Maternal Anti-Fetal Brain IgG Autoantibodies and Autism Spectrum Disorder: Current Knowledge and its Implications for Potential Therapeutics View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-09

AUTHORS

Elizabeth Fox-Edmiston, Judy Van de Water

ABSTRACT

Several studies have found a correlation between the presence of circulating maternal autoantibodies and neuronal dysfunction in the neonate. Specifically, maternal anti-brain autoantibodies, which may access the fetal compartment during gestation, have been identified as one risk factor for developing autism spectrum disorder (ASD). Studies by our laboratory elucidated seven neurodevelopmental proteins recognized by maternal autoantibodies whose presence is associated with a diagnosis of maternal autoantibody-related (MAR) autism in the child. While the specific process of anti-brain autoantibody generation is unclear and the detailed pathogenic mechanisms are currently unknown, identification of the maternal autoantibody targets increases the therapeutic possibilities. The potential therapies discussed in this review provide a framework for possible future medical interventions. More... »

PAGES

715-724

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40263-015-0279-2

DOI

http://dx.doi.org/10.1007/s40263-015-0279-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048861421

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26369920


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autism Spectrum Disorder", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoantibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fetus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin G", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulins, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunologic Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of California, Davis", 
          "id": "https://www.grid.ac/institutes/grid.27860.3b", 
          "name": [
            "Division of Rheumatology/Allergy and Clinical Immunology, University of California, Davis, 451 E. Health Sciences Drive, Suite 6510 GBSF, 95616, Davis, CA, USA", 
            "The M.I.N.D. Institute, University of California, Davis, 95616, Davis, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fox-Edmiston", 
        "givenName": "Elizabeth", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Davis", 
          "id": "https://www.grid.ac/institutes/grid.27860.3b", 
          "name": [
            "Division of Rheumatology/Allergy and Clinical Immunology, University of California, Davis, 451 E. Health Sciences Drive, Suite 6510 GBSF, 95616, Davis, CA, USA", 
            "The M.I.N.D. Institute, University of California, Davis, 95616, Davis, CA, USA", 
            "NIEHS Center for Children\u2019s Environmental Health, University of California, Davis, 95616, Davis, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van de Water", 
        "givenName": "Judy", 
        "id": "sg:person.0634643060.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634643060.67"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nri2529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002235293", 
          "https://doi.org/10.1038/nri2529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002235293", 
          "https://doi.org/10.1038/nri2529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneurol.2011.2506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003335025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2008.05.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003792815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.8483", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006494666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbi.2007.12.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008666554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1103555108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008929556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2004.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010284258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.23.021704.115723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013286597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuro.2007.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013523650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2012.06824.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014145399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneuroim.2006.05.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015219973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneuroim.2007.11.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018640749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10803-011-1378-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019004942", 
          "https://doi.org/10.1007/s10803-011-1378-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020170410", 
          "https://doi.org/10.1038/nri2155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-immunol-020711-075041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020951404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.it.2008.01.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021248825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1196/annals.1361.108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021272841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1196/annals.1361.108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021272841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd001798.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021555718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbi.2006.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022729230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0113430", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023351124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2012/985646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023780510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.2012.01137.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024252867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yhbeh.2007.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024477873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/tp.2013.47", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024563121", 
