Morphine and Ticagrelor Interaction in Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction: ATLANTIC-Morphine View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-10-23

AUTHORS

Frédéric Lapostolle, Arnoud W. van’t Hof, Christian W. Hamm, Olivier Stibbe, Patrick Ecollan, Jean-Philippe Collet, Johanne Silvain, Jens Flensted Lassen, Wim M. J. M. Heutz, Leonardo Bolognese, Warren J. Cantor, Angel Cequier, Mohamed Chettibi, Shaun G. Goodman, Christopher J. Hammett, Kurt Huber, Magnus Janzon, Béla Merkely, Robert F. Storey, Jur ten Berg, Uwe Zeymer, Muriel Licour, Anne Tsatsaris, Gilles Montalescot,

ABSTRACT

BackgroundMorphine adversely impacts the action of oral adenosine diphosphate (ADP)-receptor blockers in ST-segment elevation myocardial infarction (STEMI) patients, and is possibly associated with differing patient characteristics. This retrospective analysis investigated whether interaction between morphine use and pre-percutaneous coronary intervention (pre-PCI) ST-segment elevation resolution in STEMI patients in the ATLANTIC study was associated with differences in patient characteristics and management.MethodsATLANTIC was an international, multicenter, randomized study of treatment in the acute ambulance/hospital setting where STEMI patients received ticagrelor 180 mg ± morphine. Patient characteristics, cardiovascular history, risk factors, management, and outcomes were recorded.ResultsOpioids (97.6% morphine) were used in 921 out of 1862 patients (49.5%). There were no significant differences in age, sex or cardiovascular history, but more morphine-treated patients had anterior myocardial infarction and left-main disease. Time from chest pain to electrocardiogram and ticagrelor loading was shorter with morphine (both p = 0.01) but not total ischemic time. Morphine-treated patients more frequently received glycoprotein IIb/IIIa inhibitors (p = 0.002), thromboaspiration and stent implantation (both p < 0.001). No significant difference between the two groups was found regarding pre-PCI ≥ 70% ST-segment elevation resolution, death, myocardial infarction, stroke, urgent revascularization and definitive acute stent thrombosis. More morphine-treated patients had an absence of pre-PCI Thrombolysis in Myocardial Infarction (TIMI) 3 flow (85.8% vs. 79.7%; p = 0.001) and more had TIMI major bleeding (1.1% vs. 0.1%; p = 0.02).ConclusionsMorphine-treatment was associated with increased GP IIb/IIIa inhibitor use, less pre-PCI TIMI 3 flow, and more bleeding. Judicious morphine use is advised with non-opioid analgesics preferred for non-severe acute pain.Trial Registrationclinicaltrials.gov identifier: NCT01347580. More... »

PAGES

173-183

Journal

Author Affiliations

  • SAMU 93 - UF Recherche-Enseignement-Qualité, Université Paris 13, Sorbonne Paris Cité, Inserm U942, Hôpital Avicenne, 125, rue de Stalingrad, 93009, Bobigny, France
  • Department of Cardiology, Maastricht University Medical Center, Maastricht, The Netherlands
  • Department of Cardiology, Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany
  • Service Médical d’Urgence, Brigade de Sapeurs-Pompiers de Paris, Paris, France
  • Sorbonne Université, ACTION Study Group, Hôpital Pitié-Salpêtrière (AP-HP), 47 boul de l’Hôpital, 75013, Paris, France
  • Department of Cardiology B, Aarhus University Hospital, Skejby, Aarhus N, Denmark
  • Regionale Ambulance Voor ziening Gelderland-Midden, Arnhem, The Netherlands
  • Cardiovascular and Neurological Department, Azienda Ospedaliera Arezzo, Arezzo, Italy
  • Southlake Regional Health Centre, University of Toronto, Newmarket, ON, Canada
  • Heart Disease Institute, Hospital Universitario de Bellvitge, University of Barcelona, L’Hospitalet de Llobregat, Barcelona, Spain
  • Centre Hospito-universitaire Frantz Fanon, Blida, Algeria
  • Division of Cardiology, Canadian Heart Research Centre, St Michael’s Hospital, University of Toronto, Toronto, Canada
  • Department of Cardiology, Royal Brisbane and Women’s Hospital, Brisbane, QLD, Australia
  • 3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminenhospital, Sigmund Freud University, Medical School, Vienna, Austria
  • Department of Cardiology and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden
  • Heart and Vascular Center, Semmelweis University, Budapest, Hungary
  • Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK
  • Department of Cardiology, St Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands
  • Klinikum Ludwigshafen and Institut für Herzinfarktforschung Ludwigshafen, Ludwigshafen, Germany
  • AstraZeneca, Rueil Malmaison, France
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40256-018-0305-0

    DOI

    http://dx.doi.org/10.1007/s40256-018-0305-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107799013

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30353444


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