Comparative Efficacy and Risk of Harms of Immediate- versus Extended-Release Second-Generation Antidepressants: A Systematic Review with Network Meta-Analysis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-08

AUTHORS

Barbara Nussbaumer, Laura C. Morgan, Ursula Reichenpfader, Amy Greenblatt, Richard A. Hansen, Megan Van Noord, Linda Lux, Bradley N. Gaynes, Gerald Gartlehner

ABSTRACT

BACKGROUND: Major depressive disorder (MDD) has detrimental effects on an individual's personal life, leads to increased risk of comorbidities, and places an enormous economic burden on society. Several 'second-generation' antidepressants are available as both immediate-release (IR) and extended-release formulations. The advantage of extended-release formulations may be the potentially improved adherence and a lower risk of adverse events. OBJECTIVE: We conducted a systematic review to assess the comparative efficacy, risk of harms, and patients' adherence of IR and extended-release antidepressants for the treatment of MDD. DATA SOURCE: English-language abstracts were retrieved from PubMed, EMBASE, the Cochrane Library, PsycINFO, and International Pharmaceutical Abstracts from 1980 to October 2012, as well as from reference lists of pertinent review articles and grey literature searches. ELIGIBILITY CRITERIA: We included head-to-head randomized controlled trials (RCTs) of at least 6 weeks' duration that compared an IR formulation with an extended-release formulation of the same antidepressant in adult patients with MDD. We also included placebo-controlled trials to conduct a network meta-analysis. To assess harms and adherence, in addition to RCTs, we searched for observational studies with ≥1,000 participants and a follow-up of ≥12 weeks. STUDY APPRAISAL AND SYNTHESIS METHODS: We dually reviewed abstracts and full texts and assessed quality ratings. Lacking head-to-head evidence for many comparisons of interest, we conducted network meta-analyses using Bayesian methods. Our outcome measure of choice was response on the Hamilton Depression Rating Scale. RESULTS: We located seven head-to-head trials and 94 placebo- and active-controlled trials for network meta-analysis. Overall, our analyses indicate that IR and extended-release formulations do not differ substantially with respect to efficacy and risk of harms. The evidence is mixed with respect to differences in adherence, indicating lower adherence for IR formulations. LIMITATIONS: The lack of head-to-head comparisons for many drugs compromises our conclusions. Network meta-analyses have methodological limitations that need to be taken into consideration when interpreting findings. CONCLUSION: Available evidence currently shows no clear differences between the two formulations and therefore we cannot recommend a first choice. However, if adherence or compliance with one medication is an issue, then clinicians and patients should consider the alternative medication. If adherence or costs are a problem with one formulation, consideration of the other formulation to provide an adequate treatment trial is reasonable. More... »

PAGES

699-712

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40263-014-0169-z

DOI

http://dx.doi.org/10.1007/s40263-014-0169-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031746828

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24794101


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antidepressive Agents, Second-Generation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Delayed-Action Preparations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Depressive Disorder, Major", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Randomized Controlled Trials as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Danube University Krems", 
          "id": "https://www.grid.ac/institutes/grid.15462.34", 
          "name": [
            "Department for Evidence-Based Medicine and Clinical Epidemiology, Danube University Krems, Dr.-Karl-Dorrek Strasse 30, 3500, Krems, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nussbaumer", 
        "givenName": "Barbara", 
        "id": "sg:person.0733117013.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733117013.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RTI International", 
          "id": "https://www.grid.ac/institutes/grid.62562.35", 
          "name": [
            "Research Triangle Institute International, 3040 Cornwallis Road, PO Box 12194, 27709, Research Triangle Park, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morgan", 
        "givenName": "Laura C.", 
        "id": "sg:person.01041162042.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041162042.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Link\u00f6ping University", 
          "id": "https://www.grid.ac/institutes/grid.5640.7", 
          "name": [
            "Department for Evidence-Based Medicine and Clinical Epidemiology, Danube University Krems, Dr.-Karl-Dorrek Strasse 30, 3500, Krems, Austria", 
            "Division of Community Medicine, Department of Medical and Health Sciences, Link\u00f6ping University, SE-581 83, Link\u00f6ping, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reichenpfader", 
        "givenName": "Ursula", 
        "id": "sg:person.01045023142.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045023142.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RTI International", 
          "id": "https://www.grid.ac/institutes/grid.62562.35", 
          "name": [
            "Research Triangle Institute International, 3040 Cornwallis Road, PO Box 12194, 27709, Research Triangle Park, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Greenblatt", 
        "givenName": "Amy", 
        "id": "sg:person.01300022413.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300022413.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Auburn University", 
          "id": "https://www.grid.ac/institutes/grid.252546.2", 
          "name": [
            "Auburn University Harrison School of Pharmacy, 022 James E. Foy Hall, 36849, Auburn, AL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hansen", 
        "givenName": "Richard A.", 
        "id": "sg:person.0717203466.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717203466.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Danube University Krems", 
          "id": "https://www.grid.ac/institutes/grid.15462.34", 
          "name": [
            "Department for Evidence-Based Medicine and Clinical Epidemiology, Danube University Krems, Dr.-Karl-Dorrek Strasse 30, 3500, Krems, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van Noord", 
        "givenName": "Megan", 
        "id": "sg:person.01223523642.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223523642.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RTI International", 
          "id": "https://www.grid.ac/institutes/grid.62562.35", 
          "name": [
            "Research Triangle Institute International, 3040 Cornwallis Road, PO Box 12194, 27709, Research Triangle Park, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lux", 
        "givenName": "Linda", 
        "id": "sg:person.01230124647.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230124647.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of North Carolina at Chapel Hill", 
          "id": "https://www.grid.ac/institutes/grid.10698.36", 
          "name": [
            "Department of Psychiatry, University of North Carolina School of Medicine, Suite 304, Room J, MacNider Building, 27599-7160, Chapel Hill, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gaynes", 
