Safety and Tolerability of c-MET Inhibitors in Cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Alberto Puccini, Nagore I. Marín-Ramos, Francesca Bergamo, Marta Schirripa, Sara Lonardi, Heinz-Josef Lenz, Fotios Loupakis, Francesca Battaglin

ABSTRACT

The role of aberrant hepatocyte growth factor receptor (c-MET, also known as tyrosine-protein kinase MET)/hepatocyte growth factor (HGF) signaling in cancer progression and invasion has been extensively studied. c-MET inhibitors have shown promising pre-clinical and early phase clinical trial anti-tumor activity in several tumor types, although results of most phase III trials with these agents have been negative. To date, two small molecule c-MET inhibitors, cabozantinib and crizotinib, have been approved by regulatory authorities for the treatment of selected cancer types, but several novel c-MET inhibitors (either monoclonal antibodies or small molecule c-MET tyrosine kinase inhibitors) and treatment combinations are currently under study in different settings. Here we provide an overview of the mechanism of action and rationale of c-MET inhibition in cancer, the efficacy of approved agents, and novel promising c-MET-inhibitors and novel targeted combination strategies under development in different cancer types, with a focus on the safety profile and tolerability of these compounds. More... »

PAGES

211-233

References to SciGraph publications

  • 2019-04. Clinical Pharmacokinetics of Anaplastic Lymphoma Kinase Inhibitors in Non-Small-Cell Lung Cancer in CLINICAL PHARMACOKINETICS
  • 2017-12. Therapeutic potential of TAS-115 via c-MET and PDGFRα signal inhibition for synovial sarcoma in BMC CANCER
  • 2017-12. Norcantharidin Inhibits cell growth by suppressing the expression and phosphorylation of both EGFR and c-Met in human colon cancer cells in BMC CANCER
  • 2017-04. Effects of Renal Function on Crizotinib Pharmacokinetics: Dose Recommendations for Patients with ALK-Positive Non-Small Cell Lung Cancer in CLINICAL DRUG INVESTIGATION
  • 2017-05. A phase Ib/II study of cabozantinib (XL184) with or without erlotinib in patients with non-small cell lung cancer in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2014-12. c-MET Inhibitors in the Treatment of Lung Cancer in CURRENT TREATMENT OPTIONS IN ONCOLOGY
  • 1995-02. Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor in NATURE
  • 2013-06. A Phase 1 dose-escalation study of the safety and pharmacokinetics of once-daily oral foretinib, a multi-kinase inhibitor, in patients with solid tumors in INVESTIGATIONAL NEW DRUGS
  • 2017-05. Clinical Pharmacokinetics and Pharmacodynamics of Cabozantinib in CLINICAL PHARMACOKINETICS
  • 2018-12. Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities in MOLECULAR CANCER
  • 2013-07. Targeted therapies: Tivantinib—a cytotoxic drug in MET inhibitor's clothes? in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2016-11. Cabozantinib for metastatic breast carcinoma: results of a phase II placebo-controlled randomized discontinuation study in BREAST CANCER RESEARCH AND TREATMENT
  • 1995-02. Scatter factor/hepatocyte growth factor is essential for liver development in NATURE
  • 2018-06. A population pharmacokinetic model of cabozantinib in healthy volunteers and patients with various cancer types in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2018-06. Phase I study of the combination of crizotinib (as a MET inhibitor) and dasatinib (as a c-SRC inhibitor) in patients with advanced cancer in INVESTIGATIONAL NEW DRUGS
  • 2013-08. LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models in INVESTIGATIONAL NEW DRUGS
  • 2016-10. Preclinical and clinical evaluation of MET functions in cancer cells and in the tumor stroma in ONCOGENE
  • 2013-12. c-Met inhibitors in INFECTIOUS AGENTS AND CANCER
  • 2018-04. Evaluation of hepatic impairment on pharmacokinetics and safety of crizotinib in patients with advanced cancer in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2018-05. Long-term follow-up of overall survival for cabozantinib versus everolimus in advanced renal cell carcinoma in BRITISH JOURNAL OF CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40264-018-0780-x

    DOI

    http://dx.doi.org/10.1007/s40264-018-0780-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111442899

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30649748


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    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40264-018-0780-x'


     

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