Angiotensin-Converting Enzyme Inhibitor Use and Incident Frailty: A Longitudinal Cohort Study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Nicola Veronese, Brendon Stubbs, Lee Smith, Stefania Maggi, Sarah E. Jackson, Pinar Soysal, Jacopo Demurtas, Stefano Celotto, Ai Koyanagi

ABSTRACT

INTRODUCTION: Angiotensin-converting enzyme inhibitors (ACEI) may have several pleiotropic effects, but the literature regarding a possible relationship between ACEI use and frailty is limited. We investigated whether ACEI use is associated with lower risk of frailty in a cohort of North American individuals. METHODS: Data from the Osteoarthritis Initiative, a cohort study with 8 years of follow-up including community-dwelling adults with knee osteoarthritis or at high risk for this condition, were analyzed. ACEI use was defined through self-reported information and confirmed by a trained interviewer. Frailty was defined using the Study of Osteoporotic Fracture (SOF) index as the presence of at least two of the following criteria: (1) weight loss ≥ 5% between baseline and any subsequent follow-up visit; (2) inability to do five chair stands; and (3) low energy level according to the SOF definition. A multivariable Poisson regression analysis was used to assess the association between ACEI use at baseline and incident frailty. The data were reported as relative risks (RRs) with their 95% confidence intervals (CIs). RESULTS: The final sample consisted of 4295 adults (mean age 61.2 years, females 58.1%). At baseline, 551 participants (12.8%) used ACEI. After adjusting for 15 potential confounders, the use of ACEI was associated with a lower risk of frailty (RR 0.72; 95% CI 0.53-0.99). The adjustment for the propensity score substantially confirmed these findings (RR 0.75; 95% CI 0.54-0.996). CONCLUSION: ACEI use may be associated with a reduced risk of frailty in individuals with/at risk of knee osteoarthritis, suggesting a potential role for ACI in the prevention of frailty. More... »

PAGES

387-393

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40266-019-00642-3

DOI

http://dx.doi.org/10.1007/s40266-019-00642-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112023671

