Pharmacokinetics and Pharmacodynamics of Temocillin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-03

AUTHORS

Kevin Alexandre, Bruno Fantin

ABSTRACT

Temocillin, a 6-α-methoxy derivative of ticarcillin, is a forgotten antibiotic that has recently been rediscovered, and issues about clinical breakpoints and optimal therapeutic regimens are still ongoing. Temocillin spectrum is almost restricted to Enterobacteriaceae. The addition of the α-methoxy moiety on ticarcillin confers resistance to hydrolysis by Ambler classes A and C β-lactamases (extended spectrum β-lactamases, Klebsiella pneumoniae carbapenemase and AmpC hyperproduced enzymes). Temocillin is bactericidal, and the effect of inoculum size on its activity is relatively mild. The proportion of spontaneous resistant mutants in vitro to temocillin is low, as found in vivo. After intravenous infusion, temocillin showed a prolonged elimination half-life of approximately 5 h. The percentage of protein binding of temocillin is high (approximately 80%), and is concentration-dependent. Temocillin clearance is mainly renal, and urinary recovery is high, ranging from 72 to 82% after 24 h. Furthermore, the penetration of temocillin into bile and peritoneal fluid is high, but poor into cerebrospinal fluid. The cumulative percentage of a 24-h period during which the free drug concentration exceeds the minimum inhibitory concentration (fT > MIC) at steady-state pharmacokinetic conditions seems to be the best pharmacokinetic/pharmacodynamic (PK/PD) index correlating with temocillin efficacy. An fT > MIC of 40-50% is associated with antibacterial effect and survival in vivo. Monte Carlo simulations performed in critically ill patients showed that the 2 g every 12 h and 2 g every 8 h regimens provide a 95% probability of target attainment of 40% fT > MIC up to an MIC of 8 mg/L. In less severely ill patients or in specific foci of infection, such as urinary tract infection, a 4 g daily regimen should be adequate for strains with temocillin MIC up to 16 mg/L. Data regarding actual wild-type MIC distribution, clinical efficacy, PK profiling in volunteers or patients, and PD targets are scarce, and further studies are required to support appropriate dosing recommendations and determination of clinical breakpoints. More... »

PAGES

287-296

References to SciGraph publications

  • 1985-06. Lung Tissue Penetration of Temocillin in DRUGS
  • 1985-06. Bacteriostatic and Bactericidal Activity of Penicillins at Constant and Variable Concentrations in DRUGS
  • 1985-06. In Vitro Activity of Temocillin Against Neisseria Gonorrhoeae Including Penicillinase-Producing Strains in DRUGS
  • 1985-06. Antibacterial Activity of Temocillin in DRUGS
  • 2017-12. Mechanisms of intrinsic resistance and acquired susceptibility of Pseudomonas aeruginosa isolated from cystic fibrosis patients to temocillin, a revived antibiotic in SCIENTIFIC REPORTS
  • 1985-06. Temocillin Pharmacokinetics in Normal and Impaired Renal Function in DRUGS
  • 1985-06. In Vitro Activity of Temocillin against Clinical Isolates in DRUGS
  • 1985-06. Biliary Concentrations of Temocillin in DRUGS
  • 1985-06. Renal Clearance of Temocillin in Volunteers in DRUGS
  • 1985-06. Temocillin Penetration of Peripheral Lymph in DRUGS
  • 1985-06. Clinical Efficacy, Tolerance and Pharmacokinetics of Temocillin in Patients with Respiratory Tract Infections in DRUGS
  • 2015-08. Amoxicillin plus temocillin as an alternative empiric therapy for the treatment of severe hospital-acquired pneumonia: results from a retrospective audit in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 1985-06. Pharmacokinetics of Temocillin in Volunteers in DRUGS
  • 1985-06. Temocillin in DRUGS
  • 1985-06. In Vitro Combination-Effect of Temocillin with Ticarcillin and Aminoglycosides on Gram-Negative and Gram-Positive Bacteria in DRUGS
  • 1985-06. Therapeutic Results and Tissue Concentrations of Temocillin in Surgical Patients in DRUGS
  • 1985-06. A Study of the Penetration of Temocillin in the Cerebrospinal Fluid in DRUGS
  • 2011-08. In vitro activity of beta-lactam antibiotics against CTX-M-producing Escherichia coli in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2015-12. Activity of temocillin, mecillinam, ceftazidime, and ceftazidime/avibactam against carbapenem-non-susceptible Enterobacteriaceae without carbapenemase production in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2007-11. In vitro activity of temocillin against prevalent extended-spectrum beta-lactamases producing Enterobacteriaceae from Belgian intensive care units in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 1985-06. Biliary Concentrations of Temocillin in DRUGS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40262-017-0584-7

    DOI

    http://dx.doi.org/10.1007/s40262-017-0584-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091374162

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28849402


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Centre Hospitalier Universitaire De Rouen", 
              "id": "https://www.grid.ac/institutes/grid.41724.34", 
              "name": [
                "Infectious Diseases Department, Rouen University Hospital, GRAM (EA2656), Rouen, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alexandre", 
            "givenName": "Kevin", 
