Age at First Rotavirus Vaccination and Risk of Intussusception in Infants: A Public Health Modeling Analysis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-08

AUTHORS

Chee Fu Yung, Chia Yin Chong, Koh Cheng Thoon

ABSTRACT

INTRODUCTION: The epidemiology of naturally occurring intussusception is known to increase significantly between the ages of 3 and 8 months. Post-licensure studies have reported a fivefold and twofold increase in intussusception in the first week after the first dose and second dose, respectively, of current rotavirus vaccines (RVs). PURPOSE: We carried out a public health risk analysis to model the impact of age at first vaccination in relation to rotavirus vaccination and risk of intussusception in infants. METHOD: We created a static model for a birth cohort followed until 1 year old to estimate the number of excess intussusception hospitalizations which could be caused by three different infant rotavirus vaccination schedules. A relative risk of 5.45 in the first 7 days after the first dose and 1.75 in the first 7 days after the second dose was used in the model. RESULT: We estimated that the risk of intussusception would be the lowest at about 1 in 49,000 if both first and second dose RVs were given at <3 months of age followed by 1 in 41,000 if first dose RVs were given at <3 months and second dose RVs were given at 3-5 months. It would be highest at about 1 in 11,000 if infants received both doses when >3 months old. CONCLUSION: Our epidemiological example illustrates the importance of ensuring that the first two doses of RVs are administered in infants <3 months old whenever possible to minimize the risk of intussusception as an adverse event following rotavirus vaccination. More... »

PAGES

745-748

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40264-016-0424-y

DOI

http://dx.doi.org/10.1007/s40264-016-0424-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020260600

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27067440


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