Solubilization and Stability of Mitomycin C Solutions Prepared for Intravesical Administration View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-06

AUTHORS

Alan L. Myers, Yan-Ping Zhang, Jitesh D. Kawedia, Ximin Zhou, Stacey M. Sobocinski, Michael J. Metcalfe, Mark A. Kramer, Colin P. N. Dinney, Ashish M. Kamat

ABSTRACT

BACKGROUND: Mitomycin C (MMC) is an antitumor agent that is often administered intravesically to treat bladder cancer. Pharmacologically optimized studies have suggested varying methods to optimize delivery, with drug concentration and solution volume being the main drivers. However, these MMC concentrations (e.g. 2.0 mg/mL) supersede its solubility threshold, raising major concerns of inferior drug delivery. OBJECTIVE: In this study, we seek to confirm that the pharmacologically optimized MMC concentrations are achievable in clinical practice through careful modifications of the solution preparation methods. METHODS: MMC admixtures (1.0 and 2.0 mg/mL) were prepared in normal saline using conventional and alternative compounding methods. Conventional methodology resulted in poorly soluble solutions, with many visible particulates and crystallates. However, special compounding methods, which included incubation of solutions at 50 °C for 50 min followed by storage at 37 °C, were sufficient to solubilize drug. Chemical degradation of MMC solutions was determined over 6 h using high-performance liquid chromatography (HPLC) analytics, while physical stability was tested in parallel. RESULTS: Immediately following the 50 min incubation, both MMC solutions exhibited approximately 5-7% drug degradation. Based on the measured concentrations and linear regression of degradation plots, additional storage of these solutions at 37 °C for 5 h retained chemical stability criterion (< 10% overall drug loss). No physical changes were observed in any solutions at any test time points. CONCLUSION: We recommend that the described alternative preparation methods may improve intravesicular delivery of MMC in this urological setting, and advise that clinicians employing these changes should closely monitor patients for MMC toxicities and pharmacodynamics (change in clinical outcomes) that result from the potential enhancement of MMC exposure in the bladder. More... »

PAGES

297-304

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40268-017-0183-y

DOI

http://dx.doi.org/10.1007/s40268-017-0183-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085132322

