Adverse Drug Event Causality Analysis (ADECA): A Process for Evaluating Evidence and Assigning Drugs to Risk Categories for Sudden Death View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-06

AUTHORS

Raymond L. Woosley, Klaus Romero, Craig W. Heise, Tyler Gallo, Jared Tate, Raymond David Woosley, Sophie Ward

ABSTRACT

Growing evidence indicates that many drugs have the ability to cause a potentially lethal cardiac arrhythmia, torsades de pointes (TdP). This necessitates the development of a compilation of drugs that have this potential toxicity. Such a list is helpful in identifying the etiology of TdP in patients taking multiple drugs and assists decision making by those caring for patients at high risk of TdP. The Arizona Center for Education and Research on Therapeutics (AZCERT) has developed a process to standardize the identification of drugs and place them in risk categories for their clinical ability to cause TdP and QT prolongation. AZCERT's Adverse Drug Event Causality Analysis (ADECA) utilizes 16 types of data drawn from four sources to compile an open-source knowledge base, QTdrugs, which is maintained on the CredibleMeds.org website. Because the evidence for most drugs is incomplete, the ADECA process is used to place drugs into one of three categories that represent different levels of certainty: known TdP risk, possible TdP risk, and conditional TdP risk. Each category has strict evidentiary requirements for clinical evidence of TdP and/or QT prolongation. These are described in this paper. Because evidence can evolve over time, the ADECA process includes the continuous gathering and analysis of newly emerging evidence to revise the lists. The QTdrugs lists have proven to be a valued, readily available, commercial influence-free resource for healthcare providers, patients, researchers, and authors of consensus guidelines for the safe use of medicines. More... »

PAGES

465-474

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40264-017-0519-0

DOI

http://dx.doi.org/10.1007/s40264-017-0519-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084038524

