Granulocyte Colony-Stimulating Factor (G-CSF) for the Treatment of Spinal Cord Injury View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-11

AUTHORS

MirHojjat Khorasanizadeh, Mahsa Eskian, Alexander R. Vaccaro, Vafa Rahimi-Movaghar

ABSTRACT

Spinal cord injury (SCI) is a common medical condition with a poor prognosis for recovery and catastrophic effects on a patient's quality of life. Available treatments for SCI are limited, and the evidence suggesting their harmful side effects is more consistent than any suggestion of clinical benefit. Developing novel safe and effective therapeutic options for SCI is crucial. Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine with known multifaceted effects on the central nervous system. Herein, we review the accumulating preclinical evidence for the beneficial effects of G-CSF on functional and structural outcomes after SCI. Meanwhile we present and discuss multiple mechanisms for G-CSF's neuroprotective and neuroregenerative actions through the results of these studies. In addition, we present the available clinical evidence indicating the efficacy and safety of G-CSF administration for the treatment of acute and chronic traumatic SCI, compression myelopathy, and SCI-associated neuropathic pain. Our review indicates that although the quality of clinical evidence regarding the use of G-CSF in SCI is inadequate, the encouraging available preclinical and clinical data warrant its further clinical development, and bring new hope to the longstanding challenge that is treatment of SCI. More... »

PAGES

911-937

References to SciGraph publications

  • 2013-05. Systemic hypothermia in acute cervical spinal cord injury: a case-controlled study in SPINAL CORD
  • 2011-12. Granulocyte colony-stimulating factor increases the therapeutic efficacy of bone marrow mononuclear cell transplantation in cerebral ischemia in mice in BMC NEUROSCIENCE
  • 2004-01. Neuroprotection and acute spinal cord injury: A reappraisal in NEUROTHERAPEUTICS
  • 2013-01. Intravenous administration of granulocyte colony-stimulating factor for treating neuropathic pain associated with compression myelopathy: a phase I and IIa clinical trial in EUROPEAN SPINE JOURNAL
  • 2003-01. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis in ONCOGENE
  • 1996-02. Restoration of depressed immune function in spinal cord injury patients receiving rehabilitation therapy in SPINAL CORD
  • 2015-12. G-CSF promotes autophagy and reduces neural tissue damage after spinal cord injury in mice in LABORATORY INVESTIGATION
  • 2007-03. Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP Panel: clinical trial inclusion/exclusion criteria and ethics in SPINAL CORD
  • 2012-12. Neuroprotective therapy using granulocyte colony-stimulating factor for acute spinal cord injury: a phase I/IIa clinical trial in EUROPEAN SPINE JOURNAL
  • 2013-05. Spinal Cord Injury: A Review of Current Therapy, Future Treatments, and Basic Science Frontiers in NEUROCHEMICAL RESEARCH
  • 2001-07. Flt-3 and Its Ligand Are Expressed in Neural Crest–Derived Tumors and Promote Survival and Proliferation of Their Cell Lines in LABORATORY INVESTIGATION
  • 2003-06. Intermediate filament nestin expressions in human cord blood monocytes (HCMNCs) in ACTA NEUROCHIRURGICA
  • 2000-02. Pharmacological therapy of spinal cord injury during the acute phase in SPINAL CORD
  • 2009-12. Granulocyte-colony stimulating factor for stroke treatment: mechanisms of action and efficacy in preclinical studies in EXPERIMENTAL & TRANSLATIONAL STROKE MEDICINE
  • 2009-11. Combination of bone marrow stromal cell transplantation with mobilization by granulocyte-colony stimulating factor promotes functional recovery after spinal cord transection in ACTA NEUROCHIRURGICA
  • 1999-11. Peripheral blood stem cell mobilization and apheresis: analysis of adverse events in 94 normal donors in BONE MARROW TRANSPLANTATION
  • 2015-05. Neuroprotective therapy with granulocyte colony-stimulating factor in acute spinal cord injury: a comparison with high-dose methylprednisolone as a historical control in EUROPEAN SPINE JOURNAL
  • 2000-05. High dose methylprednisolone in the management of acute spinal cord injury – a systematic review from a clinical perspective in SPINAL CORD
  • 2012-03. Neuroprotective therapy using granulocyte colony-stimulating factor for patients with worsening symptoms of compression myelopathy, part 1: a phase I and IIa clinical trial in EUROPEAN SPINE JOURNAL
  • 2008-06. Pharmacological Management of Neuropathic Pain Following Spinal Cord Injury in CNS DRUGS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40263-017-0472-6

    DOI

    http://dx.doi.org/10.1007/s40263-017-0472-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1092332112

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29063471


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