            "id": "sg:person.01312346337.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312346337.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Beaujon Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411599.1", 
              "name": [
                "Univ. Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cit\u00e9, 75018, Paris, France", 
                "Service de M\u00e9decine Interne, H\u00f4pital Beaujon, AP-HP, 100 boulevard du G\u00e9n\u00e9ral Leclerc, 92110, Clichy, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fantin", 
            "givenName": "Bruno", 
            "id": "sg:person.0661753716.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661753716.10"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.2165/00003495-198500295-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001292113", 
              "https://doi.org/10.2165/00003495-198500295-00003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0891-5520(03)00065-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002774639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.diagmicrobio.2016.09.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002952499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003495-198500295-00020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003489130", 
              "https://doi.org/10.2165/00003495-198500295-00020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003495-198500295-00024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003515101", 
              "https://doi.org/10.2165/00003495-198500295-00024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jac/dkp208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005386688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003495-198500295-00049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006559303", 
              "https://doi.org/10.2165/00003495-198500295-00049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jac/dkr543", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006579275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/1469-0691.12697", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006599352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.20.1.38", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006638075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003495-198500295-00026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007988462", 
              "https://doi.org/10.2165/00003495-198500295-00026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jac/dkr317", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008406694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003495-198500295-00027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008720752", 
              "https://doi.org/10.2165/00003495-198500295-00027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10096-007-0370-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008960017", 
              "https://doi.org/10.1007/s10096-007-0370-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10096-007-0370-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008960017", 
              "https://doi.org/10.1007/s10096-007-0370-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcf.2010.08.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011138483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003495-198500295-00025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012467025", 
              "https://doi.org/10.2165/00003495-198500295-00025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.31.8.1271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014507826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jpba.2013.12.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014688514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003495-198500295-00028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015253811", 
              "https://doi.org/10.2165/00003495-198500295-00028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jac/dkn511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016868758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.22.3.453", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018115018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.26.3.335", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018429768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep40208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022962396", 
              "https://doi.org/10.1038/srep40208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/23744235.2015.1087648", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025418280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10096-011-1183-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026206141", 
              "https://doi.org/10.1007/s10096-011-1183-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cid/ciu027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026319506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmi.2015.06.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027029651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jac/dku542", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027227666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003495-198500295-00014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029898790", 