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28275963


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arrhythmias, Cardiac", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Death, Sudden, Cardiac", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug-Related Side Effects and Adverse Reactions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Long QT Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Torsades de Pointes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "AZCERT, 1822 E. Innovation Park Drive, 85755, Oro Valley, AZ, USA", 
            "University of Arizona, College of Medicine-Phoenix, 550 E. Van Buren St., 85004, Phoenix, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Woosley", 
        "givenName": "Raymond L.", 
        "id": "sg:person.01107263537.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107263537.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Critical Path Institute", 
          "id": "https://www.grid.ac/institutes/grid.417621.7", 
          "name": [
            "Critical Path Institute, 1730 E. River Road, 85705, Tucson, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Romero", 
        "givenName": "Klaus", 
        "id": "sg:person.01301125541.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301125541.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "University of Arizona, College of Medicine-Phoenix, 550 E. Van Buren St., 85004, Phoenix, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heise", 
        "givenName": "Craig W.", 
        "id": "sg:person.0644134663.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644134663.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "University of Arizona, College of Medicine-Phoenix, 550 E. Van Buren St., 85004, Phoenix, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gallo", 
        "givenName": "Tyler", 
        "id": "sg:person.015370245707.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015370245707.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "University of Arizona, College of Pharmacy, 1295\u00a0N. Martin Ave, 85721, Tucson, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tate", 
        "givenName": "Jared", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "Mel and Enid Zuckerman College of Public Heath, University of Arizona, 1295\u00a0N. Martin Ave, 85721, Tucson, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Woosley", 
        "givenName": "Raymond David", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "University of Arizona, College of Nursing, 1305\u00a0N. Martin Ave, 85721, Tucson, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ward", 
        "givenName": "Sophie", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.2500/105065899781389759", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001948110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2500/105065899781389759", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001948110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-2952(01)00611-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003951587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1067/mcp.2000.105761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005182291", 
          "https://doi.org/10.1067/mcp.2000.105761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3959(03)00205-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006390897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3959(03)00205-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006390897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/clpt.1994.24", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007734540", 
          "https://doi.org/10.1038/clpt.1994.24"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.285.10.1322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007847396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1003833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010119376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.164.12.1293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011129327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2125.2008.03357.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011641476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/17431380410032445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013417567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa040582", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014836976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pds.1112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015250091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pds.1112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015250091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40264-013-0032-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016062014", 
          "https://doi.org/10.1007/s40264-013-0032-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40264-013-0032-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016062014", 
          "https://doi.org/10.1007/s40264-013-0032-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/amiajnl-2014-002896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016667189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1440-1762.1999.00285.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017703657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.279.15.1200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018359649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.102.038240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022130768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/europace/eut272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024570522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.280.20.1774", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026570194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1995.03530010043033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030486396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mayocp.2013.01.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033396537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9149(87)90197-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034030688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1997.03540280045032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035004460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/clpt.1992.135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036205207", 
          "https://doi.org/10.1038/clpt.1992.135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1592/phco.24.13.1099.38090", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037720818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00002018-200225060-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038023122", 
          "https://doi.org/10.2165/00002018-200225060-00001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00002018-200225060-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038023122", 
          "https://doi.org/10.2165/00002018-200225060-00001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00002018-200225060-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038084313", 
          "https://doi.org/10.2165/00002018-200225060-00012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00002018-200225060-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038084313", 
          "https://doi.org/10.2165/00002018-200225060-00012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/eht089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038638478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bcp.12829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038842651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00002018-200730040-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044746340", 
          "https://doi.org/10.2165/00002018-200730040-00006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00002018-200730040-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044746340", 
          "https://doi.org/10.2165/00002018-200730040-00006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9343(02)01455-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045165435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.109.192704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046384723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circoutcomes.113.000651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048054187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circoutcomes.113.000651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048054187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.105.093393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048455096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1993.03500120070028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048885641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pds.885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051797413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/j.clpt.2004.06.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053328582", 
          "https://doi.org/10.1016/j.clpt.2004.06.006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1995.03530010049034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053354824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.274.1.29", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054158692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.274.1.35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054158693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.277.4.307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054161168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076395449", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/003591576505800503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076395449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082563600", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-06", 
    "datePublishedReg": "2017-06-01", 
    "description": "Growing evidence indicates that many drugs have the ability to cause a potentially lethal cardiac arrhythmia, torsades de pointes (TdP). This necessitates the development of a compilation of drugs that have this potential toxicity. Such a list is helpful in identifying the etiology of TdP in patients taking multiple drugs and assists decision making by those caring for patients at high risk of TdP. The Arizona Center for Education and Research on Therapeutics (AZCERT) has developed a process to standardize the identification of drugs and place them in risk categories for their clinical ability to cause TdP and QT prolongation. AZCERT's Adverse Drug Event Causality Analysis (ADECA) utilizes 16 types of data drawn from four sources to compile an open-source knowledge base, QTdrugs, which is maintained on the CredibleMeds.org website. Because the evidence for most drugs is incomplete, the ADECA process is used to place drugs into one of three categories that represent different levels of certainty: known TdP risk, possible TdP risk, and conditional TdP risk. Each category has strict evidentiary requirements for clinical evidence of TdP and/or QT prolongation. These are described in this paper. Because evidence can evolve over time, the ADECA process includes the continuous gathering and analysis of newly emerging evidence to revise the lists. The QTdrugs lists have proven to be a valued, readily available, commercial influence-free resource for healthcare providers, patients, researchers, and authors of consensus guidelines for the safe use of medicines.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s40264-017-0519-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096281", 
        "issn": [
          "0114-5916", 
          "1179-1942"
        ], 
        "name": "Drug Safety", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "40"
      }
    ], 
    "name": "Adverse Drug Event Causality Analysis (ADECA): A Process for Evaluating Evidence and Assigning Drugs to Risk Categories for Sudden Death", 
    "pagination": "465-474", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6c629540e4b557d8efccaec73474008f7f1c933a3f8f46ab3464d8ffb60d768d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28275963"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9002928"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s40264-017-0519-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084038524"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s40264-017-0519-0", 
      "https://app.dimensions.ai/details/publication/pub.1084038524"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89801_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs40264-017-0519-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40264-017-0519-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40264-017-0519-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40264-017-0519-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40264-017-0519-0'


 

This table displays all metadata directly associated to this object as RDF triples.

