TRAIL-Rezeptor-Agonisten, eine neue Klasse proapoptotischer Krebstherapeutika View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-03

AUTHORS

Kerstin Papenfuss, Silvia Prieske, Henning Walczak

ABSTRACT

Vor 10 Jahren konnten die Autoren erstmals zeigen, dass der „tumor necrosis factor-related apoptosis-inducing ligand“ (TRAIL) Apoptose spezifisch in Tumorzellen in vivo auslösen kann, ohne normale Zellen zu schädigen. Auf Grundlage dieser Ergebnisse ist die Biologie von TRAIL im zurückliegenden Jahrzehnt Gegenstand intensiver Forschung geworden. Dabei sind teils überraschende Erkenntnisse im Bereich der Signaltransduktion zutage getreten. Die Einbindung dieser aus der Krebsgrundlagenforschung stammenden Ergebnisse wird für die erfolgreiche klinische Entwicklung von TRAIL und agonistischen Antikörpern gegen die beiden apoptosevermittelnden TRAIL-Rezeptoren 1 und 2 von größter Bedeutung sein. In diesem Beitrag werden die Mechanismen TRAIL-induzierter apoptotischer und nichtapoptotischer Signaltransduktion zusammengefasst sowie Resistenzmechanismen und der derzeitige Entwicklungsstand von klinischen Studien, die einen TRAIL-Rezeptor-Agonisten beinhalten, diskutiert. More... »

PAGES

11-23

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  • Journal

    TITLE

    Onkopipeline

    ISSUE

    1

    VOLUME

    3

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    URI

    http://scigraph.springernature.com/pub.10.1007/s15035-010-0177-5

    DOI

    http://dx.doi.org/10.1007/s15035-010-0177-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053595544


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