Pharmacokinetics and Clinical Utility of Valproic Acid Administered via Continuous Infusion View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-01

AUTHORS

Aaron M. Cook, Muhammad S. Zafar, Sally Mathias, Alejandra M. Stewart, Ana C. Albuja, Meriem Bensalem-Owen, Siddharth Kapoor, Robert J. Baumann

ABSTRACT

INTRODUCTION: Valproic acid is a versatile antiepileptic drug that is often used in the acute care setting. Intravenous valproic acid lends itself well to a continuous infusion as it exhibits a relatively short half-life. We evaluated the pharmacokinetics and clinical efficacy of continuous infusion valproic acid in hospitalized patients with migraine and seizures. METHODS: A retrospective cohort study was performed utilizing information from the medical records of patients receiving an intravenous continuous infusion of valproic acid. Patients were included if they were aged 1 month to 85 years and they received a continuous infusion of valproic acid. Therapeutic response, common adverse effects, and the pharmacokinetic profile of valproic acid were evaluated. RESULTS: Continuous infusion valproic acid led to a concentration within the desired range (50-100 μg/ml) in 83.4% of patients, a rate that was higher in pediatric patients. The clinical response rate was also higher in pediatric patients with seizures or migraines and appeared to be better when the concentration was >75 μg/ml. Analysis of safety parameters suggests similar safety considerations to valproic acid when administered via intermittent infusion. CONCLUSIONS: Continuous infusion valproic acid appears to be a safe, effective, and predictable manner by which to administer valproic acid to pediatric and adult patients admitted to the hospital. More... »

PAGES

71-77

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40263-015-0304-5

DOI

http://dx.doi.org/10.1007/s40263-015-0304-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044539107

