Clinical Pharmacokinetics of Paclitaxel Monotherapy: An Updated Literature Review View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-01

AUTHORS

Tore B. Stage, Troels K. Bergmann, Deanna L. Kroetz

ABSTRACT

Paclitaxel is an anticancer agent efficacious in the treatment of ovarian, breast, and lung cancer. Due to a strong link between the pharmacokinetics and therapeutic efficacy of paclitaxel, we reviewed the literature on paclitaxel pharmacokinetics. Systematic data mining was performed to extract the maximum concentration (C max), clearance (CL), and time of paclitaxel plasma concentration above 0.05 µmol/L (T > 0.05 µmol/L) following monotherapy of both the widely used cremophor-diluted paclitaxel and nanoparticle albumin-bound (nab-)paclitaxel. We identified a total of 53 studies yielding 121 aggregated pharmacokinetic profiles for paclitaxel monotherapy and extracted reported mean and median estimates of pharmacokinetic parameters. Paclitaxel has been studied formally at doses of 15-825 mg/m2 and infused over 0.5-96 h; included studies examined both weekly and every 3-weeks dosing cycles. The most widely used dose of cremophor-diluted paclitaxel, 175 mg/m2 given as a 3-h infusion, leads to an interstudy median C max of 5.1 µmol/L [interquartile range (IQR) 4.5-5.7], CL of 12.0 L/h/m2 (IQR 10.9-12.9), and T > 0.05 µmol/L of 23.8 h (IQR 21.5-26.8). Importantly, the significant interindividual variation widely reported in the literature is not reflected in these interstudy estimates of pharmacokinetic parameters. Cremophor-diluted paclitaxel pharmacokinetics are non-linear following short (<6 h) but not long (>24 h) infusions. A similar pattern of non-linearity was observed for nab-paclitaxel, although the number of studies was limited. The pharmacokinetics of paclitaxel monotherapy have been widely studied at numerous dose levels of the Cremophor EL® formulation, but are less well-characterized for the newer nab-paclitaxel formulation. In conclusion, paclitaxel pharmacokinetics are non-linear for short infusion times but not for longer infusions. Whether a similar conclusion can be drawn for nab-paclitaxel formulations requires further study. More... »

PAGES

7-19

References to SciGraph publications

  • 2011-04. Impact of CYP2C8*3 on paclitaxel clearance: a population pharmacokinetic and pharmacogenomic study in 93 patients with ovarian cancer in THE PHARMACOGENOMICS JOURNAL
  • 2011-02. Association between patient reported outcomes and quantitative sensory tests for measuring long-term neurotoxicity in breast cancer survivors treated with adjuvant paclitaxel chemotherapy in BREAST CANCER RESEARCH AND TREATMENT
  • 2001-04. Pharmacokinetic modeling of paclitaxel encapsulation in Cremophor EL micelles in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2007-01. Variants in the SLCO1B3 Gene: Interethnic Distribution and Association with Paclitaxel Pharmacokinetics in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2003-01. Enhanced Oral Bioavailability of Paclitaxel by Coadministration of the P-Glycoprotein Inhibitor KR30031 in PHARMACEUTICAL RESEARCH
  • 2001-05. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux in NATURE MEDICINE
  • 1994-10. Clinical Pharmacokinetics of Paclitaxel in CLINICAL PHARMACOKINETICS
  • 2012-02. Phase I and pharmacokinetic study of nab-paclitaxel, nanoparticle albumin-bound paclitaxel, administered weekly to Japanese patients with solid tumors and metastatic breast cancer in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2003-08. Effect of valspodar on the pharmacokinetics of unbound paclitaxel in INVESTIGATIONAL NEW DRUGS
  • 1998-07. Phase II and pharmacokinetic study of paclitaxel therapy for unresectable hepatocellular carcinoma patients in BRITISH JOURNAL OF CANCER
  • 2001-01. The pharmacokinetics and pharmacodynamics of high-dose paclitaxel monotherapy (825 mg/m2 continuous infusion over 24 h) with hematopoietic support in women with metastatic breast cancer in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2009-06. Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2012-10. Phase I study of axitinib combined with paclitaxel, docetaxel or capecitabine in patients with advanced solid tumours in BRITISH JOURNAL OF CANCER
  • 2012-05. Gemfibrozil Is a Strong Inactivator of CYP2C8 in Very Small Multiple Doses in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2015-06. Pharmacokinetic drug-drug interaction study of the angiopoietin-1/angiopoietin-2-inhibiting peptibody trebananib (AMG 386) and paclitaxel in patients with advanced solid tumors in INVESTIGATIONAL NEW DRUGS
  • 1999-09. Cremophor EL causes (pseudo-) non-linear pharmacokinetics of paclitaxel in patients in BRITISH JOURNAL OF CANCER
  • 2005-08. A phase I pharmacokinetic study of the P-glycoprotein inhibitor, ONT-093, in combination with paclitaxel in patients with advanced cancer in INVESTIGATIONAL NEW DRUGS
  • 2001-10. Influence of the interval between the administration of doxorubicin and paclitaxel on the pharmacokinetics of these drugs in patients with locally advanced breast cancer in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40262-017-0563-z

    DOI

    http://dx.doi.org/10.1007/s40262-017-0563-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085997484

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28612269


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Pharmacology and Pharmaceutical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Southern Denmark", 
              "id": "https://www.grid.ac/institutes/grid.10825.3e", 
              "name": [
                "Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA", 
                "Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stage", 
            "givenName": "Tore B.", 
            "id": "sg:person.01220335076.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220335076.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sydvestjysk Sygehus", 
              "id": "https://www.grid.ac/institutes/grid.414576.5", 
              "name": [
                "Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark", 
                "Hospital Pharmacy, Hospital of South West Jutland, Esbjerg, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bergmann", 
            "givenName": "Troels K.", 
            "id": "sg:person.01114537740.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114537740.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, San Francisco", 
