Oncogenic osteomalacia and metastatic breast cancer: a case report and review of the literature View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-22

AUTHORS

Constantinos Savva, Jason Adhikaree, Srinivasan Madhusudan, Kamal Chokkalingam

ABSTRACT

Oncogenic osteomalacia is a rare paraneoplastic metabolic syndrome that is characterised by severe hypophosphataemia, hyperphosphaturia and osteomalacia secondary to renal loss of phosphate. It is commonly caused by overproduction of fibroblast growth factor-23 (FGF23) from benign tumours of mesenchymal origin. Currently, there is no clear evidence on the management of oncogenic osteomalacia in patients with metastatic solid tumours. We report a case of breast cancer-induced oncogenic osteomalacia and discuss its diagnosis and management. A 71-year-old woman with advanced breast cancer developed symptomatic oncogenic osteomalacia with raised FGF23, severe hypophosphataemia and hypocalcaemia. The electrolytic disturbances were exacerbated after the administration of bisphosphonates in the context of her oncological treatment. Systemic chemotherapy and maintenance endocrine treatment along with phosphate and calcium supplementation reduced the activity of oncogenic osteomalacia and resolved the electrolytic imbalances. To our knowledge, this is the first reported case of oncogenic osteomalacia in a patient with breast cancer. Oncogenic osteomalacia constitutes a diagnostic and therapeutic challenge. Pre-clinical and clinical evidence suggest that a possible underlying mechanism is the presence of molecular alterations in the FGF/FGFR signalling pathway leading to overexpression of FGF23. In metastatic setting, anticancer treatment can potentially lead to the normalisation of the electrolytic disturbances and reduction of the activity of oncogenic osteomalacia. The use of antiresorptive therapy in patients with bone metastases can potentially trigger FGF23 overexpression. Its use should be guided by the patients’ risk of skeletal-related events and electrolytic disturbances as well as the degree of activity of oncogenic osteomalacia. More... »

PAGES

1-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40200-019-00398-y

DOI

http://dx.doi.org/10.1007/s40200-019-00398-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112947248