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28470465


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0303", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Macromolecular and Materials Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Intravesical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Stability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitomycin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pharmaceutical Solutions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Solubility", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Pharmacy Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Myers", 
        "givenName": "Alan L.", 
        "id": "sg:person.01115217223.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115217223.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Pharmacy Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Yan-Ping", 
        "id": "sg:person.0622536036.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622536036.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Pharmacy Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawedia", 
        "givenName": "Jitesh D.", 
        "id": "sg:person.01241243675.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241243675.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Pharmacy Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Ximin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Pharmacy Medication Management and Analytics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sobocinski", 
        "givenName": "Stacey M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Urology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Metcalfe", 
        "givenName": "Michael J.", 
        "id": "sg:person.015333630473.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015333630473.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Pharmacy Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kramer", 
        "givenName": "Mark A.", 
        "id": "sg:person.0660340336.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660340336.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Urology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dinney", 
        "givenName": "Colin P. N.", 
        "id": "sg:person.012610632077.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012610632077.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Urology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kamat", 
        "givenName": "Ashish M.", 
        "id": "sg:person.016172066457.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016172066457.96"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/jnci/93.8.597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001517938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ijg.0000000000000287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002102961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ijg.0000000000000287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002102961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00061198-200202000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002333222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00061198-200202000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002333222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.20.8199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009066055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ju.0000146274.85012.e1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009093859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ju.0000146274.85012.e1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009093859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ju.0000146274.85012.e1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009093859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2011.04.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010324090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(04)82012-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012814966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tca.2012.07.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013362447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrurol.2014.52", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013908411", 
          "https://doi.org/10.1038/nrurol.2014.52"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00345-009-0384-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014761375", 
          "https://doi.org/10.1007/s00345-009-0384-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00345-009-0384-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014761375", 
          "https://doi.org/10.1007/s00345-009-0384-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0731-7085(85)80007-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017068514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1078155213480070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018272575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1078155213480070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018272575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.1g161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020497377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.1g161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020497377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5173(85)90022-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024186084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5173(85)90022-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024186084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(05)70472-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026903761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.0306-5251.2001.01449.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026966903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/iju.12639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028150546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.urolonc.2008.11.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029274002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00686169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029672729", 
          "https://doi.org/10.1007/bf00686169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00686169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029672729", 
          "https://doi.org/10.1007/bf00686169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00061198-199908000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034517699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00061198-199908000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034517699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2012.07.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036903134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpha.2013.09.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037404790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2007.02.063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037409673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-410x.2010.09654.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039804924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(01)67608-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039917404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(01)67608-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039917404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.juro.2015.05.102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041046290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2014.10.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043717691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.1g715", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043728369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.1g715", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043728369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1078155214546564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048368919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1078155214546564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048368919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2006.04.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049145003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2016.01.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052171845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2016.01.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052171845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.01.089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/a483", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070917266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/begleit", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070918606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074533853", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078334877", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082286504", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajhp/38.12.1914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082286504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajhp/38.12.1914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082286504"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-06", 
    "datePublishedReg": "2017-06-01", 
    "description": "BACKGROUND: Mitomycin C (MMC) is an antitumor agent that is often administered intravesically to treat bladder cancer. Pharmacologically optimized studies have suggested varying methods to optimize delivery, with drug concentration and solution volume being the main drivers. However, these MMC concentrations (e.g. 2.0\u00a0mg/mL) supersede its solubility threshold, raising major concerns of inferior drug delivery.\nOBJECTIVE: In this study, we seek to confirm that the pharmacologically optimized MMC concentrations are achievable in clinical practice through careful modifications of the solution preparation methods.\nMETHODS: MMC admixtures (1.0 and 2.0\u00a0mg/mL) were prepared in normal saline using conventional and alternative compounding methods. Conventional methodology resulted in poorly soluble solutions, with many visible particulates and crystallates. However, special compounding methods, which included incubation of solutions at 50\u00a0\u00b0C for 50\u00a0min followed by storage at 37\u00a0\u00b0C, were sufficient to solubilize drug. Chemical degradation of MMC solutions was determined over 6\u00a0h using high-performance liquid chromatography (HPLC) analytics, while physical stability was tested in parallel.\nRESULTS: Immediately following the 50\u00a0min incubation, both MMC solutions exhibited approximately 5-7% drug degradation. Based on the measured concentrations and linear regression of degradation plots, additional storage of these solutions at 37\u00a0\u00b0C for 5\u00a0h retained chemical stability criterion (< 10% overall drug loss). No physical changes were observed in any solutions at any test time points.\nCONCLUSION: We recommend that the described alternative preparation methods may improve intravesicular delivery of MMC in this urological setting, and advise that clinicians employing these changes should closely monitor patients for MMC toxicities and pharmacodynamics (change in clinical outcomes) that result from the potential enhancement of MMC exposure in the bladder.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s40268-017-0183-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1020803", 
        "issn": [
          "1174-5886", 
          "1179-6901"
        ], 
        "name": "Drugs in R&D", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Solubilization and Stability of Mitomycin C Solutions Prepared for Intravesical Administration", 
    "pagination": "297-304", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4cdb67e428badff6547e8a54d64c53d3e55dcde82ed485e4a913c0c80f3b04b4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28470465"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100883647"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s40268-017-0183-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1085132322"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s40268-017-0183-y", 
      "https://app.dimensions.ai/details/publication/pub.1085132322"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89826_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs40268-017-0183-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40268-017-0183-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40268-017-0183-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40268-017-0183-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40268-017-0183-y'


 

This table displays all metadata directly associated to this object as RDF triples.

