TLR4/MyD88 -mediated CCL2 production by lipopolysaccharide (endotoxin): Implications for metabolic inflammation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-06

AUTHORS

Nadeem Akhter, Amal Hasan, Steve Shenouda, Ajit Wilson, Shihab Kochumon, Shamsha Ali, Jaakko Tuomilehto, Sardar Sindhu, Rasheed Ahmad

ABSTRACT

Background: Obese human and mice were reported to have higher circularity endotoxin (LPS) levels as compared to their lean counter parts. The current study was aimed to reveal the molecular mechanisms underlying the LPS mediated induction of CCL2 in human monocytes/macrophages. Methods: Human monocytic cell line THP-1, THP-1 cells derived macrophages and primary macrophages were treated with LPS and TNF-α (positive control). CCL2 expression was determined with real-time RT-PCR and ELISA. THP-1-XBlue™ cells, THP-1-XBlue™-defMyD cells, TLR4 neutralization antibody, TLR4 siRNA and inhibitors for NF-kB and MAPK were used to study the signaling pathways. Phosphorylation of NF-kB and c-Jun was analyzed by ELISA. Results: LPS upregulates CCL2 expression at both mRNA (THP-1: 23.40 ± .071 Fold, P < 0.0001; THP-1-derived macrophages: 103 ± 0.56 Fold, < 0.0001; Primary macrophages: 48 ± 1.41 Fold, P < 0.0005) and protein (THP1 monocytes:1048 ± 5.67 pg/ml, P < 0.0001; THP-1-derived macrophages; 2014 ± 2.12, P = 0.0001; Primary macrophages: 859.5 ± 3.54, P < 0.0001) levels in human monocytic cells/macrophages. Neutralization of TLR4 blocked LPS-induced CCL-2 secretion (P < 0.0001). Silencing of TLR4 by siRNA also significantly reduced LPS-induced CCL-2 production. Furthermore, MyD88-Knockout cells treated with LPS did not produce CCL-2. NF-kB and c-Jun phosphorylation was noted in LPS treated cells. Conclusion: Overall, our data reveal that LPS induces CCL-2 in monocytes/macrophages via TLR4/MyD88 signaling which leads to the activation of NF-kB/AP-1 transcription factors. More... »

PAGES

77-84

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40200-018-0341-y

DOI

http://dx.doi.org/10.1007/s40200-018-0341-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103268977