          "https://doi.org/10.1038/tp.2013.47"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/ern.09.81", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024694539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archgenpsychiatry.2011.76", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027280665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2178-07.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027851921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri3401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033607825", 
          "https://doi.org/10.1038/nri3401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034900230", 
          "https://doi.org/10.1038/nbt1143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034900230", 
          "https://doi.org/10.1038/nbt1143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejso.2013.09.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036429247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneuroim.2009.03.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037206012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(78)90259-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038267662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(78)90259-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038267662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbi.2013.01.084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038721220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0264-410x(03)00334-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038760549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0264-410x(03)00334-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038760549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneuroim.2012.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039277634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.18.1.739", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040357134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1526-0968.2003.00017.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040425700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041874762", 
          "https://doi.org/10.1038/nm1763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.10557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042230758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2004.07.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044495633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.33333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044574000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198608213150805", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048660504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wco.0b013e3283373514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049519870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wco.0b013e3283373514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049519870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wco.0b013e3283373514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049519870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mp.2013.101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050894156", 
          "https://doi.org/10.1038/mp.2013.101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/tp.2013.50", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052159195", 
          "https://doi.org/10.1038/tp.2013.50"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cercor/bhu291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059458525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1542/peds.2008-2445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067827404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082857768", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-09", 
    "datePublishedReg": "2015-09-01", 
    "description": "Several studies have found a correlation between the presence of circulating maternal autoantibodies and neuronal dysfunction in the neonate. Specifically, maternal anti-brain autoantibodies, which may access the fetal compartment during gestation, have been identified as one risk factor for developing autism spectrum disorder (ASD). Studies by our laboratory elucidated seven neurodevelopmental proteins recognized by maternal autoantibodies whose presence is associated with a diagnosis of maternal autoantibody-related (MAR) autism in the child. While the specific process of anti-brain autoantibody generation is unclear and the detailed pathogenic mechanisms are currently unknown, identification of the maternal autoantibody targets increases the therapeutic possibilities. The potential therapies discussed in this review provide a framework for possible future medical interventions. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s40263-015-0279-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2436271", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2699307", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1111875", 
        "issn": [
          "1172-7047", 
          "1179-1934"
        ], 
        "name": "CNS Drugs", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "29"
      }
    ], 
    "name": "Maternal Anti-Fetal Brain IgG Autoantibodies and Autism Spectrum Disorder: Current Knowledge and its Implications for Potential Therapeutics", 
    "pagination": "715-724", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e8c426018f1f5aca37cb2c70165668d9af4c8df2c1775a4b1e1b4dd9d8fe0def"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26369920"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9431220"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s40263-015-0279-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048861421"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s40263-015-0279-2", 
      "https://app.dimensions.ai/details/publication/pub.1048861421"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:13", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000524.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs40263-015-0279-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40263-015-0279-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40263-015-0279-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40263-015-0279-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40263-015-0279-2'