        "givenName": "Bradley N.", 
        "id": "sg:person.01220514245.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220514245.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RTI International", 
          "id": "https://www.grid.ac/institutes/grid.62562.35", 
          "name": [
            "Department for Evidence-Based Medicine and Clinical Epidemiology, Danube University Krems, Dr.-Karl-Dorrek Strasse 30, 3500, Krems, Austria", 
            "Research Triangle Institute International, 3040 Cornwallis Road, PO Box 12194, 27709, Research Triangle Park, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gartlehner", 
        "givenName": "Gerald", 
        "id": "sg:person.0724733442.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724733442.73"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/00004850-200015010-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001031586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004850-200015010-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001031586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/9780470712184.ch8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002462072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/gme.0b013e3181d88962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002607554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/gme.0b013e3181d88962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002607554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/gme.0b013e3181d88962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002607554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arcmed.2004.12.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004574712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0149-2918(01)80090-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006319765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/yic.0b013e32830cebed", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006795240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/yic.0b013e32830cebed", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006795240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/yic.0b013e32830cebed", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006795240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/yic.0b013e32830cebed", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006795240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s0893-133x(00)00249-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007098081", 
          "https://doi.org/10.1016/s0893-133x(00)00249-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1461145711001027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008148189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.euroneuro.2005.04.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009594045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.euroneuro.2005.04.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009594045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-0327(98)00188-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010406338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0272989x12458724", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010893288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0272989x12458724", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010893288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004850-199609000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012954126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004850-199609000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012954126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1185/030079905x53243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013504332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/sim.1875", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014451574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1185/030079907x210732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014512130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004714-199406000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016708778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004714-199406000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016708778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10401239909147072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017433018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.1990.00390200073014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017990194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jcp.0b013e31822c0a68", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018328687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jcp.0b013e31822c0a68", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018328687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004850-199503000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019030963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004850-199503000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019030963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/psy.0b013e318148c19a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019661723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/psy.0b013e318148c19a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019661723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1092852900020046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020423657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-3956(02)00060-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020906331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-3956(02)00060-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020906331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.euroneuro.2004.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021012973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1192/bjp.180.6.528", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022712527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.287.14.1807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023236168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004714-200204000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023250614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004714-200204000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023250614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-4733.2008.00347.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026399947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0447.1989.tb07188.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027917570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0924-9338(97)86377-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028337464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1819.2007.01666.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028603042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004850-199409000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029629457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004850-199409000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029629457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archgenpsychiatry.2009.81", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029766285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10401239709147791", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029781291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-0327(99)00067-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030292769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eurpsy.2006.03.