263 TRIPLES      21 PREDICATES      73 URIs      27 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s40268-017-0183-y schema:about N06ebe964ca664aa2b3f4e81d544a1230
2 N566026423d9349aaa6e4fc2f1e8404e0
3 N7689d15bce794000a76bfa129c93cff2
4 N88a7aaf2ccdf4a378623b4194e2355b7
5 N95204f4a26cd4acc829f013248198baa
6 Nba9d254a5d36477c8c7fd2c6fd45c0af
7 anzsrc-for:03
8 anzsrc-for:0303
9 schema:author Nc50a6df9e9724aaa93cc87ff6606b619
10 schema:citation sg:pub.10.1007/bf00686169
11 sg:pub.10.1007/s00345-009-0384-2
12 sg:pub.10.1038/nrurol.2014.52
13 https://app.dimensions.ai/details/publication/pub.1074533853
14 https://app.dimensions.ai/details/publication/pub.1078334877
15 https://app.dimensions.ai/details/publication/pub.1082286504
16 https://doi.org/10.1016/0378-5173(85)90022-5
17 https://doi.org/10.1016/0731-7085(85)80007-8
18 https://doi.org/10.1016/j.bcp.2006.04.029
19 https://doi.org/10.1016/j.eururo.2007.02.063
20 https://doi.org/10.1016/j.eururo.2011.04.023
21 https://doi.org/10.1016/j.eururo.2012.07.033
22 https://doi.org/10.1016/j.eururo.2014.10.040
23 https://doi.org/10.1016/j.eururo.2016.01.006
24 https://doi.org/10.1016/j.jpha.2013.09.003
25 https://doi.org/10.1016/j.juro.2015.05.102
26 https://doi.org/10.1016/j.tca.2012.07.014
27 https://doi.org/10.1016/j.urolonc.2008.11.019
28 https://doi.org/10.1016/s0022-5347(01)67608-0
29 https://doi.org/10.1016/s0076-6879(04)82012-3
30 https://doi.org/10.1016/s1470-2045(05)70472-1
31 https://doi.org/10.1046/j.0306-5251.2001.01449.x
32 https://doi.org/10.1093/ajhp/38.12.1914
33 https://doi.org/10.1093/jnci/93.8.597
34 https://doi.org/10.1097/00061198-199908000-00005
35 https://doi.org/10.1097/00061198-200202000-00004
36 https://doi.org/10.1097/01.ju.0000146274.85012.e1
37 https://doi.org/10.1097/ijg.0000000000000287
38 https://doi.org/10.1111/iju.12639
39 https://doi.org/10.1111/j.1464-410x.2010.09654.x
40 https://doi.org/10.1177/1078155213480070
41 https://doi.org/10.1177/1078155214546564
42 https://doi.org/10.1200/jco.2003.01.089
43 https://doi.org/10.1200/jco.2008.20.8199
44 https://doi.org/10.1345/aph.1g161
45 https://doi.org/10.1345/aph.1g715
46 https://doi.org/10.2741/a483
47 https://doi.org/10.2741/begleit
48 schema:datePublished 2017-06
49 schema:datePublishedReg 2017-06-01
50 schema:description BACKGROUND: Mitomycin C (MMC) is an antitumor agent that is often administered intravesically to treat bladder cancer. Pharmacologically optimized studies have suggested varying methods to optimize delivery, with drug concentration and solution volume being the main drivers. However, these MMC concentrations (e.g. 2.0 mg/mL) supersede its solubility threshold, raising major concerns of inferior drug delivery. OBJECTIVE: In this study, we seek to confirm that the pharmacologically optimized MMC concentrations are achievable in clinical practice through careful modifications of the solution preparation methods. METHODS: MMC admixtures (1.0 and 2.0 mg/mL) were prepared in normal saline using conventional and alternative compounding methods. Conventional methodology resulted in poorly soluble solutions, with many visible particulates and crystallates. However, special compounding methods, which included incubation of solutions at 50 °C for 50 min followed by storage at 37 °C, were sufficient to solubilize drug. Chemical degradation of MMC solutions was determined over 6 h using high-performance liquid chromatography (HPLC) analytics, while physical stability was tested in parallel. RESULTS: Immediately following the 50 min incubation, both MMC solutions exhibited approximately 5-7% drug degradation. Based on the measured concentrations and linear regression of degradation plots, additional storage of these solutions at 37 °C for 5 h retained chemical stability criterion (< 10% overall drug loss). No physical changes were observed in any solutions at any test time points. CONCLUSION: We recommend that the described alternative preparation methods may improve intravesicular delivery of MMC in this urological setting, and advise that clinicians employing these changes should closely monitor patients for MMC toxicities and pharmacodynamics (change in clinical outcomes) that result from the potential enhancement of MMC exposure in the bladder.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree true
54 schema:isPartOf N0ba39dd18e194baaad677bdc77e454a5
55 Nb148a384161545ceb04e6d21b68027d1
56 sg:journal.1020803
57 schema:name Solubilization and Stability of Mitomycin C Solutions Prepared for Intravesical Administration
58 schema:pagination 297-304
59 schema:productId N1b59b17f947d488692236aa8c24ad69d
60 N9e9020adffb04f368c10329a7490ae60
61 Nb7a9d7e2524545dbad8e9545fb2ec801
62 Nf955fe7da43d49e7aef2374436a3c98e
63 Nfb031d9d5bae40c0bb50cb435dee9cf2
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085132322
65 https://doi.org/10.1007/s40268-017-0183-y
66 schema:sdDatePublished 2019-04-11T10:04
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher Nd9693ef250ff4db89c78d1f94ba744e2
69 schema:url https://link.springer.com/10.1007%2Fs40268-017-0183-y
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N03f4a8d409504b8aa173c8dbec784009 rdf:first N3a4bcd8bf58047eba990e278ebfc6052
74 rdf:rest Nb3afc154ead240acb59a961cdfd0b462
75 N06ebe964ca664aa2b3f4e81d544a1230 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Drug Stability