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26715390


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anticonvulsants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Data Interpretation, Statistical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infusions, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Medical Records", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Migraine Disorders", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Seizures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Valproic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Kentucky HealthCare", 
          "id": "https://www.grid.ac/institutes/grid.413001.7", 
          "name": [
            "Pharmacy Services, UK Healthcare, 800 Rose St. H110, 40536, Lexington, KY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cook", 
        "givenName": "Aaron M.", 
        "id": "sg:person.0743054301.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743054301.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "Department of Neurology, College of Medicine, University of Kentucky, Lexington, KY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zafar", 
        "givenName": "Muhammad S.", 
        "id": "sg:person.0725636411.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725636411.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "Department of Neurology, College of Medicine, University of Kentucky, Lexington, KY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mathias", 
        "givenName": "Sally", 
        "id": "sg:person.0773751611.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773751611.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "Department of Neurology, College of Medicine, University of Kentucky, Lexington, KY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stewart", 
        "givenName": "Alejandra M.", 
        "id": "sg:person.01042065011.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042065011.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "Department of Neurology, College of Medicine, University of Kentucky, Lexington, KY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Albuja", 
        "givenName": "Ana C.", 
        "id": "sg:person.01110200211.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110200211.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "Department of Neurology, College of Medicine, University of Kentucky, Lexington, KY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bensalem-Owen", 
        "givenName": "Meriem", 
        "id": "sg:person.0672342565.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672342565.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "Department of Neurology, College of Medicine, University of Kentucky, Lexington, KY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kapoor", 
        "givenName": "Siddharth", 
        "id": "sg:person.01224426611.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224426611.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "Department of Neurology, College of Medicine, University of Kentucky, Lexington, KY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baumann", 
        "givenName": "Robert J.", 
        "id": "sg:person.01272542011.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272542011.77"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0920-1211(02)00251-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009119553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0920-1211(02)00251-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009119553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1592/phco.27.4.519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015367281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.10387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025956596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.10387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025956596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.18349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029499006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.18349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029499006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2125.1998.00652.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032272867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2125.1998.00652.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032272867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1526-4610.2004.04010.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034800659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mjt.0000155113.89092.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035592288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mjt.0000155113.89092.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035592288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/head.12499", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036676458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0091270004266782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038356658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1099-081x(199907)20:5<233::aid-bdd179>3.0.co;2-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039947515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1099-081x(199907)20:5<233::aid-bdd179>3.0.co;2-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039947515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0887-8994(86)90047-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040317175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0887-8994(86)90047-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040317175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ftd.0b013e3182608e2f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042416501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ftd.0b013e3182608e2f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042416501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199809173391202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048565163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12028-012-9695-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050454608", 
          "https://doi.org/10.1007/s12028-012-9695-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000149527.47600.5a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000149527.47600.5a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000149527.47600.5a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000224880.35053.26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064348276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000224880.35053.26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064348276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000224880.35053.26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064348276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.33.2.185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064364696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.55.5.722", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064379019"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-01", 
    "datePublishedReg": "2016-01-01", 
    "description": "INTRODUCTION: Valproic acid is a versatile antiepileptic drug that is often used in the acute care setting. Intravenous valproic acid lends itself well to a continuous infusion as it exhibits a relatively short half-life. We evaluated the pharmacokinetics and clinical efficacy of continuous infusion valproic acid in hospitalized patients with migraine and seizures.\nMETHODS: A retrospective cohort study was performed utilizing information from the medical records of patients receiving an intravenous continuous infusion of valproic acid. Patients were included if they were aged 1 month to 85 years and they received a continuous infusion of valproic acid. Therapeutic response, common adverse effects, and the pharmacokinetic profile of valproic acid were evaluated.\nRESULTS: Continuous infusion valproic acid led to a concentration within the desired range (50-100 \u03bcg/ml) in 83.4% of patients, a rate that was higher in pediatric patients. The clinical response rate was also higher in pediatric patients with seizures or migraines and appeared to be better when the concentration was >75 \u03bcg/ml. Analysis of safety parameters suggests similar safety considerations to valproic acid when administered via intermittent infusion.\nCONCLUSIONS: Continuous infusion valproic acid appears to be a safe, effective, and predictable manner by which to administer valproic acid to pediatric and adult patients admitted to the hospital.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s40263-015-0304-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2705214", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1111875", 
        "issn": [
          "1172-7047", 
          "1179-1934"
        ], 
        "name": "CNS Drugs", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "30"
      }
    ], 
    "name": "Pharmacokinetics and Clinical Utility of Valproic Acid Administered via Continuous Infusion", 
    "pagination": "71-77", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d427d30f6d87fde7b33f28448afd89ff3783a4dc51672cddf1a54b77f6fde4c6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26715390"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9431220"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s40263-015-0304-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044539107"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s40263-015-0304-5", 
      "https://app.dimensions.ai/details/publication/pub.1044539107"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000524.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs40263-015-0304-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40263-015-0304-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40263-015-0304-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40263-015-0304-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40263-015-0304-5'


 

This table displays all metadata directly associated to this object as RDF triples.