              "id": "https://www.grid.ac/institutes/grid.266102.1", 
              "name": [
                "Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kroetz", 
            "givenName": "Deanna L.", 
            "id": "sg:person.0620612751.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620612751.83"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s002800000193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000550237", 
              "https://doi.org/10.1007/s002800000193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/clpt.2011.313", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001596791", 
              "https://doi.org/10.1038/clpt.2011.313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1349-7006.1994.tb02906.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003303454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1349-7006.1994.tb02906.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003303454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1742-7843.2008.00351.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003632186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/87912", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004128811", 
              "https://doi.org/10.1038/87912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.clpt.6100011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005218085", 
              "https://doi.org/10.1038/sj.clpt.6100011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001813-200306000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005871808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001813-200306000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005871808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-05-1152", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006820630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.21312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007864070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.21312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007864070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000068620", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007958626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-010-1278-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007967397", 
              "https://doi.org/10.1007/s10549-010-1278-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2125.2007.02956.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009215726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1349-7006.2001.tb01086.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009789598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1349-7006.2001.tb01086.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009789598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jjco/hye022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010277311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6690696", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012123031", 
              "https://doi.org/10.1038/sj.bjc.6690696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6690696", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012123031", 
              "https://doi.org/10.1038/sj.bjc.6690696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-8049(03)00126-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013228553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-8049(03)00126-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013228553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-8049(02)00242-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013463021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001813-199801000-00001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013543840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001813-199801000-00001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013543840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001813-199801000-00001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013543840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pbc.21310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014991574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(20010115)91:2<417::aid-cncr1016>3.0.co;2-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017263834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2125.2008.03104.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017284137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1025412509730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017655721", 
              "https://doi.org/10.1023/a:1025412509730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tpj.2010.19", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017706531", 
              "https://doi.org/10.1038/tpj.2010.19"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/abbi.1998.0730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018297979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002800100297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020722742", 
              "https://doi.org/10.1007/s002800100297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1022286422439", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023636065", 
              "https://doi.org/10.1023/a:1022286422439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/theoncologist.2014-0202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024424227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2012.407", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025415738", 
              "https://doi.org/10.1038/bjc.2012.407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-14-1758", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025917635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/dmd.30.4.438", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027676036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-07-0064", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027966775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/dmd.116.070375", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028114587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-06-1352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030004118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/phrs.1998.0360", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032710683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-008-0842-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032790666", 
