extent often defines severity, distal UC is not always less disabling than extensive disease as patients can progress to more extensive disease. In addition, severe proctitis can give rise to severe and debilitating symptoms, with a substantial impact on health-related quality of life. UC carries an increased risk of colorectal cancer (CRC) compared with CD; however, more recent data indicate a similar risk of CRC in CD with colonic involvement as with UC. Corticosteroids are widely used to induce remission in UC, and prolonged use of steroids in patients with UC is common, but corticosteroid-free maintenance of remission is an important therapeutic goal. Although biologic therapies provide a valuable treatment option in UC, they are not clinically effective in all patients and are also associated with secondary loss of response. More... »

PAGES

227-234

References to SciGraph publications

  • 2016-10-03. Recent trends and future directions for the medical treatment of ulcerative colitis in CLINICAL JOURNAL OF GASTROENTEROLOGY
  • 2015-02-05. Randomized trial of tofacitinib in active ulcerative colitis: analysis of efficacy based on patient-reported outcomes in BMC GASTROENTEROLOGY
  • 2009-01-27. Loss of Response and Requirement of Infliximab Dose Intensification in Crohn's Disease: A Review in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2015-12-02. Immunopathogenesis of IBD: current state of the art in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2016-11-10. Emerging biologics in inflammatory bowel disease in JOURNAL OF GASTROENTEROLOGY
  • 2011-02-06. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 in NATURE GENETICS
  • 2010-01-12. Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2011-03-15. Loss of Response and Need for Adalimumab Dose Intensification in Crohn's Disease: A Systematic Review in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2012-11-13. Impact of Antibodies to Infliximab on Clinical Outcomes and Serum Infliximab Levels in Patients With Inflammatory Bowel Disease (IBD): A Meta-Analysis in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2016-08-10. Gastroenterologists’ Perceptions Regarding Ulcerative Colitis and Its Management: Results from a Large-Scale Survey in ADVANCES IN THERAPY
  • 2011-06-15. Genetics and pathogenesis of inflammatory bowel disease in NATURE
  • 2015-07-19. Optimizing Biologic Agents in Ulcerative Colitis and Crohn’s Disease in CURRENT GASTROENTEROLOGY REPORTS
  • 2010-03-09. Surgery for ulcerative colitis in 1,000 patients in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40268-019-0263-2

    DOI

    http://dx.doi.org/10.1007/s40268-019-0263-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112504554

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30827006


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biological Products", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colitis, Ulcerative", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colorectal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Progression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Resistance", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gastroenterology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gastrointestinal Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glucocorticoids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Patient Selection", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Practice Guidelines as Topic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Quality of Life", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Remission Induction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Severity of Illness Index", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology, Academic Medical Center, Meibergdreef 9, 1100 DZ, Amsterdam, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.5650.6", 
              "name": [
                "Department of Gastroenterology, Academic Medical Center, Meibergdreef 9, 1100 DZ, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "D\u2019Haens", 
            "givenName": "Geert R. A. M.", 
            "id": "sg:person.010724620101.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010724620101.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre for Immunology, Blizard Institute, Queen Mary University of London, E1 2AT, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.4868.2", 
              "name": [
                "Department of Gastroenterology, The Royal London Hospital, Barts Health NHS Trust, E1 1BB, London, UK", 
                "Centre for Immunology, Blizard Institute, Queen Mary University of London, E1 2AT, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lindsay", 
            "givenName": "James O.", 
            "id": "sg:person.01250100772.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250100772.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Inflammatory Bowel Disease Clinic, University of Calgary, T6G 2X8, Calgary, AB, Canada", 
              "id": "http://www.grid.ac/institutes/grid.22072.35", 
              "name": [
                "Inflammatory Bowel Disease Clinic, University of Calgary, T6G 2X8, Calgary, AB, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Panaccione", 
