Assessing Analytical Similarity of Proposed Amgen Biosimilar ABP 501 to Adalimumab View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-08

AUTHORS

Jennifer Liu, Tamer Eris, Cynthia Li, Shawn Cao, Scott Kuhns

ABSTRACT

BACKGROUND: ABP 501 is being developed as a biosimilar to adalimumab. Comprehensive comparative analytical characterization studies have been conducted and completed. OBJECTIVE: The objective of this study was to assess analytical similarity between ABP 501 and two adalimumab reference products (RPs), licensed by the United States Food and Drug Administration (adalimumab [US]) and authorized by the European Union (adalimumab [EU]), using state-of-the-art analytical methods. METHODS: Comprehensive analytical characterization incorporating orthogonal analytical techniques was used to compare products. Physicochemical property comparisons comprised the primary structure related to amino acid sequence and post-translational modifications including glycans; higher-order structure; primary biological properties mediated by target and receptor binding; product-related substances and impurities; host-cell impurities; general properties of the finished drug product, including strength and formulation; subvisible and submicron particles and aggregates; and forced thermal degradation. RESULTS: ABP 501 had the same amino acid sequence and similar post-translational modification profiles compared with adalimumab RPs. Primary structure, higher-order structure, and biological activities were similar for the three products. Product-related size and charge variants and aggregate and particle levels were also similar. ABP 501 had very low residual host-cell protein and DNA. The finished ABP 501 drug product has the same strength with regard to protein concentration and fill volume as adalimumab RPs. ABP 501 and the RPs had a similar stability profile both in normal storage and thermal stress conditions. CONCLUSION: Based on the comprehensive analytical similarity assessment, ABP 501 was found to be similar to adalimumab with respect to physicochemical and biological properties. More... »

PAGES

321-338

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40259-016-0184-3

DOI

http://dx.doi.org/10.1007/s40259-016-0184-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038300105