              "https://doi.org/10.1007/s00280-008-0842-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-008-0842-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032790666", 
              "https://doi.org/10.1007/s00280-008-0842-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa072113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033842397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000086597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034457526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002800000215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035156827", 
              "https://doi.org/10.1007/s002800000215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bcp.12795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035438329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijrobp.2007.10.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036337865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001813-200307000-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038068812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001813-200307000-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038068812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1998.438", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039075669", 
              "https://doi.org/10.1038/bjc.1998.438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1998.438", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039075669", 
              "https://doi.org/10.1038/bjc.1998.438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10637-005-1439-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042192945", 
              "https://doi.org/10.1007/s10637-005-1439-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10637-005-1439-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042192945", 
              "https://doi.org/10.1007/s10637-005-1439-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10637-005-1439-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042192945", 
              "https://doi.org/10.1007/s10637-005-1439-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-05-0298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042395838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/phrs.1999.0477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042484341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jjco/hyp192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042984648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10637-015-0236-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043614098", 
              "https://doi.org/10.1007/s10637-015-0236-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lungcan.2004.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044979615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.29254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045472741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.21013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046655247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-07-4592", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046894549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001813-199802000-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047977415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001813-199802000-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047977415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-011-1726-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048343941", 
              "https://doi.org/10.1007/s00280-011-1726-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.11375", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049059017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-12-3786", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049149563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199601043340101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049279167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/dmd.111.040931", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049753570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-10-0062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050030494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-14-0431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050626460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0090-8258(03)00373-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050629594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0090-8258(03)00373-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050629594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-04-2291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052849950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003088-199427040-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053348338", 
              "https://doi.org/10.2165/00003088-199427040-00002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003088-199427040-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053348338", 
              "https://doi.org/10.2165/00003088-199427040-00002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1211/0022357055966", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053364736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.molpharmaceut.5b00026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055119929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm00079a019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055934394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1023/a:1011655503511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056305529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdw290", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059394806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.3007965", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062688222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-15-2525", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063215987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-040009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063224768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-15-0586", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063224919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-15-0586", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063224919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci15451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063415383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.20.2.574", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064202775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2002.04.