266 TRIPLES      21 PREDICATES      69 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s40263-015-0304-5 schema:about N1aa679d0ff524a93aea92ca30eedbeba
2 N1b727025bf714df19bea07d27805998c
3 N1d3fd61ba6764f7685a1d0fd017e1c29
4 N2f5b3e420cfc4bbba37ddf9bdb367bb5
5 N41f72984c5814a5fb59f0ae33d31c3ee
6 N4f4d1fd08d144fd19c1132ee218f2551
7 N53e74a8a1165430892711a67b6e0ff1e
8 N5cdf3502a64a473690756f40c0da8b7b
9 N5db1c09983f9456c9008c5b44ab79980
10 N6ab3ef8673f7421cb76d63514553ad35
11 N6b7a54e7fac142fd87133563c62d88ae
12 N75a478a17892492b957a605b4c2268c2
13 N9e6ea6685c0241eba6b1f9d726617bf2
14 Naa349e9a430542698fa3b4419b4de175
15 Nb36d6437f8544055a50c4b31d0cad1ca
16 Nb944a3cfddef4d4e9887d573375d4b97
17 Nd9450b110db2416ca2055a3df1fbd501
18 Nda2ae56616f74ab4b6d7e654983277b8
19 Ndb2735bf1cb8425e84a7d4f97d0ff903
20 Ne920b72b67a94c2a893526f2d95f33c0
21 Neec623ae982a42a882fec5d0d6278324
22 Nff845b721a45433da6726860e9715cdf
23 anzsrc-for:11
24 anzsrc-for:1103
25 schema:author N1399ca5ea9db40e28988a6ae974845d0
26 schema:citation sg:pub.10.1007/s12028-012-9695-z
27 https://doi.org/10.1002/(sici)1099-081x(199907)20:5<233::aid-bdd179>3.0.co;2-5
28 https://doi.org/10.1016/0887-8994(86)90047-0
29 https://doi.org/10.1016/s0920-1211(02)00251-6
30 https://doi.org/10.1046/j.1365-2125.1998.00652.x
31 https://doi.org/10.1056/nejm199809173391202
32 https://doi.org/10.1097/01.mjt.0000155113.89092.58
33 https://doi.org/10.1097/ftd.0b013e3182608e2f
34 https://doi.org/10.1111/head.12499
35 https://doi.org/10.1111/j.1526-4610.2004.04010.x
36 https://doi.org/10.1177/0091270004266782
37 https://doi.org/10.1212/01.wnl.0000149527.47600.5a
38 https://doi.org/10.1212/01.wnl.0000224880.35053.26
39 https://doi.org/10.1212/wnl.33.2.185
40 https://doi.org/10.1212/wnl.55.5.722
41 https://doi.org/10.1345/aph.10387
42 https://doi.org/10.1345/aph.18349
43 https://doi.org/10.1592/phco.27.4.519
44 schema:datePublished 2016-01
45 schema:datePublishedReg 2016-01-01
46 schema:description INTRODUCTION: Valproic acid is a versatile antiepileptic drug that is often used in the acute care setting. Intravenous valproic acid lends itself well to a continuous infusion as it exhibits a relatively short half-life. We evaluated the pharmacokinetics and clinical efficacy of continuous infusion valproic acid in hospitalized patients with migraine and seizures. METHODS: A retrospective cohort study was performed utilizing information from the medical records of patients receiving an intravenous continuous infusion of valproic acid. Patients were included if they were aged 1 month to 85 years and they received a continuous infusion of valproic acid. Therapeutic response, common adverse effects, and the pharmacokinetic profile of valproic acid were evaluated. RESULTS: Continuous infusion valproic acid led to a concentration within the desired range (50-100 μg/ml) in 83.4% of patients, a rate that was higher in pediatric patients. The clinical response rate was also higher in pediatric patients with seizures or migraines and appeared to be better when the concentration was >75 μg/ml. Analysis of safety parameters suggests similar safety considerations to valproic acid when administered via intermittent infusion. CONCLUSIONS: Continuous infusion valproic acid appears to be a safe, effective, and predictable manner by which to administer valproic acid to pediatric and adult patients admitted to the hospital.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree false
50 schema:isPartOf N1cb46b4f8dd44125807cd19fad2a6d7f
51 N8bc838b8c5644dc1a9395b4fa7f231e3
52 sg:journal.1111875
53 schema:name Pharmacokinetics and Clinical Utility of Valproic Acid Administered via Continuous Infusion
54 schema:pagination 71-77
55 schema:productId N21eeb9c0095842dcb74c1e5c418cdd70
56 N3cc1477149ab4690a5d766b14190f310
57 Nbfcc3211ba07422b830402a69d940510
58 Nc4a5f5d69ae34e95a142e80a5fb656f3
59 Nff50c6a6080346e788c69ab7a63a462f
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044539107
61 https://doi.org/10.1007/s40263-015-0304-5
62 schema:sdDatePublished 2019-04-10T19:11
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher Ncae3c0f8ba404706ba94fef41aaa4a51
65 schema:url http://link.springer.com/10.1007%2Fs40263-015-0304-5
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N1399ca5ea9db40e28988a6ae974845d0 rdf:first sg:person.0743054301.42
70 rdf:rest N7dfd20a56b144b85a287a08f3d2ca73c
71 N1aa679d0ff524a93aea92ca30eedbeba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Aged, 80 and over
73 rdf:type schema:DefinedTerm
74 N1b727025bf714df19bea07d27805998c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Male
76 rdf:type schema:DefinedTerm
77 N1cb46b4f8dd44125807cd19fad2a6d7f schema:volumeNumber 30
78 rdf:type schema:PublicationVolume
79 N1d3fd61ba6764f7685a1d0fd017e1c29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Infusions, Intravenous