285 TRIPLES      21 PREDICATES      81 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s40264-017-0519-0 schema:about N1da69c5df83342f5be445f5f2e601083
2 N299a94f099f6493992446ba7368a20a2
3 N3a9472cc830c4291b0bdbb80e8bd4ff8
4 N3ad3e30bb6224cfe8baff5a5f58755db
5 Na71517fae549432fb108d4df46180c8e
6 Nb14443147eb64f4d90be2e2dc27d6888
7 Nb7b9bddc573946d38d9a7154d02def7c
8 Nbfe07a5c06864d268c47f7940e3c73b6
9 anzsrc-for:11
10 anzsrc-for:1117
11 schema:author N36b943adea1d444483cf299545444ff7
12 schema:citation sg:pub.10.1007/s40264-013-0032-z
13 sg:pub.10.1016/j.clpt.2004.06.006
14 sg:pub.10.1038/clpt.1992.135
15 sg:pub.10.1038/clpt.1994.24
16 sg:pub.10.1067/mcp.2000.105761
17 sg:pub.10.2165/00002018-200225060-00001
18 sg:pub.10.2165/00002018-200225060-00012
19 sg:pub.10.2165/00002018-200730040-00006
20 https://app.dimensions.ai/details/publication/pub.1076395449
21 https://app.dimensions.ai/details/publication/pub.1082563600
22 https://doi.org/10.1001/archinte.164.12.1293
23 https://doi.org/10.1001/jama.1993.03500120070028
24 https://doi.org/10.1001/jama.1995.03530010043033
25 https://doi.org/10.1001/jama.1995.03530010049034
26 https://doi.org/10.1001/jama.1997.03540280045032
27 https://doi.org/10.1001/jama.274.1.29
28 https://doi.org/10.1001/jama.274.1.35
29 https://doi.org/10.1001/jama.277.4.307
30 https://doi.org/10.1001/jama.279.15.1200
31 https://doi.org/10.1001/jama.280.20.1774
32 https://doi.org/10.1001/jama.285.10.1322
33 https://doi.org/10.1002/pds.1112
34 https://doi.org/10.1002/pds.885
35 https://doi.org/10.1016/0002-9149(87)90197-4
36 https://doi.org/10.1016/j.mayocp.2013.01.013
37 https://doi.org/10.1016/s0002-9343(02)01455-9
38 https://doi.org/10.1016/s0006-2952(01)00611-6
39 https://doi.org/10.1016/s0304-3959(03)00205-7
40 https://doi.org/10.1046/j.1440-1762.1999.00285.x
41 https://doi.org/10.1056/nejmoa040582
42 https://doi.org/10.1056/nejmoa1003833
43 https://doi.org/10.1080/17431380410032445
44 https://doi.org/10.1093/eurheartj/eht089
45 https://doi.org/10.1093/europace/eut272
46 https://doi.org/10.1111/bcp.12829
47 https://doi.org/10.1111/j.1365-2125.2008.03357.x
48 https://doi.org/10.1124/jpet.102.038240
49 https://doi.org/10.1124/jpet.105.093393
50 https://doi.org/10.1136/amiajnl-2014-002896
51 https://doi.org/10.1161/circoutcomes.113.000651
52 https://doi.org/10.1161/circulationaha.109.192704
53 https://doi.org/10.1177/003591576505800503
54 https://doi.org/10.1592/phco.24.13.1099.38090
55 https://doi.org/10.2500/105065899781389759
56 schema:datePublished 2017-06
57 schema:datePublishedReg 2017-06-01
58 schema:description Growing evidence indicates that many drugs have the ability to cause a potentially lethal cardiac arrhythmia, torsades de pointes (TdP). This necessitates the development of a compilation of drugs that have this potential toxicity. Such a list is helpful in identifying the etiology of TdP in patients taking multiple drugs and assists decision making by those caring for patients at high risk of TdP. The Arizona Center for Education and Research on Therapeutics (AZCERT) has developed a process to standardize the identification of drugs and place them in risk categories for their clinical ability to cause TdP and QT prolongation. AZCERT's Adverse Drug Event Causality Analysis (ADECA) utilizes 16 types of data drawn from four sources to compile an open-source knowledge base, QTdrugs, which is maintained on the CredibleMeds.org website. Because the evidence for most drugs is incomplete, the ADECA process is used to place drugs into one of three categories that represent different levels of certainty: known TdP risk, possible TdP risk, and conditional TdP risk. Each category has strict evidentiary requirements for clinical evidence of TdP and/or QT prolongation. These are described in this paper. Because evidence can evolve over time, the ADECA process includes the continuous gathering and analysis of newly emerging evidence to revise the lists. The QTdrugs lists have proven to be a valued, readily available, commercial influence-free resource for healthcare providers, patients, researchers, and authors of consensus guidelines for the safe use of medicines.
59 schema:genre research_article
60 schema:inLanguage en
61 schema:isAccessibleForFree false