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30737759


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Research Council", 
          "id": "https://www.grid.ac/institutes/grid.5326.2", 
          "name": [
            "National Research Council, Neuroscience Institute, Aging Branch, Via Giustiniani, 2, 35128, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Veronese", 
        "givenName": "Nicola", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Anglia Ruskin University", 
          "id": "https://www.grid.ac/institutes/grid.5115.0", 
          "name": [
            "Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, SE5 8AZ, London, UK", 
            "Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, De Crespigny Park, SE5 8AF, London, UK", 
            "Faculty of Health, Social Care and Education, Anglia Ruskin University, Bishop Hall Lane, CM1 1SQ, Chelmsford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stubbs", 
        "givenName": "Brendon", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Anglia Ruskin University", 
          "id": "https://www.grid.ac/institutes/grid.5115.0", 
          "name": [
            "The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smith", 
        "givenName": "Lee", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Research Council", 
          "id": "https://www.grid.ac/institutes/grid.5326.2", 
          "name": [
            "National Research Council, Neuroscience Institute, Aging Branch, Via Giustiniani, 2, 35128, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maggi", 
        "givenName": "Stefania", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Behavioural Science and Health, University College London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jackson", 
        "givenName": "Sarah E.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bezmi\u00e2lem Vak\u0131f \u00dcniversitesi", 
          "id": "https://www.grid.ac/institutes/grid.411675.0", 
          "name": [
            "Department of Geriatric Medicine, Faculty of Medicine, Bezmialem\u00a0Vakif University, Istanbul, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soysal", 
        "givenName": "Pinar", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Primary Care Department, Azienda USL Toscana Sud Est, Grosseto, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Demurtas", 
        "givenName": "Jacopo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Primary Care Department, Aziendale AAS3 Alto Friuli, Collinare, Medio Friuli, Udine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Celotto", 
        "givenName": "Stefano", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental", 
          "id": "https://www.grid.ac/institutes/grid.469673.9", 
          "name": [
            "Research and Development Unit, Parc Sanitari Sant Joan de D\u00e9u, Universitat de Barcelona, Fundaci\u00f3 Sant Joan de D\u00e9u, Barcelona, Spain", 
            "Instituto de Salud Carlos III, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental, CIBERSAM, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koyanagi", 
        "givenName": "Ai", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/obr.12309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005091534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.maturitas.2016.11.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005946762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arr.2016.08.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006171403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/gerona/glu102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006827588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/0882-7974.12.2.277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008773981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1503/cmaj.061339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009458189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1503/cmaj.061339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009458189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7793.1999.0189o.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011343724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bor.0000000000000161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024334039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bor.0000000000000161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024334039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199512213332503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025734830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/heart.88.4.373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027105176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1532-5415.2012.04054.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027386767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.97.14.1411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030415795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa011489", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032755890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mehy.2006.01.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033739280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2015.13480", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039189193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1532-5415.2008.02121.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042161067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1503/cmaj.071062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046317446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1503/cmaj.071062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046317446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(02)08024-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047242419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmcc.1998.0806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047915772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00223-013-9758-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048551593", 
          "https://doi.org/10.1007/s00223-013-9758-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4081/ejtm.2015.5227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049523028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/gerona/59.6.m590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050030675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jamda.2015.06.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051573122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)62167-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051639531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0111952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052062512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0895-4356(99)00049-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052776345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005650-199601000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060223205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005650-199603000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060223218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arr.2017.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074244586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.2001.81.1.209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074749389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.1993.265.1.c15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082763762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jamda.2017.02.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084527530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/nu9111253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092709583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bcp.13590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101754286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bcp.13590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101754286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bcp.13590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101754286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exger.2018.04.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103795005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/acr.23735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106333583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/acr.23735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106333583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jad.2018.09.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107040014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jad.2018.09.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107040014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jad.2018.09.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107040014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.k4209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107820715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.k4209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107820715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.k4209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107820715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.k4209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107820715"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04", 
    "datePublishedReg": "2019-04-01", 
    "description": "INTRODUCTION: Angiotensin-converting enzyme inhibitors (ACEI) may have several pleiotropic effects, but the literature regarding a possible relationship between ACEI use and frailty is limited. We investigated whether ACEI use is associated with lower risk of frailty in a cohort of North American individuals.\nMETHODS: Data from the Osteoarthritis Initiative, a cohort study with 8\u00a0years of follow-up including community-dwelling adults with knee osteoarthritis or at high risk for this condition, were analyzed. ACEI use was defined through self-reported information and confirmed by a trained interviewer. Frailty was defined using the Study of Osteoporotic Fracture (SOF) index as the presence of at least two of the following criteria: (1) weight loss \u2265\u20095% between baseline and any subsequent follow-up visit; (2) inability to do five chair stands; and (3) low energy level according to the SOF definition. A multivariable Poisson regression analysis was used to assess the association between ACEI use at baseline and incident frailty. The data were reported as relative risks (RRs) with their 95% confidence intervals (CIs).\nRESULTS: The final sample consisted of 4295 adults (mean age 61.2\u00a0years, females 58.1%). At baseline, 551 participants (12.8%) used ACEI. After adjusting for 15 potential confounders, the use of ACEI was associated with a lower risk of frailty (RR 0.72; 95% CI 0.53-0.99). The adjustment for the propensity score substantially confirmed these findings (RR 0.75; 95% CI 0.54-0.996).\nCONCLUSION: ACEI use may be associated with a reduced risk of frailty in individuals with/at risk of knee osteoarthritis, suggesting a potential role for ACI in the prevention of frailty.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s40266-019-00642-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1100990", 
        "issn": [
          "1170-229X", 
          "1179-1969"
        ], 
        "name": "Drugs & Aging", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "36"
      }
    ], 
    "name": "Angiotensin-Converting Enzyme Inhibitor Use and Incident Frailty: A Longitudinal Cohort Study", 
    "pagination": "387-393", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9c3d986a8c103667165476f60fc962af78fd0314151fa113df100780c704d7db"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30737759"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9102074"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s40266-019-00642-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112023671"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s40266-019-00642-3", 
      "https://app.dimensions.ai/details/publication/pub.1112023671"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78934_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs40266-019-00642-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40266-019-00642-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40266-019-00642-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40266-019-00642-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40266-019-00642-3'


 

This table displays all metadata directly associated to this object as RDF triples.

