Recent Advances in Genetic Aspects and Treatments for Steroid-Sensitive Nephrotic Syndrome in Children View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12

AUTHORS

Kazumoto Iijima, Kandai Nozu

ABSTRACT

This article reviews recent advances in genetic aspects and treatments for steroid-sensitive nephrotic syndrome (SSNS) in children over the previous 5 years. Six genes, which have roles in Rho-like small GTPase activity, have been identified as causes of partially steroid-treatable nephrotic syndrome, and the strongest susceptible gene of SSNS has been located in the HLA DR/DQ locus. For treatment, prolongation of prednisolone therapy beyond 2 to 3 months in the initial episode of SSNS does not reduce the risk of relapse. Rituximab has been established as a treatment for complicated frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome. Rituximab could also be the first-line treatment for early-stage-uncomplicated FRNS/SDNS, although further studies are required to confirm its efficacy and safety. The understanding of pathogenesis and development of new treatments of steroid-sensitive nephrotic syndrome in children made a significant advance over the previous 5 years. More... »

PAGES

1-6

Journal

TITLE

Current Pediatrics Reports

ISSUE

N/A

VOLUME

N/A

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40124-018-0183-6

DOI

http://dx.doi.org/10.1007/s40124-018-0183-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107609023


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