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Nottingham", 
          "id": "https://www.grid.ac/institutes/grid.4563.4", 
          "name": [
            "Cancer Sciences Unit, Centre for Cancer Immunology, Faculty of Medicine, University Of Southampton, Tremona Road, SO16 6YD, Southampton, UK", 
            "Translational Oncology, Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, NG51 PB, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Savva", 
        "givenName": "Constantinos", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nottingham University Hospitals NHS Trust", 
          "id": "https://www.grid.ac/institutes/grid.240404.6", 
          "name": [
            "Translational Oncology, Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, NG51 PB, Nottingham, UK", 
            "Department of Oncology, Nottingham University Hospitals NHS Trust, NG5 1PB, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adhikaree", 
        "givenName": "Jason", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nottingham University Hospitals NHS Trust", 
          "id": "https://www.grid.ac/institutes/grid.240404.6", 
          "name": [
            "Translational Oncology, Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, NG51 PB, Nottingham, UK", 
            "Department of Oncology, Nottingham University Hospitals NHS Trust, NG5 1PB, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Madhusudan", 
        "givenName": "Srinivasan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nottingham University Hospitals NHS Trust", 
          "id": "https://www.grid.ac/institutes/grid.240404.6", 
          "name": [
            "Department of Endocrinology and Metabolic Medicine, Nottingham University Hospitals NHS Trust, NG5 1PB, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chokkalingam", 
        "givenName": "Kamal", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ejca.2015.05.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001962450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.4248/br201302002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002481057", 
          "https://doi.org/10.4248/br201302002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/erc-11-0006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002784646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ijos.2015.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003253291", 
          "https://doi.org/10.1038/ijos.2015.1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-012-1474-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007999840", 
          "https://doi.org/10.1007/s00520-012-1474-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.00474.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017252140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2016/3176978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019575822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/qjmed/hcq039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023641949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/qjmed/hcq039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023641949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1066896915617828", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023936316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1066896915617828", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023936316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.00002.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024214450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bonr.2015.11.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024287516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bonr.2015.11.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024287516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024942368", 
          "https://doi.org/10.1038/nature11412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bcr-2015-213954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025285740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje-07-0485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026206143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1359/jbmr.0301264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027309801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-14-2329", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028097305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbmr.1642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028603408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mehy.2014.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029318930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semcdb.2015.10.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033061162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/toxins2112490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036992715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-3310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039792646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-3310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039792646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.endonu.2015.10.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040565517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2215/cjn.04730510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041993573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.anl.2014.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043183817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-2727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045027125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.030577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046895860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1538-7445.am2014-ct326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063259177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2003-1768", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064246654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2012-3473", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064293926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.17925/ee.2016.12.02.104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068543260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.17925/ee.2016.12.02.104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068543260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7860/jcdr/2017/25055.9634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085640271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7860/jcdr/2017/25055.9634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085640271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrdp.2017.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090656160", 
          "https://doi.org/10.1038/nrdp.2017.44"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bonr.2017.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091876559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/js.2018-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103179337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/js.2018-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103179337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2016.34.15_suppl.e22500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106844934"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-03-22", 
    "datePublishedReg": "2019-03-22", 
    "description": "Oncogenic osteomalacia is a rare paraneoplastic metabolic syndrome that is characterised by severe hypophosphataemia, hyperphosphaturia and osteomalacia secondary to renal loss of phosphate. It is commonly caused by overproduction of fibroblast growth factor-23 (FGF23) from benign tumours of mesenchymal origin. Currently, there is no clear evidence on the management of oncogenic osteomalacia in patients with metastatic solid tumours. We report a case of breast cancer-induced oncogenic osteomalacia and discuss its diagnosis and management. A 71-year-old woman with advanced breast cancer developed symptomatic oncogenic osteomalacia with raised FGF23, severe hypophosphataemia and hypocalcaemia. The electrolytic disturbances were exacerbated after the administration of bisphosphonates in the context of her oncological treatment. Systemic chemotherapy and maintenance endocrine treatment along with phosphate and calcium supplementation reduced the activity of oncogenic osteomalacia and resolved the electrolytic imbalances. To our knowledge, this is the first reported case of oncogenic osteomalacia in a patient with breast cancer. Oncogenic osteomalacia constitutes a diagnostic and therapeutic challenge. Pre-clinical and clinical evidence suggest that a possible underlying mechanism is the presence of molecular alterations in the FGF/FGFR signalling pathway leading to overexpression of FGF23. In metastatic setting, anticancer treatment can potentially lead to the normalisation of the electrolytic disturbances and reduction of the activity of oncogenic osteomalacia. The use of antiresorptive therapy in patients with bone metastases can potentially trigger FGF23 overexpression. Its use should be guided by the patients\u2019 risk of skeletal-related events and electrolytic disturbances as well as the degree of activity of oncogenic osteomalacia.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s40200-019-00398-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1033289", 
        "issn": [
          "1726-7544", 
          "2251-6581"
        ], 
        "name": "Journal of Diabetes & Metabolic Disorders", 
        "type": "Periodical"
      }
    ], 
    "name": "Oncogenic osteomalacia and metastatic breast cancer: a case report and review of the literature", 
    "pagination": "1-6", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ac7a0220ec5b60e0588d405f0caaf8b704f480c57f49939ab471d35d28d410f3"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s40200-019-00398-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112947248"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s40200-019-00398-y", 
      "https://app.dimensions.ai/details/publication/pub.1112947248"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000364_0000000364/records_72843_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs40200-019-00398-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40200-019-00398-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40200-019-00398-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40200-019-00398-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40200-019-00398-y'


 

This table displays all metadata directly associated to this object as RDF triples.

