Switching from a Free Association of Perindopril/Amlodipine to a Fixed-Dose Combination: Increased Antihypertensive Efficacy and Tolerability View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-04-25

AUTHORS

Katarina Hatalova, Daniel Pella, Rastislav Sidlo, Robert Hatala

ABSTRACT

Background and ObjectivesAlthough single-pill, fixed-dose combinations (FDCs) are widely endorsed for the reduction of blood pressure and cardiovascular risk, studies to date have not evaluated the differences between FDCs and free associations using matched drugs and doses. The objective of this study was to determine whether switching from a free association of perindopril/amlodipine to the FDC formulation led to significant improvements in efficacy and tolerability.MethodsIn this subanalysis of the previously published SYMBIO study, we looked at the effect of switching patients from a free association of perindopril/amlodipine to an equivalent dose of FDC (N = 335). In the SYMBIO study, concomitant antihypertensive medications were allowed; however, they remained unchanged till the end of the study. Blood pressure was measured at baseline, 1, and 3 months. Targets were defined as blood pressure <140/90 mmHg or <130/80 mmHg for patients with type 2 diabetes mellitus or at high cardiovascular risk.ResultsCompared to baseline, mean blood pressure decreased significantly after 1 and 3 months of treatment with FDC perindopril/amlodipine. Mean changes from baseline were −15.6 ± 14.3/−7.7 ± 9.1 mmHg at 1 month (p < 0.0001) and −23.3 ± 16.4/−11.3 ± 9.8 mmHg at 3 months (p < 0.0001). The percentage of patients who reached their blood pressure target increased from 16.0 % at baseline to 50.6 % at 1 month, to 75.9 % at 3 months. The incidence of ankle edema decreased from 14.9 % at baseline, to 9.9 % at 1 month, to 5.4 % at 3 months. The relative risk reduction for ankle edema was −37.5 % at 1 month (vs. baseline; p < 0.001) and −57.2 % at 3 months (vs. baseline; p < 0.001).ConclusionsThese data suggest that switching from a free association of perindopril/amlodipine to the same dose of the FDC formulation led to significant improvements in efficacy and tolerability. More... »

PAGES

591-598

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40261-016-0404-0

DOI

http://dx.doi.org/10.1007/s40261-016-0404-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015553343

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27113228


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