 

This table displays all metadata directly associated to this object as RDF triples.

277 TRIPLES      21 PREDICATES      88 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s40263-015-0279-2 schema:about N122d0e689df24a8e8747fb98f1f6b192
2 N14110b91bb5a4514866ec2e6c05010d5
3 N2316f87290f845ddab6f94ed9549fa18
4 N2b296dc2fedd4444b5fe17e11a23676e
5 N3affc6fd5daf4cd29024901c4c4c6120
6 N40f6b5e752024697996cab209ea53b86
7 N534a7d7b23b34ade88c1c81be85a5fed
8 N9d6853a508534680965b11cd7c9fb573
9 Na03f4c09ccbd4501b15d2e92a21b1b1c
10 Na6ee63b9ced94b09b92712c4cb0fa2d5
11 Nf9be14aa860349369550fe9224385c0f
12 anzsrc-for:11
13 anzsrc-for:1109
14 schema:author N1d8143b4ab4440a6b0e01042adb9b246
15 schema:citation sg:pub.10.1007/s10803-011-1378-7
16 sg:pub.10.1038/mp.2013.101
17 sg:pub.10.1038/nbt1143
18 sg:pub.10.1038/nm1763
19 sg:pub.10.1038/nri2155
20 sg:pub.10.1038/nri2529
21 sg:pub.10.1038/nri3401
22 sg:pub.10.1038/tp.2013.47
23 sg:pub.10.1038/tp.2013.50
24 https://app.dimensions.ai/details/publication/pub.1082857768
25 https://doi.org/10.1001/archgenpsychiatry.2011.76
26 https://doi.org/10.1001/archneurol.2011.2506
27 https://doi.org/10.1002/14651858.cd001798.pub2
28 https://doi.org/10.1002/ana.10557
29 https://doi.org/10.1002/art.33333
30 https://doi.org/10.1016/0022-1759(78)90259-4
31 https://doi.org/10.1016/j.bbi.2006.08.005
32 https://doi.org/10.1016/j.bbi.2007.12.007
33 https://doi.org/10.1016/j.bbi.2013.01.084
34 https://doi.org/10.1016/j.biopsych.2008.05.006
35 https://doi.org/10.1016/j.coi.2004.09.002
36 https://doi.org/10.1016/j.ejso.2013.09.008
37 https://doi.org/10.1016/j.immuni.2004.07.011
38 https://doi.org/10.1016/j.it.2008.01.007
39 https://doi.org/10.1016/j.jneuroim.2006.05.025
40 https://doi.org/10.1016/j.jneuroim.2007.11.004
41 https://doi.org/10.1016/j.jneuroim.2009.03.011
42 https://doi.org/10.1016/j.jneuroim.2012.08.002
43 https://doi.org/10.1016/j.neuro.2007.10.010
44 https://doi.org/10.1016/j.yhbeh.2007.02.001
45 https://doi.org/10.1016/s0264-410x(03)00334-7
46 https://doi.org/10.1046/j.1526-0968.2003.00017.x
47 https://doi.org/10.1056/nejm198608213150805
48 https://doi.org/10.1073/pnas.1103555108
49 https://doi.org/10.1093/cercor/bhu291
50 https://doi.org/10.1097/wco.0b013e3283373514
51 https://doi.org/10.1111/j.1600-065x.2012.01137.x
52 https://doi.org/10.1111/j.1749-6632.2012.06824.x
53 https://doi.org/10.1146/annurev-immunol-020711-075041
54 https://doi.org/10.1146/annurev.immunol.18.1.739
55 https://doi.org/10.1146/annurev.immunol.23.021704.115723
56 https://doi.org/10.1155/2012/985646
57 https://doi.org/10.1196/annals.1361.108
58 https://doi.org/10.1289/ehp.8483
59 https://doi.org/10.1371/journal.pone.0113430
60 https://doi.org/10.1523/jneurosci.2178-07.2007
61 https://doi.org/10.1542/peds.2008-2445
62 https://doi.org/10.1586/ern.09.81
63 schema:datePublished 2015-09
64 schema:datePublishedReg 2015-09-01
65 schema:description Several studies have found a correlation between the presence of circulating maternal autoantibodies and neuronal dysfunction in the neonate. Specifically, maternal anti-brain autoantibodies, which may access the fetal compartment during gestation, have been identified as one risk factor for developing autism spectrum disorder (ASD). Studies by our laboratory elucidated seven neurodevelopmental proteins recognized by maternal autoantibodies whose presence is associated with a diagnosis of maternal autoantibody-related (MAR) autism in the child. While the specific process of anti-brain autoantibody generation is unclear and the detailed pathogenic mechanisms are currently unknown, identification of the maternal autoantibody targets increases the therapeutic possibilities. The potential therapies discussed in this review provide a framework for possible future medical interventions.
66 schema:genre research_article
67 schema:inLanguage en
68 schema:isAccessibleForFree true
69 schema:isPartOf N2ee9771ba91043aebc1993f7d36ed2ff
70 N6bf5a930cf6c430c88a033b8c5d64027
71 sg:journal.1111875
72 schema:name Maternal Anti-Fetal Brain IgG Autoantibodies and Autism Spectrum Disorder: Current Knowledge and its Implications for Potential Therapeutics
73 schema:pagination 715-724
74 schema:productId N2c9bccd2536d49e1bad1397e40b300e4
75 N383f32619b6245c69b888bd1466e6894
76 N5cae9a5c6e7d419981b8010d99454b35
77 N869a25d12c0f46f09fd43622911d64d7
78 N8afa669f84e34c74a45235f928b2ac66
79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048861421
80 https://doi.org/10.1007/s40263-015-0279-2
81 schema:sdDatePublished 2019-04-10T14:13
82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
83 schema:sdPublisher N5a2b4ad6a0fe43d89cbbfcb992277038
84 schema:url http://link.springer.com/10.1007%2Fs40263-015-0279-2
85 sgo:license sg:explorer/license/
86 sgo:sdDataset articles
87 rdf:type schema:ScholarlyArticle
88 N122d0e689df24a8e8747fb98f1f6b192 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Immunologic Factors
90 rdf:type schema:DefinedTerm
91 N14110b91bb5a4514866ec2e6c05010d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Immunoglobulin G
93 rdf:type schema:DefinedTerm
94 N1d8143b4ab4440a6b0e01042adb9b246 rdf:first N293fcd42e01b4536831f519a847cf7f6
95 rdf:rest N3b8f7aa8f5744590a3db9ad198347a02
96 N2316f87290f845ddab6f94ed9549fa18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Humans