81 rdf:type schema:DefinedTerm
82 N21eeb9c0095842dcb74c1e5c418cdd70 schema:name readcube_id
83 schema:value d427d30f6d87fde7b33f28448afd89ff3783a4dc51672cddf1a54b77f6fde4c6
84 rdf:type schema:PropertyValue
85 N2ea20e4d3ed8425fb3948298e385c70c rdf:first sg:person.01042065011.36
86 rdf:rest Nfa9f25f7070645b68c770491e906baac
87 N2f5b3e420cfc4bbba37ddf9bdb367bb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Medical Records
89 rdf:type schema:DefinedTerm
90 N3cc1477149ab4690a5d766b14190f310 schema:name pubmed_id
91 schema:value 26715390
92 rdf:type schema:PropertyValue
93 N41f72984c5814a5fb59f0ae33d31c3ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Data Interpretation, Statistical
95 rdf:type schema:DefinedTerm
96 N4f4d1fd08d144fd19c1132ee218f2551 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Humans
98 rdf:type schema:DefinedTerm
99 N53e74a8a1165430892711a67b6e0ff1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Adolescent
101 rdf:type schema:DefinedTerm
102 N5cdf3502a64a473690756f40c0da8b7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Seizures
104 rdf:type schema:DefinedTerm
105 N5db1c09983f9456c9008c5b44ab79980 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Infant
107 rdf:type schema:DefinedTerm
108 N6ab3ef8673f7421cb76d63514553ad35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Cohort Studies
110 rdf:type schema:DefinedTerm
111 N6b7a54e7fac142fd87133563c62d88ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Anticonvulsants
113 rdf:type schema:DefinedTerm
114 N75a478a17892492b957a605b4c2268c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Child, Preschool
116 rdf:type schema:DefinedTerm
117 N7dfd20a56b144b85a287a08f3d2ca73c rdf:first sg:person.0725636411.63
118 rdf:rest Nd0ad52d3c0a44349a7f6f9695755b2ef
119 N8bc838b8c5644dc1a9395b4fa7f231e3 schema:issueNumber 1
120 rdf:type schema:PublicationIssue
121 N9e6ea6685c0241eba6b1f9d726617bf2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Young Adult
123 rdf:type schema:DefinedTerm
124 Naa349e9a430542698fa3b4419b4de175 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Migraine Disorders
126 rdf:type schema:DefinedTerm
127 Nb037fa23bde44a24b78532f529918460 rdf:first sg:person.01224426611.81
128 rdf:rest Nd15c69ffb2ea4eacae0b84071c132870
129 Nb36d6437f8544055a50c4b31d0cad1ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Retrospective Studies
131 rdf:type schema:DefinedTerm
132 Nb944a3cfddef4d4e9887d573375d4b97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Middle Aged
134 rdf:type schema:DefinedTerm
135 Nbfcc3211ba07422b830402a69d940510 schema:name dimensions_id
136 schema:value pub.1044539107
137 rdf:type schema:PropertyValue
138 Nc4a5f5d69ae34e95a142e80a5fb656f3 schema:name nlm_unique_id
139 schema:value 9431220
140 rdf:type schema:PropertyValue
141 Ncae3c0f8ba404706ba94fef41aaa4a51 schema:name Springer Nature - SN SciGraph project
142 rdf:type schema:Organization
143 Nd0ad52d3c0a44349a7f6f9695755b2ef rdf:first sg:person.0773751611.35
144 rdf:rest N2ea20e4d3ed8425fb3948298e385c70c
145 Nd15c69ffb2ea4eacae0b84071c132870 rdf:first sg:person.01272542011.77
146 rdf:rest rdf:nil
147 Nd1d87a7417494970af098bf8012afff3 rdf:first sg:person.0672342565.62
148 rdf:rest Nb037fa23bde44a24b78532f529918460
149 Nd9450b110db2416ca2055a3df1fbd501 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Treatment Outcome
151 rdf:type schema:DefinedTerm
152 Nda2ae56616f74ab4b6d7e654983277b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Child
154 rdf:type schema:DefinedTerm
155 Ndb2735bf1cb8425e84a7d4f97d0ff903 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Valproic Acid
157 rdf:type schema:DefinedTerm
158 Ne920b72b67a94c2a893526f2d95f33c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Adult
160 rdf:type schema:DefinedTerm
161 Neec623ae982a42a882fec5d0d6278324 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Female
163 rdf:type schema:DefinedTerm
164 Nfa9f25f7070645b68c770491e906baac rdf:first sg:person.01110200211.05
165 rdf:rest Nd1d87a7417494970af098bf8012afff3
166 Nff50c6a6080346e788c69ab7a63a462f schema:name doi
167 schema:value 10.1007/s40263-015-0304-5
168 rdf:type schema:PropertyValue
169 Nff845b721a45433da6726860e9715cdf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Aged
171 rdf:type schema:DefinedTerm
172 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
173 schema:name Medical and Health Sciences
174 rdf:type schema:DefinedTerm
175 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
176 schema:name Clinical Sciences
177 rdf:type schema:DefinedTerm
178 sg:grant.2705214 http://pending.schema.org/fundedItem sg:pub.10.1007/s40263-015-0304-5
179 rdf:type schema:MonetaryGrant
180 sg:journal.1111875 schema:issn 1172-7047
181 1179-1934
182 schema:name CNS Drugs
183 rdf:type schema:Periodical
184 sg:person.01042065011.36 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