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031610395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0149-2918(01)80109-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032235284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1377/hlthaff.25.3.635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033512011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/yic.0b013e3281e2c84b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033886375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/yic.0b013e3281e2c84b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033886375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpsychires.2004.04.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033898511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0149-2918(00)88317-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034455091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hup.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034787256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00019053-200927060-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035738910", 
          "https://doi.org/10.2165/00019053-200927060-00006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00019053-200927060-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035738910", 
          "https://doi.org/10.2165/00019053-200927060-00006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1185/030079906x121039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036892250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-0773.2002.900304.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037547319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1185/030079906x115513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037651959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(98)00092-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038019962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00213-010-1822-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038684183", 
          "https://doi.org/10.1007/s00213-010-1822-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.yic.0000068045.82050.00", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039340348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.yic.0000068045.82050.00", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039340348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0924-9338(99)80714-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040565590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mjt.0b013e31802b5954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040618352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mjt.0b013e31802b5954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040618352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1185/03007990802336780", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041017613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0447.1988.tb06353.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041227463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-1842.2009.00865.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041380758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-1842.2009.00865.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041380758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1185/030079906x167273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043103436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.jcp.0000132448.65972.d9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043853723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.jcp.0000132448.65972.d9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043853723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1520-6394(2000)11:2<58::aid-da2>3.0.co;2-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044748192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpsychires.2005.07.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045762046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00044011-200727070-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046419932", 
          "https://doi.org/10.2165/00044011-200727070-00005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1185/030079906x167453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046796369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpsyc.62.6.593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047074916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0278-5846(95)00292-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047215583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clinthera.2009.07.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050093876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10401239809147030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050421937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1819.2011.02243.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050664258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0447.1993.tb03345.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051308981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/da.20222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052730610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1461145702002857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054932751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1461145709000224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054933380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1461145709000224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054933380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2006-931544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057457292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004714-200004000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060188387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004714-200004000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060188387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004714-200004000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060188387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004714-200004000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060188387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.ajp.157.3.344", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063493076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1192/bjp.164.6.802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064172121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3310/hta7270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071139743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.11m06831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072205261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v58n0904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072207078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v58n1104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072207108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v59n0305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072207165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v59n0508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072207199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v59n0703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072207227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v60n0105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072207320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