Tumorvakzinierung beim metastasierten Nierenzellkarzinom View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-03

AUTHORS

Annkristin Heine, Tobias A. W. Holderried, Peter Brossart

ABSTRACT

Das Nierenzellkarzinom (NCC) zählt zu den immunogenen Tumoren, die kaum auf eine Strahlen- oder Chemotherapie ansprechen, so dass weitere, neue Therapieoptionen dringend notwendig sind. Zur Behandlung des NCC wurden in früheren Jahren zytokinbasierte immuntherapeutische Methoden entwickelt. Basierend auf den Ergebnissen aus der Grundlagenforschung und dem wachsenden Verständnis der Mechanismen in der Pathogenese des NCC sind vor kurzem sog. „targeted therapies“ mit Tyrosinkinaseinhibitoren wie Sorafenib oder Sunitinib bzw. mTOR-(„mammalian target of rapamycin“-) Inhibitoren etabliert worden. Alternativ wurden tumorspezifische, immunologisch vermittelte Behandlungsmethoden entwickelt. Dieses Review legt einen besonderen Schwerpunkt auf die Entwicklung von Vakzinierungen mit Hilfe von dendritischen Zellen, aber auch Probleme der Immuntherapie sowie mögliche alternative Ansätze und Kombinationsmöglichkeiten werden diskutiert. More... »

PAGES

4-10

Journal

TITLE

Onkopipeline

ISSUE

1

VOLUME

3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s15035-010-0176-6

DOI

http://dx.doi.org/10.1007/s15035-010-0176-6

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