              "https://doi.org/10.2165/00003495-198500295-00014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003495-198500295-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029920610", 
              "https://doi.org/10.2165/00003495-198500295-00004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.00290-09", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030199931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003495-198500295-00018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030321132", 
              "https://doi.org/10.2165/00003495-198500295-00018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0732-8893(84)90023-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031319166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0732-8893(84)90023-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031319166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.22.1.157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034178335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003495-198500295-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035579014", 
              "https://doi.org/10.2165/00003495-198500295-00006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003495-198500295-00029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035892652", 
              "https://doi.org/10.2165/00003495-198500295-00029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jac/dku465", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036419095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jac/dkm467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037139719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10096-015-2406-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037428149", 
              "https://doi.org/10.1007/s10096-015-2406-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10096-015-2406-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037428149", 
              "https://doi.org/10.1007/s10096-015-2406-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10096-015-2406-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037428149", 
              "https://doi.org/10.1007/s10096-015-2406-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003495-198500295-00033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037476340", 
              "https://doi.org/10.2165/00003495-198500295-00033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jac/dkl043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037643780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/17843286.1989.11718041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039085661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jac/dkl046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040727706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jac/dkt383", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042619224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj2950705", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042786724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj2950705", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042786724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.medmal.2013.01.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044885594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10096-015-2498-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047822747", 
              "https://doi.org/10.1007/s10096-015-2498-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijantimicag.2015.09.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050019147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003495-198500295-00015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051068599", 
              "https://doi.org/10.2165/00003495-198500295-00015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003495-198500295-00031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052512794", 
              "https://doi.org/10.2165/00003495-198500295-00031"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/infdis/159.2.281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059701308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jac/11.4.349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059730016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jac/12.1.47", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059730145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jac/12.1.93", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059730150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jac/18.3.399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059731239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jac/dkv434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059736100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jac/dkw066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059736210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.43.2.213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083382012"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-03", 
        "datePublishedReg": "2018-03-01", 