185 schema:familyName Stewart
186 schema:givenName Alejandra M.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042065011.36
188 rdf:type schema:Person
189 sg:person.01110200211.05 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
190 schema:familyName Albuja
191 schema:givenName Ana C.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110200211.05
193 rdf:type schema:Person
194 sg:person.01224426611.81 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
195 schema:familyName Kapoor
196 schema:givenName Siddharth
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224426611.81
198 rdf:type schema:Person
199 sg:person.01272542011.77 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
200 schema:familyName Baumann
201 schema:givenName Robert J.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272542011.77
203 rdf:type schema:Person
204 sg:person.0672342565.62 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
205 schema:familyName Bensalem-Owen
206 schema:givenName Meriem
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672342565.62
208 rdf:type schema:Person
209 sg:person.0725636411.63 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
210 schema:familyName Zafar
211 schema:givenName Muhammad S.
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725636411.63
213 rdf:type schema:Person
214 sg:person.0743054301.42 schema:affiliation https://www.grid.ac/institutes/grid.413001.7
215 schema:familyName Cook
216 schema:givenName Aaron M.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743054301.42
218 rdf:type schema:Person
219 sg:person.0773751611.35 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
220 schema:familyName Mathias
221 schema:givenName Sally
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773751611.35
223 rdf:type schema:Person
224 sg:pub.10.1007/s12028-012-9695-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1050454608
225 https://doi.org/10.1007/s12028-012-9695-z
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1002/(sici)1099-081x(199907)20:5<233::aid-bdd179>3.0.co;2-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039947515
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/0887-8994(86)90047-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040317175
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s0920-1211(02)00251-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009119553
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1046/j.1365-2125.1998.00652.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032272867
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1056/nejm199809173391202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048565163
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1097/01.mjt.0000155113.89092.58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035592288
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1097/ftd.0b013e3182608e2f schema:sameAs https://app.dimensions.ai/details/publication/pub.1042416501
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1111/head.12499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036676458
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1111/j.1526-4610.2004.04010.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034800659
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1177/0091270004266782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038356658
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1212/01.wnl.0000149527.47600.5a schema:sameAs https://app.dimensions.ai/details/publication/pub.1064346726
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1212/01.wnl.0000224880.35053.26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064348276
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1212/wnl.33.2.185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064364696
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1212/wnl.55.5.722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064379019
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1345/aph.10387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025956596
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1345/aph.18349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029499006
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1592/phco.27.4.519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015367281
260 rdf:type schema:CreativeWork
261 https://www.grid.ac/institutes/grid.266539.d schema:alternateName University of Kentucky
262 schema:name Department of Neurology, College of Medicine, University of Kentucky, Lexington, KY, USA
263 rdf:type schema:Organization
264 https://www.grid.ac/institutes/grid.413001.7 schema:alternateName University of Kentucky HealthCare
265 schema:name Pharmacy Services, UK Healthcare, 800 Rose St. H110, 40536, Lexington, KY, USA
266 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...