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064202967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2003.01.058", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064203266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2003.02.153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064203417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2003.12.109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064204022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/br.2016.685", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071502688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cbt.4.8.1867", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072293832"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1999.17.2.676", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074265670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074356008", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074500185", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1999.17.8.2355", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074549852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074559833", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074701140", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2001.19.3.832", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074750693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074963956", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075031499", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075050987", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075103072", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075339682", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076596625", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077152433", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1991.9.7.1261", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077250493"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1991.9.9.1692", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077258697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082379321", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1994.12.2.241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082391827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1995.13.8.2039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082444251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1995.13.1.180", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082512486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1993.11.11.2127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082557651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1994.12.8.1621", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082562776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1994.12.12.2654", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082597535"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1996.14.3.774", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082882779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/oxfordjournals.annonc.a059287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082899248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1997.15.1.317", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083031499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1997.15.5.1953", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083094779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083196203", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1998.16.6.2188", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083277789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1998.16.9.2959", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083316816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083347495", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083347753", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cpt.674", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083855475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2002.20.2.574", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083941899"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-01", 
        "datePublishedReg": "2018-01-01", 
        "description": "Paclitaxel is an anticancer agent efficacious in the treatment of ovarian, breast, and lung cancer. Due to a strong link between the pharmacokinetics and therapeutic efficacy of paclitaxel, we reviewed the literature on paclitaxel pharmacokinetics. Systematic data mining was performed to extract the maximum concentration (C max), clearance (CL), and time of paclitaxel plasma concentration above 0.05\u00a0\u00b5mol/L (T\u00a0>\u00a00.05\u00a0\u00b5mol/L) following monotherapy of both the widely used cremophor-diluted paclitaxel and nanoparticle albumin-bound (nab-)paclitaxel. We identified a total of 53 studies yielding 121 aggregated pharmacokinetic profiles for paclitaxel monotherapy and extracted reported mean and median estimates of pharmacokinetic parameters. Paclitaxel has been studied formally at doses of 15-825\u00a0mg/m2 and infused over 0.5-96\u00a0h; included studies examined both weekly and every 3-weeks dosing cycles. The most widely used dose of cremophor-diluted paclitaxel, 175\u00a0mg/m2 given as a 3-h infusion, leads to an interstudy median C max of 5.1\u00a0\u00b5mol/L [interquartile range (IQR) 4.5-5.7], CL of 12.0\u00a0L/h/m2 (IQR 10.9-12.9), and T\u00a0>\u00a00.05\u00a0\u00b5mol/L of 23.8\u00a0h (IQR 21.5-26.8). Importantly, the significant interindividual variation widely reported in the literature is not reflected in these interstudy estimates of pharmacokinetic parameters. Cremophor-diluted paclitaxel pharmacokinetics are non-linear following short (<6\u00a0h) but not long (>24\u00a0h) infusions. A similar pattern of non-linearity was observed for nab-paclitaxel, although the number of studies was limited. The pharmacokinetics of paclitaxel monotherapy have been widely studied at numerous dose levels of the Cremophor EL\u00ae formulation, but are less well-characterized for the newer nab-paclitaxel formulation. In conclusion, paclitaxel pharmacokinetics are non-linear for short infusion times but not for longer infusions. Whether a similar conclusion can be drawn for nab-paclitaxel formulations requires further study.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s40262-017-0563-z", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.4103562", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1085321", 
