Assessment of Taste and Grittiness of Riomet® ER Strawberry, Riomet® ER Grape, Riomet® Cherry, and Metformin Immediate-Release Tablets in Healthy ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-01-16

AUTHORS

Allyson C. Marshall, Maureen Damstra, Michael Tuley, Elena L. Schifando

ABSTRACT

OBJECTIVE: This study was conducted to evaluate the taste and grittiness of two formulations of Riomet® ER (metformin hydrochloride for extended release [ER] oral suspension 100 mg/mL) differing only in their flavoring agents (strawberry and grape) in comparison with two commercially available immediate-release (IR) formulations of metformin, Riomet® Cherry (metformin hydrochloride oral solution 500 mg/5 mL) and metformin IR tablets (metformin hydrochloride IR tablets 500 mg), in healthy human subjects aged 10-70 years. METHODS: Five comparison sets (i.e., Riomet® Cherry vs. Riomet® ER Strawberry; Riomet® Cherry vs. Riomet® ER Grape; metformin IR vs. Riomet® ER Strawberry; metformin IR vs. Riomet® ER Grape; and Riomet® Cherry vs. metformin IR) were evaluated. Riomet® ER was reconstituted as instructed on the label. Metformin IR tablets were crushed one at a time into a fine powder using a pharmaceutical pill crusher and mixed with 5 mL of water. A 2.5-mL dose of each product was administered to each subject. Subjects were instructed not to swallow any of the products. Each product in the comparison set was rated by the subjects for taste and grittiness according to a 7-point hedonic facial scale and a 5-point level of agreement scale. A comparison questionnaire was also completed by the subjects after evaluating each set. In all, 56 subjects were enrolled and 55 subjects completed the study. The taste preference was statistically evaluated. RESULTS AND CONCLUSIONS: All Riomet® formulations were significantly preferred overall to metformin IR crushed tablets. Both the strawberry and the grape flavors of Riomet® ER tended to be preferred to Riomet® Cherry. More... »

PAGES

57-66

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40268-018-0260-x

DOI

http://dx.doi.org/10.1007/s40268-018-0260-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111442862

