Quality of Life After Off-Label Thrombolysis for Ischemic Stroke in Elderly Patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-10-07

AUTHORS

Capucine Diard-Detoeuf, Séverine Debiais, Mélanie Imbert, Alexandra Musikas, Marie Gaudron, Emeline Laurent, Bertrand De Toffol, Caroline Hommet, Karl Mondon

ABSTRACT

IntroductionThe use of intravenous thrombolysis with alteplase for ischemic stroke in Europe is restricted to subjects aged <80 years. Recent studies have reported the efficacy and safety of alteplase in older patients. However, data concerning the quality of life (QOL) of these elderly subjects are sparse.ObjectivesThe aim of this study was to compare the QOL of patients aged ≥80 years with that of patients aged <80 years at 3 months after thrombolysis.MethodThis was a prospective study comprising French-speaking patients aged >18 years treated using thrombolytic therapy for ischemic stroke at the Hospital of Tours (Tours, France) between June 2012 and January 2013. QOL was assessed using the Stroke Impact Scale (SIS). The presence of mood disorders or cognitive impairments was also assessed.ResultsQOL was evaluated for 62 subjects among the 83 enrolled patients who received thrombolytic treatment; 21 patients were aged >80 years. Concerning scores on the SIS, using a multivariate analysis, only the memory and thinking score was significantly and negatively associated with the elderly population [odds ratio (OR) 0.036, 95 % confidence interval (CI) 0.004–0.339; p = 0.004]. No significant difference was observed among all the other QOL scores. Neurological recovery and functional status did not differ between the two groups.ConclusionQOL after intravenous thrombolysis in the elderly population was comparable to that of younger subjects. Despite its small sample size, this study showed promising results in favor of intravenous thrombolysis in the elderly population and highlighted the importance of systematic screening for post-stroke cognitive impairment, particularly in this population. More... »

PAGES

917-926

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40266-015-0307-4

DOI

http://dx.doi.org/10.1007/s40266-015-0307-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041455368

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26446151


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