Designing and fabrication of curcumin loaded PCL/PVA multi-layer nanofibrous electrospun structures as active wound dressing View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-05

AUTHORS

Seyed Mahdi Saeed, Hamid Mirzadeh, Mojgan Zandi, Jalal Barzin

ABSTRACT

Active wound dressings play a significant role in burn and chronic wound treatment. In this study, electrospinning process is used to fabricate a novel three-layer active wound dressing based on ε-polycaprolactone (PCL), polyvinylalcohol (PVA), and curcumin (CU) as a biologically active compound. The main purpose for developing such a system is to control wound exudates, which remains a challenge, as well as enjoying the anti-bacterial property. Electrospinning process parameters are optimized by response surface methodology to achieve appropriate nanofibrous electrospun mats, and then, a three-layer dressing has been designed in view of water absorbability, anti-bacterial, and biocompatibility characteristics of the final dressing. The results illustrate that a three-layer dressing based on PCL/curcumin containing PVA as a middle layer with optimized thickness which is placed over the incision, absorbs three times exudates in comparison with pristine dressing. Anti-bacterial tests reveal that the dressing containing 16% curcumin exhibits anti-bacterial activity without sacrificing the acceptable level of cell viability. More... »

PAGES

39-48

References to SciGraph publications

  • 2016-03. Electrospun silk-based nanofibrous scaffolds: fiber diameter and oxygen transfer in PROGRESS IN BIOMATERIALS
  • 2007. CLINICAL STUDIES WITH CURCUMIN in THE MOLECULAR TARGETS AND THERAPEUTIC USES OF CURCUMIN IN HEALTH AND DISEASE
  • 2010-01. A new approach for optimization of electrospun nanofiber formation process in KOREAN JOURNAL OF CHEMICAL ENGINEERING
  • 1998-02. Burn Wound Infections: Current Status in WORLD JOURNAL OF SURGERY
  • 2013-11. Optimization of biodegradation of natural fiber (Chorchorus capsularis): HDPE composite using response surface methodology in IRANIAN POLYMER JOURNAL
  • 2007. CURCUMIN: THE INDIAN SOLID GOLD in THE MOLECULAR TARGETS AND THERAPEUTIC USES OF CURCUMIN IN HEALTH AND DISEASE
  • 2012-03. Fabrication of a porous wall and higher interconnectivity scaffold comprising gelatin/chitosan via combination of salt-leaching and lyophilization methods in IRANIAN POLYMER JOURNAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s40204-017-0062-1

    DOI

    http://dx.doi.org/10.1007/s40204-017-0062-1

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28155217


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