Systemtherapie des Mammakarzinoms View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-12

AUTHORS

Julia Aigner, Andreas Schneeweiss

ABSTRACT

Das Mammakarzinom ist weltweit der häufigste bösartige Tumor der Frau mit über 1 Mio. Neuerkrankungen pro Jahr. Die relative 5-Jahres-Überlebenszeit beträgt über alle Tumorstadien gesehen 79% und hat sich gerade innerhalb der letzten Jahre aufgrund einer effektiveren, frühzeitigeren Diagnostik und einer leitlinienorientierten Systemtherapie verbessert. Über die Bestimmung von prognostischen und prädiktiven Faktoren wird versucht, den individuellen Krankheitsverlauf möglichst genau vorherzusagen und eine Aussage über das Ansprechen auf eine spezifische Therapie zu treffen. Darauf basierend wird die leitlinienorientierte Systemtherapie zusammengestellt. Gerade die Hormon- und Chemotherapien haben sich über die letzten 25 Jahre zu einem integralen und unverzichtbaren Bestandteil sowohl in der (neo)adjuvanten als auch in der palliativen Systemtherapie entwickelt. Die Metaanalysen der Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) haben wiederholt gezeigt, dass die systemischen Therapien, bestehend aus zytotoxischen Chemotherapien und/oder endokrinen Therapien, sowohl das rezidivfreie Überleben als auch das Gesamtüberleben signifikant verbessern. Zusätzlich wurden in den letzten Jahren die therapeutischen Optionen der (neo)adjuvanten und palliativen Systemtherapie durch die heterogene Gruppe der neuen zielgerichteten Therapien und durch die Bisphosphonate erweitert. Aufgabe der kommenden Jahre ist es einerseits, diese Optionen rasch weiterzuentwickeln und in den Standard zu integrieren, andererseits durch eine verbesserte Prädiktion und Prognoseabschätzung die Über-, Unter- und Fehlbehandlung zu reduzieren. More... »

PAGES

171-184

Journal

TITLE

Onkopipeline

ISSUE

4

VOLUME

2

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s15035-009-0166-8

DOI

http://dx.doi.org/10.1007/s15035-009-0166-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034153310


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