            "givenName": "Remo", 
            "id": "sg:person.01363347323.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363347323.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Klinik f\u00fcr Innere Medizin I, Universit\u00e4tsklinikum Schleswig-Holstein, Campus Kiel, 24105, Kiel, Germany", 
              "id": "http://www.grid.ac/institutes/grid.412468.d", 
              "name": [
                "Klinik f\u00fcr Innere Medizin I, Universit\u00e4tsklinikum Schleswig-Holstein, Campus Kiel, 24105, Kiel, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schreiber", 
            "givenName": "Stefan", 
            "id": "sg:person.01223143620.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223143620.01"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrgastro.2015.186", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037380629", 
              "https://doi.org/10.1038/nrgastro.2015.186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011250403", 
              "https://doi.org/10.1038/nature10209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052303551", 
              "https://doi.org/10.1038/ng.764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12325-016-0393-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042198121", 
              "https://doi.org/10.1007/s12325-016-0393-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-016-1283-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015625622", 
              "https://doi.org/10.1007/s00535-016-1283-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2011.60", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031695820", 
              "https://doi.org/10.1038/ajg.2011.60"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00384-010-0915-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005759511", 
              "https://doi.org/10.1007/s00384-010-0915-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11894-015-0453-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040440810", 
              "https://doi.org/10.1007/s11894-015-0453-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2009.727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021345588", 
              "https://doi.org/10.1038/ajg.2009.727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12328-016-0686-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046720684", 
              "https://doi.org/10.1007/s12328-016-0686-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12876-015-0239-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008066877", 
              "https://doi.org/10.1186/s12876-015-0239-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2012.363", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002252547", 
              "https://doi.org/10.1038/ajg.2012.363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2008.88", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040472295", 
              "https://doi.org/10.1038/ajg.2008.88"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-03-02", 
        "datePublishedReg": "2019-03-02", 
        "description": "Ulcerative colitis (UC) is a chronic inflammatory bowel disease associated with considerable disease burden. We review some current misconceptions about UC in adults with the aim of optimizing care for patients. Although UC and Crohn\u2019s disease (CD) are considered discrete diseases, distinctions between them are not always clear-cut and phenotypes may change over time. Patient management should take into account disease manifestations, disease severity and extent, and response to prior treatments. Although disease extent often defines severity, distal UC is not always less disabling than extensive disease as patients can progress to more extensive disease. In addition, severe proctitis can give rise to severe and debilitating symptoms, with a substantial impact on health-related quality of life. UC carries an increased risk of colorectal cancer (CRC) compared with CD; however, more recent data indicate a similar risk of CRC in CD with colonic involvement as with UC. Corticosteroids are widely used to induce remission in UC, and prolonged use of steroids in patients with UC is common, but corticosteroid-free maintenance of remission is an important therapeutic goal. Although biologic therapies provide a valuable treatment option in UC, they are not clinically effective in all patients and are also associated with secondary loss of response.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s40268-019-0263-2", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1020803", 
            "issn": [
              "1174-5886", 
              "1179-6901"
            ], 
            "name": "Drugs in R&D", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "19"
          }
        ], 
        "keywords": [
          "ulcerative colitis", 
          "Crohn's disease", 
          "colorectal cancer", 
          "extensive disease", 
          "health-related quality", 
          "chronic inflammatory bowel disease", 
          "distal ulcerative colitis", 
          "use of steroids", 
          "valuable treatment option", 
          "inflammatory bowel disease", 
          "considerable disease burden", 
          "important therapeutic goal", 
