A Summary of Planarian Signaling Pathway for Regenerative Medicine View Full Text


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Article Info

DATE

2021-11-16

AUTHORS

Farzaneh Golfeshan, Seyed Ali Mosaddad, Hamid Babavalian, Hamid Tebyanian, Elnaz Mehrjuyan, Fatemeh Shakeri

ABSTRACT

Regenerative medicine has been increased for helping crucial diseases and injuries. Planarians have appeared as the best template for studying regeneration. A variety of stem cell properties can be studied in their environment, and planarians have been sleeted as an excellent model for surging regeneration. Planarian’s communication has not been well identified, and all attentions have been focused on four types of signaling mechanisms: cell signaling, gap junctional communication, ion fluxes and nervous system signals. The goal of recognizing these signaling pathways is that new molecular targets would be identified and use them in regenerative medicine. Planarians are the classical model for studying the signals which regulate cell proliferation and differentiation. In this review, we want to present the critical role of signal pathways in regenerative medicine. Some significant signal pathways are explained such as EGFR, Hh, Wnt, Notum, TOR, Mex3 homolog and β-catenin. More... »

PAGES

5-10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40011-021-01267-6

DOI

http://dx.doi.org/10.1007/s40011-021-01267-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1142627648


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