188 TRIPLES      21 PREDICATES      59 URIs      16 LITERALS      5 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s40200-019-00398-y schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nd8b20233869d47cfb08de85ddf97581c
4 schema:citation sg:pub.10.1007/s00520-012-1474-z
5 sg:pub.10.1038/ijos.2015.1
6 sg:pub.10.1038/nature11412
7 sg:pub.10.1038/nrdp.2017.44
8 sg:pub.10.4248/br201302002
9 https://doi.org/10.1002/jbmr.1642
10 https://doi.org/10.1016/j.anl.2014.10.001
11 https://doi.org/10.1016/j.bonr.2015.11.004
12 https://doi.org/10.1016/j.bonr.2017.09.002
13 https://doi.org/10.1016/j.ejca.2015.05.016
14 https://doi.org/10.1016/j.endonu.2015.10.011
15 https://doi.org/10.1016/j.mehy.2014.08.005
16 https://doi.org/10.1016/j.semcdb.2015.10.012
17 https://doi.org/10.1074/jbc.m109.030577
18 https://doi.org/10.1093/qjmed/hcq039
19 https://doi.org/10.1136/bcr-2015-213954
20 https://doi.org/10.1152/ajprenal.00474.2004
21 https://doi.org/10.1152/physrev.00002.2011
22 https://doi.org/10.1155/2016/3176978
23 https://doi.org/10.1158/1078-0432.ccr-10-2727
24 https://doi.org/10.1158/1078-0432.ccr-11-3310
25 https://doi.org/10.1158/1078-0432.ccr-14-2329
26 https://doi.org/10.1158/1538-7445.am2014-ct326
27 https://doi.org/10.1177/1066896915617828
28 https://doi.org/10.1200/jco.2016.34.15_suppl.e22500
29 https://doi.org/10.1210/en.2003-1768
30 https://doi.org/10.1210/jc.2012-3473
31 https://doi.org/10.1210/js.2018-00010
32 https://doi.org/10.1359/jbmr.0301264
33 https://doi.org/10.1530/eje-07-0485
34 https://doi.org/10.1530/erc-11-0006
35 https://doi.org/10.17925/ee.2016.12.02.104
36 https://doi.org/10.2215/cjn.04730510
37 https://doi.org/10.3390/toxins2112490
38 https://doi.org/10.7860/jcdr/2017/25055.9634
39 schema:datePublished 2019-03-22
40 schema:datePublishedReg 2019-03-22
41 schema:description Oncogenic osteomalacia is a rare paraneoplastic metabolic syndrome that is characterised by severe hypophosphataemia, hyperphosphaturia and osteomalacia secondary to renal loss of phosphate. It is commonly caused by overproduction of fibroblast growth factor-23 (FGF23) from benign tumours of mesenchymal origin. Currently, there is no clear evidence on the management of oncogenic osteomalacia in patients with metastatic solid tumours. We report a case of breast cancer-induced oncogenic osteomalacia and discuss its diagnosis and management. A 71-year-old woman with advanced breast cancer developed symptomatic oncogenic osteomalacia with raised FGF23, severe hypophosphataemia and hypocalcaemia. The electrolytic disturbances were exacerbated after the administration of bisphosphonates in the context of her oncological treatment. Systemic chemotherapy and maintenance endocrine treatment along with phosphate and calcium supplementation reduced the activity of oncogenic osteomalacia and resolved the electrolytic imbalances. To our knowledge, this is the first reported case of oncogenic osteomalacia in a patient with breast cancer. Oncogenic osteomalacia constitutes a diagnostic and therapeutic challenge. Pre-clinical and clinical evidence suggest that a possible underlying mechanism is the presence of molecular alterations in the FGF/FGFR signalling pathway leading to overexpression of FGF23. In metastatic setting, anticancer treatment can potentially lead to the normalisation of the electrolytic disturbances and reduction of the activity of oncogenic osteomalacia. The use of antiresorptive therapy in patients with bone metastases can potentially trigger FGF23 overexpression. Its use should be guided by the patients’ risk of skeletal-related events and electrolytic disturbances as well as the degree of activity of oncogenic osteomalacia.
42 schema:genre research_article
43 schema:inLanguage en
44 schema:isAccessibleForFree false
45 schema:isPartOf sg:journal.1033289
46 schema:name Oncogenic osteomalacia and metastatic breast cancer: a case report and review of the literature
47 schema:pagination 1-6
48 schema:productId N11ebbb17c45f4f29b9d3f9ac2259c960
49 N9bdd5cba709143c38568a7b83a0aef68
50 Nbcbc74b5c3db494bac831010ba79ed4c
51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112947248
52 https://doi.org/10.1007/s40200-019-00398-y