98 rdf:type schema:DefinedTerm
99 N293fcd42e01b4536831f519a847cf7f6 schema:affiliation https://www.grid.ac/institutes/grid.27860.3b
100 schema:familyName Fox-Edmiston
101 schema:givenName Elizabeth
102 rdf:type schema:Person
103 N2b296dc2fedd4444b5fe17e11a23676e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Female
105 rdf:type schema:DefinedTerm
106 N2c9bccd2536d49e1bad1397e40b300e4 schema:name dimensions_id
107 schema:value pub.1048861421
108 rdf:type schema:PropertyValue
109 N2ee9771ba91043aebc1993f7d36ed2ff schema:issueNumber 9
110 rdf:type schema:PublicationIssue
111 N383f32619b6245c69b888bd1466e6894 schema:name pubmed_id
112 schema:value 26369920
113 rdf:type schema:PropertyValue
114 N3affc6fd5daf4cd29024901c4c4c6120 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Risk Factors
116 rdf:type schema:DefinedTerm
117 N3b8f7aa8f5744590a3db9ad198347a02 rdf:first sg:person.0634643060.67
118 rdf:rest rdf:nil
119 N40f6b5e752024697996cab209ea53b86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Fetus
121 rdf:type schema:DefinedTerm
122 N534a7d7b23b34ade88c1c81be85a5fed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Autism Spectrum Disorder
124 rdf:type schema:DefinedTerm
125 N5a2b4ad6a0fe43d89cbbfcb992277038 schema:name Springer Nature - SN SciGraph project
126 rdf:type schema:Organization
127 N5cae9a5c6e7d419981b8010d99454b35 schema:name readcube_id
128 schema:value e8c426018f1f5aca37cb2c70165668d9af4c8df2c1775a4b1e1b4dd9d8fe0def
129 rdf:type schema:PropertyValue
130 N6bf5a930cf6c430c88a033b8c5d64027 schema:volumeNumber 29
131 rdf:type schema:PublicationVolume
132 N869a25d12c0f46f09fd43622911d64d7 schema:name nlm_unique_id
133 schema:value 9431220
134 rdf:type schema:PropertyValue
135 N8afa669f84e34c74a45235f928b2ac66 schema:name doi
136 schema:value 10.1007/s40263-015-0279-2
137 rdf:type schema:PropertyValue
138 N9d6853a508534680965b11cd7c9fb573 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Brain
140 rdf:type schema:DefinedTerm
141 Na03f4c09ccbd4501b15d2e92a21b1b1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Autoantibodies
143 rdf:type schema:DefinedTerm
144 Na6ee63b9ced94b09b92712c4cb0fa2d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Immunoglobulins, Intravenous
146 rdf:type schema:DefinedTerm
147 Nf9be14aa860349369550fe9224385c0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Pregnancy
149 rdf:type schema:DefinedTerm
150 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
151 schema:name Medical and Health Sciences
152 rdf:type schema:DefinedTerm
153 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
154 schema:name Neurosciences
155 rdf:type schema:DefinedTerm
156 sg:grant.2436271 http://pending.schema.org/fundedItem sg:pub.10.1007/s40263-015-0279-2
157 rdf:type schema:MonetaryGrant
158 sg:grant.2699307 http://pending.schema.org/fundedItem sg:pub.10.1007/s40263-015-0279-2
159 rdf:type schema:MonetaryGrant
160 sg:journal.1111875 schema:issn 1172-7047
161 1179-1934
162 schema:name CNS Drugs
163 rdf:type schema:Periodical
164 sg:person.0634643060.67 schema:affiliation https://www.grid.ac/institutes/grid.27860.3b
165 schema:familyName Van de Water
166 schema:givenName Judy
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634643060.67
168 rdf:type schema:Person
169 sg:pub.10.1007/s10803-011-1378-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019004942
170 https://doi.org/10.1007/s10803-011-1378-7
171 rdf:type schema:CreativeWork
172 sg:pub.10.1038/mp.2013.101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050894156
173 https://doi.org/10.1038/mp.2013.101
174 rdf:type schema:CreativeWork
175 sg:pub.10.1038/nbt1143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034900230
176 https://doi.org/10.1038/nbt1143
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/nm1763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041874762
179 https://doi.org/10.1038/nm1763
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/nri2155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020170410
182 https://doi.org/10.1038/nri2155
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/nri2529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002235293
185 https://doi.org/10.1038/nri2529
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/nri3401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033607825
188 https://doi.org/10.1038/nri3401
189 rdf:type schema:CreativeWork
190 sg:pub.10.1038/tp.2013.47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024563121
191 https://doi.org/10.1038/tp.2013.47
192 rdf:type schema:CreativeWork
193 sg:pub.10.1038/tp.2013.50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052159195
194 https://doi.org/10.1038/tp.2013.50
195 rdf:type schema:CreativeWork
196 https://app.dimensions.ai/details/publication/pub.1082857768 schema:CreativeWork
197 https://doi.org/10.1001/archgenpsychiatry.2011.76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027280665
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1001/archneurol.2011.2506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003335025
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1002/14651858.cd001798.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021555718