v61n0204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072207583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v61n0911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072207733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v61n1107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072207780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v61n1207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072207802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v63n0302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072208114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v63n0309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072208121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v63n0407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072208141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v63n0707", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072208219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v64n0810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072208552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v64n0912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072208579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v65n0906", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072208921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v66n1015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072209286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v67n1102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072209647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v68n1105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072210019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-155-11-201112060-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073712272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074893466", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076618873", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076880601", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076880602", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076880603", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076880605", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077129685", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077822333", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3810/pgm.11.1999.suppl1.5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077943310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078202436", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078524265", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078562016", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078945613", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079555265", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079665232", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079677271", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079784429", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082502293", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082637516", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082884381", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082884388", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082960284", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/ajp.155.3.367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083226941"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-08", 
    "datePublishedReg": "2014-08-01", 
    "description": "BACKGROUND: Major depressive disorder (MDD) has detrimental effects on an individual's personal life, leads to increased risk of comorbidities, and places an enormous economic burden on society. Several 'second-generation' antidepressants are available as both immediate-release (IR) and extended-release formulations. The advantage of extended-release formulations may be the potentially improved adherence and a lower risk of adverse events.\nOBJECTIVE: We conducted a systematic review to assess the comparative efficacy, risk of harms, and patients' adherence of IR and extended-release antidepressants for the treatment of MDD.\nDATA SOURCE: English-language abstracts were retrieved from PubMed, EMBASE, the Cochrane Library, PsycINFO, and International Pharmaceutical Abstracts from 1980 to October 2012, as well as from reference lists of pertinent review articles and grey literature searches.\nELIGIBILITY CRITERIA: We included head-to-head randomized controlled trials (RCTs) of at least 6 weeks' duration that compared an IR formulation with an extended-release formulation of the same antidepressant in adult patients with MDD. We also included placebo-controlled trials to conduct a network meta-analysis. To assess harms and adherence, in addition to RCTs, we searched for observational studies with \u22651,000 participants and a follow-up of \u226512 weeks.\nSTUDY APPRAISAL AND SYNTHESIS METHODS: We dually reviewed abstracts and full texts and assessed quality ratings. Lacking head-to-head evidence for many comparisons of interest, we conducted network meta-analyses using Bayesian methods. Our outcome measure of choice was response on the Hamilton Depression Rating Scale.\nRESULTS: We located seven head-to-head trials and 94 placebo- and active-controlled trials for network meta-analysis. Overall, our analyses indicate that IR and extended-release formulations do not differ substantially with respect to efficacy and risk of harms. The evidence is mixed with respect to differences in adherence, indicating lower adherence for IR formulations.\nLIMITATIONS: The lack of head-to-head comparisons for many drugs compromises our conclusions. Network meta-analyses have methodological limitations that need to be taken into consideration when interpreting findings.\nCONCLUSION: Available evidence currently shows no clear differences between the two formulations and therefore we cannot recommend a first choice. However, if adherence or compliance with one medication is an issue, then clinicians and patients should consider the alternative medication. If adherence or costs are a problem with one formulation, consideration of the other formulation to provide an adequate treatment trial is reasonable.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s40263-014-0169-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1111875", 
        "issn": [
          "1172-7047", 
          "1179-1934"
        ], 
        "name": "CNS Drugs", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "28"
      }
    ], 
    "name": "Comparative Efficacy and Risk of Harms of Immediate- versus Extended-Release Second-Generation Antidepressants: A Systematic Review with Network Meta-Analysis", 
    "pagination": "699-712", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "973c22f35e81c3ce6a4ac16c209087a7aa45b961de67d43c1d091490dbe9d9b6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24794101"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9431220"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s40263-014-0169-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031746828"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s40263-014-0169-z", 
      "https://app.dimensions.ai/details/publication/pub.1031746828"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000522.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs40263-014-0169-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40263-014-0169-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40263-014-0169-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40263-014-0169-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40263-014-0169-z'


 

