Does Weight Impact Anidulafungin Pharmacokinetics? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-10

AUTHORS

Vincent J. Lempers, Anne van Rongen, Eric P. van Dongen, Bert van Ramshorst, David M. Burger, Rob E. Aarnoutse, Catherijne A. Knibbe, Roger J. Brüggemann

ABSTRACT

Bodyweight has been shown to influence anidulafungin exposure, but data from obese patients are lacking. We determined anidulafungin pharmacokinetics (100-mg single dose) in eight morbidly obese subjects (body mass index >40 kg/m(2)). Anidulafungin exposure was on average 32.5 % lower compared with the general patient population, suggesting dose increases may be required in this population. More... »

PAGES

1289-1294

References to SciGraph publications

  • 2005-10. Quantification of Lean Bodyweight in CLINICAL PHARMACOKINETICS
  • 2008-09. Global burden of obesity in 2005 and projections to 2030 in INTERNATIONAL JOURNAL OF OBESITY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40262-016-0401-8

    DOI

    http://dx.doi.org/10.1007/s40262-016-0401-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032235602

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27142114


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