        "description": "Temocillin, a 6-\u03b1-methoxy derivative of ticarcillin, is a forgotten antibiotic that has recently been rediscovered, and issues about clinical breakpoints and optimal therapeutic regimens are still ongoing. Temocillin spectrum is almost restricted to Enterobacteriaceae. The addition of the \u03b1-methoxy moiety on ticarcillin confers resistance to hydrolysis by Ambler classes A and C \u03b2-lactamases (extended spectrum \u03b2-lactamases, Klebsiella pneumoniae carbapenemase and AmpC hyperproduced enzymes). Temocillin is bactericidal, and the effect of inoculum size on its activity is relatively mild. The proportion of spontaneous resistant mutants in vitro to temocillin is low, as found in vivo. After intravenous infusion, temocillin showed a prolonged elimination half-life of approximately 5\u00a0h. The percentage of protein binding of temocillin is high (approximately 80%), and is concentration-dependent. Temocillin clearance is mainly renal, and urinary recovery is high, ranging from 72 to 82% after 24\u00a0h. Furthermore, the penetration of temocillin into bile and peritoneal fluid is high, but poor into cerebrospinal fluid. The cumulative percentage of a 24-h period during which the free drug concentration exceeds the minimum inhibitory concentration (fT\u00a0>\u00a0MIC) at steady-state pharmacokinetic conditions seems to be the best pharmacokinetic/pharmacodynamic (PK/PD) index correlating with temocillin efficacy. An fT\u00a0>\u00a0MIC of 40-50% is associated with antibacterial effect and survival in vivo. Monte Carlo simulations performed in critically ill patients showed that the 2\u00a0g every 12\u00a0h and 2\u00a0g every 8\u00a0h regimens provide a 95% probability of target attainment of 40% fT\u00a0>\u00a0MIC up to an MIC of 8\u00a0mg/L. In less severely ill patients or in specific foci of infection, such as urinary tract infection, a 4\u00a0g daily regimen should be adequate for strains with temocillin MIC up to 16\u00a0mg/L. Data regarding actual wild-type MIC distribution, clinical efficacy, PK profiling in volunteers or patients, and PD targets are scarce, and further studies are required to support appropriate dosing recommendations and determination of clinical breakpoints.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s40262-017-0584-7", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1085321", 
            "issn": [
              "0312-5963", 
              "1179-1926"
            ], 
            "name": "Clinical Pharmacokinetics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "57"
          }
        ], 
        "name": "Pharmacokinetics and Pharmacodynamics of Temocillin", 
        "pagination": "287-296", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d71cfeb684275a3e5e8e129bf84620634573c6efab1ff9ea3924af1db9fc2bdd"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28849402"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "7606849"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s40262-017-0584-7"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1091374162"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s40262-017-0584-7", 
          "https://app.dimensions.ai/details/publication/pub.1091374162"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T21:30", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000484.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007/s40262-017-0584-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40262-017-0584-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40262-017-0584-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40262-017-0584-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40262-017-0584-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    275 TRIPLES      21 PREDICATES      87 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s40262-017-0584-7 schema:about anzsrc-for:11
    2 anzsrc-for:1103
    3 schema:author Ndec6051a240c443cbcd5771449d823ae
    4 schema:citation sg:pub.10.1007/s10096-007-0370-9
    5 sg:pub.10.1007/s10096-011-1183-4
    6 sg:pub.10.1007/s10096-015-2406-x
    7 sg:pub.10.1007/s10096-015-2498-3
    8 sg:pub.10.1038/srep40208
    9 sg:pub.10.2165/00003495-198500295-00003
    10 sg:pub.10.2165/00003495-198500295-00004
    11 sg:pub.10.2165/00003495-198500295-00006
    12 sg:pub.10.2165/00003495-198500295-00014
    13 sg:pub.10.2165/00003495-198500295-00015
    14 sg:pub.10.2165/00003495-198500295-00018
    15 sg:pub.10.2165/00003495-198500295-00020
    16 sg:pub.10.2165/00003495-198500295-00024
    17 sg:pub.10.2165/00003495-198500295-00025
    18 sg:pub.10.2165/00003495-198500295-00026
    19 sg:pub.10.2165/00003495-198500295-00027
    20 sg:pub.10.2165/00003495-198500295-00028
    21 sg:pub.10.2165/00003495-198500295-00029
    22 sg:pub.10.2165/00003495-198500295-00031
    23 sg:pub.10.2165/00003495-198500295-00033
    24 sg:pub.10.2165/00003495-198500295-00049
    25 https://doi.org/10.1016/0732-8893(84)90023-3
    26 https://doi.org/10.1016/j.cmi.2015.06.007
    27 https://doi.org/10.1016/j.diagmicrobio.2016.09.012
    28 https://doi.org/10.1016/j.ijantimicag.2015.09.005
    29 https://doi.org/10.1016/j.jcf.2010.08.015
    30 https://doi.org/10.1016/j.jpba.2013.12.002
    31 https://doi.org/10.1016/j.medmal.2013.01.006
    32 https://doi.org/10.1016/s0891-5520(03)00065-5
    33 https://doi.org/10.1042/bj2950705
    34 https://doi.org/10.1080/17843286.1989.11718041
    35 https://doi.org/10.1093/cid/ciu027
    36 https://doi.org/10.1093/infdis/159.2.281
    37 https://doi.org/10.1093/jac/11.4.349
    38 https://doi.org/10.1093/jac/12.1.47
    39 https://doi.org/10.1093/jac/12.1.93
    40 https://doi.org/10.1093/jac/18.3.399