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27461107


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0301", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Analytical Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adalimumab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biosimilar Pharmaceuticals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CHO Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calorimetry, Differential Scanning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatography, High Pressure Liquid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Circular Dichroism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cricetulus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Stability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dynamic Light Scattering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrophoresis, Capillary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Isoelectric Point", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spectroscopy, Fourier Transform Infrared", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ultracentrifugation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Amgen (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417886.4", 
          "name": [
            "Amgen Inc., One Amgen Center Drive, 91320, Thousand Oaks, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Jennifer", 
        "id": "sg:person.010321752455.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010321752455.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amgen (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417886.4", 
          "name": [
            "Amgen Inc., One Amgen Center Drive, 91320, Thousand Oaks, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eris", 
        "givenName": "Tamer", 
        "id": "sg:person.011117333055.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011117333055.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amgen (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417886.4", 
          "name": [
            "Amgen Inc., One Amgen Center Drive, 91320, Thousand Oaks, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Cynthia", 
        "id": "sg:person.0741462774.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741462774.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amgen (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417886.4", 
          "name": [
            "Amgen Inc., One Amgen Center Drive, 91320, Thousand Oaks, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cao", 
        "givenName": "Shawn", 
        "id": "sg:person.01160334666.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160334666.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amgen (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417886.4", 
          "name": [
            "Amgen Inc., One Amgen Center Drive, 91320, Thousand Oaks, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuhns", 
        "givenName": "Scott", 
        "id": "sg:person.01330503651.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330503651.13"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.trac.2013.02.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001234657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd3746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001392750", 
          "https://doi.org/10.1038/nrd3746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00216-014-8299-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001962384", 
          "https://doi.org/10.1007/s00216-014-8299-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/j.jasms.2009.07.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002706972", 
          "https://doi.org/10.1016/j.jasms.2009.07.017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m210665200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003877317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m202069200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006387301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-2263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012578684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3495(00)76713-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014356043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/elps.201300471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021579801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/89.15.1110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025908337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m510171200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032188024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/mabs.20737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036092920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2015/427235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038991520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpba.2013.02.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039887061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/19420862.2016.1172150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041531417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m609064200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041975498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40259-016-0185-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042463549", 
          "https://doi.org/10.1007/s40259-016-0185-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40259-016-0185-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042463549", 
          "https://doi.org/10.1007/s40259-016-0185-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cyto.2008.11.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044711621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/glycob/cwr027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046776228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/btpr.731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047878732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/19420862.2015.1073429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058413319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/blr.2006.25.447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059238419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/mabs.11986", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072305514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/mabs.23995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072305648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/mabs.25864", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072305688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/mabs.32221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072305878"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-08", 
    "datePublishedReg": "2016-08-01", 
    "description": "BACKGROUND: ABP\u00a0501 is being developed as a biosimilar to adalimumab. Comprehensive comparative analytical characterization studies have been conducted and completed.\nOBJECTIVE: The objective of this study was to assess analytical similarity between ABP\u00a0501 and two adalimumab reference products (RPs), licensed by the United States Food and Drug Administration (adalimumab [US]) and authorized by the European Union (adalimumab [EU]), using state-of-the-art analytical methods.\nMETHODS: Comprehensive analytical characterization incorporating orthogonal analytical techniques was used to compare products. Physicochemical property comparisons comprised the primary structure related to amino acid sequence and post-translational modifications including glycans; higher-order structure; primary biological properties mediated by target and receptor binding; product-related substances and impurities; host-cell impurities; general properties of the finished drug product, including strength and formulation; subvisible and submicron particles and aggregates; and forced thermal degradation.\nRESULTS: ABP\u00a0501 had the same amino acid sequence and similar post-translational modification profiles compared with adalimumab RPs. Primary structure, higher-order structure, and biological activities were similar for the three products. Product-related size and charge variants and aggregate and particle levels were also similar. ABP\u00a0501 had very low residual host-cell protein and DNA. The finished ABP\u00a0501 drug product has the same strength with regard to protein concentration and fill volume as adalimumab RPs. ABP\u00a0501 and the RPs had a similar stability profile both in normal storage and thermal stress conditions.\nCONCLUSION: Based on the comprehensive analytical similarity assessment, ABP\u00a0501 was found to be similar to adalimumab with respect to physicochemical and biological properties.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s40259-016-0184-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1111842", 
        "issn": [
          "1173-8804", 
          "1179-190X"
        ], 
        "name": "BioDrugs", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "30"
      }
    ], 
    "name": "Assessing Analytical Similarity of Proposed Amgen Biosimilar ABP 501 to Adalimumab", 
    "pagination": "321-338", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b672a6a0844e7bb488abb6160a3707c4345bfe5b917444ce3679d01c34a04ee6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27461107"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9705305"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s40259-016-0184-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038300105"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s40259-016-0184-3", 
      "https://app.dimensions.ai/details/publication/pub.1038300105"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:44", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70068_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs40259-016-0184-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40259-016-0184-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40259-016-0184-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40259-016-0184-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40259-016-0184-3'


 

This table displays all metadata directly associated to this object as RDF triples.

