Preparation and in vivo evaluation of nanoliposomes containing melphalan after intravitreal injection in albino rabbits View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-08-03

AUTHORS

Masood Naseripour, Majid Abrishami, Ahad Sedaghat, Mojtaba Abrishami, Mozhgan Rezaei Kanavi, Navid Mosallaei, Khalil Ghasemi Falavarjani, Rama Pourmatin, Omid Safarian, Bizhan Malaekeh-Nikouei

ABSTRACT

The aim of present study was to evaluate the stability and toxicity of different doses of liposomal melphalan in rabbit eyes and to investigate the pathological and electrophysiological changes after administration of different doses of free form of melphalan. Liposomes containing melphalan were prepared by solvent evaporation method and mean size of these liposomes and encapsulation efficacy of nanoliposomes were determined. In albino rabbits, intravitreal injections of 10, 20, and 40 µg doses of liposomal melphalan and Alkeran® as the commercial product was performed. The rabbits were euthanized at days 2, 7, 14, and 28, and the eyes were enucleated. Vitreous and aqueous samples and electrophysiological recordings were obtained before euthanization. Histological examination was performed after enucleation. Particle size of prepared liposomes was 143.6 ± 3.2 nm. Liposomes have protected melphalan completely from any undesirable release or hydrolysis for 48 h. In a histopathological study, signs of retinal toxicity were found in all doses in the liposomal group at least at one time point during the study. In melphalan injected eyes, histopathological toxicity was found in the 40 µg dose. Extensive variability was found in electrophysiological recordings, and significant waveform changes were found in all injected eyes at least on one occasion during the study. Intraocular administration of liposomal melphalan cannot prolong the drug clearance time of this drug in the vitreous humor. In the 40 µg injected eyes, significant retinal atrophic changes were detected in all eyes throughout the study, and electrophysiological results were consistent with histopathological findings. More... »

PAGES

575-582

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s40005-016-0271-y

DOI

http://dx.doi.org/10.1007/s40005-016-0271-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006016728