251 TRIPLES      21 PREDICATES      67 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s40266-019-00642-3 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N8c6aea747d5347c6b473af6a9b1bd340
4 schema:citation sg:pub.10.1007/s00223-013-9758-y
5 https://doi.org/10.1001/jama.2015.13480
6 https://doi.org/10.1002/acr.23735
7 https://doi.org/10.1006/jmcc.1998.0806
8 https://doi.org/10.1016/j.arr.2016.08.006
9 https://doi.org/10.1016/j.arr.2017.01.003
10 https://doi.org/10.1016/j.exger.2018.04.023
11 https://doi.org/10.1016/j.jad.2018.09.036
12 https://doi.org/10.1016/j.jamda.2015.06.025
13 https://doi.org/10.1016/j.jamda.2017.02.009
14 https://doi.org/10.1016/j.maturitas.2016.11.006
15 https://doi.org/10.1016/j.mehy.2006.01.047
16 https://doi.org/10.1016/s0140-6736(02)08024-8
17 https://doi.org/10.1016/s0140-6736(12)62167-9
18 https://doi.org/10.1016/s0895-4356(99)00049-9
19 https://doi.org/10.1037/0882-7974.12.2.277
20 https://doi.org/10.1056/nejm199512213332503
21 https://doi.org/10.1056/nejmoa011489
22 https://doi.org/10.1093/gerona/59.6.m590
23 https://doi.org/10.1093/gerona/glu102
24 https://doi.org/10.1097/00005650-199601000-00006
25 https://doi.org/10.1097/00005650-199603000-00003
26 https://doi.org/10.1097/bor.0000000000000161
27 https://doi.org/10.1111/bcp.13590
28 https://doi.org/10.1111/j.1469-7793.1999.0189o.x
29 https://doi.org/10.1111/j.1532-5415.2008.02121.x
30 https://doi.org/10.1111/j.1532-5415.2012.04054.x
31 https://doi.org/10.1111/obr.12309
32 https://doi.org/10.1136/bmj.k4209
33 https://doi.org/10.1136/heart.88.4.373
34 https://doi.org/10.1152/ajpcell.1993.265.1.c15
35 https://doi.org/10.1152/physrev.2001.81.1.209
36 https://doi.org/10.1161/01.cir.97.14.1411
37 https://doi.org/10.1371/journal.pone.0111952
38 https://doi.org/10.1503/cmaj.061339
39 https://doi.org/10.1503/cmaj.071062
40 https://doi.org/10.3390/nu9111253
41 https://doi.org/10.4081/ejtm.2015.5227
42 schema:datePublished 2019-04
43 schema:datePublishedReg 2019-04-01
44 schema:description INTRODUCTION: Angiotensin-converting enzyme inhibitors (ACEI) may have several pleiotropic effects, but the literature regarding a possible relationship between ACEI use and frailty is limited. We investigated whether ACEI use is associated with lower risk of frailty in a cohort of North American individuals. METHODS: Data from the Osteoarthritis Initiative, a cohort study with 8 years of follow-up including community-dwelling adults with knee osteoarthritis or at high risk for this condition, were analyzed. ACEI use was defined through self-reported information and confirmed by a trained interviewer. Frailty was defined using the Study of Osteoporotic Fracture (SOF) index as the presence of at least two of the following criteria: (1) weight loss ≥ 5% between baseline and any subsequent follow-up visit; (2) inability to do five chair stands; and (3) low energy level according to the SOF definition. A multivariable Poisson regression analysis was used to assess the association between ACEI use at baseline and incident frailty. The data were reported as relative risks (RRs) with their 95% confidence intervals (CIs). RESULTS: The final sample consisted of 4295 adults (mean age 61.2 years, females 58.1%). At baseline, 551 participants (12.8%) used ACEI. After adjusting for 15 potential confounders, the use of ACEI was associated with a lower risk of frailty (RR 0.72; 95% CI 0.53-0.99). The adjustment for the propensity score substantially confirmed these findings (RR 0.75; 95% CI 0.54-0.996). CONCLUSION: ACEI use may be associated with a reduced risk of frailty in individuals with/at risk of knee osteoarthritis, suggesting a potential role for ACI in the prevention of frailty.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree false
48 schema:isPartOf N884c5263c79a41f8a1f5374bb5936f96
49 Nb658e214cd204180baff7a9009beca3b
50 sg:journal.1100990
51 schema:name Angiotensin-Converting Enzyme Inhibitor Use and Incident Frailty: A Longitudinal Cohort Study
52 schema:pagination 387-393
53 schema:productId N16d6db94d0a34c44af2f36e6706417c3
54 N24d268dc8b6c4eeebd25b9ebd6bf53e4
55 N83419e32d9434cd3b577ce48942fa2d0
56 N9b7af57610304bf98152f7dfde70c688
57 Ncf2bc83bcd8a4cad9b61280189a7e3c6
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112023671
59 https://doi.org/10.1007/s40266-019-00642-3
60 schema:sdDatePublished 2019-04-11T13:17
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N7a0518a343dc427fb8ab478424a37b1e
63 schema:url https://link.springer.com/10.1007%2Fs40266-019-00642-3
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N03279c8059ff4d74adfd6a26c3d478f3 rdf:first N0ef1139b70fe428199d2a3c749acaf5b
68 rdf:rest N54114ae835794fe8b491ab620df496cb
69 N075f1ad4f6ed48ef834389b6eddd8acf schema:affiliation https://www.grid.ac/institutes/grid.5326.2
70 schema:familyName Veronese
71 schema:givenName Nicola
72 rdf:type schema:Person
73 N0ef1139b70fe428199d2a3c749acaf5b schema:affiliation https://www.grid.ac/institutes/grid.5326.2
74 schema:familyName Maggi
75 schema:givenName Stefania
76 rdf:type schema:Person
77 N16d6db94d0a34c44af2f36e6706417c3 schema:name readcube_id
78 schema:value 9c3d986a8c103667165476f60fc962af78fd0314151fa113df100780c704d7db
79 rdf:type schema:PropertyValue