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30649711


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0304", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medicinal and Biomolecular Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Oral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemistry, Pharmaceutical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Delayed-Action Preparations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Compounding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flavoring Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypoglycemic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metformin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Taste", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "TKL Research, Inc., One Promenade Boulevard, Suite 1201, Fair Lawn, NJ 07410 USA", 
          "id": "http://www.grid.ac/institutes/grid.478080.3", 
          "name": [
            "TKL Research, Inc., One Promenade Boulevard, Suite 1201, Fair Lawn, NJ 07410 USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marshall", 
        "givenName": "Allyson C.", 
        "id": "sg:person.01052462562.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052462562.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "TKL Research, Inc., One Promenade Boulevard, Suite 1201, Fair Lawn, NJ 07410 USA", 
          "id": "http://www.grid.ac/institutes/grid.478080.3", 
          "name": [
            "TKL Research, Inc., One Promenade Boulevard, Suite 1201, Fair Lawn, NJ 07410 USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Damstra", 
        "givenName": "Maureen", 
        "id": "sg:person.01074654174.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074654174.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "TKL Research, Inc., One Promenade Boulevard, Suite 1201, Fair Lawn, NJ 07410 USA", 
          "id": "http://www.grid.ac/institutes/grid.478080.3", 
          "name": [
            "TKL Research, Inc., One Promenade Boulevard, Suite 1201, Fair Lawn, NJ 07410 USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tuley", 
        "givenName": "Michael", 
        "id": "sg:person.07612461606.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07612461606.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sun Pharmaceuticals Industries, Inc., 2 Independence Way, Princeton, NJ 08540 USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Sun Pharmaceuticals Industries, Inc., 2 Independence Way, Princeton, NJ 08540 USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schifando", 
        "givenName": "Elena L.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s40272-017-0223-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084859832", 
          "https://doi.org/10.1007/s40272-017-0223-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12603-017-0886-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083879238", 
          "https://doi.org/10.1007/s12603-017-0886-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11096-013-9836-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041705771", 
          "https://doi.org/10.1007/s11096-013-9836-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12887-015-0447-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043042919", 
          "https://doi.org/10.1186/s12887-015-0447-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1208/s12248-013-9511-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003107014", 
          "https://doi.org/10.1208/s12248-013-9511-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00228-012-1417-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008592913", 
          "https://doi.org/10.1007/s00228-012-1417-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40268-013-0012-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006916931", 
          "https://doi.org/10.1007/s40268-013-0012-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11096-007-9142-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004938071", 
          "https://doi.org/10.1007/s11096-007-9142-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40265-014-0297-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011438503", 
          "https://doi.org/10.1007/s40265-014-0297-2"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-01-16", 
    "datePublishedReg": "2019-01-16", 
    "description": "OBJECTIVE: This study was conducted to evaluate the taste and grittiness of two formulations of Riomet\u00ae ER (metformin hydrochloride for extended release [ER] oral suspension 100\u00a0mg/mL) differing only in their flavoring agents (strawberry and grape) in comparison with two commercially available immediate-release (IR) formulations of metformin, Riomet\u00ae Cherry (metformin hydrochloride oral solution 500\u00a0mg/5\u00a0mL) and metformin IR tablets (metformin hydrochloride IR tablets 500\u00a0mg), in healthy human subjects aged 10-70\u00a0years.\nMETHODS: Five comparison sets (i.e., Riomet\u00ae Cherry vs. Riomet\u00ae ER Strawberry; Riomet\u00ae Cherry vs. Riomet\u00ae ER Grape; metformin IR vs. Riomet\u00ae ER Strawberry; metformin IR vs. Riomet\u00ae ER Grape; and Riomet\u00ae Cherry vs. metformin IR) were evaluated. Riomet\u00ae ER was reconstituted as instructed on the label. Metformin IR tablets were crushed one at a time into a fine powder using a pharmaceutical pill crusher and mixed with 5\u00a0mL of water. A 2.5-mL dose of each product was administered to each subject. Subjects were instructed not to swallow any of the products. Each product in the comparison set was rated by the subjects for taste and grittiness according to a 7-point hedonic facial scale and a 5-point level of agreement scale. A comparison questionnaire was also completed by the subjects after evaluating each set. In all, 56 subjects were enrolled and 55 subjects completed the study. The taste preference was statistically evaluated.\nRESULTS AND CONCLUSIONS: All Riomet\u00ae formulations were significantly preferred overall to metformin IR crushed tablets. Both the strawberry and the grape flavors of Riomet\u00ae ER tended to be preferred to Riomet\u00ae Cherry.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s40268-018-0260-x", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1020803", 
        "issn": [
          "1174-5886", 
          "1179-6901"
        ], 
        "name": "Drugs in R&D", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "keywords": [
      "IR tablets", 
      "healthy human subjects", 
      "immediate-release formulation", 
      "assessment of taste", 
      "metformin IR", 
      "healthy subjects", 
      "immediate release tablets", 
      "human subjects", 
      "taste preferences", 
      "subjects", 
      "mL of water", 
      "facial scale", 
      "agreement scale", 
      "flavoring agent", 
      "tablets", 
      "metformin", 
      "ER", 
      "grittiness", 
      "dose", 
      "grape flavor", 
      "study", 
      "questionnaire", 
      "conclusion", 
      "mL", 
      "agents", 
      "years", 
      "taste", 
      "assessment", 
      "levels", 
      "comparison sets", 
      "scale", 
      "comparison questionnaire", 
      "time", 
      "comparison", 
      "products", 
      "results", 
      "cherry", 
      "formulation", 
      "strawberry", 
      "preferences", 
      "labels", 
      "grapes", 
      "flavor", 
      "set", 
      "IR", 
      "water", 
      "powder", 
      "fine powder", 
      "crusher", 
      "formulations of Riomet", 
      "Riomet", 
      "available immediate-release (IR) formulations", 
      "metformin IR tablets", 
      "pharmaceutical pill crusher", 
      "pill crusher", 
      "hedonic facial scale", 
      "Grittiness of Riomet", 
      "ER Strawberry", 
      "ER Grape", 
      "Metformin Immediate-Release Tablets"
    ], 
    "name": "Assessment of Taste and Grittiness of Riomet\u00ae ER Strawberry, Riomet\u00ae ER Grape, Riomet\u00ae Cherry, and Metformin Immediate-Release Tablets in Healthy Subjects", 
    "pagination": "57-66", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111442862"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s40268-018-0260-x"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30649711"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s40268-018-0260-x", 
      "https://app.dimensions.ai/details/publication/pub.1111442862"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:43", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_798.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s40268-018-0260-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40268-018-0260-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40268-018-0260-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40268-018-0260-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40268-018-0260-x'


 

This table displays all metadata directly associated to this object as RDF triples.