239 TRIPLES      21 PREDICATES      70 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s40259-016-0184-3 schema:about N1c76e042179f46d9adb80d9a7ad2ac35
2 N2f0eb40ca3924960b39ccabd69488ced
3 N2fde26e821d7486693072c4f0e061c9f
4 N33fe56355cd449f186a1b456a138e38a
5 N3d930bfa37a64f9ca77ad49bf074a0f2
6 N5003e5bda1094092b60b58b095ec48db
7 N6811c91052714a53bb16b1eb96190bfb
8 N7cde8ed4b130459983f6740470711846
9 N80a34a7ef59d482ea415de65207554cd
10 Na91dacd253dd4ace9b9546b225c2d87e
11 Nbcf065d3260641e68d69269c31e1f49e
12 Nbfdb13f2c1414963ac3d3bd84d9eda42
13 Nc13aa820043649aebd9000fcd7172c04
14 Nd332eadf465944d29046235a56f13a00
15 Nec9a321fbd064890a8813e36d39f5cb0
16 anzsrc-for:03
17 anzsrc-for:0301
18 schema:author Nf78136dfb72d4838bb628c0da50aeaeb
19 schema:citation sg:pub.10.1007/s00216-014-8299-1
20 sg:pub.10.1007/s40259-016-0185-2
21 sg:pub.10.1016/j.jasms.2009.07.017
22 sg:pub.10.1038/nrd3746
23 https://doi.org/10.1002/btpr.731
24 https://doi.org/10.1002/elps.201300471
25 https://doi.org/10.1016/j.cyto.2008.11.008
26 https://doi.org/10.1016/j.jpba.2013.02.040
27 https://doi.org/10.1016/j.trac.2013.02.014
28 https://doi.org/10.1016/s0006-3495(00)76713-0
29 https://doi.org/10.1074/jbc.m202069200
30 https://doi.org/10.1074/jbc.m210665200
31 https://doi.org/10.1074/jbc.m510171200
32 https://doi.org/10.1074/jbc.m609064200
33 https://doi.org/10.1080/19420862.2015.1073429
34 https://doi.org/10.1080/19420862.2016.1172150
35 https://doi.org/10.1089/blr.2006.25.447
36 https://doi.org/10.1093/glycob/cwr027
37 https://doi.org/10.1093/jnci/89.15.1110
38 https://doi.org/10.1155/2015/427235
39 https://doi.org/10.1158/1078-0432.ccr-04-2263
40 https://doi.org/10.4161/mabs.11986
41 https://doi.org/10.4161/mabs.20737
42 https://doi.org/10.4161/mabs.23995
43 https://doi.org/10.4161/mabs.25864
44 https://doi.org/10.4161/mabs.32221
45 schema:datePublished 2016-08
46 schema:datePublishedReg 2016-08-01
47 schema:description BACKGROUND: ABP 501 is being developed as a biosimilar to adalimumab. Comprehensive comparative analytical characterization studies have been conducted and completed. OBJECTIVE: The objective of this study was to assess analytical similarity between ABP 501 and two adalimumab reference products (RPs), licensed by the United States Food and Drug Administration (adalimumab [US]) and authorized by the European Union (adalimumab [EU]), using state-of-the-art analytical methods. METHODS: Comprehensive analytical characterization incorporating orthogonal analytical techniques was used to compare products. Physicochemical property comparisons comprised the primary structure related to amino acid sequence and post-translational modifications including glycans; higher-order structure; primary biological properties mediated by target and receptor binding; product-related substances and impurities; host-cell impurities; general properties of the finished drug product, including strength and formulation; subvisible and submicron particles and aggregates; and forced thermal degradation. RESULTS: ABP 501 had the same amino acid sequence and similar post-translational modification profiles compared with adalimumab RPs. Primary structure, higher-order structure, and biological activities were similar for the three products. Product-related size and charge variants and aggregate and particle levels were also similar. ABP 501 had very low residual host-cell protein and DNA. The finished ABP 501 drug product has the same strength with regard to protein concentration and fill volume as adalimumab RPs. ABP 501 and the RPs had a similar stability profile both in normal storage and thermal stress conditions. CONCLUSION: Based on the comprehensive analytical similarity assessment, ABP 501 was found to be similar to adalimumab with respect to physicochemical and biological properties.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree true
51 schema:isPartOf N1ea4c8b083c9497bb26d6814443f318f
52 N93af14ca1c3f4ee6a99aa57b893d4795
53 sg:journal.1111842
54 schema:name Assessing Analytical Similarity of Proposed Amgen Biosimilar ABP 501 to Adalimumab
55 schema:pagination 321-338
56 schema:productId N26a07f726d594dc2814ab064b14ba2f9
57 N40ec705137b24499ad31a12bbe18c066
58 N5460a0b08fd44f52bf59c2b440a11113
59 N6c520f6a13c548cd85d864316d5456f7
60 N9a009bf409594d17a0e9b273e2c60a54
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038300105
62 https://doi.org/10.1007/s40259-016-0184-3
63 schema:sdDatePublished 2019-04-11T12:44
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher N34fcc7e296894a1ea3b10eafd35bb243
66 schema:url https://link.springer.com/10.1007%2Fs40259-016-0184-3