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1002/ana.10557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042230758
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1002/art.33333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044574000
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/0022-1759(78)90259-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038267662
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.bbi.2006.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022729230
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.bbi.2007.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008666554
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.bbi.2013.01.084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038721220
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.biopsych.2008.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003792815
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.coi.2004.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010284258
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.ejso.2013.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036429247
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.immuni.2004.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044495633
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.it.2008.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021248825
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.jneuroim.2006.05.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015219973
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/j.jneuroim.2007.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018640749
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/j.jneuroim.2009.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037206012
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/j.jneuroim.2012.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039277634
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/j.neuro.2007.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013523650
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/j.yhbeh.2007.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024477873
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/s0264-410x(03)00334-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038760549
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1046/j.1526-0968.2003.00017.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040425700
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1056/nejm198608213150805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048660504
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1073/pnas.1103555108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008929556
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1093/cercor/bhu291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059458525
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1097/wco.0b013e3283373514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049519870
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1111/j.1600-065x.2012.01137.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024252867
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1111/j.1749-6632.2012.06824.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014145399
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1146/annurev-immunol-020711-075041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020951404
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1146/annurev.immunol.18.1.739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040357134
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1146/annurev.immunol.23.021704.115723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013286597
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1155/2012/985646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023780510
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1196/annals.1361.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021272841
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1289/ehp.8483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006494666
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1371/journal.pone.0113430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023351124
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1523/jneurosci.2178-07.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027851921
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1542/peds.2008-2445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067827404
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1586/ern.09.81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024694539
272 rdf:type schema:CreativeWork
273 https://www.grid.ac/institutes/grid.27860.3b schema:alternateName University of California, Davis
274 schema:name Division of Rheumatology/Allergy and Clinical Immunology, University of California, Davis, 451 E. Health Sciences Drive, Suite 6510 GBSF, 95616, Davis, CA, USA
275 NIEHS Center for Children’s Environmental Health, University of California, Davis, 95616, Davis, CA, USA
276 The M.I.N.D. Institute, University of California, Davis, 95616, Davis, CA, USA
277 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...