80 N24b8e011d85e4ed18df8a91d3ed282a0 rdf:first Nc5c128de48e9401ba3bbb5df786b8c06
81 rdf:rest N95f7387b5da74ac89b3c9d14d87ac007
82 N24d268dc8b6c4eeebd25b9ebd6bf53e4 schema:name dimensions_id
83 schema:value pub.1112023671
84 rdf:type schema:PropertyValue
85 N254f62f724754db099683371b3f9d282 rdf:first N79eb008e6301478b8da72d78a92d91b8
86 rdf:rest N8f5207411989401387a2b334d05f2ac1
87 N3ac7f5ded0b440399e9f631075be8b62 schema:affiliation https://www.grid.ac/institutes/grid.5115.0
88 schema:familyName Stubbs
89 schema:givenName Brendon
90 rdf:type schema:Person
91 N54114ae835794fe8b491ab620df496cb rdf:first N65d70aa4260b46cda8975aee34a54f7b
92 rdf:rest N24b8e011d85e4ed18df8a91d3ed282a0
93 N555788b18f7b40169206c32c4d582c04 rdf:first Nbfbd2e336d18492183c76ed3cd0f807b
94 rdf:rest N03279c8059ff4d74adfd6a26c3d478f3
95 N65d70aa4260b46cda8975aee34a54f7b schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
96 schema:familyName Jackson
97 schema:givenName Sarah E.
98 rdf:type schema:Person
99 N79eb008e6301478b8da72d78a92d91b8 schema:affiliation Na736b8a7d59044f39914be333af2e76c
100 schema:familyName Celotto
101 schema:givenName Stefano
102 rdf:type schema:Person
103 N7a0518a343dc427fb8ab478424a37b1e schema:name Springer Nature - SN SciGraph project
104 rdf:type schema:Organization
105 N82f00c32e6884b62b60510faab0b98bb schema:name Primary Care Department, Azienda USL Toscana Sud Est, Grosseto, Italy
106 rdf:type schema:Organization
107 N83419e32d9434cd3b577ce48942fa2d0 schema:name nlm_unique_id
108 schema:value 9102074
109 rdf:type schema:PropertyValue
110 N884c5263c79a41f8a1f5374bb5936f96 schema:volumeNumber 36
111 rdf:type schema:PublicationVolume
112 N8c6aea747d5347c6b473af6a9b1bd340 rdf:first N075f1ad4f6ed48ef834389b6eddd8acf
113 rdf:rest Nebe54df08840413ca5b0c071d2b69c73
114 N8dcbd12027f8416e89f63644d82810dc schema:affiliation N82f00c32e6884b62b60510faab0b98bb
115 schema:familyName Demurtas
116 schema:givenName Jacopo
117 rdf:type schema:Person
118 N8f5207411989401387a2b334d05f2ac1 rdf:first Nc31b4d5975ef45d1bacc1ed165e24471
119 rdf:rest rdf:nil
120 N95f7387b5da74ac89b3c9d14d87ac007 rdf:first N8dcbd12027f8416e89f63644d82810dc
121 rdf:rest N254f62f724754db099683371b3f9d282
122 N9b7af57610304bf98152f7dfde70c688 schema:name pubmed_id
123 schema:value 30737759
124 rdf:type schema:PropertyValue
125 Na736b8a7d59044f39914be333af2e76c schema:name Primary Care Department, Aziendale AAS3 Alto Friuli, Collinare, Medio Friuli, Udine, Italy
126 rdf:type schema:Organization
127 Nb658e214cd204180baff7a9009beca3b schema:issueNumber 4
128 rdf:type schema:PublicationIssue
129 Nbfbd2e336d18492183c76ed3cd0f807b schema:affiliation https://www.grid.ac/institutes/grid.5115.0
130 schema:familyName Smith
131 schema:givenName Lee
132 rdf:type schema:Person
133 Nc31b4d5975ef45d1bacc1ed165e24471 schema:affiliation https://www.grid.ac/institutes/grid.469673.9
134 schema:familyName Koyanagi
135 schema:givenName Ai
136 rdf:type schema:Person
137 Nc5c128de48e9401ba3bbb5df786b8c06 schema:affiliation https://www.grid.ac/institutes/grid.411675.0
138 schema:familyName Soysal
139 schema:givenName Pinar
140 rdf:type schema:Person
141 Ncf2bc83bcd8a4cad9b61280189a7e3c6 schema:name doi
142 schema:value 10.1007/s40266-019-00642-3
143 rdf:type schema:PropertyValue
144 Nebe54df08840413ca5b0c071d2b69c73 rdf:first N3ac7f5ded0b440399e9f631075be8b62
145 rdf:rest N555788b18f7b40169206c32c4d582c04
146 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
147 schema:name Medical and Health Sciences
148 rdf:type schema:DefinedTerm
149 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
150 schema:name Clinical Sciences
151 rdf:type schema:DefinedTerm
152 sg:journal.1100990 schema:issn 1170-229X
153 1179-1969
154 schema:name Drugs & Aging
155 rdf:type schema:Periodical
156 sg:pub.10.1007/s00223-013-9758-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1048551593
157 https://doi.org/10.1007/s00223-013-9758-y
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1001/jama.2015.13480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039189193
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1002/acr.23735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106333583
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1006/jmcc.1998.0806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047915772
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1016/j.arr.2016.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006171403
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1016/j.arr.2017.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074244586
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1016/j.exger.2018.04.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103795005
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/j.jad.2018.09.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107040014
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1016/j.jamda.2015.06.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051573122
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/j.jamda.2017.02.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084527530
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/j.maturitas.2016.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005946762