            "issn": [
              "0312-5963", 
              "1179-1926"
            ], 
            "name": "Clinical Pharmacokinetics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "57"
          }
        ], 
        "name": "Clinical Pharmacokinetics of Paclitaxel Monotherapy: An Updated Literature Review", 
        "pagination": "7-19", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "ef9b6a9f9411f515d72d9e1290045a2c924c014818df8e16ea234347dd7cf7b0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28612269"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "7606849"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s40262-017-0563-z"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1085997484"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s40262-017-0563-z", 
          "https://app.dimensions.ai/details/publication/pub.1085997484"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T10:37", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113673_00000004.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs40262-017-0563-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40262-017-0563-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40262-017-0563-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40262-017-0563-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40262-017-0563-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    435 TRIPLES      21 PREDICATES      142 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s40262-017-0563-z schema:about anzsrc-for:11
    2 anzsrc-for:1115
    3 schema:author Nf9506aa76e94493fa9e8132511fd8df2
    4 schema:citation sg:pub.10.1007/s00280-008-0842-3
    5 sg:pub.10.1007/s00280-011-1726-5
    6 sg:pub.10.1007/s002800000193
    7 sg:pub.10.1007/s002800000215
    8 sg:pub.10.1007/s002800100297
    9 sg:pub.10.1007/s10549-010-1278-0
    10 sg:pub.10.1007/s10637-005-1439-x
    11 sg:pub.10.1007/s10637-015-0236-4
    12 sg:pub.10.1023/a:1022286422439
    13 sg:pub.10.1023/a:1025412509730
    14 sg:pub.10.1038/87912
    15 sg:pub.10.1038/bjc.1998.438
    16 sg:pub.10.1038/bjc.2012.407
    17 sg:pub.10.1038/clpt.2011.313
    18 sg:pub.10.1038/sj.bjc.6690696
    19 sg:pub.10.1038/sj.clpt.6100011
    20 sg:pub.10.1038/tpj.2010.19
    21 sg:pub.10.2165/00003088-199427040-00002
    22 https://app.dimensions.ai/details/publication/pub.1074356008
    23 https://app.dimensions.ai/details/publication/pub.1074500185
    24 https://app.dimensions.ai/details/publication/pub.1074559833
    25 https://app.dimensions.ai/details/publication/pub.1074701140
    26 https://app.dimensions.ai/details/publication/pub.1074963956
    27 https://app.dimensions.ai/details/publication/pub.1075031499
    28 https://app.dimensions.ai/details/publication/pub.1075050987
    29 https://app.dimensions.ai/details/publication/pub.1075103072
    30 https://app.dimensions.ai/details/publication/pub.1075339682
    31 https://app.dimensions.ai/details/publication/pub.1076596625
    32 https://app.dimensions.ai/details/publication/pub.1077152433
    33 https://app.dimensions.ai/details/publication/pub.1082379321
    34 https://app.dimensions.ai/details/publication/pub.1083196203
    35 https://app.dimensions.ai/details/publication/pub.1083347495
    36 https://app.dimensions.ai/details/publication/pub.1083347753
    37 https://doi.org/10.1002/1097-0142(20010115)91:2<417::aid-cncr1016>3.0.co;2-9
    38 https://doi.org/10.1002/cncr.11375
    39 https://doi.org/10.1002/cncr.21312
    40 https://doi.org/10.1002/cncr.29254
    41 https://doi.org/10.1002/cpt.674
    42 https://doi.org/10.1002/ijc.21013
    43 https://doi.org/10.1002/pbc.21310
    44 https://doi.org/10.1006/abbi.1998.0730
    45 https://doi.org/10.1006/phrs.1998.0360
    46 https://doi.org/10.1006/phrs.1999.0477
    47 https://doi.org/10.1016/j.ijrobp.2007.10.011
    48 https://doi.org/10.1016/j.lungcan.2004.01.001
    49 https://doi.org/10.1016/s0090-8258(03)00373-1
    50 https://doi.org/10.1016/s0959-8049(02)00242-3
    51 https://doi.org/10.1016/s0959-8049(03)00126-6
    52 https://doi.org/10.1021/acs.molpharmaceut.5b00026
    53 https://doi.org/10.1021/jm00079a019
    54 https://doi.org/10.1023/a:1011655503511
    55 https://doi.org/10.1056/nejm199601043340101
    56 https://doi.org/10.1056/nejmoa072113
    57 https://doi.org/10.1093/annonc/mdw290
    58 https://doi.org/10.1093/jjco/hye022
    59 https://doi.org/10.1093/jjco/hyp192
    60 https://doi.org/10.1093/oxfordjournals.annonc.a059287
    61 https://doi.org/10.1097/00001813-199801000-00001
    62 https://doi.org/10.1097/00001813-199802000-00004
    63 https://doi.org/10.1097/00001813-200306000-00007
    64 https://doi.org/10.1097/00001813-200307000-00005
    65 https://doi.org/10.1111/bcp.12795
    66 https://doi.org/10.1111/j.1349-7006.1994.tb02906.x
    67 https://doi.org/10.1111/j.1349-7006.2001.tb01086.x
    68 https://doi.org/10.1111/j.1365-2125.2007.02956.x
    69 https://doi.org/10.1111/j.1365-2125.2008.03104.x
    70 https://doi.org/10.1111/j.1742-7843.2008.00351.x
    71 https://doi.org/10.1124/dmd.111.040931
    72 https://doi.org/10.1124/dmd.116.070375
    73 https://doi.org/10.1124/dmd.30.4.438
    74 https://doi.org/10.1126/scitranslmed.3007965
    75 https://doi.org/10.1158/0008-5472.can-15-2525
    76 https://doi.org/10.1158/1078-0432.ccr-04-2291
    77 https://doi.org/10.1158/1078-0432.ccr-040009
    78 https://doi.org/10.1158/1078-0432.ccr-05-0298
    79 https://doi.org/10.1158/1078-0432.ccr-05-1152
    80 https://doi.org/10.1158/1078-0432.ccr-06-1352
    81 https://doi.org/10.1158/1078-0432.ccr-07-0064
    82 https://doi.org/10.1158/1078-0432.ccr-07-4592
    83 https://doi.org/10.1158/1078-0432.ccr-10-0062
    84 https://doi.org/10.1158/1078-0432.ccr-12-3786
    85 https://doi.org/10.1158/1078-0432.ccr-14-1758
    86 https://doi.org/10.1158/1078-0432.ccr-15-0586
    87 https://doi.org/10.1158/1535-7163.mct-14-0431
    88 https://doi.org/10.1159/000068620
    89 https://doi.org/10.1159/000086597
    90 https://doi.org/10.1172/jci15451
    91 https://doi.org/10.1200/jco.1991.9.7.1261
    92 https://doi.org/10.1200/jco.1991.9.9.1692
    93 https://doi.org/10.1200/jco.1993.11.11.2127
    94 https://doi.org/10.1200/jco.1994.12.12.2654