    41 https://doi.org/10.1093/jac/dkl043
    42 https://doi.org/10.1093/jac/dkl046
    43 https://doi.org/10.1093/jac/dkm467
    44 https://doi.org/10.1093/jac/dkn511
    45 https://doi.org/10.1093/jac/dkp208
    46 https://doi.org/10.1093/jac/dkr317
    47 https://doi.org/10.1093/jac/dkr543
    48 https://doi.org/10.1093/jac/dkt383
    49 https://doi.org/10.1093/jac/dku465
    50 https://doi.org/10.1093/jac/dku542
    51 https://doi.org/10.1093/jac/dkv434
    52 https://doi.org/10.1093/jac/dkw066
    53 https://doi.org/10.1111/1469-0691.12697
    54 https://doi.org/10.1128/aac.00290-09
    55 https://doi.org/10.1128/aac.20.1.38
    56 https://doi.org/10.1128/aac.22.1.157
    57 https://doi.org/10.1128/aac.22.3.453
    58 https://doi.org/10.1128/aac.26.3.335
    59 https://doi.org/10.1128/aac.31.8.1271
    60 https://doi.org/10.1128/aac.43.2.213
    61 https://doi.org/10.3109/23744235.2015.1087648
    62 schema:datePublished 2018-03
    63 schema:datePublishedReg 2018-03-01
    64 schema:description Temocillin, a 6-α-methoxy derivative of ticarcillin, is a forgotten antibiotic that has recently been rediscovered, and issues about clinical breakpoints and optimal therapeutic regimens are still ongoing. Temocillin spectrum is almost restricted to Enterobacteriaceae. The addition of the α-methoxy moiety on ticarcillin confers resistance to hydrolysis by Ambler classes A and C β-lactamases (extended spectrum β-lactamases, Klebsiella pneumoniae carbapenemase and AmpC hyperproduced enzymes). Temocillin is bactericidal, and the effect of inoculum size on its activity is relatively mild. The proportion of spontaneous resistant mutants in vitro to temocillin is low, as found in vivo. After intravenous infusion, temocillin showed a prolonged elimination half-life of approximately 5 h. The percentage of protein binding of temocillin is high (approximately 80%), and is concentration-dependent. Temocillin clearance is mainly renal, and urinary recovery is high, ranging from 72 to 82% after 24 h. Furthermore, the penetration of temocillin into bile and peritoneal fluid is high, but poor into cerebrospinal fluid. The cumulative percentage of a 24-h period during which the free drug concentration exceeds the minimum inhibitory concentration (fT > MIC) at steady-state pharmacokinetic conditions seems to be the best pharmacokinetic/pharmacodynamic (PK/PD) index correlating with temocillin efficacy. An fT > MIC of 40-50% is associated with antibacterial effect and survival in vivo. Monte Carlo simulations performed in critically ill patients showed that the 2 g every 12 h and 2 g every 8 h regimens provide a 95% probability of target attainment of 40% fT > MIC up to an MIC of 8 mg/L. In less severely ill patients or in specific foci of infection, such as urinary tract infection, a 4 g daily regimen should be adequate for strains with temocillin MIC up to 16 mg/L. Data regarding actual wild-type MIC distribution, clinical efficacy, PK profiling in volunteers or patients, and PD targets are scarce, and further studies are required to support appropriate dosing recommendations and determination of clinical breakpoints.
    65 schema:genre research_article
    66 schema:inLanguage en
    67 schema:isAccessibleForFree false
    68 schema:isPartOf N3125bb47c5da434bab95b13ffad843e5
    69 N8cc710dd5ab146f4b10acf63c37d106a
    70 sg:journal.1085321
    71 schema:name Pharmacokinetics and Pharmacodynamics of Temocillin
    72 schema:pagination 287-296
    73 schema:productId N21935566d89d4c909527c1499f7ef052
    74 N83973c5633714ee394ebd21593bced80
    75 Nc4d809a6e6b143f9ad5eb73df49b59a4
    76 Ncd5b0bfb010f429c807cc31d70553a0c
    77 Nfe47d377a3fd486dbd4d2016680a627f
    78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091374162
    79 https://doi.org/10.1007/s40262-017-0584-7
    80 schema:sdDatePublished 2019-04-10T21:30
    81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    82 schema:sdPublisher N35292e74e0554d2e999df96d38e7251e
    83 schema:url http://link.springer.com/10.1007/s40262-017-0584-7
    84 sgo:license sg:explorer/license/
    85 sgo:sdDataset articles
    86 rdf:type schema:ScholarlyArticle
    87 N21935566d89d4c909527c1499f7ef052 schema:name nlm_unique_id
    88 schema:value 7606849
    89 rdf:type schema:PropertyValue
    90 N3125bb47c5da434bab95b13ffad843e5 schema:issueNumber 3
    91 rdf:type schema:PublicationIssue
    92 N35292e74e0554d2e999df96d38e7251e schema:name Springer Nature - SN SciGraph project
    93 rdf:type schema:Organization
    94 N83973c5633714ee394ebd21593bced80 schema:name dimensions_id
    95 schema:value pub.1091374162
    96 rdf:type schema:PropertyValue
    97 N8cc710dd5ab146f4b10acf63c37d106a schema:volumeNumber 57
    98 rdf:type schema:PublicationVolume
    99 N987f5001c964486eb8df85d275a277de rdf:first sg:person.0661753716.10
    100 rdf:rest rdf:nil
    101 Nc4d809a6e6b143f9ad5eb73df49b59a4 schema:name readcube_id
    102 schema:value d71cfeb684275a3e5e8e129bf84620634573c6efab1ff9ea3924af1db9fc2bdd
    103 rdf:type schema:PropertyValue
    104 Ncd5b0bfb010f429c807cc31d70553a0c schema:name pubmed_id
    105 schema:value 28849402
    106 rdf:type schema:PropertyValue
    107 Ndec6051a240c443cbcd5771449d823ae rdf:first sg:person.01312346337.12
    108 rdf:rest N987f5001c964486eb8df85d275a277de
    109 Nfe47d377a3fd486dbd4d2016680a627f schema:name doi
    110 schema:value 10.1007/s40262-017-0584-7