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1113", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Ophthalmology and Optometry", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran", 
          "id": "http://www.grid.ac/institutes/grid.490421.a", 
          "name": [
            "Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Naseripour", 
        "givenName": "Masood", 
        "id": "sg:person.0750243113.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750243113.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Retina Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran", 
          "id": "http://www.grid.ac/institutes/grid.411583.a", 
          "name": [
            "Retina Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abrishami", 
        "givenName": "Majid", 
        "id": "sg:person.01262431076.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262431076.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran", 
          "id": "http://www.grid.ac/institutes/grid.490421.a", 
          "name": [
            "Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sedaghat", 
        "givenName": "Ahad", 
        "id": "sg:person.01273462772.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273462772.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran", 
          "id": "http://www.grid.ac/institutes/grid.411705.6", 
          "name": [
            "Retina Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran", 
            "Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abrishami", 
        "givenName": "Mojtaba", 
        "id": "sg:person.0767501776.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767501776.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran", 
          "id": "http://www.grid.ac/institutes/grid.411600.2", 
          "name": [
            "Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kanavi", 
        "givenName": "Mozhgan Rezaei", 
        "id": "sg:person.01005406144.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005406144.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran", 
          "id": "http://www.grid.ac/institutes/grid.411583.a", 
          "name": [
            "School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mosallaei", 
        "givenName": "Navid", 
        "id": "sg:person.01140017233.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140017233.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran", 
          "id": "http://www.grid.ac/institutes/grid.490421.a", 
          "name": [
            "Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Falavarjani", 
        "givenName": "Khalil Ghasemi", 
        "id": "sg:person.01065306070.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065306070.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran", 
          "id": "http://www.grid.ac/institutes/grid.490421.a", 
          "name": [
            "Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pourmatin", 
        "givenName": "Rama", 
        "id": "sg:person.01022006153.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022006153.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shahid Beheshti University of Medical Sciences, Tehran, Iran", 
          "id": "http://www.grid.ac/institutes/grid.411600.2", 
          "name": [
            "Shahid Beheshti University of Medical Sciences, Tehran, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Safarian", 
        "givenName": "Omid", 
        "id": "sg:person.01140070742.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140070742.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, P.O. Box 91775-1365, Mashhad, Iran", 
          "id": "http://www.grid.ac/institutes/grid.411583.a", 
          "name": [
            "Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, P.O. Box 91775-1365, Mashhad, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malaekeh-Nikouei", 
        "givenName": "Bizhan", 
        "id": "sg:person.0705730507.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705730507.38"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/eye.2012.175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039405881", 
          "https://doi.org/10.1038/eye.2012.175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10633-008-9155-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048157101", 
          "https://doi.org/10.1007/s10633-008-9155-4"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-08-03", 
    "datePublishedReg": "2016-08-03", 
    "description": "The aim of present study was to evaluate the stability and toxicity of different doses of liposomal melphalan in rabbit eyes and to investigate the pathological and electrophysiological changes after administration of different doses of free form of melphalan. Liposomes containing melphalan were prepared by solvent evaporation method and mean size of these liposomes and encapsulation efficacy of nanoliposomes were determined. In albino rabbits, intravitreal injections of 10, 20, and 40\u00a0\u00b5g doses of liposomal melphalan and Alkeran\u00ae as the commercial product was performed. The rabbits were euthanized at days 2, 7, 14, and 28, and the eyes were enucleated. Vitreous and aqueous samples and electrophysiological recordings were obtained before euthanization. Histological examination was performed after enucleation. Particle size of prepared liposomes was 143.6\u00a0\u00b1\u00a03.2\u00a0nm. Liposomes have protected melphalan completely from any undesirable release or hydrolysis for 48\u00a0h. In a histopathological study, signs of retinal toxicity were found in all doses in the liposomal group at least at one time point during the study. In melphalan injected eyes, histopathological toxicity was found in the 40\u00a0\u00b5g dose. Extensive variability was found in electrophysiological recordings, and significant waveform changes were found in all injected eyes at least on one occasion during the study. Intraocular administration of liposomal melphalan cannot prolong the drug clearance time of this drug in the vitreous humor. In the 40\u00a0\u00b5g injected eyes, significant retinal atrophic changes were detected in all eyes throughout the study, and electrophysiological results were consistent with histopathological findings.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s40005-016-0271-y", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1044391", 
        "issn": [
          "2093-5552", 
          "2093-6214"
        ], 
        "name": "Journal of Pharmaceutical Investigation", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "46"
      }
    ], 
    "keywords": [
      "injected eye", 
      "intravitreal injection", 
      "albino rabbits", 
      "electrophysiological recordings", 
      "different doses", 
      "significant waveform changes", 
      "retinal toxicity", 
      "histopathological findings", 
      "atrophic changes", 
      "histopathological study", 
      "electrophysiological changes", 
      "histopathological toxicity", 
      "histological examination", 
      "intraocular administration", 
      "melphalan", 
      "day 2", 
      "rabbit eyes", 
      "vitreous humor", 
      "doses", 
      "time points", 
      "clearance time", 
      "electrophysiological results", 
      "vivo evaluation", 
      "liposomal group", 
      "eyes", 
      "rabbits", 
      "administration", 
      "waveform changes", 
      "present study", 
      "toxicity", 
      "injection", 
      "prepared liposomes", 
      "encapsulation efficacy", 
      "Alkeran", 
      "recordings", 
      "enucleation", 
      "euthanization", 
      "liposomes", 
      "nanoliposomes", 
      "study", 
      "dose", 
      "extensive variability", 
      "drugs", 
      "efficacy", 
      "examination", 
      "free form", 
      "signs", 
      "changes", 
      "group", 
      "aim", 
      "findings", 
      "release", 
      "solvent evaporation method", 
      "occasions", 
      "evaluation", 
      "humor", 
      "samples", 
      "time", 
      "size", 
      "preparation", 
      "variability", 
      "commercial products", 
      "results", 
      "form", 
      "method", 
      "point", 
      "hydrolysis", 
      "evaporation method", 
      "products", 
      "undesirable release", 
      "stability", 
      "particle size", 
      "aqueous samples"
    ], 
    "name": "Preparation and in vivo evaluation of nanoliposomes containing melphalan after intravitreal injection in albino rabbits", 
    "pagination": "575-582", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1006016728"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s40005-016-0271-y"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s40005-016-0271-y", 
      "https://app.dimensions.ai/details/publication/pub.1006016728"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T21:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_711.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s40005-016-0271-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s40005-016-0271-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s40005-016-0271-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s40005-016-0271-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s40005-016-0271-y'


 

This table displays all metadata directly associated to this object as RDF triples.