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N1c76e042179f46d9adb80d9a7ad2ac35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Animals
72 rdf:type schema:DefinedTerm
73 N1ea4c8b083c9497bb26d6814443f318f schema:volumeNumber 30
74 rdf:type schema:PublicationVolume
75 N26a07f726d594dc2814ab064b14ba2f9 schema:name nlm_unique_id
76 schema:value 9705305
77 rdf:type schema:PropertyValue
78 N28c2f5170fe84a82aa61f8c749fbbe45 rdf:first sg:person.011117333055.71
79 rdf:rest N2cbe43bc239c4c619e21e4416a83adf5
80 N2cbe43bc239c4c619e21e4416a83adf5 rdf:first sg:person.0741462774.69
81 rdf:rest Ne2ddebd95c68478494e1dc48b3544aca
82 N2f0eb40ca3924960b39ccabd69488ced schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Chromatography, High Pressure Liquid
84 rdf:type schema:DefinedTerm
85 N2fde26e821d7486693072c4f0e061c9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Cricetulus
87 rdf:type schema:DefinedTerm
88 N33fe56355cd449f186a1b456a138e38a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name CHO Cells
90 rdf:type schema:DefinedTerm
91 N34fcc7e296894a1ea3b10eafd35bb243 schema:name Springer Nature - SN SciGraph project
92 rdf:type schema:Organization
93 N3d930bfa37a64f9ca77ad49bf074a0f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Circular Dichroism
95 rdf:type schema:DefinedTerm
96 N40ec705137b24499ad31a12bbe18c066 schema:name doi
97 schema:value 10.1007/s40259-016-0184-3
98 rdf:type schema:PropertyValue
99 N5003e5bda1094092b60b58b095ec48db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Calorimetry, Differential Scanning
101 rdf:type schema:DefinedTerm
102 N5460a0b08fd44f52bf59c2b440a11113 schema:name dimensions_id
103 schema:value pub.1038300105
104 rdf:type schema:PropertyValue
105 N6811c91052714a53bb16b1eb96190bfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Peptide Mapping
107 rdf:type schema:DefinedTerm
108 N6c520f6a13c548cd85d864316d5456f7 schema:name pubmed_id
109 schema:value 27461107
110 rdf:type schema:PropertyValue
111 N7c3bb4204d91462da54e6969d90755ef rdf:first sg:person.01330503651.13
112 rdf:rest rdf:nil
113 N7cde8ed4b130459983f6740470711846 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Biosimilar Pharmaceuticals
115 rdf:type schema:DefinedTerm
116 N80a34a7ef59d482ea415de65207554cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Drug Stability
118 rdf:type schema:DefinedTerm
119 N93af14ca1c3f4ee6a99aa57b893d4795 schema:issueNumber 4
120 rdf:type schema:PublicationIssue
121 N9a009bf409594d17a0e9b273e2c60a54 schema:name readcube_id
122 schema:value b672a6a0844e7bb488abb6160a3707c4345bfe5b917444ce3679d01c34a04ee6
123 rdf:type schema:PropertyValue
124 Na91dacd253dd4ace9b9546b225c2d87e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Dynamic Light Scattering
126 rdf:type schema:DefinedTerm
127 Nbcf065d3260641e68d69269c31e1f49e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Spectroscopy, Fourier Transform Infrared
129 rdf:type schema:DefinedTerm
130 Nbfdb13f2c1414963ac3d3bd84d9eda42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Isoelectric Point
132 rdf:type schema:DefinedTerm
133 Nc13aa820043649aebd9000fcd7172c04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Adalimumab
135 rdf:type schema:DefinedTerm
136 Nd332eadf465944d29046235a56f13a00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Electrophoresis, Capillary
138 rdf:type schema:DefinedTerm
139 Ne2ddebd95c68478494e1dc48b3544aca rdf:first sg:person.01160334666.78
140 rdf:rest N7c3bb4204d91462da54e6969d90755ef
141 Nec9a321fbd064890a8813e36d39f5cb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Ultracentrifugation
143 rdf:type schema:DefinedTerm
144 Nf78136dfb72d4838bb628c0da50aeaeb rdf:first sg:person.010321752455.60
145 rdf:rest N28c2f5170fe84a82aa61f8c749fbbe45
146 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
147 schema:name Chemical Sciences
148 rdf:type schema:DefinedTerm
149 anzsrc-for:0301 schema:inDefinedTermSet anzsrc-for:
150 schema:name Analytical Chemistry
151 rdf:type schema:DefinedTerm
152 sg:journal.1111842 schema:issn 1173-8804
153 1179-190X
154 schema:name BioDrugs
155 rdf:type schema:Periodical
156 sg:person.010321752455.60 schema:affiliation https://www.grid.ac/institutes/grid.417886.4
157 schema:familyName Liu
158 schema:givenName Jennifer
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010321752455.60
160 rdf:type schema:Person
161 sg:person.011117333055.71 schema:affiliation https://www.grid.ac/institutes/grid.417886.4
162 schema:familyName Eris
163 schema:givenName Tamer
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011117333055.71
165 rdf:type schema:Person