    95 https://doi.org/10.1200/jco.1994.12.2.241
    96 https://doi.org/10.1200/jco.1994.12.8.1621
    97 https://doi.org/10.1200/jco.1995.13.1.180
    98 https://doi.org/10.1200/jco.1995.13.8.2039
    99 https://doi.org/10.1200/jco.1996.14.3.774
    100 https://doi.org/10.1200/jco.1997.15.1.317
    101 https://doi.org/10.1200/jco.1997.15.5.1953
    102 https://doi.org/10.1200/jco.1998.16.6.2188
    103 https://doi.org/10.1200/jco.1998.16.9.2959
    104 https://doi.org/10.1200/jco.1999.17.2.676
    105 https://doi.org/10.1200/jco.1999.17.8.2355
    106 https://doi.org/10.1200/jco.20.2.574
    107 https://doi.org/10.1200/jco.2001.19.3.832
    108 https://doi.org/10.1200/jco.2002.04.006
    109 https://doi.org/10.1200/jco.2002.20.2.574
    110 https://doi.org/10.1200/jco.2003.01.058
    111 https://doi.org/10.1200/jco.2003.02.153
    112 https://doi.org/10.1200/jco.2003.12.109
    113 https://doi.org/10.1211/0022357055966
    114 https://doi.org/10.1634/theoncologist.2014-0202
    115 https://doi.org/10.3892/br.2016.685
    116 https://doi.org/10.4161/cbt.4.8.1867
    117 schema:datePublished 2018-01
    118 schema:datePublishedReg 2018-01-01
    119 schema:description Paclitaxel is an anticancer agent efficacious in the treatment of ovarian, breast, and lung cancer. Due to a strong link between the pharmacokinetics and therapeutic efficacy of paclitaxel, we reviewed the literature on paclitaxel pharmacokinetics. Systematic data mining was performed to extract the maximum concentration (C <sub>max</sub>), clearance (CL), and time of paclitaxel plasma concentration above 0.05 µmol/L (T &gt; 0.05 µmol/L) following monotherapy of both the widely used cremophor-diluted paclitaxel and nanoparticle albumin-bound (nab-)paclitaxel. We identified a total of 53 studies yielding 121 aggregated pharmacokinetic profiles for paclitaxel monotherapy and extracted reported mean and median estimates of pharmacokinetic parameters. Paclitaxel has been studied formally at doses of 15-825 mg/m<sup>2</sup> and infused over 0.5-96 h; included studies examined both weekly and every 3-weeks dosing cycles. The most widely used dose of cremophor-diluted paclitaxel, 175 mg/m<sup>2</sup> given as a 3-h infusion, leads to an interstudy median C <sub>max</sub> of 5.1 µmol/L [interquartile range (IQR) 4.5-5.7], CL of 12.0 L/h/m<sup>2</sup> (IQR 10.9-12.9), and T &gt; 0.05 µmol/L of 23.8 h (IQR 21.5-26.8). Importantly, the significant interindividual variation widely reported in the literature is not reflected in these interstudy estimates of pharmacokinetic parameters. Cremophor-diluted paclitaxel pharmacokinetics are non-linear following short (&lt;6 h) but not long (&gt;24 h) infusions. A similar pattern of non-linearity was observed for nab-paclitaxel, although the number of studies was limited. The pharmacokinetics of paclitaxel monotherapy have been widely studied at numerous dose levels of the Cremophor EL<sup>®</sup> formulation, but are less well-characterized for the newer nab-paclitaxel formulation. In conclusion, paclitaxel pharmacokinetics are non-linear for short infusion times but not for longer infusions. Whether a similar conclusion can be drawn for nab-paclitaxel formulations requires further study.
    120 schema:genre research_article
    121 schema:inLanguage en
    122 schema:isAccessibleForFree false
    123 schema:isPartOf Nab56ba1e09ca4b19b6a27ada5a5c7038
    124 Nf007745ca9e346f29e8240f5e7c221e9
    125 sg:journal.1085321
    126 schema:name Clinical Pharmacokinetics of Paclitaxel Monotherapy: An Updated Literature Review
    127 schema:pagination 7-19
    128 schema:productId N0b98aa768db94e08b4bdde6d2ec21c64
    129 N2f7adb472526461db4c4b358c0755e29
    130 N3ba3fdc28dd94919929d1d4b6475e659
    131 N9e0ab03ce8254395b091648ef0032b97
    132 Nf131ca7f010d4e95a29319b2b5fb1ee0
    133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085997484
    134 https://doi.org/10.1007/s40262-017-0563-z
    135 schema:sdDatePublished 2019-04-11T10:37
    136 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    137 schema:sdPublisher N58400c77a4c849a18d2b40322538db77
    138 schema:url https://link.springer.com/10.1007%2Fs40262-017-0563-z
    139 sgo:license sg:explorer/license/
    140 sgo:sdDataset articles
    141 rdf:type schema:ScholarlyArticle
    142 N0b98aa768db94e08b4bdde6d2ec21c64 schema:name nlm_unique_id
    143 schema:value 7606849
    144 rdf:type schema:PropertyValue
    145 N2f7adb472526461db4c4b358c0755e29 schema:name doi
    146 schema:value 10.1007/s40262-017-0563-z
    147 rdf:type schema:PropertyValue
    148 N3ba3fdc28dd94919929d1d4b6475e659 schema:name pubmed_id
    149 schema:value 28612269
    150 rdf:type schema:PropertyValue
    151 N58400c77a4c849a18d2b40322538db77 schema:name Springer Nature - SN SciGraph project
    152 rdf:type schema:Organization
    153 N9e0ab03ce8254395b091648ef0032b97 schema:name readcube_id
    154 schema:value ef9b6a9f9411f515d72d9e1290045a2c924c014818df8e16ea234347dd7cf7b0
    155 rdf:type schema:PropertyValue
    156 Nab56ba1e09ca4b19b6a27ada5a5c7038 schema:issueNumber 1
    157 rdf:type schema:PublicationIssue
    158 Ncead1f2277e0414083e3196fc827e726 rdf:first sg:person.01114537740.75
    159 rdf:rest Nf66cc0ddf06c4c428d736b889f7410fa
    160 Nf007745ca9e346f29e8240f5e7c221e9 schema:volumeNumber 57
    161 rdf:type schema:PublicationVolume
    162 Nf131ca7f010d4e95a29319b2b5fb1ee0 schema:name dimensions_id
    163 schema:value pub.1085997484
    164 rdf:type schema:PropertyValue
    165 Nf66cc0ddf06c4c428d736b889f7410fa rdf:first sg:person.0620612751.83
    166 rdf:rest rdf:nil
    167 Nf9506aa76e94493fa9e8132511fd8df2 rdf:first sg:person.01220335076.07
    168 rdf:rest Ncead1f2277e0414083e3196fc827e726
    169 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    170 schema:name Medical and Health Sciences
    171 rdf:type schema:DefinedTerm
    172 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
    173 schema:name Pharmacology and Pharmaceutical Sciences
    174 rdf:type schema:DefinedTerm
    175 sg:grant.4103562 http://pending.schema.org/fundedItem sg:pub.10.1007/s40262-017-0563-z
    176 rdf:type schema:MonetaryGrant
    177 sg:journal.1085321 schema:issn 0312-5963
    178 1179-1926
    179 schema:name Clinical Pharmacokinetics
    180 rdf:type schema:Periodical
    181 sg:person.01114537740.75 schema:affiliation https://www.grid.ac/institutes/grid.414576.5
    182 schema:familyName Bergmann
    183 schema:givenName Troels K.