53 schema:sdDatePublished 2019-04-11T12:53
54 schema:sdLicense https://scigraph.springernature.com/explorer/license/
55 schema:sdPublisher N887c602358634407877be9a2c3da32a1
56 schema:url https://link.springer.com/10.1007%2Fs40200-019-00398-y
57 sgo:license sg:explorer/license/
58 sgo:sdDataset articles
59 rdf:type schema:ScholarlyArticle
60 N11ebbb17c45f4f29b9d3f9ac2259c960 schema:name dimensions_id
61 schema:value pub.1112947248
62 rdf:type schema:PropertyValue
63 N1a440e08a1d643f69442c68da1f33338 schema:affiliation https://www.grid.ac/institutes/grid.4563.4
64 schema:familyName Savva
65 schema:givenName Constantinos
66 rdf:type schema:Person
67 N2675379fd5764b1194694e8adda4ad42 schema:affiliation https://www.grid.ac/institutes/grid.240404.6
68 schema:familyName Chokkalingam
69 schema:givenName Kamal
70 rdf:type schema:Person
71 N4a4def3610294987bc649c628c6c2ce0 rdf:first N2675379fd5764b1194694e8adda4ad42
72 rdf:rest rdf:nil
73 N60731715490a49dcb43702d9bebc9129 schema:affiliation https://www.grid.ac/institutes/grid.240404.6
74 schema:familyName Adhikaree
75 schema:givenName Jason
76 rdf:type schema:Person
77 N809713da65e643d29d1e657d4be58a81 schema:affiliation https://www.grid.ac/institutes/grid.240404.6
78 schema:familyName Madhusudan
79 schema:givenName Srinivasan
80 rdf:type schema:Person
81 N887c602358634407877be9a2c3da32a1 schema:name Springer Nature - SN SciGraph project
82 rdf:type schema:Organization
83 N8cddb59bb6d845aeb99cbcec075f7eca rdf:first N809713da65e643d29d1e657d4be58a81
84 rdf:rest N4a4def3610294987bc649c628c6c2ce0
85 N9bdd5cba709143c38568a7b83a0aef68 schema:name readcube_id
86 schema:value ac7a0220ec5b60e0588d405f0caaf8b704f480c57f49939ab471d35d28d410f3
87 rdf:type schema:PropertyValue
88 Nb252581a84f04ee9a20e129004a2e934 rdf:first N60731715490a49dcb43702d9bebc9129
89 rdf:rest N8cddb59bb6d845aeb99cbcec075f7eca
90 Nbcbc74b5c3db494bac831010ba79ed4c schema:name doi
91 schema:value 10.1007/s40200-019-00398-y
92 rdf:type schema:PropertyValue
93 Nd8b20233869d47cfb08de85ddf97581c rdf:first N1a440e08a1d643f69442c68da1f33338
94 rdf:rest Nb252581a84f04ee9a20e129004a2e934
95 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
96 schema:name Medical and Health Sciences
97 rdf:type schema:DefinedTerm
98 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
99 schema:name Oncology and Carcinogenesis
100 rdf:type schema:DefinedTerm
101 sg:journal.1033289 schema:issn 1726-7544
102 2251-6581
103 schema:name Journal of Diabetes & Metabolic Disorders
104 rdf:type schema:Periodical
105 sg:pub.10.1007/s00520-012-1474-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1007999840
106 https://doi.org/10.1007/s00520-012-1474-z
107 rdf:type schema:CreativeWork
108 sg:pub.10.1038/ijos.2015.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003253291
109 https://doi.org/10.1038/ijos.2015.1
110 rdf:type schema:CreativeWork
111 sg:pub.10.1038/nature11412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024942368
112 https://doi.org/10.1038/nature11412
113 rdf:type schema:CreativeWork
114 sg:pub.10.1038/nrdp.2017.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090656160
115 https://doi.org/10.1038/nrdp.2017.44
116 rdf:type schema:CreativeWork
117 sg:pub.10.4248/br201302002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002481057
118 https://doi.org/10.4248/br201302002
119 rdf:type schema:CreativeWork
120 https://doi.org/10.1002/jbmr.1642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028603408
121 rdf:type schema:CreativeWork
122 https://doi.org/10.1016/j.anl.2014.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043183817
123 rdf:type schema:CreativeWork
124 https://doi.org/10.1016/j.bonr.2015.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024287516
125 rdf:type schema:CreativeWork
126 https://doi.org/10.1016/j.bonr.2017.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091876559
127 rdf:type schema:CreativeWork
128 https://doi.org/10.1016/j.ejca.2015.05.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001962450
129 rdf:type schema:CreativeWork
130 https://doi.org/10.1016/j.endonu.2015.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040565517
131 rdf:type schema:CreativeWork