257 TRIPLES      22 PREDICATES      114 URIs      95 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s40268-018-0260-x schema:about N01cdcdfae51c4321bdf1d426d1b54e0e
2 N10466aaa1f5946cb8f6ef7a57f7a5656
3 N14da5bcf95294f3abcc1ee6736dc7d45
4 N18c6b53e7ffd4f4ba32d101739eac95e
5 N1c80146f24c94c1aad227758492e09d9
6 N3764c1950b9d4abb93add09a3006f3e9
7 N3b65c6c676354fec8f541cb346342d09
8 N4e048eaa94384d1887687c667864485f
9 N68fe255b18cb4f6fab434c830eeb78d2
10 N9c8264679dcd49cf91f8939a164a47ab
11 N9c8816fb89c24fd3933202dbc401207d
12 Na3cba763ae7342e8a10af78200e40f0f
13 Na3d3fb7cee5c4575bb3f3c25b2c13d4e
14 Nd13dc00683274db185c3197956d8a2d3
15 Ne5f54f53c98041958a224867f11d6ed9
16 Ne63e3fb6c4d64f99af097b8b74fb5e1a
17 Nf2ef3d4c63104eabae3fe086716e4961
18 anzsrc-for:03
19 anzsrc-for:0304
20 anzsrc-for:11
21 anzsrc-for:1115
22 schema:author N4e5c93febd1d4c589b82cbddc109fe6c
23 schema:citation sg:pub.10.1007/s00228-012-1417-0
24 sg:pub.10.1007/s11096-007-9142-y
25 sg:pub.10.1007/s11096-013-9836-2
26 sg:pub.10.1007/s12603-017-0886-3
27 sg:pub.10.1007/s40265-014-0297-2
28 sg:pub.10.1007/s40268-013-0012-x
29 sg:pub.10.1007/s40272-017-0223-7
30 sg:pub.10.1186/s12887-015-0447-z
31 sg:pub.10.1208/s12248-013-9511-5
32 schema:datePublished 2019-01-16
33 schema:datePublishedReg 2019-01-16
34 schema:description OBJECTIVE: This study was conducted to evaluate the taste and grittiness of two formulations of Riomet<sup>®</sup> ER (metformin hydrochloride for extended release [ER] oral suspension 100 mg/mL) differing only in their flavoring agents (strawberry and grape) in comparison with two commercially available immediate-release (IR) formulations of metformin, Riomet<sup>®</sup> Cherry (metformin hydrochloride oral solution 500 mg/5 mL) and metformin IR tablets (metformin hydrochloride IR tablets 500 mg), in healthy human subjects aged 10-70 years. METHODS: Five comparison sets (i.e., Riomet<sup>®</sup> Cherry vs. Riomet<sup>®</sup> ER Strawberry; Riomet<sup>®</sup> Cherry vs. Riomet<sup>®</sup> ER Grape; metformin IR vs. Riomet<sup>®</sup> ER Strawberry; metformin IR vs. Riomet<sup>®</sup> ER Grape; and Riomet<sup>®</sup> Cherry vs. metformin IR) were evaluated. Riomet<sup>®</sup> ER was reconstituted as instructed on the label. Metformin IR tablets were crushed one at a time into a fine powder using a pharmaceutical pill crusher and mixed with 5 mL of water. A 2.5-mL dose of each product was administered to each subject. Subjects were instructed not to swallow any of the products. Each product in the comparison set was rated by the subjects for taste and grittiness according to a 7-point hedonic facial scale and a 5-point level of agreement scale. A comparison questionnaire was also completed by the subjects after evaluating each set. In all, 56 subjects were enrolled and 55 subjects completed the study. The taste preference was statistically evaluated. RESULTS AND CONCLUSIONS: All Riomet<sup>®</sup> formulations were significantly preferred overall to metformin IR crushed tablets. Both the strawberry and the grape flavors of Riomet<sup>®</sup> ER tended to be preferred to Riomet<sup>®</sup> Cherry.
35 schema:genre article
36 schema:inLanguage en
37 schema:isAccessibleForFree true
38 schema:isPartOf N330d553efd004fbbb5b49b355baea817
39 N493daba7e7cb47fda9de394203d949a8
40 sg:journal.1020803
41 schema:keywords ER
42 ER Grape
43 ER Strawberry
44 Grittiness of Riomet
45 IR
46 IR tablets
47 Metformin Immediate-Release Tablets
48 Riomet
49 agents
50 agreement scale
51 assessment
52 assessment of taste
53 available immediate-release (IR) formulations
54 cherry
55 comparison
56 comparison questionnaire
57 comparison sets
58 conclusion
59 crusher
60 dose
61 facial scale
62 fine powder
63 flavor
64 flavoring agent
65 formulation
66 formulations of Riomet
67 grape flavor
68 grapes
69 grittiness
70 healthy human subjects
71 healthy subjects
72 hedonic facial scale
73 human subjects
74 immediate release tablets
75 immediate-release formulation
76 labels
77 levels
78 mL
79 mL of water
80 metformin
81 metformin IR
82 metformin IR tablets