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30288388


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Dasman Diabetes Institute", 
          "id": "https://www.grid.ac/institutes/grid.452356.3", 
          "name": [
            "Immunology Unit, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, 15462, Dasman, Kuwait"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akhter", 
        "givenName": "Nadeem", 
        "id": "sg:person.010003023641.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010003023641.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dasman Diabetes Institute", 
          "id": "https://www.grid.ac/institutes/grid.452356.3", 
          "name": [
            "Immunology Unit, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, 15462, Dasman, Kuwait"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hasan", 
        "givenName": "Amal", 
        "id": "sg:person.01175501463.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175501463.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dasman Diabetes Institute", 
          "id": "https://www.grid.ac/institutes/grid.452356.3", 
          "name": [
            "Immunology Unit, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, 15462, Dasman, Kuwait"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shenouda", 
        "givenName": "Steve", 
        "id": "sg:person.010600404241.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010600404241.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dasman Diabetes Institute", 
          "id": "https://www.grid.ac/institutes/grid.452356.3", 
          "name": [
            "Immunology Unit, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, 15462, Dasman, Kuwait"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilson", 
        "givenName": "Ajit", 
        "id": "sg:person.011375764641.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011375764641.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dasman Diabetes Institute", 
          "id": "https://www.grid.ac/institutes/grid.452356.3", 
          "name": [
            "Immunology Unit, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, 15462, Dasman, Kuwait"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kochumon", 
        "givenName": "Shihab", 
        "id": "sg:person.010736232615.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010736232615.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dasman Diabetes Institute", 
          "id": "https://www.grid.ac/institutes/grid.452356.3", 
          "name": [
            "Immunology Unit, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, 15462, Dasman, Kuwait"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ali", 
        "givenName": "Shamsha", 
        "id": "sg:person.07604213411.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07604213411.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dasman Diabetes Institute", 
          "id": "https://www.grid.ac/institutes/grid.452356.3", 
          "name": [
            "Immunology Unit, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, 15462, Dasman, Kuwait"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tuomilehto", 
        "givenName": "Jaakko", 
        "id": "sg:person.0777517431.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777517431.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dasman Diabetes Institute", 
          "id": "https://www.grid.ac/institutes/grid.452356.3", 
          "name": [
            "Immunology Unit, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, 15462, Dasman, Kuwait"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sindhu", 
        "givenName": "Sardar", 
        "id": "sg:person.016542777254.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016542777254.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dasman Diabetes Institute", 
          "id": "https://www.grid.ac/institutes/grid.452356.3", 
          "name": [
            "Immunology Unit, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, 15462, Dasman, Kuwait"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahmad", 
        "givenName": "Rasheed", 
        "id": "sg:person.01356167104.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356167104.09"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.2337/db06-1491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001015195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-2478(01)00328-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001592021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db07-1403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002057993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci26498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002144373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m601284200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002776101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.169.4.1485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006350765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc10-2197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008549429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000366310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012168792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0099382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013933554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2006.05.170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020629097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0090683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030593194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cyto.2008.01.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034337077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2006.050617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037123625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1465-9921-8-24", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037476622", 
          "https://doi.org/10.1186/1465-9921-8-24"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12950-015-0077-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040642225", 
          "https://doi.org/10.1186/s12950-015-0077-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12950-015-0077-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040642225", 
          "https://doi.org/10.1186/s12950-015-0077-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.21138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047154067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000447798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048576365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-9255-9-48", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050478083", 
          "https://doi.org/10.1186/1476-9255-9-48"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-02-137711", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051571448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00039.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063195914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074538108", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000475298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084930575"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-06", 
    "datePublishedReg": "2018-06-01", 
    "description": "Background: Obese human and mice were reported to have higher circularity endotoxin (LPS) levels as compared to their lean counter parts. The current study was aimed to reveal the molecular mechanisms underlying the LPS mediated induction of CCL2 in human monocytes/macrophages.\nMethods: Human monocytic cell line THP-1, THP-1 cells derived macrophages and primary macrophages were treated with LPS and TNF-\u03b1 (positive control). CCL2 expression was determined with real-time RT-PCR and ELISA. THP-1-XBlue\u2122 cells, THP-1-XBlue\u2122-defMyD cells, TLR4 neutralization antibody, TLR4 siRNA and inhibitors for NF-kB and MAPK were used to study the signaling pathways. Phosphorylation of NF-kB and c-Jun was analyzed by ELISA.\nResults: LPS upregulates CCL2 expression at both mRNA (THP-1: 23.40\u2009\u00b1\u2009.071 Fold, P\u2009<\u00a00.0001; THP-1-derived macrophages: 103\u2009\u00b1\u20090.56 Fold, < 0.0001; Primary macrophages: 48\u2009\u00b1\u20091.41 Fold, P\u2009<\u20090.0005) and protein (THP1 monocytes:1048\u2009\u00b1\u20095.67\u00a0pg/ml, P\u2009<\u20090.0001; THP-1-derived macrophages; 2014\u2009\u00b1\u20092.12, P\u2009=\u20090.0001; Primary macrophages: 859.5\u2009\u00b1\u20093.54, P\u2009<\u20090.0001) levels in human monocytic cells/macrophages. Neutralization of TLR4 blocked LPS-induced CCL-2 secretion (P\u2009<\u20090.0001). Silencing of TLR4 by siRNA also significantly reduced LPS-induced CCL-2 production. Furthermore, MyD88-Knockout cells treated with LPS did not produce CCL-2. NF-kB and c-Jun phosphorylation was noted in LPS treated cells.\nConclusion: Overall, our data reveal that LPS induces CCL-2 in monocytes/macrophages via TLR4/MyD88 signaling which leads to the activation of NF-kB/AP-1 transcription factors.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s40200-018-0341-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1033289", 
        "issn": [
          "1726-7544", 
          "2251-6581"
        ], 
        "name": "Journal of Diabetes & Metabolic Disorders", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "TLR4/MyD88 -mediated CCL2 production by lipopolysaccharide (endotoxin): Implications for metabolic inflammation", 
    "pagination": "77-84", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5e0c17e821b84340f1f93e1d48a7583c61128c2c504fbfad0ad847b865a954c4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30288388"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101590741"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s40200-018-0341-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1103268977"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s40200-018-0341-y", 
      "https://app.dimensions.ai/details/publication/pub.1103268977"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000565.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs40200-018-0341-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40200-018-0341-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40200-018-0341-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40200-018-0341-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40200-018-0341-y'


 

This table displays all metadata directly associated to this object as RDF triples.