    184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114537740.75
    185 rdf:type schema:Person
    186 sg:person.01220335076.07 schema:affiliation https://www.grid.ac/institutes/grid.10825.3e
    187 schema:familyName Stage
    188 schema:givenName Tore B.
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220335076.07
    190 rdf:type schema:Person
    191 sg:person.0620612751.83 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
    192 schema:familyName Kroetz
    193 schema:givenName Deanna L.
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620612751.83
    195 rdf:type schema:Person
    196 sg:pub.10.1007/s00280-008-0842-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032790666
    197 https://doi.org/10.1007/s00280-008-0842-3
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1007/s00280-011-1726-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048343941
    200 https://doi.org/10.1007/s00280-011-1726-5
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1007/s002800000193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000550237
    203 https://doi.org/10.1007/s002800000193
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1007/s002800000215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035156827
    206 https://doi.org/10.1007/s002800000215
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1007/s002800100297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020722742
    209 https://doi.org/10.1007/s002800100297
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1007/s10549-010-1278-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007967397
    212 https://doi.org/10.1007/s10549-010-1278-0
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1007/s10637-005-1439-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042192945
    215 https://doi.org/10.1007/s10637-005-1439-x
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1007/s10637-015-0236-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043614098
    218 https://doi.org/10.1007/s10637-015-0236-4
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1023/a:1022286422439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023636065
    221 https://doi.org/10.1023/a:1022286422439
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1023/a:1025412509730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017655721
    224 https://doi.org/10.1023/a:1025412509730
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/87912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004128811
    227 https://doi.org/10.1038/87912
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/bjc.1998.438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039075669
    230 https://doi.org/10.1038/bjc.1998.438
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/bjc.2012.407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025415738
    233 https://doi.org/10.1038/bjc.2012.407
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/clpt.2011.313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001596791
    236 https://doi.org/10.1038/clpt.2011.313
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/sj.bjc.6690696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012123031
    239 https://doi.org/10.1038/sj.bjc.6690696
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/sj.clpt.6100011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005218085
    242 https://doi.org/10.1038/sj.clpt.6100011
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/tpj.2010.19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017706531
    245 https://doi.org/10.1038/tpj.2010.19
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.2165/00003088-199427040-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053348338
    248 https://doi.org/10.2165/00003088-199427040-00002
    249 rdf:type schema:CreativeWork
    250 https://app.dimensions.ai/details/publication/pub.1074356008 schema:CreativeWork
    251 https://app.dimensions.ai/details/publication/pub.1074500185 schema:CreativeWork
    252 https://app.dimensions.ai/details/publication/pub.1074559833 schema:CreativeWork
    253 https://app.dimensions.ai/details/publication/pub.1074701140 schema:CreativeWork
    254 https://app.dimensions.ai/details/publication/pub.1074963956 schema:CreativeWork
    255 https://app.dimensions.ai/details/publication/pub.1075031499 schema:CreativeWork
    256 https://app.dimensions.ai/details/publication/pub.1075050987 schema:CreativeWork
    257 https://app.dimensions.ai/details/publication/pub.1075103072 schema:CreativeWork
    258 https://app.dimensions.ai/details/publication/pub.1075339682 schema:CreativeWork
    259 https://app.dimensions.ai/details/publication/pub.1076596625 schema:CreativeWork
    260 https://app.dimensions.ai/details/publication/pub.1077152433 schema:CreativeWork
    261 https://app.dimensions.ai/details/publication/pub.1082379321 schema:CreativeWork
    262 https://app.dimensions.ai/details/publication/pub.1083196203 schema:CreativeWork
    263 https://app.dimensions.ai/details/publication/pub.1083347495 schema:CreativeWork
    264 https://app.dimensions.ai/details/publication/pub.1083347753 schema:CreativeWork
    265 https://doi.org/10.1002/1097-0142(20010115)91:2<417::aid-cncr1016>3.0.co;2-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017263834
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1002/cncr.11375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049059017
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1002/cncr.21312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007864070
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1002/cncr.29254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045472741
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1002/cpt.674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083855475
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1002/ijc.21013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046655247
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1002/pbc.21310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014991574
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1006/abbi.1998.0730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018297979
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1006/phrs.1998.0360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032710683
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1006/phrs.1999.0477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042484341
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.ijrobp.2007.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036337865
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.lungcan.2004.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044979615
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/s0090-8258(03)00373-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050629594
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/s0959-8049(02)00242-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013463021
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/s0959-8049(03)00126-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013228553
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1021/acs.molpharmaceut.5b00026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055119929
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1021/jm00079a019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055934394
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1023/a:1011655503511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056305529
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1056/nejm199601043340101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049279167
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1056/nejmoa072113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033842397
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1093/annonc/mdw290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059394806
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1093/jjco/hye022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010277311
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1093/jjco/hyp192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042984648
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1093/oxfordjournals.annonc.a059287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082899248
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1097/00001813-199801000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013543840