166 sg:person.01160334666.78 schema:affiliation https://www.grid.ac/institutes/grid.417886.4
167 schema:familyName Cao
168 schema:givenName Shawn
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160334666.78
170 rdf:type schema:Person
171 sg:person.01330503651.13 schema:affiliation https://www.grid.ac/institutes/grid.417886.4
172 schema:familyName Kuhns
173 schema:givenName Scott
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330503651.13
175 rdf:type schema:Person
176 sg:person.0741462774.69 schema:affiliation https://www.grid.ac/institutes/grid.417886.4
177 schema:familyName Li
178 schema:givenName Cynthia
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741462774.69
180 rdf:type schema:Person
181 sg:pub.10.1007/s00216-014-8299-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001962384
182 https://doi.org/10.1007/s00216-014-8299-1
183 rdf:type schema:CreativeWork
184 sg:pub.10.1007/s40259-016-0185-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042463549
185 https://doi.org/10.1007/s40259-016-0185-2
186 rdf:type schema:CreativeWork
187 sg:pub.10.1016/j.jasms.2009.07.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002706972
188 https://doi.org/10.1016/j.jasms.2009.07.017
189 rdf:type schema:CreativeWork
190 sg:pub.10.1038/nrd3746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001392750
191 https://doi.org/10.1038/nrd3746
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1002/btpr.731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047878732
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1002/elps.201300471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021579801
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/j.cyto.2008.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044711621
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/j.jpba.2013.02.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039887061
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.trac.2013.02.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001234657
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/s0006-3495(00)76713-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014356043
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1074/jbc.m202069200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006387301
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1074/jbc.m210665200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003877317
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1074/jbc.m510171200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032188024
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1074/jbc.m609064200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041975498
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1080/19420862.2015.1073429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058413319
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1080/19420862.2016.1172150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041531417
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1089/blr.2006.25.447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059238419
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1093/glycob/cwr027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046776228
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1093/jnci/89.15.1110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025908337
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1155/2015/427235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038991520
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1158/1078-0432.ccr-04-2263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012578684
226 rdf:type schema:CreativeWork
227 https://doi.org/10.4161/mabs.11986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072305514
228 rdf:type schema:CreativeWork
229 https://doi.org/10.4161/mabs.20737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036092920
230 rdf:type schema:CreativeWork
231 https://doi.org/10.4161/mabs.23995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072305648
232 rdf:type schema:CreativeWork
233 https://doi.org/10.4161/mabs.25864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072305688
234 rdf:type schema:CreativeWork
235 https://doi.org/10.4161/mabs.32221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072305878
236 rdf:type schema:CreativeWork
237 https://www.grid.ac/institutes/grid.417886.4 schema:alternateName Amgen (United States)
238 schema:name Amgen Inc., One Amgen Center Drive, 91320, Thousand Oaks, CA, USA
239 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...