Drug-Induced Kidney Injury in the Elderly View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-10

AUTHORS

Sana Khan, Valentina Loi, Mitchell H. Rosner

ABSTRACT

The incidence of acute kidney injury in the elderly has grown over the past decade. One of the primary drivers is drug-induced nephrotoxicity, which is the result of a combination of the unique susceptibilities to kidney injury and the increased use of medications in the elderly population. Specific drug classes are associated with increased rates of kidney injury including agents that block the renin angiotensin system, antimicrobials, and chemotherapeutic agents. Mechanistically, injury may be due to hemodynamic effects, tubular or glomerular toxicity, and interstitial nephritis. Early recognition of nephrotoxicity is critical, as are preventative steps when applicable. Unfortunately, treatment for established drug-induced kidney injury is limited and supportive care is required. Limiting exposure to nephrotoxic drugs is critical in decreasing the incidence of acute kidney injury in the elderly patient. More... »

PAGES

729-741

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40266-017-0484-4

    DOI

    http://dx.doi.org/10.1007/s40266-017-0484-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091222437

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28815461


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