193 TRIPLES      21 PREDICATES      51 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s40200-018-0341-y schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N29fbc7ee46ec41e08fdcb29cdbcdff70
4 schema:citation sg:pub.10.1186/1465-9921-8-24
5 sg:pub.10.1186/1476-9255-9-48
6 sg:pub.10.1186/s12950-015-0077-0
7 https://app.dimensions.ai/details/publication/pub.1074538108
8 https://doi.org/10.1002/hep.21138
9 https://doi.org/10.1016/j.bbrc.2006.05.170
10 https://doi.org/10.1016/j.cyto.2008.01.006
11 https://doi.org/10.1016/s0165-2478(01)00328-5
12 https://doi.org/10.1074/jbc.m601284200
13 https://doi.org/10.1084/jem.169.4.1485
14 https://doi.org/10.1152/ajpregu.00039.2002
15 https://doi.org/10.1159/000366310
16 https://doi.org/10.1159/000447798
17 https://doi.org/10.1159/000475298
18 https://doi.org/10.1172/jci26498
19 https://doi.org/10.1182/blood-2008-02-137711
20 https://doi.org/10.1371/journal.pone.0090683
21 https://doi.org/10.1371/journal.pone.0099382
22 https://doi.org/10.2337/db06-1491
23 https://doi.org/10.2337/db07-1403
24 https://doi.org/10.2337/dc10-2197
25 https://doi.org/10.2353/ajpath.2006.050617
26 schema:datePublished 2018-06
27 schema:datePublishedReg 2018-06-01
28 schema:description Background: Obese human and mice were reported to have higher circularity endotoxin (LPS) levels as compared to their lean counter parts. The current study was aimed to reveal the molecular mechanisms underlying the LPS mediated induction of CCL2 in human monocytes/macrophages. Methods: Human monocytic cell line THP-1, THP-1 cells derived macrophages and primary macrophages were treated with LPS and TNF-α (positive control). CCL2 expression was determined with real-time RT-PCR and ELISA. THP-1-XBlue™ cells, THP-1-XBlue™-defMyD cells, TLR4 neutralization antibody, TLR4 siRNA and inhibitors for NF-kB and MAPK were used to study the signaling pathways. Phosphorylation of NF-kB and c-Jun was analyzed by ELISA. Results: LPS upregulates CCL2 expression at both mRNA (THP-1: 23.40 ± .071 Fold, P < 0.0001; THP-1-derived macrophages: 103 ± 0.56 Fold, < 0.0001; Primary macrophages: 48 ± 1.41 Fold, P < 0.0005) and protein (THP1 monocytes:1048 ± 5.67 pg/ml, P < 0.0001; THP-1-derived macrophages; 2014 ± 2.12, P = 0.0001; Primary macrophages: 859.5 ± 3.54, P < 0.0001) levels in human monocytic cells/macrophages. Neutralization of TLR4 blocked LPS-induced CCL-2 secretion (P < 0.0001). Silencing of TLR4 by siRNA also significantly reduced LPS-induced CCL-2 production. Furthermore, MyD88-Knockout cells treated with LPS did not produce CCL-2. NF-kB and c-Jun phosphorylation was noted in LPS treated cells. Conclusion: Overall, our data reveal that LPS induces CCL-2 in monocytes/macrophages via TLR4/MyD88 signaling which leads to the activation of NF-kB/AP-1 transcription factors.
29 schema:genre research_article
30 schema:inLanguage en
31 schema:isAccessibleForFree true
32 schema:isPartOf N16fef08404eb4fee92d03648e7ff73ab
33 Ne4ddf41a69a049998bab42034b15bc16
34 sg:journal.1033289
35 schema:name TLR4/MyD88 -mediated CCL2 production by lipopolysaccharide (endotoxin): Implications for metabolic inflammation
36 schema:pagination 77-84
37 schema:productId N0f42895423e84d469f8780271d50e57b
38 N103059dc488a4f6394c92c84f8f8a501
39 N4a432062f3924401898cf1f151626c70
40 N96753f38c48b42c19b27fef8b485b309
41 Nbab05823bc2744528bfbae096aff6669
42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103268977
43 https://doi.org/10.1007/s40200-018-0341-y
44 schema:sdDatePublished 2019-04-10T20:05
45 schema:sdLicense https://scigraph.springernature.com/explorer/license/
46 schema:sdPublisher N74ae5bd816754ba193f2d01af4df7a49
47 schema:url https://link.springer.com/10.1007%2Fs40200-018-0341-y
48 sgo:license sg:explorer/license/
49 sgo:sdDataset articles
50 rdf:type schema:ScholarlyArticle
51 N0f42895423e84d469f8780271d50e57b schema:name readcube_id
52 schema:value 5e0c17e821b84340f1f93e1d48a7583c61128c2c504fbfad0ad847b865a954c4