217 TRIPLES      21 PREDICATES      99 URIs      89 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s40005-016-0271-y schema:about anzsrc-for:11
2 anzsrc-for:1113
3 schema:author N5ef9d0268b7e47f98ba528ab020acb2a
4 schema:citation sg:pub.10.1007/s10633-008-9155-4
5 sg:pub.10.1038/eye.2012.175
6 schema:datePublished 2016-08-03
7 schema:datePublishedReg 2016-08-03
8 schema:description The aim of present study was to evaluate the stability and toxicity of different doses of liposomal melphalan in rabbit eyes and to investigate the pathological and electrophysiological changes after administration of different doses of free form of melphalan. Liposomes containing melphalan were prepared by solvent evaporation method and mean size of these liposomes and encapsulation efficacy of nanoliposomes were determined. In albino rabbits, intravitreal injections of 10, 20, and 40 µg doses of liposomal melphalan and Alkeran® as the commercial product was performed. The rabbits were euthanized at days 2, 7, 14, and 28, and the eyes were enucleated. Vitreous and aqueous samples and electrophysiological recordings were obtained before euthanization. Histological examination was performed after enucleation. Particle size of prepared liposomes was 143.6 ± 3.2 nm. Liposomes have protected melphalan completely from any undesirable release or hydrolysis for 48 h. In a histopathological study, signs of retinal toxicity were found in all doses in the liposomal group at least at one time point during the study. In melphalan injected eyes, histopathological toxicity was found in the 40 µg dose. Extensive variability was found in electrophysiological recordings, and significant waveform changes were found in all injected eyes at least on one occasion during the study. Intraocular administration of liposomal melphalan cannot prolong the drug clearance time of this drug in the vitreous humor. In the 40 µg injected eyes, significant retinal atrophic changes were detected in all eyes throughout the study, and electrophysiological results were consistent with histopathological findings.
9 schema:genre article
10 schema:isAccessibleForFree false
11 schema:isPartOf Nbfe19ac23b78402385b575d6d0def13e
12 Nca2775fdae10433bae7fa16cfce691cd
13 sg:journal.1044391
14 schema:keywords Alkeran
15 administration
16 aim
17 albino rabbits
18 aqueous samples
19 atrophic changes
20 changes
21 clearance time
22 commercial products
23 day 2
24 different doses
25 dose
26 doses
27 drugs
28 efficacy
29 electrophysiological changes
30 electrophysiological recordings
31 electrophysiological results
32 encapsulation efficacy
33 enucleation
34 euthanization
35 evaluation
36 evaporation method
37 examination
38 extensive variability
39 eyes
40 findings
41 form
42 free form
43 group
44 histological examination
45 histopathological findings
46 histopathological study
47 histopathological toxicity
48 humor
49 hydrolysis
50 injected eye
51 injection
52 intraocular administration
53 intravitreal injection
54 liposomal group
55 liposomes
56 melphalan
57 method
58 nanoliposomes
59 occasions
60 particle size
61 point
62 preparation
63 prepared liposomes
64 present study
65 products
66 rabbit eyes
67 rabbits
68 recordings
69 release
70 results
71 retinal toxicity
72 samples
73 significant waveform changes
74 signs
75 size
76 solvent evaporation method
77 stability
78 study
79 time
80 time points
81 toxicity
82 undesirable release
83 variability
84 vitreous humor
85 vivo evaluation
86 waveform changes
87 schema:name Preparation and in vivo evaluation of nanoliposomes containing melphalan after intravitreal injection in albino rabbits
88 schema:pagination 575-582
89 schema:productId N6a22d866b18b45cca041fae2d0216810
90 Nb08ee014d1e946599e938df796d30a0c
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006016728
92 https://doi.org/10.1007/s40005-016-0271-y
93 schema:sdDatePublished 2022-11-24T21:01
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher Nfeec6b6050cc40c89f04e7ef5fb7590d
96 schema:url https://doi.org/10.1007/s40005-016-0271-y
97 sgo:license sg:explorer/license/
98 sgo:sdDataset articles
99 rdf:type schema:ScholarlyArticle
100 N0a789a84ebe04d18a05d463e11a0fc44 rdf:first sg:person.01262431076.35
101 rdf:rest N536cc701f43b486f8839d49c542e0704
102 N140be7e72df54959bcc5b95b9ea18d2c rdf:first sg:person.01065306070.78
103 rdf:rest Nd88eb1e0a9e348459b3c9755fc03dd2b
104 N2fd103c4052a4cf7b4a3306088685ba2 rdf:first sg:person.01005406144.60
105 rdf:rest Nd8e4c1a437e6407ba79df0eecefb60a1
106 N4ad9b8b822b74e2d88be038c571f1285 rdf:first sg:person.0705730507.38
107 rdf:rest rdf:nil
108 N536cc701f43b486f8839d49c542e0704 rdf:first sg:person.01273462772.20
109 rdf:rest N57bbb46df33c465a801da01bd7627cfd
110 N57bbb46df33c465a801da01bd7627cfd rdf:first sg:person.0767501776.94
111 rdf:rest N2fd103c4052a4cf7b4a3306088685ba2
112 N5ef9d0268b7e47f98ba528ab020acb2a rdf:first sg:person.0750243113.14
113 rdf:rest N0a789a84ebe04d18a05d463e11a0fc44
114 N6a22d866b18b45cca041fae2d0216810 schema:name dimensions_id
115 schema:value pub.1006016728
116 rdf:type schema:PropertyValue
117 N6f73c90ace8f4576a92c36eddf6b2a95 rdf:first sg:person.01140070742.93
118 rdf:rest N4ad9b8b822b74e2d88be038c571f1285