          "severe proctitis", 
          "colonic involvement", 
          "biologic therapy", 
          "bowel disease", 
          "disease extent", 
          "treatment options", 
          "disease burden", 
          "disease manifestations", 
          "patient management", 
          "similar risk", 
          "therapeutic goals", 
          "prior treatment", 
          "patients", 
          "disease severity", 
          "discrete disease", 
          "disease", 
          "remission", 
          "recent data", 
          "severity", 
          "risk", 
          "proctitis", 
          "corticosteroids", 
          "colitis", 
          "secondary loss", 
          "symptoms", 
          "therapy", 
          "cancer", 
          "steroids", 
          "response", 
          "care", 
          "manifestations", 
          "adults", 
          "treatment", 
          "substantial impact", 
          "burden", 
          "involvement", 
          "current misconceptions", 
          "phenotype", 
          "aim", 
          "options", 
          "extent", 
          "management", 
          "life", 
          "loss", 
          "maintenance", 
          "use", 
          "misconceptions", 
          "addition", 
          "data", 
          "quality", 
          "time", 
          "impact", 
          "rise", 
          "goal", 
          "distinction", 
          "sand", 
          "account disease manifestations", 
          "corticosteroid-free maintenance"
        ], 
        "name": "Ulcerative Colitis: Shifting Sands", 
        "pagination": "227-234", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1112504554"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s40268-019-0263-2"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30827006"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s40268-019-0263-2", 
          "https://app.dimensions.ai/details/publication/pub.1112504554"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-11-01T18:34", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_797.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s40268-019-0263-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40268-019-0263-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40268-019-0263-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40268-019-0263-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40268-019-0263-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    279 TRIPLES      22 PREDICATES      125 URIs      104 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s40268-019-0263-2 schema:about N07573fb928004cd6943f8fa292b006e1
    2 N289d86a213124413b56bbb2c9a1c843d
    3 N5c27dbd84b414fe2936c40c92f9f39a0
    4 N75034e80ae36442fbdd27dfdcf5953d2
    5 N7c43b6ecf97f4a8a918ddbdfd3a1ff94
    6 N92bc9177b7154306aac522a3c947f23b
    7 N93f6d79f38984478b2e0efd6449bf472
    8 Na6019af505ad4447b339f053cbe3eebf
    9 Nb7742af829404dadac60bf363bfa3e7f
    10 Nc96b41a06c4a490b8fc8375d17a0dc37
    11 Nd240751bbb564eaa934d517077c3b8fc
    12 Ndd1eff5fb9c946e1821e51898b3413d4
    13 Nde75d6dfe98a457bbf5328ac76d55249
    14 Ne3a1fcd4c73a4a049dfab3d4ea96a18e
    15 Ned51809bb6cc4a9292637aa5756e5b4c
    16 Nf10ee99260ec45fe84562bbe97af59bf
    17 anzsrc-for:11
    18 anzsrc-for:1112
    19 schema:author N1a52655c86fe427bb4c77f595cc6aecc
    20 schema:citation sg:pub.10.1007/s00384-010-0915-8
    21 sg:pub.10.1007/s00535-016-1283-0
    22 sg:pub.10.1007/s11894-015-0453-1
    23 sg:pub.10.1007/s12325-016-0393-7
    24 sg:pub.10.1007/s12328-016-0686-z
    25 sg:pub.10.1038/ajg.2008.88
    26 sg:pub.10.1038/ajg.2009.727
    27 sg:pub.10.1038/ajg.2011.60
    28 sg:pub.10.1038/ajg.2012.363
    29 sg:pub.10.1038/nature10209
    30 sg:pub.10.1038/ng.764
    31 sg:pub.10.1038/nrgastro.2015.186
    32 sg:pub.10.1186/s12876-015-0239-9
    33 schema:datePublished 2019-03-02
    34 schema:datePublishedReg 2019-03-02
    35 schema:description Ulcerative colitis (UC) is a chronic inflammatory bowel disease associated with considerable disease burden. We review some current misconceptions about UC in adults with the aim of optimizing care for patients. Although UC and Crohn’s disease (CD) are considered discrete diseases, distinctions between them are not always clear-cut and phenotypes may change over time. Patient management should take into account disease manifestations, disease severity and extent, and response to prior treatments. Although disease extent often defines severity, distal UC is not always less disabling than extensive disease as patients can progress to more extensive disease. In addition, severe proctitis can give rise to severe and debilitating symptoms, with a substantial impact on health-related quality of life. UC carries an increased risk of colorectal cancer (CRC) compared with CD; however, more recent data indicate a similar risk of CRC in CD with colonic involvement as with UC. Corticosteroids are widely used to induce remission in UC, and prolonged use of steroids in patients with UC is common, but corticosteroid-free maintenance of remission is an important therapeutic goal. Although biologic therapies provide a valuable treatment option in UC, they are not clinically effective in all patients and are also associated with secondary loss of response.