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1097/00001813-199802000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047977415
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1097/00001813-200306000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005871808
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1097/00001813-200307000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038068812
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1111/bcp.12795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035438329
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1111/j.1349-7006.1994.tb02906.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003303454
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1111/j.1349-7006.2001.tb01086.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009789598
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1111/j.1365-2125.2007.02956.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009215726
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1111/j.1365-2125.2008.03104.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017284137
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1111/j.1742-7843.2008.00351.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003632186
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1124/dmd.111.040931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049753570
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1124/dmd.116.070375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028114587
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1124/dmd.30.4.438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027676036
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1126/scitranslmed.3007965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062688222
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1158/0008-5472.can-15-2525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063215987
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1158/1078-0432.ccr-04-2291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052849950
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1158/1078-0432.ccr-040009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063224768
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1158/1078-0432.ccr-05-0298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042395838
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1158/1078-0432.ccr-05-1152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006820630
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1158/1078-0432.ccr-06-1352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030004118
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1158/1078-0432.ccr-07-0064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027966775
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1158/1078-0432.ccr-07-4592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046894549
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1158/1078-0432.ccr-10-0062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050030494
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1158/1078-0432.ccr-12-3786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049149563
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1158/1078-0432.ccr-14-1758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025917635
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1158/1078-0432.ccr-15-0586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063224919
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1158/1535-7163.mct-14-0431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050626460
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1159/000068620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007958626
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1159/000086597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034457526
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1172/jci15451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063415383
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1200/jco.1991.9.7.1261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077250493
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1200/jco.1991.9.9.1692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077258697
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1200/jco.1993.11.11.2127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082557651
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1200/jco.1994.12.12.2654 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082597535
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1200/jco.1994.12.2.241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082391827
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1200/jco.1994.12.8.1621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082562776
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1200/jco.1995.13.1.180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082512486
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1200/jco.1995.13.8.2039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082444251
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1200/jco.1996.14.3.774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082882779
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1200/jco.1997.15.1.317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083031499
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1200/jco.1997.15.5.1953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083094779
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1200/jco.1998.16.6.2188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083277789
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1200/jco.1998.16.9.2959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083316816
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1200/jco.1999.17.2.676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074265670
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1200/jco.1999.17.8.2355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074549852
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1200/jco.20.2.574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202775
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1200/jco.2001.19.3.832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074750693
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1200/jco.2002.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202967
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1200/jco.2002.20.2.574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083941899
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1200/jco.2003.01.058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203266
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1200/jco.2003.02.153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203417
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1200/jco.2003.12.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204022
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1211/0022357055966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053364736
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1634/theoncologist.2014-0202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024424227
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.3892/br.2016.685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071502688
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.4161/cbt.4.8.1867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072293832
    424 rdf:type schema:CreativeWork
    425 https://www.grid.ac/institutes/grid.10825.3e schema:alternateName University of Southern Denmark
    426 schema:name Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark
    427 Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA
    428 rdf:type schema:Organization
    429 https://www.grid.ac/institutes/grid.266102.1 schema:alternateName University of California, San Francisco
    430 schema:name Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA
    431 rdf:type schema:Organization
    432 https://www.grid.ac/institutes/grid.414576.5 schema:alternateName Sydvestjysk Sygehus
    433 schema:name Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark
    434 Hospital Pharmacy, Hospital of South West Jutland, Esbjerg, Denmark
    435 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...