119 Nb08ee014d1e946599e938df796d30a0c schema:name doi
120 schema:value 10.1007/s40005-016-0271-y
121 rdf:type schema:PropertyValue
122 Nbfe19ac23b78402385b575d6d0def13e schema:volumeNumber 46
123 rdf:type schema:PublicationVolume
124 Nca2775fdae10433bae7fa16cfce691cd schema:issueNumber 6
125 rdf:type schema:PublicationIssue
126 Nd88eb1e0a9e348459b3c9755fc03dd2b rdf:first sg:person.01022006153.85
127 rdf:rest N6f73c90ace8f4576a92c36eddf6b2a95
128 Nd8e4c1a437e6407ba79df0eecefb60a1 rdf:first sg:person.01140017233.20
129 rdf:rest N140be7e72df54959bcc5b95b9ea18d2c
130 Nfeec6b6050cc40c89f04e7ef5fb7590d schema:name Springer Nature - SN SciGraph project
131 rdf:type schema:Organization
132 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
133 schema:name Medical and Health Sciences
134 rdf:type schema:DefinedTerm
135 anzsrc-for:1113 schema:inDefinedTermSet anzsrc-for:
136 schema:name Ophthalmology and Optometry
137 rdf:type schema:DefinedTerm
138 sg:journal.1044391 schema:issn 2093-5552
139 2093-6214
140 schema:name Journal of Pharmaceutical Investigation
141 schema:publisher Springer Nature
142 rdf:type schema:Periodical
143 sg:person.01005406144.60 schema:affiliation grid-institutes:grid.411600.2
144 schema:familyName Kanavi
145 schema:givenName Mozhgan Rezaei
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005406144.60
147 rdf:type schema:Person
148 sg:person.01022006153.85 schema:affiliation grid-institutes:grid.490421.a
149 schema:familyName Pourmatin
150 schema:givenName Rama
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022006153.85
152 rdf:type schema:Person
153 sg:person.01065306070.78 schema:affiliation grid-institutes:grid.490421.a
154 schema:familyName Falavarjani
155 schema:givenName Khalil Ghasemi
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065306070.78
157 rdf:type schema:Person
158 sg:person.01140017233.20 schema:affiliation grid-institutes:grid.411583.a
159 schema:familyName Mosallaei
160 schema:givenName Navid
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140017233.20
162 rdf:type schema:Person
163 sg:person.01140070742.93 schema:affiliation grid-institutes:grid.411600.2
164 schema:familyName Safarian
165 schema:givenName Omid
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140070742.93
167 rdf:type schema:Person
168 sg:person.01262431076.35 schema:affiliation grid-institutes:grid.411583.a
169 schema:familyName Abrishami
170 schema:givenName Majid
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262431076.35
172 rdf:type schema:Person
173 sg:person.01273462772.20 schema:affiliation grid-institutes:grid.490421.a
174 schema:familyName Sedaghat
175 schema:givenName Ahad
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273462772.20
177 rdf:type schema:Person
178 sg:person.0705730507.38 schema:affiliation grid-institutes:grid.411583.a
179 schema:familyName Malaekeh-Nikouei
180 schema:givenName Bizhan
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705730507.38
182 rdf:type schema:Person
183 sg:person.0750243113.14 schema:affiliation grid-institutes:grid.490421.a
184 schema:familyName Naseripour
185 schema:givenName Masood
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750243113.14
187 rdf:type schema:Person
188 sg:person.0767501776.94 schema:affiliation grid-institutes:grid.411705.6
189 schema:familyName Abrishami
190 schema:givenName Mojtaba
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767501776.94
192 rdf:type schema:Person
193 sg:pub.10.1007/s10633-008-9155-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048157101
194 https://doi.org/10.1007/s10633-008-9155-4
195 rdf:type schema:CreativeWork
196 sg:pub.10.1038/eye.2012.175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039405881
197 https://doi.org/10.1038/eye.2012.175
198 rdf:type schema:CreativeWork
199 grid-institutes:grid.411583.a schema:alternateName Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, P.O. Box 91775-1365, Mashhad, Iran
200 Retina Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
201 School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
202 schema:name Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, P.O. Box 91775-1365, Mashhad, Iran
203 Retina Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
204 School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
205 rdf:type schema:Organization
206 grid-institutes:grid.411600.2 schema:alternateName Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
207 Shahid Beheshti University of Medical Sciences, Tehran, Iran
208 schema:name Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
209 Shahid Beheshti University of Medical Sciences, Tehran, Iran
210 rdf:type schema:Organization
211 grid-institutes:grid.411705.6 schema:alternateName Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
212 schema:name Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
213 Retina Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
214 rdf:type schema:Organization
215 grid-institutes:grid.490421.a schema:alternateName Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
216 schema:name Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
217 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...