    111 rdf:type schema:PropertyValue
    112 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    113 schema:name Medical and Health Sciences
    114 rdf:type schema:DefinedTerm
    115 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    116 schema:name Clinical Sciences
    117 rdf:type schema:DefinedTerm
    118 sg:journal.1085321 schema:issn 0312-5963
    119 1179-1926
    120 schema:name Clinical Pharmacokinetics
    121 rdf:type schema:Periodical
    122 sg:person.01312346337.12 schema:affiliation https://www.grid.ac/institutes/grid.41724.34
    123 schema:familyName Alexandre
    124 schema:givenName Kevin
    125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312346337.12
    126 rdf:type schema:Person
    127 sg:person.0661753716.10 schema:affiliation https://www.grid.ac/institutes/grid.411599.1
    128 schema:familyName Fantin
    129 schema:givenName Bruno
    130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661753716.10
    131 rdf:type schema:Person
    132 sg:pub.10.1007/s10096-007-0370-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008960017
    133 https://doi.org/10.1007/s10096-007-0370-9
    134 rdf:type schema:CreativeWork
    135 sg:pub.10.1007/s10096-011-1183-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026206141
    136 https://doi.org/10.1007/s10096-011-1183-4
    137 rdf:type schema:CreativeWork
    138 sg:pub.10.1007/s10096-015-2406-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037428149
    139 https://doi.org/10.1007/s10096-015-2406-x
    140 rdf:type schema:CreativeWork
    141 sg:pub.10.1007/s10096-015-2498-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047822747
    142 https://doi.org/10.1007/s10096-015-2498-3
    143 rdf:type schema:CreativeWork
    144 sg:pub.10.1038/srep40208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022962396
    145 https://doi.org/10.1038/srep40208
    146 rdf:type schema:CreativeWork
    147 sg:pub.10.2165/00003495-198500295-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001292113
    148 https://doi.org/10.2165/00003495-198500295-00003
    149 rdf:type schema:CreativeWork
    150 sg:pub.10.2165/00003495-198500295-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029920610
    151 https://doi.org/10.2165/00003495-198500295-00004
    152 rdf:type schema:CreativeWork
    153 sg:pub.10.2165/00003495-198500295-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035579014
    154 https://doi.org/10.2165/00003495-198500295-00006
    155 rdf:type schema:CreativeWork
    156 sg:pub.10.2165/00003495-198500295-00014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029898790
    157 https://doi.org/10.2165/00003495-198500295-00014
    158 rdf:type schema:CreativeWork
    159 sg:pub.10.2165/00003495-198500295-00015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051068599
    160 https://doi.org/10.2165/00003495-198500295-00015
    161 rdf:type schema:CreativeWork
    162 sg:pub.10.2165/00003495-198500295-00018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030321132
    163 https://doi.org/10.2165/00003495-198500295-00018
    164 rdf:type schema:CreativeWork
    165 sg:pub.10.2165/00003495-198500295-00020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003489130
    166 https://doi.org/10.2165/00003495-198500295-00020
    167 rdf:type schema:CreativeWork
    168 sg:pub.10.2165/00003495-198500295-00024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003515101
    169 https://doi.org/10.2165/00003495-198500295-00024
    170 rdf:type schema:CreativeWork
    171 sg:pub.10.2165/00003495-198500295-00025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012467025
    172 https://doi.org/10.2165/00003495-198500295-00025
    173 rdf:type schema:CreativeWork
    174 sg:pub.10.2165/00003495-198500295-00026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007988462
    175 https://doi.org/10.2165/00003495-198500295-00026
    176 rdf:type schema:CreativeWork
    177 sg:pub.10.2165/00003495-198500295-00027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008720752
    178 https://doi.org/10.2165/00003495-198500295-00027
    179 rdf:type schema:CreativeWork
    180 sg:pub.10.2165/00003495-198500295-00028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015253811
    181 https://doi.org/10.2165/00003495-198500295-00028
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.2165/00003495-198500295-00029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035892652
    184 https://doi.org/10.2165/00003495-198500295-00029
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.2165/00003495-198500295-00031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052512794
    187 https://doi.org/10.2165/00003495-198500295-00031
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.2165/00003495-198500295-00033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037476340
    190 https://doi.org/10.2165/00003495-198500295-00033
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.2165/00003495-198500295-00049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006559303
    193 https://doi.org/10.2165/00003495-198500295-00049
    194 rdf:type schema:CreativeWork
    195 https://doi.org/10.1016/0732-8893(84)90023-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031319166
    196 rdf:type schema:CreativeWork
    197 https://doi.org/10.1016/j.cmi.2015.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027029651
