Cost-Effectiveness Analysis of High-Efficiency Hemodiafiltration Versus Low-Flux Hemodialysis Based on the Canadian Arm of the CONTRAST Study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Renee Lévesque, Daniele Marcelli, Héloïse Cardinal, Marie-Line Caron, Muriel P. C. Grooteman, Michiel L. Bots, Peter J. Blankestijn, Menso J. Nubé, Aileen Grassmann, Bernard Canaud, Afschin Gandjour

ABSTRACT

AIM: The aim of this study was to assess the cost effectiveness of high-efficiency on-line hemodiafiltration (OL-HDF) compared with low-flux hemodialysis (LF-HD) for patients with end-stage renal disease (ESRD) based on the Canadian (Centre Hospitalier de l'Université de Montréal) arm of a parallel-group randomized controlled trial (RCT), the CONvective TRAnsport STudy. METHODS: An economic evaluation was conducted for the period of the RCT (74 months). In addition, a Markov state transition model was constructed to simulate costs and health benefits over lifetime. The primary outcome was costs per quality-adjusted life-year (QALY) gained. The analysis had the perspective of the Quebec public healthcare system. RESULTS: A total of 130 patients were randomly allocated to OL-HDF (n = 67) and LF-HD (n = 63). The cost-utility ratio of OL-HDF versus LF-HD was Can$53,270 per QALY gained over lifetime. This ratio was fairly robust in the sensitivity analysis. The cost-utility ratio was lower than that of LF-HD compared with no treatment (immediate death), which was Can$93,008 per QALY gained. CONCLUSIONS: High-efficiency OL-HDF can be considered a cost-effective treatment for ESRD in a Canadian setting. Further research is needed to assess cost effectiveness in other settings and healthcare systems. More... »

PAGES

647-659

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40258-015-0179-0

DOI

http://dx.doi.org/10.1007/s40258-015-0179-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029532424

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26071951


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