This table displays all metadata directly associated to this object as RDF triples.

503 TRIPLES      21 PREDICATES      154 URIs      27 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s40263-014-0169-z schema:about N43151f7b1bae4e5ba22833d49d79c64b
2 N69adf65b21464bf6808305824957c370
3 N7a527ed4d42340a388c3fb9640ef05b4
4 N8b3fa2276a7c4b76ac3aaa2fc61f7216
5 Ncf0c01a98159426da4bb69056dc9958b
6 Ne2e9e19264c743e0ba23951b72b493b1
7 anzsrc-for:11
8 anzsrc-for:1103
9 schema:author N034b842f4fd740058218a3f6e8b6715b
10 schema:citation sg:pub.10.1007/s00213-010-1822-y
11 sg:pub.10.1016/s0893-133x(00)00249-9
12 sg:pub.10.2165/00019053-200927060-00006
13 sg:pub.10.2165/00044011-200727070-00005
14 https://app.dimensions.ai/details/publication/pub.1074893466
15 https://app.dimensions.ai/details/publication/pub.1076618873
16 https://app.dimensions.ai/details/publication/pub.1076880601
17 https://app.dimensions.ai/details/publication/pub.1076880602
18 https://app.dimensions.ai/details/publication/pub.1076880603
19 https://app.dimensions.ai/details/publication/pub.1076880605
20 https://app.dimensions.ai/details/publication/pub.1077129685
21 https://app.dimensions.ai/details/publication/pub.1077822333
22 https://app.dimensions.ai/details/publication/pub.1078202436
23 https://app.dimensions.ai/details/publication/pub.1078524265
24 https://app.dimensions.ai/details/publication/pub.1078562016
25 https://app.dimensions.ai/details/publication/pub.1078945613
26 https://app.dimensions.ai/details/publication/pub.1079555265
27 https://app.dimensions.ai/details/publication/pub.1079665232
28 https://app.dimensions.ai/details/publication/pub.1079677271
29 https://app.dimensions.ai/details/publication/pub.1079784429
30 https://app.dimensions.ai/details/publication/pub.1082502293
31 https://app.dimensions.ai/details/publication/pub.1082637516
32 https://app.dimensions.ai/details/publication/pub.1082884381
33 https://app.dimensions.ai/details/publication/pub.1082884388
34 https://app.dimensions.ai/details/publication/pub.1082960284
35 https://doi.org/10.1001/archgenpsychiatry.2009.81
36 https://doi.org/10.1001/archinte.1990.00390200073014
37 https://doi.org/10.1001/archpsyc.62.6.593
38 https://doi.org/10.1001/jama.287.14.1807
39 https://doi.org/10.1002/(sici)1520-6394(2000)11:2<58::aid-da2>3.0.co;2-h
40 https://doi.org/10.1002/9780470712184.ch8
41 https://doi.org/10.1002/da.20222
42 https://doi.org/10.1002/hup.1262
43 https://doi.org/10.1002/sim.1875
44 https://doi.org/10.1016/0278-5846(95)00292-8
45 https://doi.org/10.1016/j.arcmed.2004.12.018
46 https://doi.org/10.1016/j.clinthera.2009.07.006
47 https://doi.org/10.1016/j.euroneuro.2004.01.002
48 https://doi.org/10.1016/j.euroneuro.2005.04.012
49 https://doi.org/10.1016/j.eurpsy.2006.03.004
50 https://doi.org/10.1016/j.jpsychires.2004.04.011
51 https://doi.org/10.1016/j.jpsychires.2005.07.009
52 https://doi.org/10.1016/s0006-3223(98)00092-4
53 https://doi.org/10.1016/s0022-3956(02)00060-2
54 https://doi.org/10.1016/s0149-2918(00)88317-4
55 https://doi.org/10.1016/s0149-2918(01)80090-4
56 https://doi.org/10.1016/s0149-2918(01)80109-0
57 https://doi.org/10.1016/s0165-0327(98)00188-8
58 https://doi.org/10.1016/s0165-0327(99)00067-1
59 https://doi.org/10.1016/s0924-9338(97)86377-8
60 https://doi.org/10.1016/s0924-9338(99)80714-7
61 https://doi.org/10.1017/s1092852900020046
62 https://doi.org/10.1017/s1461145702002857
63 https://doi.org/10.1017/s1461145709000224
64 https://doi.org/10.1017/s1461145711001027
65 https://doi.org/10.1034/j.1600-0773.2002.900304.x
66 https://doi.org/10.1055/s-2006-931544
67 https://doi.org/10.1097/00004714-199406000-00004
68 https://doi.org/10.1097/00004714-200004000-00003
69 https://doi.org/10.1097/00004714-200204000-00006
70 https://doi.org/10.1097/00004850-199409000-00001
71 https://doi.org/10.1097/00004850-199503000-00001
72 https://doi.org/10.1097/00004850-199609000-00002
73 https://doi.org/10.1097/00004850-200015010-00004
74 https://doi.org/10.1097/01.jcp.0000132448.65972.d9
75 https://doi.org/10.1097/01.yic.0000068045.82050.00
76 https://doi.org/10.1097/gme.0b013e3181d88962
77 https://doi.org/10.1097/jcp.0b013e31822c0a68
78 https://doi.org/10.1097/mjt.0b013e31802b5954
79 https://doi.org/10.1097/psy.0b013e318148c19a
80 https://doi.org/10.1097/yic.0b013e3281e2c84b
81 https://doi.org/10.1097/yic.0b013e32830cebed
82 https://doi.org/10.1111/j.1440-1819.2007.01666.x
83 https://doi.org/10.1111/j.1440-1819.2011.02243.x
84 https://doi.org/10.1111/j.1471-1842.2009.00865.x
85 https://doi.org/10.1111/j.1524-4733.2008.00347.x
86 https://doi.org/10.1111/j.1600-0447.1988.tb06353.x
87 https://doi.org/10.1111/j.1600-0447.1989.tb07188.x
88 https://doi.org/10.1111/j.1600-0447.1993.tb03345.x
89 https://doi.org/10.1176/ajp.155.3.367
90 https://doi.org/10.1176/appi.ajp.157.3.344
91 https://doi.org/10.1177/0272989x12458724
92 https://doi.org/10.1185/030079905x53243
93 https://doi.org/10.1185/030079906x115513
94 https://doi.org/10.1185/030079906x121039
95 https://doi.org/10.1185/030079906x167273
96 https://doi.org/10.1185/030079906x167453
97 https://doi.org/10.1185/030079907x210732
98 https://doi.org/10.1185/03007990802336780
99 https://doi.org/10.1192/bjp.164.6.802
100 https://doi.org/10.1192/bjp.180.6.528
101 https://doi.org/10.1377/hlthaff.25.3.635
102 https://doi.org/10.3109/10401239709147791
103 https://doi.org/10.3109/10401239809147030
104 https://doi.org/10.3109/10401239909147072
105 https://doi.org/10.3310/hta7270
106 https://doi.org/10.3810/pgm.11.1999.suppl1.5
107 https://doi.org/10.4088/jcp.11m06831
108 https://doi.org/10.4088/jcp.v58n0904
109 https://doi.org/10.4088/jcp.v58n1104
110 https://doi.org/10.4088/jcp.v59n0305
111 https://doi.org/10.4088/jcp.v59n0508
112 https://doi.org/10.4088/jcp.v59n0703
113 https://doi.org/10.4088/jcp.v60n0105
114 https://doi.org/10.4088/jcp.v61n0204
115 https://doi.org/10.4088/jcp.v61n0911
116 https://doi.org/10.4088/jcp.v61n1107
117 https://doi.org/10.4088/jcp.v61n1207
118 https://doi.org/10.4088/jcp.v63n0302
119 https://doi.org/10.4088/jcp.v63n0309
120 https://doi.org/10.4088/jcp.v63n0407
121 https://doi.org/10.4088/jcp.v63n0707
122 https://doi.org/10.4088/jcp.v64n0810
123 https://doi.org/10.4088/jcp.v64n0912
124 https://doi.org/10.4088/jcp.v65n0906
125 https://doi.org/10.4088/jcp.v66n1015
126 https://doi.org/10.4088/jcp.v67n1102
127 https://doi.org/10.4088/jcp.v68n1105
128 https://doi.org/10.7326/0003-4819-155-11-201112060-00009
129 schema:datePublished 2014-08
130 schema:datePublishedReg 2014-08-01