    36 schema:genre article
    37 schema:inLanguage en
    38 schema:isAccessibleForFree true
    39 schema:isPartOf N04ef35b609f840f6bf924fe4a58c8ca2
    40 N4eea38966614414691522b152ee9d109
    41 sg:journal.1020803
    42 schema:keywords Crohn's disease
    43 account disease manifestations
    44 addition
    45 adults
    46 aim
    47 biologic therapy
    48 bowel disease
    49 burden
    50 cancer
    51 care
    52 chronic inflammatory bowel disease
    53 colitis
    54 colonic involvement
    55 colorectal cancer
    56 considerable disease burden
    57 corticosteroid-free maintenance
    58 corticosteroids
    59 current misconceptions
    60 data
    61 discrete disease
    62 disease
    63 disease burden
    64 disease extent
    65 disease manifestations
    66 disease severity
    67 distal ulcerative colitis
    68 distinction
    69 extensive disease
    70 extent
    71 goal
    72 health-related quality
    73 impact
    74 important therapeutic goal
    75 inflammatory bowel disease
    76 involvement
    77 life
    78 loss
    79 maintenance
    80 management
    81 manifestations
    82 misconceptions
    83 options
    84 patient management
    85 patients
    86 phenotype
    87 prior treatment
    88 proctitis
    89 quality
    90 recent data
    91 remission
    92 response
    93 rise
    94 risk
    95 sand
    96 secondary loss
    97 severe proctitis
    98 severity
    99 similar risk
    100 steroids
    101 substantial impact
    102 symptoms
    103 therapeutic goals
    104 therapy
    105 time
    106 treatment
    107 treatment options
    108 ulcerative colitis
    109 use
    110 use of steroids
    111 valuable treatment option
    112 schema:name Ulcerative Colitis: Shifting Sands
    113 schema:pagination 227-234
    114 schema:productId N11539e451be947a689f2dda3630768eb
    115 N46ecbdfc99dc4cf78103300d37859e38
    116 Nabe3fe61b3634995bc8a8171776422de
    117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112504554
    118 https://doi.org/10.1007/s40268-019-0263-2
    119 schema:sdDatePublished 2021-11-01T18:34
    120 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    121 schema:sdPublisher Ndeebd3c3bafc4300b60c2c9ca3debfb7
    122 schema:url https://doi.org/10.1007/s40268-019-0263-2
    123 sgo:license sg:explorer/license/
    124 sgo:sdDataset articles
    125 rdf:type schema:ScholarlyArticle
    126 N04ef35b609f840f6bf924fe4a58c8ca2 schema:issueNumber 2
    127 rdf:type schema:PublicationIssue
    128 N07573fb928004cd6943f8fa292b006e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Biological Products
    130 rdf:type schema:DefinedTerm
    131 N11539e451be947a689f2dda3630768eb schema:name dimensions_id
    132 schema:value pub.1112504554
    133 rdf:type schema:PropertyValue
    134 N1a52655c86fe427bb4c77f595cc6aecc rdf:first sg:person.010724620101.42
    135 rdf:rest Ne67cebdaf5264556940727c085f10949
    136 N289d86a213124413b56bbb2c9a1c843d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Severity of Illness Index
    138 rdf:type schema:DefinedTerm
    139 N46ecbdfc99dc4cf78103300d37859e38 schema:name doi
    140 schema:value 10.1007/s40268-019-0263-2
    141 rdf:type schema:PropertyValue
    142 N4eea38966614414691522b152ee9d109 schema:volumeNumber 19
    143 rdf:type schema:PublicationVolume
    144 N5c27dbd84b414fe2936c40c92f9f39a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Glucocorticoids
    146 rdf:type schema:DefinedTerm
    147 N695c330eb3394036b0442d5238b26aab rdf:first sg:person.01363347323.34
    148 rdf:rest N9ccd79a3fb2542a0bccbc3a14a010847
    149 N75034e80ae36442fbdd27dfdcf5953d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Treatment Outcome
    151 rdf:type schema:DefinedTerm
    152 N7c43b6ecf97f4a8a918ddbdfd3a1ff94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Drug Resistance
    154 rdf:type schema:DefinedTerm
    155 N92bc9177b7154306aac522a3c947f23b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Practice Guidelines as Topic
    157 rdf:type schema:DefinedTerm
    158 N93f6d79f38984478b2e0efd6449bf472 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Patient Selection
    160 rdf:type schema:DefinedTerm
    161 N9ccd79a3fb2542a0bccbc3a14a010847 rdf:first sg:person.01223143620.01
    162 rdf:rest rdf:nil
    163 Na6019af505ad4447b339f053cbe3eebf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Adult
    165 rdf:type schema:DefinedTerm
    166 Nabe3fe61b3634995bc8a8171776422de schema:name pubmed_id
    167 schema:value 30827006
    168 rdf:type schema:PropertyValue
    169 Nb7742af829404dadac60bf363bfa3e7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Gastroenterology
    171 rdf:type schema:DefinedTerm
    172 Nc96b41a06c4a490b8fc8375d17a0dc37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Colitis, Ulcerative
    174 rdf:type schema:DefinedTerm
    175 Nd240751bbb564eaa934d517077c3b8fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Humans
    177 rdf:type schema:DefinedTerm
    178 Ndd1eff5fb9c946e1821e51898b3413d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Quality of Life
    180 rdf:type schema:DefinedTerm
    181 Nde75d6dfe98a457bbf5328ac76d55249 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Gastrointestinal Agents
    183 rdf:type schema:DefinedTerm
    184 Ndeebd3c3bafc4300b60c2c9ca3debfb7 schema:name Springer Nature - SN SciGraph project
    185 rdf:type schema:Organization
    186 Ne3a1fcd4c73a4a049dfab3d4ea96a18e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Colorectal Neoplasms
    188 rdf:type schema:DefinedTerm
    189 Ne67cebdaf5264556940727c085f10949 rdf:first sg:person.01250100772.34
    190 rdf:rest N695c330eb3394036b0442d5238b26aab
    191 Ned51809bb6cc4a9292637aa5756e5b4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Remission Induction
    193 rdf:type schema:DefinedTerm
    194 Nf10ee99260ec45fe84562bbe97af59bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Disease Progression
    196 rdf:type schema:DefinedTerm
    197 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    198 schema:name Medical and Health Sciences
    199 rdf:type schema:DefinedTerm
    200 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    201 schema:name Oncology and Carcinogenesis
    202 rdf:type schema:DefinedTerm
    203 sg:journal.1020803 schema:issn 1174-5886
    204 1179-6901
    205 schema:name Drugs in R&D
    206 schema:publisher Springer Nature
    207 rdf:type schema:Periodical
    208 sg:person.010724620101.42 schema:affiliation grid-institutes:grid.5650.6
    209 schema:familyName D’Haens
    210 schema:givenName Geert R. A. M.