83 pharmaceutical pill crusher
84 pill crusher
85 powder
86 preferences
87 products
88 questionnaire
89 results
90 scale
91 set
92 strawberry
93 study
94 subjects
95 tablets
96 taste
97 taste preferences
98 time
99 water
100 years
101 schema:name Assessment of Taste and Grittiness of Riomet® ER Strawberry, Riomet® ER Grape, Riomet® Cherry, and Metformin Immediate-Release Tablets in Healthy Subjects
102 schema:pagination 57-66
103 schema:productId N202659ae396b48fca62d77cf73a47c25
104 N3f950c7ea76b405a83d6de84a50760a1
105 Nda1f4cdad3ee4d928ed6f5a3b65e485f
106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111442862
107 https://doi.org/10.1007/s40268-018-0260-x
108 schema:sdDatePublished 2021-12-01T19:43
109 schema:sdLicense https://scigraph.springernature.com/explorer/license/
110 schema:sdPublisher N02d728040ded439595733ecf9b0de012
111 schema:url https://doi.org/10.1007/s40268-018-0260-x
112 sgo:license sg:explorer/license/
113 sgo:sdDataset articles
114 rdf:type schema:ScholarlyArticle
115 N01cdcdfae51c4321bdf1d426d1b54e0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Flavoring Agents
117 rdf:type schema:DefinedTerm
118 N02d728040ded439595733ecf9b0de012 schema:name Springer Nature - SN SciGraph project
119 rdf:type schema:Organization
120 N10466aaa1f5946cb8f6ef7a57f7a5656 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Aged
122 rdf:type schema:DefinedTerm
123 N14da5bcf95294f3abcc1ee6736dc7d45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Metformin
125 rdf:type schema:DefinedTerm
126 N18c6b53e7ffd4f4ba32d101739eac95e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Drug Compounding
128 rdf:type schema:DefinedTerm
129 N1c80146f24c94c1aad227758492e09d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Young Adult
131 rdf:type schema:DefinedTerm
132 N202659ae396b48fca62d77cf73a47c25 schema:name doi
133 schema:value 10.1007/s40268-018-0260-x
134 rdf:type schema:PropertyValue
135 N330d553efd004fbbb5b49b355baea817 schema:issueNumber 1
136 rdf:type schema:PublicationIssue
137 N3730bfaf5dc742579549d72f6f7316b7 schema:affiliation grid-institutes:None
138 schema:familyName Schifando
139 schema:givenName Elena L.
140 rdf:type schema:Person
141 N3764c1950b9d4abb93add09a3006f3e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Adult
143 rdf:type schema:DefinedTerm
144 N3b65c6c676354fec8f541cb346342d09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Middle Aged
146 rdf:type schema:DefinedTerm
147 N3f950c7ea76b405a83d6de84a50760a1 schema:name dimensions_id
148 schema:value pub.1111442862
149 rdf:type schema:PropertyValue
150 N493daba7e7cb47fda9de394203d949a8 schema:volumeNumber 19
151 rdf:type schema:PublicationVolume
152 N4e048eaa94384d1887687c667864485f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Administration, Oral
154 rdf:type schema:DefinedTerm
155 N4e5c93febd1d4c589b82cbddc109fe6c rdf:first sg:person.01052462562.03
156 rdf:rest Nfa198f0c1e174c2d94ffd45c6b3d4957
157 N68fe255b18cb4f6fab434c830eeb78d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Hypoglycemic Agents
159 rdf:type schema:DefinedTerm
160 N97a108b9129b4870be85c6c5adcbb681 rdf:first N3730bfaf5dc742579549d72f6f7316b7
161 rdf:rest rdf:nil
162 N9c8264679dcd49cf91f8939a164a47ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Humans
164 rdf:type schema:DefinedTerm
165 N9c8816fb89c24fd3933202dbc401207d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Chemistry, Pharmaceutical
167 rdf:type schema:DefinedTerm
168 Na3cba763ae7342e8a10af78200e40f0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Delayed-Action Preparations
170 rdf:type schema:DefinedTerm
171 Na3d3fb7cee5c4575bb3f3c25b2c13d4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Female
173 rdf:type schema:DefinedTerm
174 Nd13dc00683274db185c3197956d8a2d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Adolescent
176 rdf:type schema:DefinedTerm
177 Nda1f4cdad3ee4d928ed6f5a3b65e485f schema:name pubmed_id
178 schema:value 30649711
179 rdf:type schema:PropertyValue
180 Ne56f5dc87fd745378b371ce55b51bae1 rdf:first sg:person.07612461606.78