131 schema:description BACKGROUND: Major depressive disorder (MDD) has detrimental effects on an individual's personal life, leads to increased risk of comorbidities, and places an enormous economic burden on society. Several 'second-generation' antidepressants are available as both immediate-release (IR) and extended-release formulations. The advantage of extended-release formulations may be the potentially improved adherence and a lower risk of adverse events. OBJECTIVE: We conducted a systematic review to assess the comparative efficacy, risk of harms, and patients' adherence of IR and extended-release antidepressants for the treatment of MDD. DATA SOURCE: English-language abstracts were retrieved from PubMed, EMBASE, the Cochrane Library, PsycINFO, and International Pharmaceutical Abstracts from 1980 to October 2012, as well as from reference lists of pertinent review articles and grey literature searches. ELIGIBILITY CRITERIA: We included head-to-head randomized controlled trials (RCTs) of at least 6 weeks' duration that compared an IR formulation with an extended-release formulation of the same antidepressant in adult patients with MDD. We also included placebo-controlled trials to conduct a network meta-analysis. To assess harms and adherence, in addition to RCTs, we searched for observational studies with ≥1,000 participants and a follow-up of ≥12 weeks. STUDY APPRAISAL AND SYNTHESIS METHODS: We dually reviewed abstracts and full texts and assessed quality ratings. Lacking head-to-head evidence for many comparisons of interest, we conducted network meta-analyses using Bayesian methods. Our outcome measure of choice was response on the Hamilton Depression Rating Scale. RESULTS: We located seven head-to-head trials and 94 placebo- and active-controlled trials for network meta-analysis. Overall, our analyses indicate that IR and extended-release formulations do not differ substantially with respect to efficacy and risk of harms. The evidence is mixed with respect to differences in adherence, indicating lower adherence for IR formulations. LIMITATIONS: The lack of head-to-head comparisons for many drugs compromises our conclusions. Network meta-analyses have methodological limitations that need to be taken into consideration when interpreting findings. CONCLUSION: Available evidence currently shows no clear differences between the two formulations and therefore we cannot recommend a first choice. However, if adherence or compliance with one medication is an issue, then clinicians and patients should consider the alternative medication. If adherence or costs are a problem with one formulation, consideration of the other formulation to provide an adequate treatment trial is reasonable.
132 schema:genre research_article
133 schema:inLanguage en
134 schema:isAccessibleForFree false
135 schema:isPartOf N7a7287d0cc0d460aa1a0f964f7bd592d
136 Nfa0cb956798c4135afe1b7aac8401e43
137 sg:journal.1111875
138 schema:name Comparative Efficacy and Risk of Harms of Immediate- versus Extended-Release Second-Generation Antidepressants: A Systematic Review with Network Meta-Analysis
139 schema:pagination 699-712
140 schema:productId N7a7a3fe9b4094e298b35faea05f726a7
141 N8c618f40c46d47c6accd07d3bd934b54
142 Nadb8b11e22814b19b09d65e47191581d
143 Nc075081648d344cba1c2b13c8d882dcb
144 Ndf6d08ffbf394fa7b1789b921bb58b98
145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031746828
146 https://doi.org/10.1007/s40263-014-0169-z
147 schema:sdDatePublished 2019-04-10T16:45
148 schema:sdLicense https://scigraph.springernature.com/explorer/license/
149 schema:sdPublisher Nbd1271f8ccea4939b00f30d86a71fc77
150 schema:url http://link.springer.com/10.1007%2Fs40263-014-0169-z
151 sgo:license sg:explorer/license/
152 sgo:sdDataset articles
153 rdf:type schema:ScholarlyArticle
154 N034b842f4fd740058218a3f6e8b6715b rdf:first sg:person.0733117013.53
155 rdf:rest Nd0bae0b131364a1bb9efbe55908423c2
156 N3efc5afb18dc4772b875f7167d3ea9f3 rdf:first sg:person.01300022413.49
157 rdf:rest Nc4d996d04116482593fc3b9f4b4240b3
158 N43151f7b1bae4e5ba22833d49d79c64b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Depressive Disorder, Major
160 rdf:type schema:DefinedTerm
161 N5d2179f0a1c74bd78b77df8658b70d87 rdf:first sg:person.01230124647.31
162 rdf:rest Nfee1472e6055450bbbcee7476948b6d8
163 N5ed6a4a6c76c47d4b5685376a6bcf259 rdf:first sg:person.01223523642.05
164 rdf:rest N5d2179f0a1c74bd78b77df8658b70d87
165 N69adf65b21464bf6808305824957c370 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Delayed-Action Preparations
167 rdf:type schema:DefinedTerm
168 N7a527ed4d42340a388c3fb9640ef05b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Randomized Controlled Trials as Topic
170 rdf:type schema:DefinedTerm
171 N7a7287d0cc0d460aa1a0f964f7bd592d schema:issueNumber 8
172 rdf:type schema:PublicationIssue
173 N7a7a3fe9b4094e298b35faea05f726a7 schema:name dimensions_id
174 schema:value pub.1031746828
175 rdf:type schema:PropertyValue
176 N8b3fa2276a7c4b76ac3aaa2fc61f7216 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Risk
178 rdf:type schema:DefinedTerm
179 N8c618f40c46d47c6accd07d3bd934b54 schema:name pubmed_id
180 schema:value 24794101
181 rdf:type schema:PropertyValue
182 Nadb8b11e22814b19b09d65e47191581d schema:name doi
183 schema:value 10.1007/s40263-014-0169-z
184 rdf:type schema:PropertyValue
185 Nbd1271f8ccea4939b00f30d86a71fc77 schema:name Springer Nature - SN SciGraph project
186 rdf:type schema:Organization
187 Nc0363b97c9f54333b6935b0125aa7e07 rdf:first sg:person.01045023142.69
188 rdf:rest N3efc5afb18dc4772b875f7167d3ea9f3
189 Nc075081648d344cba1c2b13c8d882dcb schema:name readcube_id
190 schema:value 973c22f35e81c3ce6a4ac16c209087a7aa45b961de67d43c1d091490dbe9d9b6
191 rdf:type schema:PropertyValue
192 Nc4d996d04116482593fc3b9f4b4240b3 rdf:first sg:person.0717203466.34
193 rdf:rest N5ed6a4a6c76c47d4b5685376a6bcf259
194 Ncf0c01a98159426da4bb69056dc9958b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Humans
196 rdf:type schema:DefinedTerm
197 Nd0bae0b131364a1bb9efbe55908423c2 rdf:first sg:person.01041162042.03
198 rdf:rest Nc0363b97c9f54333b6935b0125aa7e07
199 Ndf6d08ffbf394fa7b1789b921bb58b98 schema:name nlm_unique_id
200 schema:value 9431220
201 rdf:type schema:PropertyValue
202 Ne2e9e19264c743e0ba23951b72b493b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Antidepressive Agents, Second-Generation
204 rdf:type schema:DefinedTerm
205 Nfa0cb956798c4135afe1b7aac8401e43 schema:volumeNumber 28
206 rdf:type schema:PublicationVolume
207 Nfb9b697d08f04a40ad97eca5a1bd0ee0 rdf:first sg:person.0724733442.73
208 rdf:rest rdf:nil
209 Nfee1472e6055450bbbcee7476948b6d8 rdf:first sg:person.01220514245.29
210 rdf:rest Nfb9b697d08f04a40ad97eca5a1bd0ee0
211 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
212 schema:name Medical and Health Sciences
213 rdf:type schema:DefinedTerm
214 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
215 schema:name Clinical Sciences
216 rdf:type schema:DefinedTerm
217 sg:journal.1111875 schema:issn 1172-7047
218 1179-1934
219 schema:name CNS Drugs
220 rdf:type schema:Periodical
221 sg:person.01041162042.03 schema:affiliation https://www.grid.ac/institutes/grid.62562.35
222 schema:familyName Morgan
223 schema:givenName Laura C.
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041162042.03
225 rdf:type schema:Person
226 sg:person.01045023142.69 schema:affiliation https://www.grid.ac/institutes/grid.5640.7
227 schema:familyName Reichenpfader
228 schema:givenName Ursula
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045023142.69
230 rdf:type schema:Person
231 sg:person.01220514245.29 schema:affiliation https://www.grid.ac/institutes/grid.10698.36
232 schema:familyName Gaynes
233 schema:givenName Bradley N.
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220514245.29
235 rdf:type schema:Person
236 sg:person.01223523642.05 schema:affiliation https://www.grid.ac/institutes/grid.15462.34
237 schema:familyName Van Noord
238 schema:givenName Megan
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223523642.05
240 rdf:type schema:Person
241 sg:person.01230124647.31 schema:affiliation https://www.grid.ac/institutes/grid.62562.35
242 schema:familyName Lux
243 schema:givenName Linda
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230124647.31
245 rdf:type schema:Person
246 sg:person.01300022413.49 schema:affiliation https://www.grid.ac/institutes/grid.62562.35
247 schema:familyName Greenblatt
248 schema:givenName Amy
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300022413.49
250 rdf:type schema:Person
251 sg:person.0717203466.34 schema:affiliation https://www.grid.ac/institutes/grid.252546.2
252 schema:familyName Hansen
253 schema:givenName Richard A.