77 rdf:type schema:DefinedTerm
78 N0ba39dd18e194baaad677bdc77e454a5 schema:issueNumber 2
79 rdf:type schema:PublicationIssue
80 N1b59b17f947d488692236aa8c24ad69d schema:name doi
81 schema:value 10.1007/s40268-017-0183-y
82 rdf:type schema:PropertyValue
83 N281b1cb0b0124dbd8fdcd6875df1ca67 rdf:first Nef5ad91ca8f84912acd018843de5bd81
84 rdf:rest N03f4a8d409504b8aa173c8dbec784009
85 N3a4bcd8bf58047eba990e278ebfc6052 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
86 schema:familyName Sobocinski
87 schema:givenName Stacey M.
88 rdf:type schema:Person
89 N566026423d9349aaa6e4fc2f1e8404e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Mitomycin
91 rdf:type schema:DefinedTerm
92 N5d281272a715434fbb0a477919acac61 rdf:first sg:person.016172066457.96
93 rdf:rest rdf:nil
94 N7689d15bce794000a76bfa129c93cff2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Solubility
96 rdf:type schema:DefinedTerm
97 N88a7aaf2ccdf4a378623b4194e2355b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Administration, Intravesical
99 rdf:type schema:DefinedTerm
100 N8f97cd875c284fe2ac2c1d2b8564caa4 rdf:first sg:person.0622536036.23
101 rdf:rest Na7457da383464cb784dde5e980d7e067
102 N9069cbb3f104434abe38821d5b50eecf rdf:first sg:person.0660340336.16
103 rdf:rest Na2b8aacbd4cc42f8b07efb1a29982dbb
104 N95204f4a26cd4acc829f013248198baa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Pharmaceutical Solutions
106 rdf:type schema:DefinedTerm
107 N9e9020adffb04f368c10329a7490ae60 schema:name dimensions_id
108 schema:value pub.1085132322
109 rdf:type schema:PropertyValue
110 Na2b8aacbd4cc42f8b07efb1a29982dbb rdf:first sg:person.012610632077.22
111 rdf:rest N5d281272a715434fbb0a477919acac61
112 Na7457da383464cb784dde5e980d7e067 rdf:first sg:person.01241243675.57
113 rdf:rest N281b1cb0b0124dbd8fdcd6875df1ca67
114 Nb148a384161545ceb04e6d21b68027d1 schema:volumeNumber 17
115 rdf:type schema:PublicationVolume
116 Nb3afc154ead240acb59a961cdfd0b462 rdf:first sg:person.015333630473.23
117 rdf:rest N9069cbb3f104434abe38821d5b50eecf
118 Nb7a9d7e2524545dbad8e9545fb2ec801 schema:name pubmed_id
119 schema:value 28470465
120 rdf:type schema:PropertyValue
121 Nba9d254a5d36477c8c7fd2c6fd45c0af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Antineoplastic Agents
123 rdf:type schema:DefinedTerm
124 Nc50a6df9e9724aaa93cc87ff6606b619 rdf:first sg:person.01115217223.05
125 rdf:rest N8f97cd875c284fe2ac2c1d2b8564caa4
126 Nd9693ef250ff4db89c78d1f94ba744e2 schema:name Springer Nature - SN SciGraph project
127 rdf:type schema:Organization
128 Nef5ad91ca8f84912acd018843de5bd81 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
129 schema:familyName Zhou
130 schema:givenName Ximin
131 rdf:type schema:Person
132 Nf955fe7da43d49e7aef2374436a3c98e schema:name nlm_unique_id
133 schema:value 100883647
134 rdf:type schema:PropertyValue
135 Nfb031d9d5bae40c0bb50cb435dee9cf2 schema:name readcube_id
136 schema:value 4cdb67e428badff6547e8a54d64c53d3e55dcde82ed485e4a913c0c80f3b04b4
137 rdf:type schema:PropertyValue
138 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
139 schema:name Chemical Sciences
140 rdf:type schema:DefinedTerm
141 anzsrc-for:0303 schema:inDefinedTermSet anzsrc-for:
142 schema:name Macromolecular and Materials Chemistry
143 rdf:type schema:DefinedTerm
144 sg:journal.1020803 schema:issn 1174-5886
145 1179-6901
146 schema:name Drugs in R&D
147 rdf:type schema:Periodical
148 sg:person.01115217223.05 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
149 schema:familyName Myers
150 schema:givenName Alan L.
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115217223.05
152 rdf:type schema:Person
153 sg:person.01241243675.57 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
154 schema:familyName Kawedia
155 schema:givenName Jitesh D.
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241243675.57
157 rdf:type schema:Person
158 sg:person.012610632077.22 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
159 schema:familyName Dinney
160 schema:givenName Colin P. N.
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012610632077.22
162 rdf:type schema:Person
163 sg:person.015333630473.23 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
164 schema:familyName Metcalfe
165 schema:givenName Michael J.
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015333630473.23
167 rdf:type schema:Person
168 sg:person.016172066457.96 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
169 schema:familyName Kamat
170 schema:givenName Ashish M.
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016172066457.96
172 rdf:type schema:Person
173 sg:person.0622536036.23 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
174 schema:familyName Zhang
175 schema:givenName Yan-Ping
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622536036.23
177 rdf:type schema:Person
178 sg:person.0660340336.16 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
179 schema:familyName Kramer
180 schema:givenName Mark A.
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660340336.16
182 rdf:type schema:Person
183 sg:pub.10.1007/bf00686169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029672729
184 https://doi.org/10.1007/bf00686169
185 rdf:type schema:CreativeWork