62 schema:isPartOf N3f2073429f96487a9af48bce3c10cb8a
63 N68e6321dd84e4792a50137735fb0826a
64 sg:journal.1096281
65 schema:name Adverse Drug Event Causality Analysis (ADECA): A Process for Evaluating Evidence and Assigning Drugs to Risk Categories for Sudden Death
66 schema:pagination 465-474
67 schema:productId N12e06e0ec47546628d4c1de200268a30
68 N19bcba2aa5004be6a0639dc35e4ba604
69 N2747527b55a64bba821a2e164fa70a70
70 N53ceb93ba57c48099872b687c2861cc1
71 Ne27ca41e0fe24f14bb69033ef177abb2
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084038524
73 https://doi.org/10.1007/s40264-017-0519-0
74 schema:sdDatePublished 2019-04-11T09:55
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher N0a411f17d3e04c7ba527d9f5ada1e38a
77 schema:url https://link.springer.com/10.1007%2Fs40264-017-0519-0
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N06b78485c5cf42818db4a2d843e9d8a2 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
82 schema:familyName Tate
83 schema:givenName Jared
84 rdf:type schema:Person
85 N0a411f17d3e04c7ba527d9f5ada1e38a schema:name Springer Nature - SN SciGraph project
86 rdf:type schema:Organization
87 N12e06e0ec47546628d4c1de200268a30 schema:name nlm_unique_id
88 schema:value 9002928
89 rdf:type schema:PropertyValue
90 N19bcba2aa5004be6a0639dc35e4ba604 schema:name doi
91 schema:value 10.1007/s40264-017-0519-0
92 rdf:type schema:PropertyValue
93 N1da69c5df83342f5be445f5f2e601083 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Risk Factors
95 rdf:type schema:DefinedTerm
96 N2747527b55a64bba821a2e164fa70a70 schema:name pubmed_id
97 schema:value 28275963
98 rdf:type schema:PropertyValue
99 N299a94f099f6493992446ba7368a20a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Death, Sudden, Cardiac
101 rdf:type schema:DefinedTerm
102 N369bbdaf6dbd47578bd6664d0c3ed18d rdf:first Nd2d704936af14b6993b447ec7233ab79
103 rdf:rest rdf:nil
104 N36b943adea1d444483cf299545444ff7 rdf:first sg:person.01107263537.70
105 rdf:rest N40099980bfcc45cf83e01ea568b4d330
106 N3a9472cc830c4291b0bdbb80e8bd4ff8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Animals
108 rdf:type schema:DefinedTerm
109 N3ad3e30bb6224cfe8baff5a5f58755db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Long QT Syndrome
111 rdf:type schema:DefinedTerm
112 N3f2073429f96487a9af48bce3c10cb8a schema:issueNumber 6
113 rdf:type schema:PublicationIssue
114 N40099980bfcc45cf83e01ea568b4d330 rdf:first sg:person.01301125541.46
115 rdf:rest N6a9166334954433fa25f0b7a5af26c06
116 N4dd767f896de4b2ba809ea0004eb47d8 rdf:first N06b78485c5cf42818db4a2d843e9d8a2
117 rdf:rest Nd8fad2209f334986a0f07f02ce4ec74c
118 N53ceb93ba57c48099872b687c2861cc1 schema:name readcube_id
119 schema:value 6c629540e4b557d8efccaec73474008f7f1c933a3f8f46ab3464d8ffb60d768d
120 rdf:type schema:PropertyValue
121 N68e6321dd84e4792a50137735fb0826a schema:volumeNumber 40
122 rdf:type schema:PublicationVolume
123 N6a9166334954433fa25f0b7a5af26c06 rdf:first sg:person.0644134663.17
124 rdf:rest Nf07bc7821522408bbca0e2f460ca2074
125 Na71517fae549432fb108d4df46180c8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Humans
127 rdf:type schema:DefinedTerm
128 Nb14443147eb64f4d90be2e2dc27d6888 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Drug-Related Side Effects and Adverse Reactions
130 rdf:type schema:DefinedTerm
131 Nb7b9bddc573946d38d9a7154d02def7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Arrhythmias, Cardiac
133 rdf:type schema:DefinedTerm
134 Nbfe07a5c06864d268c47f7940e3c73b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Torsades de Pointes
136 rdf:type schema:DefinedTerm
137 Nd2d704936af14b6993b447ec7233ab79 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
138 schema:familyName Ward
139 schema:givenName Sophie
140 rdf:type schema:Person
141 Nd8fad2209f334986a0f07f02ce4ec74c rdf:first Nefb8f6aeaa7941fe8555a37ca07037bb
142 rdf:rest N369bbdaf6dbd47578bd6664d0c3ed18d
143 Ne27ca41e0fe24f14bb69033ef177abb2 schema:name dimensions_id
144 schema:value pub.1084038524
145 rdf:type schema:PropertyValue
146 Nefb8f6aeaa7941fe8555a37ca07037bb schema:affiliation https://www.grid.ac/institutes/grid.134563.6
147 schema:familyName Woosley
148 schema:givenName Raymond David
149 rdf:type schema:Person
150 Nf07bc7821522408bbca0e2f460ca2074 rdf:first sg:person.015370245707.26