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717203466.34
255 rdf:type schema:Person
256 sg:person.0724733442.73 schema:affiliation https://www.grid.ac/institutes/grid.62562.35
257 schema:familyName Gartlehner
258 schema:givenName Gerald
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724733442.73
260 rdf:type schema:Person
261 sg:person.0733117013.53 schema:affiliation https://www.grid.ac/institutes/grid.15462.34
262 schema:familyName Nussbaumer
263 schema:givenName Barbara
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733117013.53
265 rdf:type schema:Person
266 sg:pub.10.1007/s00213-010-1822-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1038684183
267 https://doi.org/10.1007/s00213-010-1822-y
268 rdf:type schema:CreativeWork
269 sg:pub.10.1016/s0893-133x(00)00249-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007098081
270 https://doi.org/10.1016/s0893-133x(00)00249-9
271 rdf:type schema:CreativeWork
272 sg:pub.10.2165/00019053-200927060-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035738910
273 https://doi.org/10.2165/00019053-200927060-00006
274 rdf:type schema:CreativeWork
275 sg:pub.10.2165/00044011-200727070-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046419932
276 https://doi.org/10.2165/00044011-200727070-00005
277 rdf:type schema:CreativeWork
278 https://app.dimensions.ai/details/publication/pub.1074893466 schema:CreativeWork
279 https://app.dimensions.ai/details/publication/pub.1076618873 schema:CreativeWork
280 https://app.dimensions.ai/details/publication/pub.1076880601 schema:CreativeWork
281 https://app.dimensions.ai/details/publication/pub.1076880602 schema:CreativeWork
282 https://app.dimensions.ai/details/publication/pub.1076880603 schema:CreativeWork
283 https://app.dimensions.ai/details/publication/pub.1076880605 schema:CreativeWork
284 https://app.dimensions.ai/details/publication/pub.1077129685 schema:CreativeWork
285 https://app.dimensions.ai/details/publication/pub.1077822333 schema:CreativeWork
286 https://app.dimensions.ai/details/publication/pub.1078202436 schema:CreativeWork
287 https://app.dimensions.ai/details/publication/pub.1078524265 schema:CreativeWork
288 https://app.dimensions.ai/details/publication/pub.1078562016 schema:CreativeWork
289 https://app.dimensions.ai/details/publication/pub.1078945613 schema:CreativeWork
290 https://app.dimensions.ai/details/publication/pub.1079555265 schema:CreativeWork
291 https://app.dimensions.ai/details/publication/pub.1079665232 schema:CreativeWork
292 https://app.dimensions.ai/details/publication/pub.1079677271 schema:CreativeWork
293 https://app.dimensions.ai/details/publication/pub.1079784429 schema:CreativeWork
294 https://app.dimensions.ai/details/publication/pub.1082502293 schema:CreativeWork
295 https://app.dimensions.ai/details/publication/pub.1082637516 schema:CreativeWork
296 https://app.dimensions.ai/details/publication/pub.1082884381 schema:CreativeWork
297 https://app.dimensions.ai/details/publication/pub.1082884388 schema:CreativeWork
298 https://app.dimensions.ai/details/publication/pub.1082960284 schema:CreativeWork
299 https://doi.org/10.1001/archgenpsychiatry.2009.81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029766285
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1001/archinte.1990.00390200073014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017990194
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1001/archpsyc.62.6.593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047074916
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1001/jama.287.14.1807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023236168
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1002/(sici)1520-6394(2000)11:2<58::aid-da2>3.0.co;2-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1044748192
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1002/9780470712184.ch8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002462072
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1002/da.20222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052730610
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1002/hup.1262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034787256
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1002/sim.1875 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014451574
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/0278-5846(95)00292-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047215583
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.arcmed.2004.12.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004574712
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.clinthera.2009.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050093876
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/j.euroneuro.2004.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021012973
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/j.euroneuro.2005.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009594045
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/j.eurpsy.2006.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031610395
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/j.jpsychires.2004.04.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033898511
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/j.jpsychires.2005.07.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045762046
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/s0006-3223(98)00092-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038019962
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/s0022-3956(02)00060-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020906331
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/s0149-2918(00)88317-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034455091
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/s0149-2918(01)80090-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006319765
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/s0149-2918(01)80109-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032235284
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/s0165-0327(98)00188-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010406338
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1016/s0165-0327(99)00067-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030292769
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1016/s0924-9338(97)86377-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028337464
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1016/s0924-9338(99)80714-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040565590
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1017/s1092852900020046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020423657
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1017/s1461145702002857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054932751
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1017/s1461145709000224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054933380
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1017/s1461145711001027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008148189
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1034/j.1600-0773.2002.900304.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037547319
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1055/s-2006-931544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057457292
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1097/00004714-199406000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016708778
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1097/00004714-200004000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060188387
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1097/00004714-200204000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023250614
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1097/00004850-199409000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029629457
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1097/00004850-199503000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019030963
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1097/00004850-199609000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012954126
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1097/00004850-200015010-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001031586
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1097/01.jcp.0000132448.65972.d9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043853723
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1097/01.yic.0000068045.82050.00 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039340348
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1097/gme.0b013e3181d88962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002607554