    198 rdf:type schema:CreativeWork
    199 https://doi.org/10.1016/j.diagmicrobio.2016.09.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002952499
    200 rdf:type schema:CreativeWork
    201 https://doi.org/10.1016/j.ijantimicag.2015.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050019147
    202 rdf:type schema:CreativeWork
    203 https://doi.org/10.1016/j.jcf.2010.08.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011138483
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1016/j.jpba.2013.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014688514
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1016/j.medmal.2013.01.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044885594
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1016/s0891-5520(03)00065-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002774639
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1042/bj2950705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042786724
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1080/17843286.1989.11718041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039085661
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1093/cid/ciu027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026319506
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1093/infdis/159.2.281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059701308
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1093/jac/11.4.349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059730016
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1093/jac/12.1.47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059730145
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1093/jac/12.1.93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059730150
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1093/jac/18.3.399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059731239
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1093/jac/dkl043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037643780
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1093/jac/dkl046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040727706
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1093/jac/dkm467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037139719
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1093/jac/dkn511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016868758
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1093/jac/dkp208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005386688
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1093/jac/dkr317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008406694
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1093/jac/dkr543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006579275
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1093/jac/dkt383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042619224
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1093/jac/dku465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036419095
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1093/jac/dku542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027227666
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1093/jac/dkv434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059736100
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1093/jac/dkw066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059736210
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1111/1469-0691.12697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006599352
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1128/aac.00290-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030199931
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1128/aac.20.1.38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006638075
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1128/aac.22.1.157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034178335
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1128/aac.22.3.453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018115018
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1128/aac.26.3.335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018429768
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1128/aac.31.8.1271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014507826
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1128/aac.43.2.213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083382012
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.3109/23744235.2015.1087648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025418280
    268 rdf:type schema:CreativeWork
    269 https://www.grid.ac/institutes/grid.411599.1 schema:alternateName Beaujon Hospital
    270 schema:name Service de Médecine Interne, Hôpital Beaujon, AP-HP, 100 boulevard du Général Leclerc, 92110, Clichy, France
    271 Univ. Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité, 75018, Paris, France
    272 rdf:type schema:Organization
    273 https://www.grid.ac/institutes/grid.41724.34 schema:alternateName Centre Hospitalier Universitaire De Rouen
    274 schema:name Infectious Diseases Department, Rouen University Hospital, GRAM (EA2656), Rouen, France
    275 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...