132 https://doi.org/10.1016/j.mehy.2014.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029318930
133 rdf:type schema:CreativeWork
134 https://doi.org/10.1016/j.semcdb.2015.10.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033061162
135 rdf:type schema:CreativeWork
136 https://doi.org/10.1074/jbc.m109.030577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046895860
137 rdf:type schema:CreativeWork
138 https://doi.org/10.1093/qjmed/hcq039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023641949
139 rdf:type schema:CreativeWork
140 https://doi.org/10.1136/bcr-2015-213954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025285740
141 rdf:type schema:CreativeWork
142 https://doi.org/10.1152/ajprenal.00474.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017252140
143 rdf:type schema:CreativeWork
144 https://doi.org/10.1152/physrev.00002.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024214450
145 rdf:type schema:CreativeWork
146 https://doi.org/10.1155/2016/3176978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019575822
147 rdf:type schema:CreativeWork
148 https://doi.org/10.1158/1078-0432.ccr-10-2727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045027125
149 rdf:type schema:CreativeWork
150 https://doi.org/10.1158/1078-0432.ccr-11-3310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039792646
151 rdf:type schema:CreativeWork
152 https://doi.org/10.1158/1078-0432.ccr-14-2329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028097305
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1158/1538-7445.am2014-ct326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063259177
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1177/1066896915617828 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023936316
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1200/jco.2016.34.15_suppl.e22500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106844934
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1210/en.2003-1768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064246654
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1210/jc.2012-3473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064293926
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1210/js.2018-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103179337
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1359/jbmr.0301264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027309801
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1530/eje-07-0485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026206143
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1530/erc-11-0006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002784646
171 rdf:type schema:CreativeWork
172 https://doi.org/10.17925/ee.2016.12.02.104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068543260
173 rdf:type schema:CreativeWork
174 https://doi.org/10.2215/cjn.04730510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041993573
175 rdf:type schema:CreativeWork
176 https://doi.org/10.3390/toxins2112490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036992715
177 rdf:type schema:CreativeWork
178 https://doi.org/10.7860/jcdr/2017/25055.9634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085640271
179 rdf:type schema:CreativeWork
180 https://www.grid.ac/institutes/grid.240404.6 schema:alternateName Nottingham University Hospitals NHS Trust
181 schema:name Department of Endocrinology and Metabolic Medicine, Nottingham University Hospitals NHS Trust, NG5 1PB, Nottingham, UK
182 Department of Oncology, Nottingham University Hospitals NHS Trust, NG5 1PB, Nottingham, UK
183 Translational Oncology, Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, NG51 PB, Nottingham, UK
184 rdf:type schema:Organization
185 https://www.grid.ac/institutes/grid.4563.4 schema:alternateName University of Nottingham
186 schema:name Cancer Sciences Unit, Centre for Cancer Immunology, Faculty of Medicine, University Of Southampton, Tremona Road, SO16 6YD, Southampton, UK
187 Translational Oncology, Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, NG51 PB, Nottingham, UK
188 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...