186 sg:pub.10.1007/s00345-009-0384-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014761375
187 https://doi.org/10.1007/s00345-009-0384-2
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/nrurol.2014.52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013908411
190 https://doi.org/10.1038/nrurol.2014.52
191 rdf:type schema:CreativeWork
192 https://app.dimensions.ai/details/publication/pub.1074533853 schema:CreativeWork
193 https://app.dimensions.ai/details/publication/pub.1078334877 schema:CreativeWork
194 https://app.dimensions.ai/details/publication/pub.1082286504 schema:CreativeWork
195 https://doi.org/10.1016/0378-5173(85)90022-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024186084
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/0731-7085(85)80007-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017068514
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/j.bcp.2006.04.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049145003
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.eururo.2007.02.063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037409673
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.eururo.2011.04.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010324090
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.eururo.2012.07.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036903134
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.eururo.2014.10.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043717691
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.eururo.2016.01.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052171845
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.jpha.2013.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037404790
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.juro.2015.05.102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041046290
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.tca.2012.07.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013362447
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.urolonc.2008.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029274002
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/s0022-5347(01)67608-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039917404
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/s0076-6879(04)82012-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012814966
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/s1470-2045(05)70472-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026903761
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1046/j.0306-5251.2001.01449.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026966903
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1093/ajhp/38.12.1914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082286504
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1093/jnci/93.8.597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001517938
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1097/00061198-199908000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034517699
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1097/00061198-200202000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002333222
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1097/01.ju.0000146274.85012.e1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009093859
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1097/ijg.0000000000000287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002102961
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1111/iju.12639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028150546
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1111/j.1464-410x.2010.09654.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039804924
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1177/1078155213480070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018272575
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1177/1078155214546564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048368919
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1200/jco.2003.01.089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203281
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1200/jco.2008.20.8199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009066055
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1345/aph.1g161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020497377
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1345/aph.1g715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043728369
254 rdf:type schema:CreativeWork
255 https://doi.org/10.2741/a483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070917266
256 rdf:type schema:CreativeWork
257 https://doi.org/10.2741/begleit schema:sameAs https://app.dimensions.ai/details/publication/pub.1070918606
258 rdf:type schema:CreativeWork
259 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
260 schema:name Department of Pharmacy Medication Management and Analytics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA
261 Department of Pharmacy Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA
262 Department of Urology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, TX, USA
263 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...