151 rdf:rest N4dd767f896de4b2ba809ea0004eb47d8
152 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
153 schema:name Medical and Health Sciences
154 rdf:type schema:DefinedTerm
155 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
156 schema:name Public Health and Health Services
157 rdf:type schema:DefinedTerm
158 sg:journal.1096281 schema:issn 0114-5916
159 1179-1942
160 schema:name Drug Safety
161 rdf:type schema:Periodical
162 sg:person.01107263537.70 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
163 schema:familyName Woosley
164 schema:givenName Raymond L.
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107263537.70
166 rdf:type schema:Person
167 sg:person.01301125541.46 schema:affiliation https://www.grid.ac/institutes/grid.417621.7
168 schema:familyName Romero
169 schema:givenName Klaus
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301125541.46
171 rdf:type schema:Person
172 sg:person.015370245707.26 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
173 schema:familyName Gallo
174 schema:givenName Tyler
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015370245707.26
176 rdf:type schema:Person
177 sg:person.0644134663.17 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
178 schema:familyName Heise
179 schema:givenName Craig W.
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644134663.17
181 rdf:type schema:Person
182 sg:pub.10.1007/s40264-013-0032-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1016062014
183 https://doi.org/10.1007/s40264-013-0032-z
184 rdf:type schema:CreativeWork
185 sg:pub.10.1016/j.clpt.2004.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053328582
186 https://doi.org/10.1016/j.clpt.2004.06.006
187 rdf:type schema:CreativeWork
188 sg:pub.10.1038/clpt.1992.135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036205207
189 https://doi.org/10.1038/clpt.1992.135
190 rdf:type schema:CreativeWork
191 sg:pub.10.1038/clpt.1994.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007734540
192 https://doi.org/10.1038/clpt.1994.24
193 rdf:type schema:CreativeWork
194 sg:pub.10.1067/mcp.2000.105761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005182291
195 https://doi.org/10.1067/mcp.2000.105761
196 rdf:type schema:CreativeWork
197 sg:pub.10.2165/00002018-200225060-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038023122
198 https://doi.org/10.2165/00002018-200225060-00001
199 rdf:type schema:CreativeWork
200 sg:pub.10.2165/00002018-200225060-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038084313
201 https://doi.org/10.2165/00002018-200225060-00012
202 rdf:type schema:CreativeWork
203 sg:pub.10.2165/00002018-200730040-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044746340
204 https://doi.org/10.2165/00002018-200730040-00006
205 rdf:type schema:CreativeWork
206 https://app.dimensions.ai/details/publication/pub.1076395449 schema:CreativeWork
207 https://app.dimensions.ai/details/publication/pub.1082563600 schema:CreativeWork
208 https://doi.org/10.1001/archinte.164.12.1293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011129327
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1001/jama.1993.03500120070028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048885641
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1001/jama.1995.03530010043033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030486396
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1001/jama.1995.03530010049034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053354824
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1001/jama.1997.03540280045032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035004460
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1001/jama.274.1.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054158692
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1001/jama.274.1.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054158693
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1001/jama.277.4.307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054161168
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1001/jama.279.15.1200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018359649