53 rdf:type schema:PropertyValue
54 N103059dc488a4f6394c92c84f8f8a501 schema:name pubmed_id
55 schema:value 30288388
56 rdf:type schema:PropertyValue
57 N16fef08404eb4fee92d03648e7ff73ab schema:volumeNumber 17
58 rdf:type schema:PublicationVolume
59 N205659885cf0401296ab5422f1766f18 rdf:first sg:person.01175501463.10
60 rdf:rest N707ba028e8854b77b8e3cea4ddd833c6
61 N29fbc7ee46ec41e08fdcb29cdbcdff70 rdf:first sg:person.010003023641.30
62 rdf:rest N205659885cf0401296ab5422f1766f18
63 N4a432062f3924401898cf1f151626c70 schema:name dimensions_id
64 schema:value pub.1103268977
65 rdf:type schema:PropertyValue
66 N707ba028e8854b77b8e3cea4ddd833c6 rdf:first sg:person.010600404241.62
67 rdf:rest Na6b9ebaf9ac14bed84798ad89fac7595
68 N74ae5bd816754ba193f2d01af4df7a49 schema:name Springer Nature - SN SciGraph project
69 rdf:type schema:Organization
70 N821f61b651c74c20928846eb9ed9c13b rdf:first sg:person.0777517431.61
71 rdf:rest N8ee67215af9b4338a13512e91e56d540
72 N8ee67215af9b4338a13512e91e56d540 rdf:first sg:person.016542777254.39
73 rdf:rest Nd1fb75d27a734bd69b2045845492eca4
74 N96753f38c48b42c19b27fef8b485b309 schema:name doi
75 schema:value 10.1007/s40200-018-0341-y
76 rdf:type schema:PropertyValue
77 Na6b9ebaf9ac14bed84798ad89fac7595 rdf:first sg:person.011375764641.64
78 rdf:rest Nbf090f44772e406e8ffbcfde90cb4a9c
79 Nb13da2290be545d7a3b42e0d6588159b rdf:first sg:person.07604213411.38
80 rdf:rest N821f61b651c74c20928846eb9ed9c13b
81 Nbab05823bc2744528bfbae096aff6669 schema:name nlm_unique_id
82 schema:value 101590741
83 rdf:type schema:PropertyValue
84 Nbf090f44772e406e8ffbcfde90cb4a9c rdf:first sg:person.010736232615.89
85 rdf:rest Nb13da2290be545d7a3b42e0d6588159b
86 Nd1fb75d27a734bd69b2045845492eca4 rdf:first sg:person.01356167104.09
87 rdf:rest rdf:nil
88 Ne4ddf41a69a049998bab42034b15bc16 schema:issueNumber 1
89 rdf:type schema:PublicationIssue
90 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
91 schema:name Biological Sciences
92 rdf:type schema:DefinedTerm
93 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
94 schema:name Biochemistry and Cell Biology
95 rdf:type schema:DefinedTerm
96 sg:journal.1033289 schema:issn 1726-7544
97 2251-6581
98 schema:name Journal of Diabetes & Metabolic Disorders
99 rdf:type schema:Periodical
100 sg:person.010003023641.30 schema:affiliation https://www.grid.ac/institutes/grid.452356.3
101 schema:familyName Akhter
102 schema:givenName Nadeem
103 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010003023641.30
104 rdf:type schema:Person
105 sg:person.010600404241.62 schema:affiliation https://www.grid.ac/institutes/grid.452356.3
106 schema:familyName Shenouda
107 schema:givenName Steve
108 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010600404241.62
109 rdf:type schema:Person
110 sg:person.010736232615.89 schema:affiliation https://www.grid.ac/institutes/grid.452356.3
111 schema:familyName Kochumon
112 schema:givenName Shihab
113 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010736232615.89
114 rdf:type schema:Person
115 sg:person.011375764641.64 schema:affiliation https://www.grid.ac/institutes/grid.452356.3
116 schema:familyName Wilson
117 schema:givenName Ajit
118 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011375764641.64
119 rdf:type schema:Person
120 sg:person.01175501463.10 schema:affiliation https://www.grid.ac/institutes/grid.452356.3
121 schema:familyName Hasan
122 schema:givenName Amal
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175501463.10
124 rdf:type schema:Person
125 sg:person.01356167104.09 schema:affiliation https://www.grid.ac/institutes/grid.452356.3
126 schema:familyName Ahmad
127 schema:givenName Rasheed
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356167104.09
129 rdf:type schema:Person
130 sg:person.016542777254.39 schema:affiliation https://www.grid.ac/institutes/grid.452356.3
131 schema:familyName Sindhu