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/j.mehy.2006.01.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033739280
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/s0140-6736(02)08024-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047242419
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/s0140-6736(12)62167-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051639531
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/s0895-4356(99)00049-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052776345
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1037/0882-7974.12.2.277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008773981
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1056/nejm199512213332503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025734830
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1056/nejmoa011489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032755890
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1093/gerona/59.6.m590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050030675
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1093/gerona/glu102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006827588
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1097/00005650-199601000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060223205
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1097/00005650-199603000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060223218
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1097/bor.0000000000000161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024334039
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1111/bcp.13590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101754286
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1111/j.1469-7793.1999.0189o.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011343724
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1111/j.1532-5415.2008.02121.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042161067
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1111/j.1532-5415.2012.04054.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027386767
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1111/obr.12309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005091534
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1136/bmj.k4209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107820715
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1136/heart.88.4.373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027105176
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1152/ajpcell.1993.265.1.c15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082763762
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1152/physrev.2001.81.1.209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074749389
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1161/01.cir.97.14.1411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030415795
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1371/journal.pone.0111952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052062512
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1503/cmaj.061339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009458189
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1503/cmaj.071062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046317446
228 rdf:type schema:CreativeWork
229 https://doi.org/10.3390/nu9111253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092709583
230 rdf:type schema:CreativeWork
231 https://doi.org/10.4081/ejtm.2015.5227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049523028
232 rdf:type schema:CreativeWork
233 https://www.grid.ac/institutes/grid.411675.0 schema:alternateName Bezmiâlem Vakıf Üniversitesi
234 schema:name Department of Geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
235 rdf:type schema:Organization
236 https://www.grid.ac/institutes/grid.469673.9 schema:alternateName Centro de Investigación Biomédica en Red de Salud Mental
237 schema:name Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain
238 Research and Development Unit, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, Barcelona, Spain
239 rdf:type schema:Organization
240 https://www.grid.ac/institutes/grid.5115.0 schema:alternateName Anglia Ruskin University
241 schema:name Faculty of Health, Social Care and Education, Anglia Ruskin University, Bishop Hall Lane, CM1 1SQ, Chelmsford, UK
242 Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, De Crespigny Park, SE5 8AF, London, UK
243 Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, SE5 8AZ, London, UK
244 The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UK
245 rdf:type schema:Organization
246 https://www.grid.ac/institutes/grid.5326.2 schema:alternateName National Research Council
247 schema:name National Research Council, Neuroscience Institute, Aging Branch, Via Giustiniani, 2, 35128, Padua, Italy
248 rdf:type schema:Organization
249 https://www.grid.ac/institutes/grid.83440.3b schema:alternateName University College London
250 schema:name Department of Behavioural Science and Health, University College London, London, UK
251 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...