181 rdf:rest N97a108b9129b4870be85c6c5adcbb681
182 Ne5f54f53c98041958a224867f11d6ed9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Male
184 rdf:type schema:DefinedTerm
185 Ne63e3fb6c4d64f99af097b8b74fb5e1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Child
187 rdf:type schema:DefinedTerm
188 Nf2ef3d4c63104eabae3fe086716e4961 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Taste
190 rdf:type schema:DefinedTerm
191 Nfa198f0c1e174c2d94ffd45c6b3d4957 rdf:first sg:person.01074654174.34
192 rdf:rest Ne56f5dc87fd745378b371ce55b51bae1
193 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
194 schema:name Chemical Sciences
195 rdf:type schema:DefinedTerm
196 anzsrc-for:0304 schema:inDefinedTermSet anzsrc-for:
197 schema:name Medicinal and Biomolecular Chemistry
198 rdf:type schema:DefinedTerm
199 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
200 schema:name Medical and Health Sciences
201 rdf:type schema:DefinedTerm
202 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
203 schema:name Pharmacology and Pharmaceutical Sciences
204 rdf:type schema:DefinedTerm
205 sg:journal.1020803 schema:issn 1174-5886
206 1179-6901
207 schema:name Drugs in R&D
208 schema:publisher Springer Nature
209 rdf:type schema:Periodical
210 sg:person.01052462562.03 schema:affiliation grid-institutes:grid.478080.3
211 schema:familyName Marshall
212 schema:givenName Allyson C.
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052462562.03
214 rdf:type schema:Person
215 sg:person.01074654174.34 schema:affiliation grid-institutes:grid.478080.3
216 schema:familyName Damstra
217 schema:givenName Maureen
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074654174.34
219 rdf:type schema:Person
220 sg:person.07612461606.78 schema:affiliation grid-institutes:grid.478080.3
221 schema:familyName Tuley
222 schema:givenName Michael
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07612461606.78
224 rdf:type schema:Person
225 sg:pub.10.1007/s00228-012-1417-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008592913
226 https://doi.org/10.1007/s00228-012-1417-0
227 rdf:type schema:CreativeWork
228 sg:pub.10.1007/s11096-007-9142-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1004938071
229 https://doi.org/10.1007/s11096-007-9142-y
230 rdf:type schema:CreativeWork
231 sg:pub.10.1007/s11096-013-9836-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041705771
232 https://doi.org/10.1007/s11096-013-9836-2
233 rdf:type schema:CreativeWork
234 sg:pub.10.1007/s12603-017-0886-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083879238
235 https://doi.org/10.1007/s12603-017-0886-3
236 rdf:type schema:CreativeWork
237 sg:pub.10.1007/s40265-014-0297-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011438503
238 https://doi.org/10.1007/s40265-014-0297-2
239 rdf:type schema:CreativeWork
240 sg:pub.10.1007/s40268-013-0012-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006916931
241 https://doi.org/10.1007/s40268-013-0012-x
242 rdf:type schema:CreativeWork
243 sg:pub.10.1007/s40272-017-0223-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084859832
244 https://doi.org/10.1007/s40272-017-0223-7
245 rdf:type schema:CreativeWork
246 sg:pub.10.1186/s12887-015-0447-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1043042919
247 https://doi.org/10.1186/s12887-015-0447-z
248 rdf:type schema:CreativeWork
249 sg:pub.10.1208/s12248-013-9511-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003107014
250 https://doi.org/10.1208/s12248-013-9511-5
251 rdf:type schema:CreativeWork
252 grid-institutes:None schema:alternateName Sun Pharmaceuticals Industries, Inc., 2 Independence Way, Princeton, NJ 08540 USA
253 schema:name Sun Pharmaceuticals Industries, Inc., 2 Independence Way, Princeton, NJ 08540 USA
254 rdf:type schema:Organization
255 grid-institutes:grid.478080.3 schema:alternateName TKL Research, Inc., One Promenade Boulevard, Suite 1201, Fair Lawn, NJ 07410 USA
256 schema:name TKL Research, Inc., One Promenade Boulevard, Suite 1201, Fair Lawn, NJ 07410 USA
257 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...