132 schema:givenName Sardar
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016542777254.39
134 rdf:type schema:Person
135 sg:person.07604213411.38 schema:affiliation https://www.grid.ac/institutes/grid.452356.3
136 schema:familyName Ali
137 schema:givenName Shamsha
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07604213411.38
139 rdf:type schema:Person
140 sg:person.0777517431.61 schema:affiliation https://www.grid.ac/institutes/grid.452356.3
141 schema:familyName Tuomilehto
142 schema:givenName Jaakko
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777517431.61
144 rdf:type schema:Person
145 sg:pub.10.1186/1465-9921-8-24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037476622
146 https://doi.org/10.1186/1465-9921-8-24
147 rdf:type schema:CreativeWork
148 sg:pub.10.1186/1476-9255-9-48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050478083
149 https://doi.org/10.1186/1476-9255-9-48
150 rdf:type schema:CreativeWork
151 sg:pub.10.1186/s12950-015-0077-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040642225
152 https://doi.org/10.1186/s12950-015-0077-0
153 rdf:type schema:CreativeWork
154 https://app.dimensions.ai/details/publication/pub.1074538108 schema:CreativeWork
155 https://doi.org/10.1002/hep.21138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047154067
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1016/j.bbrc.2006.05.170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020629097
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1016/j.cyto.2008.01.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034337077
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1016/s0165-2478(01)00328-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001592021
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1074/jbc.m601284200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002776101
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1084/jem.169.4.1485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006350765
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1152/ajpregu.00039.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063195914
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1159/000366310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012168792
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1159/000447798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048576365
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1159/000475298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084930575
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1172/jci26498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002144373
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1182/blood-2008-02-137711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051571448
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1371/journal.pone.0090683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030593194
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1371/journal.pone.0099382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013933554
182 rdf:type schema:CreativeWork
183 https://doi.org/10.2337/db06-1491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001015195
184 rdf:type schema:CreativeWork
185 https://doi.org/10.2337/db07-1403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002057993
186 rdf:type schema:CreativeWork
187 https://doi.org/10.2337/dc10-2197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008549429
188 rdf:type schema:CreativeWork
189 https://doi.org/10.2353/ajpath.2006.050617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037123625
190 rdf:type schema:CreativeWork
191 https://www.grid.ac/institutes/grid.452356.3 schema:alternateName Dasman Diabetes Institute
192 schema:name Immunology Unit, Dasman Diabetes Institute (DDI), Al-Soor Street, P.O. Box 1180, 15462, Dasman, Kuwait
193 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...