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1001/jama.280.20.1774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026570194
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1001/jama.285.10.1322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007847396
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1002/pds.1112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015250091
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1002/pds.885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051797413
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/0002-9149(87)90197-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034030688
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.mayocp.2013.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033396537
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/s0002-9343(02)01455-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045165435
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0006-2952(01)00611-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003951587
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/s0304-3959(03)00205-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006390897
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1046/j.1440-1762.1999.00285.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017703657
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1056/nejmoa040582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014836976
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1056/nejmoa1003833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010119376
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1080/17431380410032445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013417567
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1093/eurheartj/eht089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038638478
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1093/europace/eut272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024570522
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1111/bcp.12829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038842651
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1111/j.1365-2125.2008.03357.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011641476
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1124/jpet.102.038240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022130768
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1124/jpet.105.093393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048455096
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1136/amiajnl-2014-002896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016667189
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1161/circoutcomes.113.000651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048054187
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1161/circulationaha.109.192704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046384723
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1177/003591576505800503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076395449
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1592/phco.24.13.1099.38090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037720818
273 rdf:type schema:CreativeWork
274 https://doi.org/10.2500/105065899781389759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001948110
275 rdf:type schema:CreativeWork
276 https://www.grid.ac/institutes/grid.134563.6 schema:alternateName University of Arizona
277 schema:name AZCERT, 1822 E. Innovation Park Drive, 85755, Oro Valley, AZ, USA
278 Mel and Enid Zuckerman College of Public Heath, University of Arizona, 1295 N. Martin Ave, 85721, Tucson, AZ, USA
279 University of Arizona, College of Medicine-Phoenix, 550 E. Van Buren St., 85004, Phoenix, AZ, USA
280 University of Arizona, College of Nursing, 1305 N. Martin Ave, 85721, Tucson, AZ, USA
281 University of Arizona, College of Pharmacy, 1295 N. Martin Ave, 85721, Tucson, AZ, USA
282 rdf:type schema:Organization
283 https://www.grid.ac/institutes/grid.417621.7 schema:alternateName Critical Path Institute
284 schema:name Critical Path Institute, 1730 E. River Road, 85705, Tucson, AZ, USA
285 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...