    211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010724620101.42
    212 rdf:type schema:Person
    213 sg:person.01223143620.01 schema:affiliation grid-institutes:grid.412468.d
    214 schema:familyName Schreiber
    215 schema:givenName Stefan
    216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223143620.01
    217 rdf:type schema:Person
    218 sg:person.01250100772.34 schema:affiliation grid-institutes:grid.4868.2
    219 schema:familyName Lindsay
    220 schema:givenName James O.
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250100772.34
    222 rdf:type schema:Person
    223 sg:person.01363347323.34 schema:affiliation grid-institutes:grid.22072.35
    224 schema:familyName Panaccione
    225 schema:givenName Remo
    226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363347323.34
    227 rdf:type schema:Person
    228 sg:pub.10.1007/s00384-010-0915-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005759511
    229 https://doi.org/10.1007/s00384-010-0915-8
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1007/s00535-016-1283-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015625622
    232 https://doi.org/10.1007/s00535-016-1283-0
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1007/s11894-015-0453-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040440810
    235 https://doi.org/10.1007/s11894-015-0453-1
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1007/s12325-016-0393-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042198121
    238 https://doi.org/10.1007/s12325-016-0393-7
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1007/s12328-016-0686-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1046720684
    241 https://doi.org/10.1007/s12328-016-0686-z
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/ajg.2008.88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040472295
    244 https://doi.org/10.1038/ajg.2008.88
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/ajg.2009.727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021345588
    247 https://doi.org/10.1038/ajg.2009.727
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/ajg.2011.60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031695820
    250 https://doi.org/10.1038/ajg.2011.60
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/ajg.2012.363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002252547
    253 https://doi.org/10.1038/ajg.2012.363
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/nature10209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011250403
    256 https://doi.org/10.1038/nature10209
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/ng.764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052303551
    259 https://doi.org/10.1038/ng.764
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/nrgastro.2015.186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037380629
    262 https://doi.org/10.1038/nrgastro.2015.186
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1186/s12876-015-0239-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008066877
    265 https://doi.org/10.1186/s12876-015-0239-9
    266 rdf:type schema:CreativeWork
    267 grid-institutes:grid.22072.35 schema:alternateName Inflammatory Bowel Disease Clinic, University of Calgary, T6G 2X8, Calgary, AB, Canada
    268 schema:name Inflammatory Bowel Disease Clinic, University of Calgary, T6G 2X8, Calgary, AB, Canada
    269 rdf:type schema:Organization
    270 grid-institutes:grid.412468.d schema:alternateName Klinik für Innere Medizin I, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105, Kiel, Germany
    271 schema:name Klinik für Innere Medizin I, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105, Kiel, Germany
    272 rdf:type schema:Organization
    273 grid-institutes:grid.4868.2 schema:alternateName Centre for Immunology, Blizard Institute, Queen Mary University of London, E1 2AT, London, UK
    274 schema:name Centre for Immunology, Blizard Institute, Queen Mary University of London, E1 2AT, London, UK
    275 Department of Gastroenterology, The Royal London Hospital, Barts Health NHS Trust, E1 1BB, London, UK
    276 rdf:type schema:Organization
    277 grid-institutes:grid.5650.6 schema:alternateName Department of Gastroenterology, Academic Medical Center, Meibergdreef 9, 1100 DZ, Amsterdam, The Netherlands
    278 schema:name Department of Gastroenterology, Academic Medical Center, Meibergdreef 9, 1100 DZ, Amsterdam, The Netherlands
    279 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...