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1097/jcp.0b013e31822c0a68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018328687
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1097/mjt.0b013e31802b5954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040618352
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1097/psy.0b013e318148c19a schema:sameAs https://app.dimensions.ai/details/publication/pub.1019661723
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1097/yic.0b013e3281e2c84b schema:sameAs https://app.dimensions.ai/details/publication/pub.1033886375
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1097/yic.0b013e32830cebed schema:sameAs https://app.dimensions.ai/details/publication/pub.1006795240
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1111/j.1440-1819.2007.01666.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028603042
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1111/j.1440-1819.2011.02243.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050664258
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1111/j.1471-1842.2009.00865.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041380758
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1111/j.1524-4733.2008.00347.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026399947
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1111/j.1600-0447.1988.tb06353.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041227463
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1111/j.1600-0447.1989.tb07188.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027917570
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1111/j.1600-0447.1993.tb03345.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051308981
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1176/ajp.155.3.367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083226941
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1176/appi.ajp.157.3.344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063493076
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1177/0272989x12458724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010893288
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1185/030079905x53243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013504332
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1185/030079906x115513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037651959
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1185/030079906x121039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036892250
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1185/030079906x167273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043103436
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1185/030079906x167453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046796369
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1185/030079907x210732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014512130
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1185/03007990802336780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041017613
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1192/bjp.164.6.802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064172121
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1192/bjp.180.6.528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022712527
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1377/hlthaff.25.3.635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033512011
432 rdf:type schema:CreativeWork
433 https://doi.org/10.3109/10401239709147791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029781291
434 rdf:type schema:CreativeWork
435 https://doi.org/10.3109/10401239809147030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050421937
436 rdf:type schema:CreativeWork
437 https://doi.org/10.3109/10401239909147072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017433018
438 rdf:type schema:CreativeWork
439 https://doi.org/10.3310/hta7270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071139743
440 rdf:type schema:CreativeWork
441 https://doi.org/10.3810/pgm.11.1999.suppl1.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077943310
442 rdf:type schema:CreativeWork
443 https://doi.org/10.4088/jcp.11m06831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072205261
444 rdf:type schema:CreativeWork
445 https://doi.org/10.4088/jcp.v58n0904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072207078
446 rdf:type schema:CreativeWork
447 https://doi.org/10.4088/jcp.v58n1104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072207108
448 rdf:type schema:CreativeWork
449 https://doi.org/10.4088/jcp.v59n0305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072207165
450 rdf:type schema:CreativeWork
451 https://doi.org/10.4088/jcp.v59n0508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072207199
452 rdf:type schema:CreativeWork
453 https://doi.org/10.4088/jcp.v59n0703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072207227
454 rdf:type schema:CreativeWork
455 https://doi.org/10.4088/jcp.v60n0105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072207320
456 rdf:type schema:CreativeWork
457 https://doi.org/10.4088/jcp.v61n0204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072207583
458 rdf:type schema:CreativeWork
459 https://doi.org/10.4088/jcp.v61n0911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072207733
460 rdf:type schema:CreativeWork
461 https://doi.org/10.4088/jcp.v61n1107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072207780
462 rdf:type schema:CreativeWork
463 https://doi.org/10.4088/jcp.v61n1207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072207802
464 rdf:type schema:CreativeWork
465 https://doi.org/10.4088/jcp.v63n0302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072208114
466 rdf:type schema:CreativeWork
467 https://doi.org/10.4088/jcp.v63n0309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072208121
468 rdf:type schema:CreativeWork
469 https://doi.org/10.4088/jcp.v63n0407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072208141
470 rdf:type schema:CreativeWork
471 https://doi.org/10.4088/jcp.v63n0707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072208219
472 rdf:type schema:CreativeWork
473 https://doi.org/10.4088/jcp.v64n0810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072208552
474 rdf:type schema:CreativeWork
475 https://doi.org/10.4088/jcp.v64n0912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072208579
476 rdf:type schema:CreativeWork
477 https://doi.org/10.4088/jcp.v65n0906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072208921
478 rdf:type schema:CreativeWork
479 https://doi.org/10.4088/jcp.v66n1015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072209286
480 rdf:type schema:CreativeWork
481 https://doi.org/10.4088/jcp.v67n1102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072209647
482 rdf:type schema:CreativeWork
483 https://doi.org/10.4088/jcp.v68n1105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072210019
484 rdf:type schema:CreativeWork
485 https://doi.org/10.7326/0003-4819-155-11-201112060-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073712272
486 rdf:type schema:CreativeWork
487 https://www.grid.ac/institutes/grid.10698.36 schema:alternateName University of North Carolina at Chapel Hill
488 schema:name Department of Psychiatry, University of North Carolina School of Medicine, Suite 304, Room J, MacNider Building, 27599-7160, Chapel Hill, NC, USA
489 rdf:type schema:Organization
490 https://www.grid.ac/institutes/grid.15462.34 schema:alternateName Danube University Krems
491 schema:name Department for Evidence-Based Medicine and Clinical Epidemiology, Danube University Krems, Dr.-Karl-Dorrek Strasse 30, 3500, Krems, Austria
492 rdf:type schema:Organization
493 https://www.grid.ac/institutes/grid.252546.2 schema:alternateName Auburn University
494 schema:name Auburn University Harrison School of Pharmacy, 022 James E. Foy Hall, 36849, Auburn, AL, USA
495 rdf:type schema:Organization
496 https://www.grid.ac/institutes/grid.5640.7 schema:alternateName Linköping University
497 schema:name Department for Evidence-Based Medicine and Clinical Epidemiology, Danube University Krems, Dr.-Karl-Dorrek Strasse 30, 3500, Krems, Austria
498 Division of Community Medicine, Department of Medical and Health Sciences, Linköping University, SE-581 83, Linköping, Sweden
499 rdf:type schema:Organization
500 https://www.grid.ac/institutes/grid.62562.35 schema:alternateName RTI International
501 schema:name Department for Evidence-Based Medicine and Clinical Epidemiology, Danube University Krems, Dr.-Karl-Dorrek Strasse 30, 3500, Krems, Austria
502 Research Triangle Institute International, 3040 Cornwallis Road, PO Box 12194, 27709, Research Triangle Park, NC, USA
503 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...